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Influencing factors of early post-traumatic stress disorder in young and middle-aged individuals with open globe injuries in west China:a cross-sectional study

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International Journal of ophthalmology(English edition) 2025年第1期18卷 146-153页

作者： Yi-Man Li Xin Zhang Ji-Hong Zeng Hong-Mei Luo Department of ophthalmology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these ***:A total of 280 patients who underwent ocular trauma surgery between January 2023 and January 2024 were selected through convenience *** were collected using a custom-designed demographic questionnaire,the Connor-Davidson Resilience Scale(CDRISC),the Cognitive Emotion Regulation Questionnaire(C-ERRI),and the PTSD Checklist-Civilian Version(PCL-C).Univariate analysis and stepwise multiple linear regression analysis were performed to determine the factors affecting PTSD in these ***:The average PTSD score for the patients was 33.22±*** scores for individual PTSD dimensions,ranked from highest to lowest,were recurrent traumatic experiences,heightened arousal,avoidance reactions,and social *** PTSD symptoms were observed in 85 patients(30.36%).Univariate analysis indicated that gender,postoperative vision,marital status,psychological resilience,and rumination were significant factors affecting PTSD symptoms(χ^(2)/t=6.53,17.88,8.83,2.17,and 14.1,respectively;all P<0.05).Pearson correlation analysis showed a positive correlation between rumination and PTSD symptoms(r=0.73,P<0.01)and a negative correlation between psychological resilience and PTSD symptoms(r=-0.14,P<0.05).Stepwise multiple linear regression analysis identified postoperative vision(notably eye removal),rumination levels,and psychological resilience(optimism)as major factors influencing PTSD in these patients(R^(2)=0.57,P<0.001).CONCLUSION:Young and middle-aged patients with open globe injuries have a high incidence of *** risk factors for early PTSD include primary enucleation,high levels of rumination,and low psychological resilience(optimism).Conversely,patients with good postoperative vision recovery,low rumination l

关键词： young and middle-aged open globe injuries post-traumatic stress disorder rumination psychological resilience

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Corneal lipid degeneration following herpes zoster ophthalmicus keratitis

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International Journal of ophthalmology(English edition) 2025年第1期18卷 181-183页

作者： Asako Kodama Fumitaka Kobayashi Department of ophthalmology Eiju General HospitalTokyo 110-8645Japan

Dear Editor,I am *** Kodama,affiliated with the Department of ophthalmology at Eiju General Hospital in Tokyo,***-zoster virus(VZV)induces two distinct states:the primary infection(varicella)and secondary endogenous reactivation of latent VZV in herpes zoster *** herpes zoster lesions typically manifest on the trunk and abdomen,the most frequently involved cranial nerve is the trigeminal nerve.

关键词： zoster degeneration herpes

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Vitreous amyloidosis caused by Lys55Asn mutation in TTR with peripheral neuropathy onset:a case report of FAP-related complications

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International Journal of ophthalmology(English edition) 2025年第1期18卷 184-186页

作者： Yi-Wen Xue Yi-Qin Xiao Department of ophthalmology Huashan HospitalFudan UniversityShanghai 200040China

Dear Editor,We present a case of vitreous amyloidosis in a patient who was previously confirmed as familial amyloidosis polyneuropathy(FAP)because of peripheral neuropathy symptom *** though the patient had already undergone liver transplantation 5y prior,the extracellular deposition of amyloid in vitreous body greatly infected the patient’s visual function.

关键词： amyloid neuropathy function.

