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The Patatin-Containing Phospholipase A pPLAIIα Modulates Oxylipin Formation and Water Loss in Arabidopsis thaliana

Molecular Plant 2012年第2期5卷 452-460页

作者： Wen-Yu Yang Yong Zheng Sung Chul Bahn Xiang-Qing Pan Mao-Yin Li Hieu Sy Vu Mary R.Roth Brad Scheu Ruth Welt Yue-Yun Hong Xue-Min Wang Department of Biology University of MissouriSt LouisMO 63121USA Donald Danforth Plant Science Center St LouisMO 63132USA Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life SciencesHuaZhong Normal UniversityWuhan 430079China Kansas Lipidomics Research Center Division of BiologyKansas State UniversityManhattanKS 66506USA National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China

The patatin-related phospholipase A （pPLA） hydrolyzes membrane glycerolipids to produce monoacyl compounds and free fatty acids. Phospholipids are cleaved by pPLAIIα at the sn-1 and sn-2 positions, and galactolipids, including those containing oxophytodienoic acids, can also serve as substrates. Ablation of pPLAIIα decreased lysophosphatidylcholine and lysophosphatidylethanolamine levels, but increased free linolenic acid. pPLAIIα-deficient plants displayed a higher level of jasmonic acid and methyl jasmonate, as well as the oxylipin-biosynthetic intermediates 13-hydroperoxylinolenic acid and 12-oxophytodienoic acid than wild-type （WT） plants. The expression of genes involved in oxylipin production was also higher in the pPLAIlec-deficient mutant than in WT plants. The mutant plants lost water more quickly than WT plants. The stomata of WT and mutant plants responded similarly to abscisic acid. In response to desiccation, the mutant and WT leaves produced abscisic acid at the same rate, but, after 4 h of desiccation, the jasmonic acid level was much higher in mutant than WT leaves. These results indicate that pPLAIIα negatively regulates oxylipin production and suggest a role in the removal of oxidatively modified fatty acids from membranes.

关键词： patatin-related phospholipase A oxidative modified lipids jasmonate synthesis water loss Arabidopsis thaliana.

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核用304不锈钢辐照促进应力腐蚀开裂研究

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金属学报 2019年第3期55卷 349-361页

作者：邓平孙晨彭群家韩恩厚柯伟焦治杰中国科学院金属研究所中国科学院核用材料与安全性评价重点实验室沈阳110016 中国科学技术大学材料科学与工程学院沈阳110016 国家电投集团科学技术研究院有限公司北京102209 苏州热工研究院有限公司苏州215004 Department of Nuclear Engineering and Radiological sciences University of Michigan

采用2 MeV质子束在360℃对国产核用304不锈钢试样进行了辐照实验,利用高温高压水环境的慢应变速率拉伸实验(SSRT)和SEM、EBSD、TEM等研究了核用304不锈钢辐照促进应力腐蚀开裂(IASCC)机理。结果表明,慢应变速率拉伸过程中辐照促进材料... 详细信息

采用2 MeV质子束在360℃对国产核用304不锈钢试样进行了辐照实验,利用高温高压水环境的慢应变速率拉伸实验(SSRT)和SEM、EBSD、TEM等研究了核用304不锈钢辐照促进应力腐蚀开裂(IASCC)机理。结果表明,慢应变速率拉伸过程中辐照促进材料晶界和表面滑移台阶处形成应变集中,且其程度随辐照剂量增加而增加。滑移台阶穿过或终止于晶界,终止于晶界的台阶造成晶界处产生不连续滑移,易将位错传输到晶界,在晶界区域形成位错塞积和残余应变集中。而台阶不连续滑移的形成则受毗邻晶粒的Schmidt因子对的类型影响。另一方面,辐照促进晶界发生贫Cr富Ni元素偏析,其偏析程度随辐照剂量增加而增加。SSRT实验后辐照试样表面发生明显的沿晶应力腐蚀开裂,且裂纹数量随辐照剂量和外加应变增加而增加。同时,裂纹尖端区域发生明显晶界腐蚀,且氧化物宽度和长度随辐照剂量增加而增加。分析认为,辐照致晶界应变集中和元素偏析的协同作用造成材料变形行为和晶界腐蚀行为变化是IASCC发生的关键因素。

