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Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering

bio-Design and Manufacturing 2019年第4期2卷 225-241页

作者： Joao bcosta Joana Silva-correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira Joao Espregueira-Mendes Rui LReis Joaquim M.Oliveira b′s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 Barco GmrPortugal IcVS/3b’s-PT Government Associate Laboratory Braga/GuimaraesPortugal The Discoveries centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017 BarcoGuimar'sPortugal Ripoll y De Prado Sports clinic:Murcia-Madrid FIFA Medical centre of Excellence MurciaSpain Orthopedic Department centro Hospitalar Póvoa de Varzim Vila do CondePortugal clínica do Dragao Espregueira-Mendes Sports CentreFIFA Medical Centre of ExcellencePortoPortugal Dom Henrique Research centre PortoPortugal Orthopedic Department University of MinhoBragaPortugal

The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TcP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. by its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMcs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TcP and SF16/TcP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patie

关键词： Patient-specific Indirect printing Hierarchical Silk fibroin Enzymatic-cross-linking Meniscus

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When insulating polymers meet conjugated polymers:the noncovalent bonding does matter

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Journal of Semiconductors 2023年第11期44卷 5-7页

作者： Zhonggao bu chengyi Xiao Jie Sun Weiwei Li Liming Ding beijing advanced Innovation center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029China center for Excellence in Nanoscience(cAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China

Insulating polymers are characterized by a predominantlyσ-covalent structure,which localize electrons in the atoms and exhibit *** polymers typically adopt a more linear and extended conformation,as the repeating units are connected by single covalent bonds,resulting in a relatively straight and extended chain *** most insulating polymers,the contour length(L_(c))is significantly larger than their persistence length(Lp)due to the rotation of c−c single bonds(Fig.1(a)).consequently,this leads to a flexible,random-coil chain *** structural feature contributes to the great mechanical durability and resistance to crack initiation during stretching or bending *** contrast,conjugated polymers possess aπ-conjugated molecular structure,allowing electron mobility along the main chain,called delocalization,which imparts semiconducting properties[1,2].The presence of rigid,alternating single and multiple bonds results in comparable Lc and Lp,thereby yielding a stiff or semi-flexible conformation(Fig.1(b))[3,4].As a consequence,most conjugated polymers are prone to fracture under low strain levels(<10%)[5−7].

关键词： structure conjugated bonds

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Ratiometric fluorescent Si-FITc nanoprobe for immunoassay of SARS-coV-2 nucleocapsid protein

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Nano Research 2023年第2期16卷 2859-2865页

作者： Guobin Mao Silu Ye Wen Yin Yang Yang Xinghu Ji Jin He Yingxia Liu Junbiao Dai Zhike He Yingxin Ma cAS Key Laboratory of Quantitative Engineering biology Guangdong Provincial Key Laboratory of Synthetic Genomics and Shenzhen Key Laboratory of Synthetic GenomicsShenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Agricultural Microbiology College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China college of chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China

coronavirus disease 2019(cOVID-19)highlights the importance of rapid and reliable diagnostic assays for the management of virus ***,we developed a one-pot hydrothermal method to prepare Si-FITc nanoparticles(NPs)for the fluorescent immunoassay of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)nucleocapsid protein(N protein).The synthesis of Si-FITc NPs did not need post-modification,which addressed the issue of quantum yield reduction during the coupling ***-FITc NPs showed two distinct peaks,Si fluorescence atλem=385 nm and FITc fluorescence atλem=490 *** the presence of KMnO_(4),Si fluorescence was decreased and FITc fluorescence was ***,in the presence of N protein,catalase(cAT)-linked secondary antibody/reporter antibody/N protein/capture antibody immunocomplexes were formed on ***,hydrogen peroxide(H_(2)O_(2))and Si-FITc NPs/KMnO_(4)were injected into the microplate *** decomposition of H_(2)O_(2)by cAT resulted in remaining of KMnO_(4),which changed the fluorescence intensity ratio of Si-FITc *** fluorescence intensity ratio correlated significantly with the N protein concentration ranging from 0.02 to 50.00 ng/mL,and the detection limit was 0.003 ng/mL,which was more sensitive than the commercial ELISA kit with a detection limit of 0.057 ng/*** N protein concentration can be accurately determined in human ***,the cOVID-19 and non-cOVID-19 patients were distinguishable by this ***,the ratiometric fluorescent immunoassay can be used for SARS-coV-2 infection diagnosis with a high sensitivity and selectivity.