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A cross-sectional study of the association between dietary inflammatory index and glaucoma prevalence in a US population

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International Journal of ophthalmology(English edition) 2025年第1期18卷 139-145页

作者： Wen-Li Chen Li-Xia Zhang Department of ophthalmology Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000Zhejiang ProvinceChina Eye Hospital China Academy of Chinese Medical SciencesBeijing 100040China

AIM:To assess the relationship between dietary inflammatory index(DII)and prevalence of glaucoma among individuals aged 40y and above in the United ***:Participants were drawn from 2 cycles of the National Health and Nutrition Examination Survey(NHANES,2005-2008)for a cross-sectional *** was calculated from 24-hour dietary recall questionnaire conducted by experienced researchers and data analyzed in R according to the NHANES user guide,“Stratified Multi-stage Probability Sampling”.The relationship between DII and glaucoma was evaluated by multi-factor logistic regression analysis and the existence of a non-linear association examined by restricted cubic spline(RCS)***:A total of 5359 subjects were included and the cross-sectional analysis weighted to represent the US population of 109 *** was elevated in glaucoma patients(P<0.001)and smoking and alcohol use contributed to significant differences(P<0.001).DII correlated negatively with Healthy Eating Index(HEI)-2015(Spearman rank correlation coefficient,r=-0.49).RCS analysis showed a linear relationship between DII and glaucoma risk(P of non-linear relationship=0.575).CONCLUSION:An increased DII is strongly associated with high risk of glaucoma and diet-induced inflammation should be controlled to delay glaucoma progression.

关键词： glaucoma risk factors dietar y inflammatory index National Health and Nutrition Examination Survey restricted cubic spline regression cross-sectional study

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Lycium barbarum polysaccharide inhibits retinal neovascularization and inflammation in vitro and in vivo

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International Journal of ophthalmology(English edition) 2025年第2期18卷 216-221页

作者： Bin Wu Xue Wang Wei Zhang Xin Wang Qi-Miao Wang Ya-Ju Pang Yi-Chun Kong Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteClinical College of Ophthalmology Tianjin Medical UniversityTianjin 300102China Department of ophthalmology Tianjin Hospital of Integrated Traditional Chinese and Western MedicineTianjin 300100China

AIM:To explore the effect and mechanism of Lycium barbarum polysaccharide(LBP)inhibiting retinal ***:In vitro tests were performed on human retinal microvascular endothelial cells(HRECs)from three groups,including control group(normal oxygen),hypoxic group(hypoxia at 37℃,1%O_(2),5%CO_(2),and 94%N2),and LBP group(hypoxic group with LBP 100μg/mL).In vivo experiments,C57 mice were divided into three groups:control group(normal rearing group),the oxygen-induced ischemic retinopathy(OIR)group,and the OIR with 50 mg/kg LBP *** neovascularization was observed by fluorescein angiography and *** thickness was evaluated by Hematoxylin and eosin(HE)*** expression of epidermal growth factor receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),mammalian target of rapamycin(mTOR),phosphorylated mammalian target of rapamycin(p-mTOR),protein kinase B(AKT),phosphorylated protein kinase B(p-AKT),interleukin-1β(IL-1β),inducible nitric oxide synthase(iNOS),and tumor necrosis factor-α(TNF-α)in each group were analyzed by Western ***-1βlevel in retina was analyzed using immunohistochemical ***:The increased area of neovascular clusters in OIR mice was significantly decreased by *** thickness of OIR mice was significantly thinner compared with normal oxygenated mice and was increased in LBP *** with those in the hypoxic groups,Western blotting of HRECs and retinal tissues revealed that the expression of EGFR,PI3K,p-mTOR,p-AKT,IL-1β,iNOS,and TNF-αdecreased in the LBP group but was still greater than that in control ***,IL-1βwas reduced in retinal sections treated with *** the scratch test,the cell migration of the hypoxic group was significantly greater than that of the control group,while LBP treatment attenuated this increase in ***:LBP reduces retinal neovascularization and inflammation in vivo and inhibits the migration of HRECs in vitro by regulating the EGFR/PI3K/Akt

关键词： Lycium barbarum polysaccharide neovascularization epidermal growth factor receptor retina

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A new tube chamber system for evaluation of anterior chamber pressure during phacoemulsification tested in porcine eyes

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International Journal of ophthalmology(English edition) 2025年第1期18卷 9-14页

作者： Fumiaki Higashijima Makoto Hatano Manami Ohta Tadahiko Ogata Takuya Yoshimoto Atsushige Ashimori Makiko Wakuta Kazuhiro Kimura Department of ophthalmology Yamaguchi University Graduate School of MedicineUbe CityYamaguchi 755-8585Japan

