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Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: a retrospective study

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Burns & Trauma 2021年第1期9卷 454-463页

作者： Moris Topaz Itamar Ashkenazi Oren Barzel Seema Biswas Dan Atar Nurit Shadmi Itzhak Siev-Ner Sheba Medical Center Ramat GanIsrael Hillel Yaffe Medical Center HaderaIsrael Rambam Medical Center HaifaIsrael Galilee Medical Center NahariyaIsrael Soroka Medical Center Beer ShevaIsrael adi negev rehabilitation hospital MerhavimIsrael

Background:Following combat-related,extensive soft tissue injury from gunshot wounds or blasts,prolonged duration from injury to full wound closure is associated with infection,increased morbidity and mortality,failure to mobilize,poor functional outcome and increased *** purpose of this study was to evaluate a novel treatment enabling early primary closure of combat ***:This was a retrospective study of 10 soldiers and civilians with extensive combat-related soft tissue limb injuries(5 gunshot wounds,5 blasts)treated using the TopClosure^(■)Tension Relief System(TRS)with simultaneous administration of regulated oxygen-enriched and irrigation negative pressure-assisted wound therapy(ROINPT)via the Vcareα^(■)***:Nine patients were treated during the acute phase of injury and one was treated following removal of a flap due to deep infection 20 years after injury and flap *** patients had upper limb injury and the rest lower limb *** the aid of the TRS and/or ROINPT,immediate primary closure during reconstruction was achieved in 6 patients and delayed primary closure in *** one patient required a skin graft to close a small area of the wound after most of the wound had been closed by delayed primary *** closure was achieved within 0–37 days(median:12.5 days,interquartile range:2.75–19.75)from ***:The TRS is a novel device for effective,early skin stretching and secure wound closure through the application of stress relaxation and mechanical creep,achieving primary closure of large defects using a simplified surgical technique and reducing the need for closure using skin grafts and flaps and the use of tissue *** supplemental oxygen to the wound by ROINPT reverses the reduced oxygen levels inherent in conventional negative pressure-assisted wound therapy,mitigating anaerobic contamination and reducing *** may accelerate the evacuation of infectious materia

关键词： Soft tissue injury Combat injuries Limb injuries Stress relaxation Mechanical creep Tension relief systems

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Osteogenic Effect of Low Intensity Pulsed Ultrasound on Rat adipose-derived Stem Cells in vitro

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第1期32卷 75-81页

作者：江渟许涛郭风劲陈安民肖铮铮张迪 Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Orthopedics the Third Affiliated HospitalAnhui Medical Univeristy Department of rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

The osteogenic in vitro effect of low intensity pulsed ultrasound (LIPUS) on SD rat adi-pose-derived stem cells (ADSCs) was *** ADSCs underwent LIPUS (intensity=100 mW/cm2) or sham exposure for 8 min per treatment once everyday in vitro,and then the alkaline phos-phatase (ALP) activity and mineralized nodule formation were assessed to evaluate the osteogenic effect of LIPUS on *** further explore the underlying mechanism,the osteogenic-related gene mRNA expression was determined by using reverse transcriptase-polymerase chain reaction (RT-PCR) at 1st,3rd,5th,7th day after exposure *** blot was used to evaluate the protein expression levels of two osteogenic differentiation associated genes at 7th and 14th day *** was found that ALP activity was increased after LIPUS exposure and LIPUS resulted in mineralized nodule formation of ADSCs in ***-treated ADSCs displayed higher mRNA expression levels of runt-related transcription factor 2 (Runx2),osteocalcin (OCN),ALP and bone sialoprotein (BSP) genes than con-trols,and the protein levels of Runx2 and BSP were also *** results suggested that LIPUS may induce the osteogenic differentiation of ADSCs in vitro.

关键词： low intensity pulsed ultrasound adipose-derived stem cells osteogenic differentiation

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