关键词： Si-FITc nanoparticles ratiometric fluorescent probe SARS-coV-2 ELISA

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current molecular methods for the detection of hepatitis c virus in high risk group population:A systematic review

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World Journal of Virology 2015年第1期4卷 25-32页

作者： Rushna Firdaus Kallol Saha Aritra biswas Provash chandra Sadhukhan IcMR Virus Unit I.D and B.G Hospital CampusGB-4 (East Wing)BeliaghataKolkata 700010India

Hepatitis c virus(HcV) is an emerging infection worldwide and the numbers of persons infected are increasing every year. Poor blood transfusion methods along with unsafe injection practices are potential sources for the rapid spread of infection. Early detection of HcV is the need of the hour especially in high riskgroup population as these individuals are severely immunocompromised. Enzyme Immunoassays are the most common detection techniques but they provide no evidence of active viremia or identification of infected individuals in the antibody-negative phase and their efficacy is limited in individuals within high risk group population. Molecular virological techniques have an important role in detecting active infection with utmost specificity and sensitivity. Technologies for assessment of HcV antibody and RNA levels have improved remarkably, as well as our understanding of how to best use these tests in patient management. This review aims to give an overview of the different serological and molecular methods employed in detecting HcV infection used nowadays. Additionally, the review gives an insight in the new molecular techniques that are being developed to improve the detection techniques particularly in High Risk Group population who are severely immunocompromised.

关键词： Molecular detection Enzyme immunoassay High risk group population Nucleic acid amplification assays Polymerase chain reaction

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Tribological behaviour of AZ31 magnesium alloy reinforced by bimodal size b_(4)c after precipitation hardening

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Journal of Magnesium and Alloys 2022年第11期10卷 3267-3280页

作者： Seyed Kiomars Moheimani Azadeh Keshtgar Saeed Khademzadeh Morteza Tayebi Ali Rajaee Abdollah Saboori advanced Materials Research center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran Department of Research and Development Nejat Darya CompanyBoushehrIran center for Risk and Reliability University of MarylandCollege ParkMD 20742United States Department of Industrial Engineering University of Padova35131 PadovaItaly Young Researchers and Elites club Science and Research BranchIslamic Azad UniversityTehranIran Department of Materials and Polymer Engineering Hakim Sabzevari UniversitySabzevarIran Integrated Additive Manufacturing center(IAM) Department of Management and Production Engineering(DIGEP)Politecnico di TorinoCorso Duca Degli Abruzzi2410129TorinoItaly

This study investigated dry sliding wear properties of AZ31 magnesium alloy and b_(4)c-reinforced AZ31 composites containing 5, 10, and 20 wt.% b_(4)c with bimodal sizes under different loadings(10-80 N) at various sliding speeds(0.1-1 m/s) via the pin-on-disc *** evaluations showed that when the distribution of b_(4)c particles was uniform the hardness of the composites increased by enhancing the reinforcement content. The unreinforced alloy and the composite samples were examined to determine the wear mechanism maps and identify the dominant wear mechanisms in each wear condition and reinforcement content. For this purpose, wear rates and friction coefficients were recorded during the wear tests and worn surfaces were characterized by scanning electron microscopy and energy dispersive X-ray spectrometry analyses. The determined wear mechanisms were abrasion, oxidation, delamination, adhesion, and plastic deformation as a result of thermal softening and melting. The wear evaluations revealed that the composites containing 5 and 10 wt.% b_(4)c had a significantly higher wear resistance in all the conditions. However, 20 wt.% b_(4)c/AZ31 composite had a lower resistance at high sliding speeds(0.5-1 m/s) and high loadings(40-80 N) in comparison with the unreinforced alloy. The highest wear resistance was obtained at high sliding speeds and low loadings with the domination of oxidative wear.

