检索结果-南通市图书馆

同方期刊数据库

Studies on sensitivity to tension and gating pathway of MscL by molecular dynamic simulation

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2013年第2期29卷 256-266页

作者： Jun-Yu Xie Guang-Hong Ding Mechanics and Engineering science Fudan University Shanghai research center of acupuncture and Maridians

Mechanosensitive（MS） ion channels play an important role in various physiological *** the determination of the structure of mechanosensitive channel of large conductance（MscL） makes the simulation study possible,it has not so far been possible to directly simulate the gating mechanism of MscL in atomic *** this article,MscL has been studied via molecular dynamic（MD） simulations to gain a detailed description of the sensitivity to lateral tension and the gating *** undergoes conformational rearrangement in sustaining lateral tension,and the open state is obtained when 2.0 MPa lateral tension is directly applied on the pure *** the opening process,Loop region responds to tension first,and the mechanical sensitivity is followed by S1 ***（TM） bundle is the key position for channel opening,and the motion of TM1 helices finally realizes the significant expansion of the constricted gating pore.C-terminus domain presents expansion later during the TM *** our study,return of the whole protein to the initial closed state is achieved only in the early opening *** the relaxation from the open state,the TM helices are the most mobile domain,which is different from the opening process.

关键词： Molecular dynamic simulation·MscL·Lateral tension·Sensitivity·Gating pathway

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei Xiong center of Materials science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Hypothesis, Modern researches and Clinical Applications of Cutaneous Regions in Traditional Chinese Medicine

在线全文

学校读者我要写书评

暂无评论

Journal of acupuncture and Tuina science 2014年第2期12卷 125-130,I0001,I0002页

作者： Fan Lei Yin Lei-miao Shanghai research Institute of acupuncture and meridian

As one of the most important concepts in traditional Chinese medicine, cutaneous regions have a close relationship with skin in modern medicine. According to the doctrine of traditional Chinese medicine, the cutaneous regions are the corresponding projections of twelve meridians in the superficial layer of the body and play an important role in body surface-viscera correlation. The symptoms of visceral disorders will reflect on cutaneous regions and one of the major patterns of manifestation is referred visceral pain accompanied by tenderness and hyperalgesia on the body surface. On the contrary, cutaneous regions participate in the treatment of visceral disorders. As major clinical applications of the cutaneous regions hypothesis, superficial acupuncture, subcutaneous needling, massage(tuina), moxibustion, and wrist-ankle acupuncture have achieved favorable therapeutic outcomes in clinical practice. Modern researches have gained insights into the biological background of cutaneous regions, however, further studies are needed to clarify the mechanisms.

关键词： Cutaneous Regions Body Surface-viscera Correlation Superficialacupuncture Subcutaneous Needling Massage Tuina MoxibustionTherapy Wrist-ankle acupuncture

acupuncture for migraine without aura:a systematic review and metaanalysis

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2018年第5期16卷 312-321页

作者： Jia Xu Fu-qing Zhang Jian Pei Jun Ji Department of acupuncture Longhua HospitalShanghai University of Traditional Chinese Medicine Literature and Information Section Shanghai Research Institute of Acupuncture and Meridian

Background： Migraine without aura （MWoA）, the most common type of migraine, has great impacts on quality of life for migraineurs. acupuncture is used in the treatment and prevention of migraine for its analgesic effects. Objective： The aim of this systematic review and meta-analysis is to systematically assess the therapeutic and preventive effect of acupuncture treatment and its safety for MWoA,Search strategy： Nine electronic databases （PubMed, MEDLINE, Cochrane Library, Lilacs, Embase, China National Knowledge Infrastructure （CNKI）, Chongqing VIP （CQV1P）, Wanfang Data and Chinese Clinical Trial Registry （ChiCTR）） were systematically searched from their beginning through June 2017 using MeSH terms such as ＂acupuncture, acupuncture therapy, electro-acupuncture, ear acupuncture, acupuncture points, acupuncture analgesia,＂ and ＂migraine disorders, cluster headache.＂ Manual searching included other conference abstracts and reference lists. Inclusion criteria： Randomized controlled trials （RCTs） with a clinical diagnosis of MWoA, which were treated with acupuncture versus oral medication or sham acupuncture treatment. Data extraction and analysis： Two evaluators screened and collected literature independently; they extracted information on participants, study design, interventions, follow-up, withdrawal and adverse events and assessed risk of bias and quality of the acupuncture intervention. The primary outcomes were frequency of migraine （FM） and number of migraine days （NM）. Secondary outcomes included the visual analogue scale （VAS） score, effective rate （ER） and adverse events. Pooled estimates were calculated as mean difference （MD） with 95% confidence interval （CI） for continuous data and relative risk （RR） with 95% CI for dichotomous data. Results： Overall, 14 RCTs including 1155 participants were identified. The analysis found that acupunc- ture had a significant advantage over medication in reducing FM （MD）=-1.50; 95% CI： -2.32 to -0.68; P〈 0.001） and VAS scor

关键词： acupuncture Migraine without aura Meta-analysis Systematic review

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine research center JiujiangJiangxi ProvinceChina center for Cognitive science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan Bing Hu center for Advanced Interdisciplinary science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Oceanic science Letters 2025年第1期18卷 24-31页

作者： Tiantian Tang Jiaying He Huihang Sun Jingjia Luo Institute for Climate and Application research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

Monogenic gene therapy for glaucoma and optic nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli Guo Takayuki Harada Visual research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

Contralateral S1 function is involved in electroacupuncture treatment-mediated recovery after focal unilateral M1 infarction

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2022年第6期17卷 1310-1317页

作者： Lu-Lu Yao Si Yuan Zhen-Nan Wu Jian-Yu Luo Xiao-Rong Tang Chun-Zhi Tang Shuai Cui Neng-Gui Xu South China research center for acupuncture and Moxibustion Medical College of Acupuncture Moxibustion and RehabilitationGuangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina research Institute of acupuncture and meridian Anhui University of Chinese MedicineHefeiAnhui ProvinceChina

acupuncture at acupoints Baihui(GV20)and Dazhui(GV14)has been shown to promote functional recovery after ***,the contribution of the contralateral primary sensory cortex(S1)to recovery remains *** this study,unilateral local ischemic infarction of the primary motor cortex(M1)was induced by photothrombosis in a mouse ***(EA)was subsequently performed at acupoints GV20 and GV14 and neuronal activity and functional connectivity of contralateral S1 and M1 were detected using in vivo and in vitro electrophysiological recording *** results showed that blood perfusion and neuronal interaction between contralateral M1 and S1 is impaired after unilateral M1 *** neuronal excitability and activity were also disturbed,which was rescued by ***,the effectiveness of EA treatment was inhibited after virus-mediated neuronal ablation of the contralateral *** conclude that neuronal activity of the contralateral S1 is important for EA-mediated recovery after focal M1 *** study provides insight into how the S1-M1 circuit might be involved in the mechanism of EA treatment of unilateral cerebral *** animal experiments were approved by the Committee for Care and Use of research Animals of Guangzhou University of Chinese Medicine(approval No.20200407009)April 7,2020.

关键词： brain plasticity electroacupuncture electrophysiology recording neuronal activity primary motor cortex primary sensory cortex stroke