AIM:To measure the optimal anterior chamber pressure(ACP)for safe phacoemulsification using a new tube chamber system with internal pressure measurement function in the porcine ***:The 20-gauge and 21-gauge straight tips with yellow and orange sleeves,respectively,were covered by a test chamber combined with a pressure sensor for measuring *** was measured for 20s from 10s after starting aspiration in the linear mode using vacuum levels of 200 and 150 mm Hg with a 20-gauge tip,and 300 and 250 mm Hg with a 21-gauge *** a porcine eye,a pressure sensor fixed with a 0.9 mm corneal incision measured *** the posterior capsule contact assay,porcine eyes were treated as described above,and the ultrasonic needle tip was held at the height of the iris and aspirated for 30s in linear mode at a vacuum of 200 and 150 mm Hg for the 20-gauge tip,and 300 and 250 mm Hg for the 21-gauge *** bottle height at which the posterior capsule accidentally contacted the ultrasonic tip was recorded,and the estimated ACP was ***:The internal pressure of the new tube chamber system and ACP from the porcine eye closely matched proportional changes at vacuum levels of 200 and 150 mm Hg with 20-gauge ***,proportional changes at vacuum levels of 300 and 250 mm Hg with the 21-gauge tip were nearly *** bottle height at which the posterior capsule contacted with the tip and estimated ACP were 57.5±12.6 cm(20.2±7.9 mm Hg)at 200 mm Hg with a 20-gauge tip,35.0±10.0 cm(16.6±6.3 mm Hg)at 150 mm Hg with a 20-gauge tip,47.5±12.6 cm(18.7±8.7 mm Hg)at 300 mm Hg with a 21-gauge tip,and 32.5±5.0 cm(15.7±3.5 mm Hg)at 250 mm Hg with a 21-gauge ***:A comprehensive understanding of this chamber system’s characteristics and usage can resolve anterior chamber instability caused by changing preoperative settings on the phaco machine.

关键词： test chamber cataract surgery settings anterior chamber stability

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Mitochondrial transplantation:a promising strategy for the treatment of retinal degenerative diseases

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Neural Regeneration Research 2025年第12期20卷 3370-3387页

作者： Jing Chi Bin Fan Yulin Li Qing Jiao Guang-Yu Li Department of ophthalmology The Second Norman Bethune Hospital of Jilin UniversityChangchunJilin ProvinceChina

The retina,a crucial neural tissue,is responsible for transforming light signals into visual information,a process that necessitates a significant amount of ***,the primary powerhouses of the cell,play an integral role in retinal physiology by fulfilling the high-energy requirements of photoreceptors and secondary neurons through oxidative *** a healthy state,mitochondria ensure proper visual function by facilitating efficient conversion and transduction of visual ***,in retinal degenerative diseases,mitochondrial dysfunction significantly contributes to disease progression,involving a decline in membrane potential,the occurrence of DNA mutations,increased oxidative stress,and imbalances in quality-control *** abnormalities lead to an inadequate energy supply,the exacerbation of oxidative damage,and the activation of cell death pathways,ultimately resulting in neuronal injury and dysfunction in the *** transplantation has emerged as a promising strategy for addressing these *** procedure aims to restore metabolic activity and function in compromised cells through the introduction of healthy mitochondria,thereby enhancing the cellular energy production capacity and offering new strategies for the treatment of retinal degenerative *** mitochondrial transplantation presents operational and safety challenges that require further investigation,it has demonstrated potential for reviving the vitality of retinal *** review offers a comprehensive examination of the principles and techniques underlying mitochondrial transplantation and its prospects for application in retinal degenerative diseases,while also delving into the associated technical and safety challenges,thereby providing references and insights for future research and treatment.