关键词：核用不锈钢质子辐照局部变形腐蚀辐照促进应力腐蚀开裂

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Early Diagnosis of Lung Tumors for Extending Patients’ Life Using Deep Neural Networks

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Computers, Materials & Continua 2023年第7期76卷 993-1007页

作者： A.Manju R.Kaladevi Shanmugasundaram Hariharan Shih-Yu Chen Vinay Kukreja Pradip Kumar Sharma Fayez Alqahtani Amr Tolba Jin Wang Department of Computer Science and Engineering SRM Institute of Science and TechnologyRamapuramChennaiIndia Department of Computer Science and Engineering Saveetha Engineering CollegeChennaiIndia Department of Computer Science and Engineering Vardhaman College of EngineeringHyderabadIndia Department of Computer Science and Information Engineering National Yunlin University of Science and TechnologyYunlin 64002Taiwan Intelligence Recognition Industry Service Research Center National Yunlin University of Science and TechnologyYunlin 64002Taiwan Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Department of Computing Science University of AberdeenAberdeenUK Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh 12372Saudi Arabia Computer Science Department Community CollegeKing Saud UniversityRiyadh 11437Saudi Arabia School of Computer&Communication Engineering Changsha University of Science&TechnologyChangshaChina

The medical community has more concern on lung cancer *** experts’physical segmentation of lung cancers is time-consuming and needs to be *** research study’s objective is to diagnose lung tumors at an early stage to extend the life of humans using deep learning ***-Aided Diagnostic(CAD)system aids in the diagnosis and shortens the time necessary to detect the tumor *** application of Deep Neural Networks(DNN)has also been exhibited as an excellent and effective method in classification and segmentation *** research aims to separate lung cancers from images of Magnetic Resonance Imaging(MRI)with threshold *** Honey hook process categorizes lung cancer based on characteristics retrieved using several *** this principle,the work presents a solution for image compression utilizing a Deep Wave Auto-Encoder(DWAE).The combination of the two approaches significantly reduces the overall size of the feature set required for any future classification process performed using *** proposed DWAE-DNN image classifier is applied to a lung imaging dataset with Radial Basis Function(RBF)*** study reported promising results with an accuracy of 97.34%,whereas using the Decision Tree(DT)classifier has an accuracy of 94.24%.The proposed approach(DWAE-DNN)is found to classify the images with an accuracy of 98.67%,either as malignant or normal *** contrast to the accuracy requirements,the work also uses the benchmark standards like specificity,sensitivity,and precision to evaluate the efficiency of the *** is found from an investigation that the DT classifier provides the maximum performance in the DWAE-DNN depending on the network’s performance on image testing,as shown by the data acquired by the categorizers themselves.

关键词： Lung tumor deep wave auto encoder decision tree classifier deep neural networks extraction techniques

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基于辣椒基因组测序探究辣味在种群中的进化

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辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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Lipopolysaccharide Enhances the Production of Nicotine-Induced Prostaglandin E2 by an Increase in Cyclooxygenase-2 Expression in Osteoblasts

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Acta Biochimica et Biophysica Sinica 2007年第3期39卷 163-172页

作者： Maiko SHOJI Natsuko TANABE Narihiro MITSUI Naoto SUZUKI Osamu TAKEICHI Tomoko KATONO Akira MOROZUMI Masao MAENO Department of Oral Health sciences Nihon University School of DentistryTokyo 101-8310Japan Division of Functional Morphology Dental Research Center.Nihon University School ofDentistryTokyo 101-8310Japan Nihon University Grndudte School of Dentistry Tokyo 101-8310Japan Division of Functional Morphology Dental Research Center.Nihon University School of DentistryTokyo 101-8310Japan Department of Endodontics Nihon University School of DentisityTokyo 101-8310Japan Division of Advanced Dental Treatment Dental Research CenterNihon University School of DentistryTokyo 101-8310Japan Nihon University Graduate School of Dentistry Tokyo 101-8310Japan

