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microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

JOURNAL OF GENETICS AND GENOMICS 2024年第9期51卷 911-921页

作者： Chen, Xinghan Shen, Yueru Song, Zheng Wang, Xinliang Yao, Huaitong Cai, Yuan Zhao, Zi-Ang Hu, Bing Univ Sci & Technol China Hefei Natl Res Ctr Phys Sci Microscale Hefei 230026 Anhui Peoples R China Univ Sci & Technol China Ctr Adv Interdisciplinary Sci & Biomed IHM Div Life Sci & Med Hefei 230026 Anhui Peoples R China Univ Sci & Technol China Affiliated Hosp USTC 1 Div Life Sci & Med Hefei 230026 Anhui Peoples R China

MicroRNAs (miRNAs) play a significant role in axon regeneration following spinal cord injury. However, the functions of numerous miRNAs in axon regeneration within the central nervous system (CNS) remain largely unexplored. Here, we elucidate the positive role of microRNA-2184 (miR-2184) in axon regeneration within zebrafish Mauthner cells (M-cells). The upregulation of miR-2184 in a single M-cell can facilitate axon regeneration, while the specific sponge-induced silencing of miR-2184 leads to impeded regeneration. We show that syt3, , a downstream target of miR-2184, negatively regulates axon regeneration, and the regeneration suppression modulated by syt3 depends on its binding to Ca2 & thorn;. 2 & thorn; . Furthermore, pharmacological stimulation of the cAMP/PKA pathway suggests that changes in the readily releasable pool may affect axon regeneration. Our data indicate that miR-2184 promotes axon regeneration of M-cells within the CNS by modulating the downstream target syt3, , providing valuable insights into potential therapeutic strategies. Copyright (c) 2024, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

关键词： Axon regeneration Axon ablation miR-2184 syt3 Readily releasable pool READILY RELEASABLE POOL CA2+ SENSORS SMALL RNAS PHOSPHORYLATION SYNAPSES SPONGES FORM SIZE

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Hexapedal Robotic Platform for Amphibious Locomotion on Ground and Water Surface

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Journal of Bionic Engineering 2016年第1期13卷 39-47页

作者： HyunGyu Kim DongGyu Lee Yanheng Liu Kyungmin Jeong TaeWon Seo School of Mechanical Engineering Yeungnam University Gyeongsan 712-749 Republic of Korea Nuclear Convergence technology div. Korea Atomic Energy Research Institute Daejeon 305-353 Republic of Korea

Bio-inspiration is a starting point from which to design engineering products by learning the secrets of living creatures. We present the design, analysis, and experimental results of a robotic platform inspired by the basilisk lizard, which is well known for its ability to run on water surface. The goal is to develop a robotic platform for amphibious locomotion on ground and water using a single configuration. A tripod gait is achieved with a hexapedal configuration and four-bar-based repeated motion of the legs. The hexapedal configuration is empirically proven to have an advantage in terms of rolling stability on water. On ground, the tripod gait can satisfy the requirements of static stability to make the center of gravity and center of pressure occur at the same position. The footpad design was determined based on an empirical study of the rolling stability and lifting force. The theoretical background and experimental results are presented to validate the ability of the proposed design to run on water and on the ground.

关键词： amphibious locomotion bio-inspiration hexapedal empirical study water-running robot

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Low cycle fatigue behavior of high strength gun steels

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Journal of University of Science and technology Beijing 2004年第3期11卷 268-272页

作者： Maoqiu Wang Han Dong Qi Wang Changgang Fan div.sion of Structural Materials, Central Iron & Steel Research Institute, Beijing 100081, China div. of Structural Mat. Central Iron and Steel Res. Inst. Beijing 100081 China