关键词： age-related macular degeneration Leber’s hereditary optic neuropathy mitochondrial transfer mitochondrial transplantation retinal degenerative diseases

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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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Anatomic characteristics of the lacrimal sac and adjacent bony structures–a computed tomographicdacryocystography research

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International Journal of ophthalmology(English edition) 2025年第2期18卷 251-257页

作者： Xin-Han Cui Yan-Wen Fang Li-Min Zhang Ji-Ni Qiu Chao-Ran Zhang Yan Wang Eye Institute and Department of ophthalmology Eye and ENT Hospital of Fudan UniversityShanghai 200031China NHC Key laboratory of Myopia and Related Eye Diseases Key Laboratory of Myopia and Related Eye DiseasesChinese Academy of Medical SciencesShanghai 200031China Shanghai Key Laboratory of Visual Impairment and Restoration Shanghai 200031China Department of ophthalmology Children’s Hospital of KaifengKaifeng 475000Henan ProvinceChina

AIM:To describe the anatomic characteristics of the lacrimal sac and its adjacent bone structures and to provide surgical recommendations for endoscopic dacryocystorhinostomy(EN-DCR).METHODS:This retrospective comparative study involved 118 sides with complete nasolacrimal duct obstruction and 83 unaffected sides from 126 *** tomographic-dacryocystography(CT-DCG)scans were performed before lacrimal surgery,and image reconstruction was used to obtain continuous 0.75-mm axial,coronal,and segmental sections for *** morphology of the lacrimal sac and its relationship with adjacent bony structures were determined for measurement,as well as the obstructed ***:The height of the lacrimal sac was 12.99±2.10 mm in this *** operculum of the middle turbinate(OMT)was located vertically in the lower third of the lacrimal ***,the junction between the maxillary bone and the lacrimal bone(MB-LB)was close to,mostly(60.2%)posterior to,the lacrimal *** uncinate process was more frequently attached to the lacrimal bones(75.1%).The obstructions were generally located around the entrance of the nasolacrimal duct(NLD).However,some were placed higher,with 7.63%blocked not lower than the *** was a negative correlation between the diameter of the lacrimal sac and the level of obstruction(r=-0.35,P<0.01).CONCLUSION:In this study,the OMT and MB-LB can be served as the landmarks in *** uncinectomy should be performed in most *** obstructions were generally located around the entrance of the NLD,but some extreme individual variations strongly implies the importance of CT-DCG scanning before surgery.

关键词： lacrimal sac nasolacrimal duct obstruction endoscopic dacryocystorhinostomy computed tomographic-dacryocystography

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An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing

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Chinese Chemical Letters 2025年第2期36卷 307-313页

作者： Jiajia Wang XinXin Ge Yajing Xiang Xiaoliang Qi Ying Li Hangbin Xu Erya Cai Chaofan Zhang Yulong Lan Xiaojing Chen Yizuo Shi Zhangping Li Jianliang Shen National Engineering Research Center of ophthalmology and Optometry Eye HospitalWenzhou Medical University School of Chemical Engineering Nanjing University of Science&Technology School&Hospital of Stomatology Wenzhou Medical University Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of Sciences The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital

Diabetic wound healing is often complicated due to bacterial infections that intensify inflammation. Employing hydrogel dressings with inherent antibacterial properties can significantly reduce reliance on antibiotics for treating infected wounds in diabetics. Traditional hydrogels typically rely on the infiltration of bacteria into their porous structure to manifest antibacterial effects. However, this infiltration process is not only prolonged but can also exacerbate inflammation, further delaying the healing of the ***, promptly capturing and eliminating bacteria is crucial for enhancing the antibacterial efficiency of the hydrogel. In this context, we present a multifunctional hydrogel dressing, termed SIP, designed to tackle drug-resistant bacterial infections in diabetic wounds. This dressing integrates ionic liquid functional groups into a sericin-based matrix: phenylboronic acid for the immobilization of bacteria and imidazole for their subsequent annihilation. Expectedly, the SIP system demonstrates potent antibacterial activity against methicillin-resistant Staphylococcus aureus, verified through in vitro and in vivo experiments. As a result, SIP emerges as a promising candidate in the realm of hydrogel dressings with innate antibacterial properties, showcasing considerable potential for addressing diabetic wounds plagued by drug-resistant bacterial infections.

关键词： Diabetic wound healing Hydrogels Ionic liquids Methicillin-resistant Staphylococcus aureus infection Sericin

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