Previous studies have indicated that lipopolysaccharide（LPS）from Gram-negative bacteria inplaque induces the release of prostaglandin E2（PGE2）,which promotes alveolar bone resorption in periodontitis,and that tobacco smoking might be an important risk factor for the development and severity of *** determined the effect of nicotine and LPS on alkaline phosphatase（ALPase）activity,PGE2production,and the expression of cyclooxygenase（COX-1,COX-2）,PGE2receptors Ep1-4,and macrophage colonystimulating factor（M-CSF）in human osteoblastic Saos-2 *** cells were cultured with 10-3M nicotinein the presence of 0,1,or 10μg/ml LPS,or with LPS *** activity decreased in cells cultured withnicotine or LPS alone,and decreased further in those cultured with both nicotine and LPS,whereas PGE2production significantly increased in the former and increased further in the *** itself,nicotine did notaffect expression of COX-1,COX-2,any of the PGE2receptors,or M-CSF,but when both nicotine and LPSwere present,expression of COX-2,Ep3,Ep4,and M-CSF increased *** addition of10-4M indomethacin eliminated the effects of nicotine and LPS on ALPase activity,PGE2production,and M-CSF *** of protein kinase A was high in cells cultured with nicotine and *** suggest that LPS enhances the production of nicotine-induced PGE2by an increase in COX-2 expres-sion in osteoblasts,that nicotine-LPS-induced PGE2interacts with the osteoblast Ep4 receptor primarily inautocrine or paracrine mode,and that the nicotine-LPS-induced PGE2then decreases ALPase activity andincreases M-CSF expression.

关键词： nicotine lipopolysaccharide prostaglandin E2 cyclooxygenase-2 Ep4 receptor

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崩塌滑坡堵江堰塞湖灾害链铁路减灾选线策略

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铁道标准设计 2019年第6期63卷 17-22页

作者：王承振姚令侃黄艺丹 Sarfraz Ali 西南交通大学土木工程学院成都610031 高速铁路线路工程教育部重点实验室成都610031 陆地交通地质灾害防治技术国家工程实验室成都610031 National University of sciences and Technology (NUST) College of Civil Engineering Pakistan24080

青藏高原南缘是崩塌滑坡堵江形成堰塞湖灾害链的高风险区,而我国铁路缺乏应对堰塞湖灾害的经验。铁路灾后改建工程线路优化设计将产生直接减灾效益,而新建铁路在选线阶段就采取一些主动减灾策略,也是风险调控的重要手段。为此,以中巴经... 详细信息

青藏高原南缘是崩塌滑坡堵江形成堰塞湖灾害链的高风险区,而我国铁路缺乏应对堰塞湖灾害的经验。铁路灾后改建工程线路优化设计将产生直接减灾效益,而新建铁路在选线阶段就采取一些主动减灾策略,也是风险调控的重要手段。为此,以中巴经济走廊中拟建哈维连至喀什铁路Attabad堰塞湖段为研究对象,根据堰塞湖灾害特点,通过将改建工程分段设计,并对不同改建线路方案进行技术经济指标比较,完成该段改建线路设计。基于上述工作,提出以有利地形控制溢流口开挖深度、宜尽量利用既有工程、在离开湖区后集中展线尽快与既有线联接、有条件时可提高限制坡度等灾后绕湖铁路选线设计要点与高位选线、酌情预留提高限坡措施的条件、尽量不跨河等新建铁路减灾选线设计策略,希望为铁路应对崩塌滑坡堵江堰塞湖灾害链提供参考。

关键词：铁路选线方案比选滑坡堵江减灾策略堰塞湖灾害链

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Time-Reversal UWB Positioning Beacon for railway Application

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Wireless Engineering and Technology 2013年第1期4卷 28-39页