The low cycle fatigue (LCF) behavior of two high strength steels, withnominal chemical compositions (mass fraction, %) of 0.40C-1.5Cr-3Ni-0.4Mo-0.2V (PCrNi3MoV) and0.25C-3Cr-3Mo-0.8Ni-0.1Nb (25Cr3Mo3NiNb), was investigated by using the smooth bar specimenssubjected to strained-controlled push-pull loading. It is found that both steels show cyclicsoftening, but 25Cr3Mo3NiNb steel has a lower tendency to cyclic softening. 25Cr3Mo3NiNb steel hashigher fatigue ductility, and its transition fatigue life is almost three times that of PCrNi3MoV.25Cr3Mo3NiNb steel also shows higher LCF life either at a given total strain amplitude above 0.5% orat any given plastic strain amplitude, despite its lower monotonic tensile strength than that ofPCrNi3MoV. It also means that 25Cr3Mo3NiNb steel can endure higher total strain amplitude andplastic strain amplitude at a given number of reversals to failure within 10~4. 25Cr3Mo3NiNb steelis expected to be a good gun steel with high LCF properties because only several thousand firingsare required for gun barrel in most cases.

关键词： high strength steel low cycle fatigue mechanical property

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Global classical solutions for 3D compressible magneto-micropolar fluids without resistivity and spin viscosity in a strip domain

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Science China Mathematics 2024年

作者： Zefu Feng Guangyi Hong Changjiang Zhu School of Mathematical Sciences Chongqing Normal University School of Mathematics South China University of Technology

In this paper, we consider 3D compressible magneto-micropolar fluids without resistivity and spin viscosity in a strip domain. The prominent character of the governing model is the presence of the microstructure,a linear coupling structure involving derivatives of the velocity fields, which along with the lack of spin viscosity brings several challenges to the analysis. By exploiting the two-tier energy method developed in Guo and Tice(Arch Ration Mech Anal, 2013), we prove the global existence of classical solutions to the governing model around a uniform magnetic field that is non-parallel to the horizontal boundary. Moreover, we show that the solution converges to the steady state at an almost exponential rate as time goes to infinity. One of the main ingredients in our analysis, compared with previous works on micropolar fluids, is that we deal with the microstructure by establishing some delicate estimates based on the analysis of the div.curl decomposition, and the coupling between the fluid velocity and the vorticity of angular velocity.

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Influence of WSD on Cross-Language Information Retrieval

Influence of WSD on Cross-Language Information Retrieval

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第一届自然语言处理联合学术会议

作者： In-Su Kang Seung-Hoon Na Jong-Hyeok Lee div. of Electrical and Computer Engineering Pohang University of Science and Technology（POSTECH）Advanced Information Technology Research Center（AITrc） div. of Electrical and Computer Engineering Pohang University of Science and Technology（POSTECH）Advanced Information Technology Research Center（AITrc） div. of Electrical and Computer Engineering Pohang University of Science and Technology（POSTECH）Advanced Information Technology Research Center（AITrc）

＜正＞Translation ambiguity is a major problem in dictionary-based cross-language information retrieval. This paper proposes a statistical word sense disambiguation （WSD） approach for translation ambiguity resolution. Then, with respect to CLIR effectiveness, the pure effect of a disambiguation module will be explored on the following issues: normalization of translation probability, contribution of disambiguation weight to target term weighting, influences of WSD performance. In our investigation, we do not use pretranslation or post-translation methods to exclude any mixing effects on CLIR.

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THE INVARIANT REPRESENTATION OF SPINS WITH APPLICATIONS IN THE THEORY OF FINITE DEFORMATIONS

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Acta Mechanica Sinica 1990年第2期6卷 133-140页

作者： Wang Wenbiao (div.of Physics,Graduate School Univ.of Science and technology of China,Beijing 100039)Duan Zhuping (Lab.for Non-linear Mechanics of Continuous Media,Institute of Mechanics,Academia Sinica,Beijing 100080) div. of Physics Graduate School Univ. of Science and Technology of China Beijing Lab. for Non-linear Mechanics of Continuous Media Institute of Mechanics Beijing

Based on the general solution given to a kind of linear tensor equations,the spin of a symmetric tensor is derived in an invariant *** result is applied to find the spins of the left and the tight stretch tensors and the relation among different rotation rate tensors has been *** to work conjugacy,the relations between Cauchy stress and the stresses conjugate to Hill's generalized strains are ***,the logarithmic strain,its time rate and the conjugate stress have been discussed in de- *** results are important in modeling the constitutive relations for finite deformations in continuum me- chanics.