关键词： b_(4)c AZ31 alloy Metal matrix composite Wear mechanism bimodal

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Intrinsic Mechanisms of Morphological Engineering and carbon Doping for Improved Photocatalysis of 2D/2D carbon Nitride Van Der Waals Heterojunction

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Energy & Environmental Materials 2023年第3期6卷 96-106页

作者： Jinqiang Zhang Xiaoli Zhao Lin chen Shuli Li Haijun chen Yuezhao Zhu Shuaijun Wang Yang Liu Huayang Zhang Xiaoguang Duan Mingbo Wu Shaobin Wang Hongqi Sun School of Engineering Edith Cowan University270 Joondalup DriveJoondalupWA 6027Australia college of chemical Engineering China University of Petroleum(East china) Qingdao 266580China Jiangsu Key Laboratory of Process Enhancement and New Energy Equipment Technology School of Mechanical and Power EngineeringNanjing Tech UniversityNanjing 211816China center for Integrated Nanostructure Physics Institute for Basic Science(IBS)Sungkyunkwan UniversitySuwon 16419Republic of Korea School of chemical Engineering and advanced Materials The University of AdelaideAdelaide SA 5005Australia State Key Laboratory of Heavy Oil ProcessingInstitute of New EnergyCollege of Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China

Van der Waals(VDW)heterojunctions in a 2D/2D contact provide the highest area for the separation and transfer of charge *** this work,a top-down strategy with a gas erosion process was employed to fabricate a 2D/2D carbon nitride VDW heterojunction in carbon nitride(g-c_(3)N_(4))with carbon-rich carbon *** created 2D semiconducting channel in the VDW structure exhibits enhanced electric field exposure and radiation absorption,which facilitates the separation of the charge carriers and their ***,compared with bulk g-c_(3)N_(4)and its nanosheets,the photocatalytic performance of the fabricated carbon nitride VDW heterojunction in the water splitting reaction to hydrogen is improved by 8.6 and 3.3 times,respectively,while maintaining satisfactory ***,the finite element method(FEM)was employed to evaluate and clarify the contributions of the formation of VDW heterojunction to enhanced photocatalysis,in agreement quantitatively with experimental *** study provides a new and effective strategy for the modification and more insights to performance improvement on polymeric semiconductors in photocatalysis and energy conversion.

关键词： carbon nitride Van der Waals heterojunctions enhanced electric field exposure improved radiation absorption photocatalytic water splitting promoted dynamics of charge carriers

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Synthesis and Evaluation of Glyceride Prodrugs of Naproxen

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Open Journal of Medicinal chemistry 2013年第3期3卷 87-92页

作者： Vivekkumar K. Redasani Sanjay b. bari H. R. Patel Institute of Pharmaceutical Education and Research Shirpur India R. c. Patel Institute of Pharmaceutical Education and Research Shirpur India

The glyceride ester derivatives 6a and 6b were prepared by reacting 1,2,3-trihydroxy propane 1,3-dipalmitate/stearate with (S)-naproxen as potential prodrugs. The synthesis was achieved successfully with the aid of N,N’-dicyclohexyl- carbodiimide. These prodrugs were evaluated for anti inflammatory, analgesic and gastroprotective activity. It was found that prodrugs 6a and 6b showed less irritation to gastric mucosa as indicated by ulcer index. The synthesized glyceride esters were found to possess good pharmacological profile as shown by results of anti inflammatory and analgesic activity. The aqueous studies were performed in order to ensure the release of prodrugs. both prodrugs were found to stable at acidic pH while undergoes hydrolysis at pH 7.4. These findings suggest that the glyceride prodrugs 6a and 6b might be used as potential biolabile derivatives.