作者： Bouna Fall Fouzia Elbahhar Marc Heddebaut Atika Rivenq Université Lille Nord de France Lille France Institut Francais des sciences et Technologies des Transports de L’aménagement et des Réseaux (IFSTTAR) Laboratoire Electronique Ondes et Signaux Pour les Transports (LEOST) Villeneuve d’Ascq France Université Lille Nord de France Lille France Institut Francais des sciences et Technologies des Transports de L’aménagement et des Réseaux (IFSTTAR) Laboratoire Electronique Ondes et Signaux Pour les Transports (LEOST) Villeneuve d’Ascq France Université de Valenciennes et du Hainaut-Cambrésis (UVHC) Institut D’électronique de Microélectronique et de Nanotechnologie (IEMN) Département Opto-Acousto-Electronique (DOAE) Valenciennes France Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) Villeneuve d’Ascq France Université Lille Nord de France Lille France Université de Valenciennes et du Hainaut-Cambrésis (UVHC) Institut D’électronique de Microélectronique et de Nanotechnologie (IEMN) Département Opto-Acousto-Electronique (DOAE) Valenciennes France Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) Villeneuve d’Ascq France

This paper studies a new positioning beacon for railway transport using Ultra Wideband (UWB) radio and Time Reversal (TR) techniques. UWB radio has the potential to offer a good level of performance in terms of localization accuracy. Time Reversal channel pre-filtering facilitates signal detection and also helps increasing the received energy in the targeted area. In this paper, we evaluate the characteristics of TR technique in terms of temporal focusing. The theoretical and simulation results for Power Delay Profile, equivalent channel model and focusing gain of TR-UWB are given. We analyze the contribution of Time Reversal associated with UWB technology to enhance the localization resolution. The IEEE 802.15.3achannel models are used to evaluate the performance of this system. In terms of localization error, the theoretical and simulation results show that TR-UWB technique delivers improved performance over the UWB localization approach.

关键词： UWB Time Reversal Focusing Gain Channel Model Power Delay Profile TDOA Localization Error

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VERNAUZATION1 Modulates Root System Architecture in Wheat and Barley

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Molecular Plant 2018年第1期11卷 226-229页

作者： Kai P. Voss-Fels Hannah Robinson Stephen R. Mudge Cecile Richard Saul Newman Benjamin Wittkop Andreas Stahl Wolfgang Friedt Matthias Frisch lulian Gabur Anika Miller-Cooper Bradley C. Campbell Alison Kelly Glen Fox Jack Christopher Mandy Christopher Karine Chenu Jerome Franckowiak Emma S. Mace Andrew K. Borrell Howard Eagles David R. Jordan Jose R. Botella Graeme Hammer lan D. Godwin Ben Trevaskis Rod J. Snowdon Lee T. Hickey Department of Plant Breeding IFZ Research Centre for Biosystems Land Use and Nutrition Justus Uebig University Heinrich-Buff-Ring 26-32 35392 Giessen Germany Queensland Alliance for Agriculture and Food Innovation The University of Queensland St Lucia QLD 4072 Australia School of Agriculture and Food sciences The University of Queensland Brisbane QLD 4072 Australia CSIRO Agriculture Canberra ACT 2601 Australia Department of Biometry and Population Genetics IFZ Research Centre for Biosystems Land Use and Nutrition Justus Liebig University Heinrich-Buff-Ring 26-32 35392 Giessen Germany Department of Agriculture and Fisheries Leslie Research FacilRy Toowoomba QLD 4350 Australia Queensland Alliance for Agriculture and Food Innovation The University of Queensland roowoomba QLD 4350 Australia Department of Agronomy and Plant Genetics University of Minnesota St Paul MN USA Department of Agriculture and Fisheries Hermitage Research Facility Warwick QLD 4370 Australia Queensland Alliance for Agriculture and Food Innovation Hermitage Research Facility The University of Queensland Warwick QLD 4370 Australia These authors contributed equally to this article.

Dear Editor Roots play a key role in plant growth regulation. It is well described that the below-ground plant architecture has a significant impact on plant performance under abiotic constraints and maintains stabili...