关键词： spin generalized strain rate conjugate stress finite deformation

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Laser Surface Hardening of 9CrSi Steel

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Journal of Materials Science & technology 2002年第1期18卷 17-20页

作者： Nunghee RYU and Sunggoon KANGdiv.sion of Materials Science and Engineering, College of Engineering, Hanyang University, Korea [ Manuscript received August 7, 2001, in revised form September 20, 2001] div. of Mat. Sci. and Eng. Coll. of Eng. Hanyang Univ. Hanyang South Korea

The effects of laser hardening parameters such as beam power, beam diameter and scanning rate on microstructure and hardness of 9CrSi steel were investigated. The microstructure of the surface layer of 9CrSi steel was changed from pearlite to martensite, retained austenite and carbide by laser hardening. The depth of the hardened layer increased with increasing laser energy density and the surface hardeness increased by 3-5 times as high as the untreated steel. The laser hardened surface had good wear resistance due to martensite and carbide in the surface layer. The wear mode at low speed was abrasive, while the wear mode at high speed was adhesive.

关键词： Laser hardening Martensite Hardeness Phase trasformation

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Well-Posedness of Stochastic Continuity Equations on Riemannian Manifolds

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 81-122页

作者： Luca GALIMBERTI Kenneth H.KARLSEN Department of Mathematical Sciences NTNU Norwegian University of Science and TechnologyN-7491 TrondheimNorway Department of mathematics University of OsloP.O.Box 1053BlindernN-0316 OsloNorway

The authors analyze continuity equations with Stratonovich stochasticity,■ρ+div.[ρo(u(t,x)+∑_(i=1)^(N)a_(i)(x)w_(i)(t))]=0defined on a smooth closed Riemannian manifold M with metric *** velocity field u is perturbed by Gaussian noise terms Wi(t),:WN(t)driven by smooth spatially dependent vector fields a1(x),...,aN(x)on *** velocity u belongs to L_(t)^(1)W_(x)^(1,2)with div. u bounded in Lf,for p>d+2,where d is the dimension of M(they do not assume div.(h) u∈L_(t,x)^(∞)).For carefully chosen noise vector fields ai(and the number N of them),they show that the initial-value problem is well-posed in the class of weak L^(2) solutions,although the problem can be ill-posed in the deterministic case because of concentration *** proof of this“regularization by noise”result is based on a L^(2) estimate,which is obtained by a duality method,and a weak compactness argument.

关键词： Stochastic continuity equation Riemannian manifold Hyperbolic equa-tion Non-smooth velocity field Weak solution Existence Uniqueness

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SICE benchmark problem:starting speed control of SI engines

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Control Theory and technology 2019年第2期17卷 138-147页

作者： Junichi KAKO advanced Powertrain Planning&Management div.Toyota Motor Corporation ShizuokaJapan

Starting the engine and quickly adjusting the engine speed to the target value after that will always be a challenge for vehicles with an internal combustion engines at development sites in the automotive *** SICE Research Committee on advanced Powertrain Control Theory provided this task as a benchmark problem with the engine *** as control developers in the industry are provided actual engines,many of the academic experts have acquired engine models,analyzed behavior and constructed controls,and solved control *** summarize this activity by explaining the methods by many challengers that achieved the target performance.

关键词： Engine start control benchmark problem engine model

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Effect of annealing temperatures on dynamic impact mechanical properties of high manganese TWIP steel

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Baosteel Technical Research 2008年第1期2卷 37-40页

作者： Liang Gaofei Lin Changqing Fang Yuan advanced technology div. Baosteel Research Institute Baoshan Iron ＆ Steel Co. Ltd. Shanghai 201900 China

Results presented in this paper contribute to the investigation of the effect of annealing temperatures ranging from 800 to 1000 ℃ on the dynamic impact mechanical properties of high manganese TWIP steel. The properties were measured by using an instrumented Charpy impact tester. The impact absorbing energy initially increases with the annealing temperature, climaxes at 900 ℃, and then decreases. The dynamic crack extension resistance curve indicates that the crack initiation force decreases with the annealing temperature, and the steel annealed at 900 ℃ has the best ability against crack expansion

关键词： TWIP steel dynamics mechanical properties annealing

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