关键词： Naproxen Glyceride Prodrugs Anti-Inflammatory Analgesic Gastroprotective Hydrolysis Kinetics

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Photocatalytic Decarboxylative Minisci Reaction catalyzed by Palladium-Loaded Gallium Nitride

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Precision chemistry 2023年第7期1卷 437-442页

作者： Lida Tan Hyotaik Kang Mingxin Liu Hui Su Jing-Tan Han chao-Jun Li Department of chemistry and FQRNT Centre for Green Chemistry and CatalysisMcGill UniversityMontrealQC H3A 0B8Canada State Key Laboratory of Applied Organic chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhouGansu 730000China

The decarboxylative Minisci reaction is a versatile tool for the direct c-H alkylation of heteroarenes,where stoichiometric amounts of oxidants or expensive,precious metal reagents are commonly ***,we reported a photodriven decarboxylative Minisci reaction enabled by a gallium nitride-based heterogeneous photocatalyst under mild *** method can be effectively applied to a broad substrate scope of acids,including primary,secondary,and tertiary carboxylic acids and N-heteroarenes *** practic.b.lity and robustness of the approach are demonstrated for the functionalization of biologically active compounds.

关键词： Heterogeneous catalysis Minisci reaction Photocatalytic decarboxylation N-heteroarenes c-H alkylation Gallium nitride

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中性化离子束在横向磁场中的传输

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强激光与粒子束 1989年第2期1卷 118-128页

作者：李仁骏 A.Fisher 范茹玉 A.Ron N.Rostoker F.J.Wessel 中国原子能科学研究院 Dept.of physics U.c.I 西北核技术研究所 Physics Dept T.H.I Dept.of Physics U.c.I

在真空介质中,由两种磁绝缘离子二极管产生的中性化离子束在横向磁场中b(?)400Gs传输了2m以上的距离反磁信号以及极化电场测量证实:不论在低β0.01<β<1或在高β情况(1<β<300)下。束传输的机制都是由于的漂移结果。其中β=4πnm_1r_n^... 详细信息

在真空介质中,由两种磁绝缘离子二极管产生的中性化离子束在横向磁场中b(?)400Gs传输了2m以上的距离反磁信号以及极化电场测量证实:不论在低β0.01b^2。是束能量密度与横向磁场能量密度之比。在高β下,我们观察到磁场b向束中的快速扩散。

关键词：中性化离子束磁场传输二极管

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Water absorption characteristics of canarium Schweinfurthii fruits

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Information Processing in Agriculture 2019年第3期6卷 386-395页

作者： James chinaka Ehiem Victor Ifeanyichukwu Obiora Ndirika Udochukwu Nelson Onwuka Yvan Gariepy Vijayan Raghavan Department of Agricultural and bio-Resources Engineering Michael Okpara University of AgricultureUmudikeP.M.B.7267UmuahiaAbia StateNigeria Department of bioresources Engineering McGill UniversityMacdonald Campus21111 LakeshoreSte-Anne-de-BellevueQuebec H9X 3V9Canada

Water absorption characteristics of two varieties of canarium Schweinfurthii ***(canarium Schweinfurthii *** and short)essential for predicting their suitable absorption conditions was investigated at three different temperatures(35,50,65c).Increase in moisture content of the fruits was measured at one-hour interval until constant values were obtained after five successive intervals of moisture *** of soluble constituents,textural and nutritive qualities of the rehydrated products and their thermodynamic.b.havior were also measured and *** results obtained revealed that saturation time for 35,50 and 65c of long and short varieties are 14,18 and 40 h and 18,22 and 36 h *** of absorption of the fruits differ significantly(p>0.05)with temperature and not with the *** absorption rate of canarium Schweinfurthii *** and short varieties are 2.71 and 2.25 kg/h *** moisture bearing capacity,textural,and nutritive qualities of the reconstituted products showed no significant difference among varieties at different temperatures *** soaked at 35c produced reusable residual water,retained their nutritive values and soluble constituent more than other soaking temperatures ***,the absorption reaction is endothermic with negative entropy and Gibbs energy values were above *** model had the best quality for describing the absorption characteristics of both canarium Schweifurthii ***.

关键词： Absorption canarium Thermodynamics Temperature Fruits Moisture

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