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Determination of the best materials for development and designing product using a multi-criteria decision-making

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railway sciences 2024年第5期3卷 541-557页

作者： Rabia Hassan Zeeshan Ahmad Arfeen Mehreen Kausar Azam Zain ul Abiden Akhtar Abubakar Siddique Department of Management Economicsand Industrial Engineering DIGPolitecnico di MilanoMilanItaly Department of Electrical Engineering College of Engineering and SciencesInstitute of Business Management SindhKarachiPakistan Department of Electrical Engineering The Islamia University of Bahawalpur PakistanBahawalpurPakistan Department of Industrial Manufacturing NED University of Engineering and TechnologyKarachiPakistan Department of Information and Communication Engineering The Islamia University of Bahawalpur PakistanBahawalpurPakistan Department of Electrical Engineering Khwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan Muhammad Rashid Department of Electrical Engineering Faculty of ScienceThe Islamia University of Bahawalpur PakistanBahawalpurPakistan

Purpose–Material selection,driven by wide and often conflicting objectives,is an important,sometimes difficult problem in material *** this context,multi-criteria decision-making(MCDM)methodologies are *** approach of MCDM is needed to cater to criteria of material assortment *** firms are now concerned about increasing their productivity using mathematical *** occupy a gap in the previous literature this research recommends an integrated MCDM and mathematical Bi-objective model for the selection of *** addition,by using the Technique for Order Preference by Similarity to Ideal Solution(TOPSIS),the inherent ambiguities of decision-makers in paired evaluations are considered in this *** goes on to construct a mathematical bi-objective model for determining the best item to ***/methodology/approach–The entropy perspective is implemented in this paper to evaluate the weight parameters,while the TOPSIS technique is used to determine the best and worst intermediate pipe materials for automotive exhaust *** intermediate pipes are used to join the components of the exhaust *** materials usually used to manufacture intermediate pipe are SUS 436LM,SUS 430,SUS 304,SUS 436L,SUH 409 L,SUS 441 L and SUS *** seven materials are evaluated based on tensile strength(TS),hardness(H),elongation(E),yield strength(YS)and cost(C).A hybrid methodology combining entropy-based criteria weighting,with the TOPSIS for alternative ranking,is pursued to identify the optimal design material for an engineered application in this *** study aims to help while filling the information gap in selecting the most suitable material for use in the exhaust intermediate *** that,the authors searched for and considered eight materials and evaluated them on the following five criteria:(1)TS,(2)YS,(3)H,(4)E and(5)*** first two criteria have been chosen because they can have a lot of influence on the behav

关键词： TOPSIS Multi-criteria decision-making Entropy method Material selection

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冰川区铁路选线要点——以中巴经济走廊为例

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铁道科学与工程学报 2020年第10期17卷 2485-2492页

作者：韩笑姚令侃魏永幸黄艺丹 Sarfraz Ali 西南交通大学土木工程学院四川成都610031 西南交通大学高速铁路线路工程教育部重点实验室四川成都610031 西南交通大学陆地交通地质灾害防治技术国家工程实验室四川成都610031 中铁二院工程集团有限责任公司四川成都610031 National University of sciences and Technology(NUST)College of Civil Engineering Pakistan 24080

中巴经济走廊是“一带一路倡议”的先试区和重点项目区,拟建中巴铁路是其重要组成部分,但铁路行经的喀喇昆仑山脉为全球山谷冰川最发育的区域,我国尚无在冰川区修建铁路的经验。鉴此,以中巴经济走廊Gilgit至Khunjerb段为研究区,研究沿... 详细信息

中巴经济走廊是“一带一路倡议”的先试区和重点项目区,拟建中巴铁路是其重要组成部分,但铁路行经的喀喇昆仑山脉为全球山谷冰川最发育的区域,我国尚无在冰川区修建铁路的经验。鉴此,以中巴经济走廊Gilgit至Khunjerb段为研究区,研究沿线大陆性冰川、海洋性冰川和跃动冰川的分布以及各类冰川的活动性特点,定义冰川直接作用区和间接作用区且分析相应的成灾模式,并据此提出选线要点;最后针对中巴铁路沿线四大冰川群,分别提出选线设计建议。研究成果对冰川区铁路选线设计具有普适性指导意义。

关键词：中巴经济走廊铁路选线冰川活动性减灾策略

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