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短、长及有覆膜的CP支架用于儿童和成人主动脉缩窄、肺动脉和腔静脉狭窄治疗以及fontan吻合术:对53例患者60个支架的评估

世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 52-53页

作者： Ewert P. Schubert S. Peters B. 任付先 abteilung für angeborene herzfehler Deutsches Herzzentrum Berlin Augustenburger Platz 1 13353 Berlin Germany

Objective: To evaluate the feasibility and usefulness of the Cheatham platinum(CP) stent in a broad spectrum of lesions. Methods: retrospective analysis of 60 implanted CP stents(11-80 mm lengths, 12 covered) between September 2001 and March 2004. Patients: 53 patients aged 2.5-68 years(median 17 years). Body weight ranged from 12-95 kg(median 52 kg). Thirty six patients had aortic(re)coarctation; seven of them had functionally interrupted aortic arches. Thirteen patients had pulmonary artery stenosis and four had stenosis of caval veins or conduits in a total cavopulmonary connection(TCPC). results: Arterial pressure gradients dropped from 33 mmHg(range 20-80 mmHg) to 5 mmHg(range 0-10 mmHg) and pressure gradients in TCPC or caval veins dropped from 4 mm Hg(range 4-20 mmHg) to 0 mmHg(range 0-3 mmHg). All stents were placed in the target lesion without complications. Three stent fractures without clinical instability were noted. Conclusions: The CP stent is suitable for the treatment of vessel stenosis in congenital heart diseases from childhood to adulthood. Whether these good results will be stable in the long term needs to be investigated.

关键词：支架治疗 CP fontan 主动脉缩窄腔静脉靶病变交通支压力梯度先天性心脏病 platinum

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关于bosentan治疗先天性心脏病合并肺动脉高压成年患者的首次开放性、前瞻性、多中心研究

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 31-31页

作者： Schulze-Neick I. Gilbert N. Ewert r. 任付先 abteilung fü r angeborene herzfehler Deutsches Herzzentrum Berlin Augustenburger Platz 1 13353 Berlin Germany Dr.

Background: Endothelin receptor antagonism has been introduced as an effective oral therapy of patients with idiopathic pulmonary arterial hypertension. In view of the pathophysiologic and histologic similarities between idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease(PAH-CHD), there is a rationale for treating these patients with the oral dual(ETA/ETB) endothelin receptor antagonist bosentan. Methods: Thirty-three patients with PAH-CHD(43± 14 years, 23 with Eisenmenger syndrome) were treated with bosentan for a mean of 2.1± 0.5 years. Efficacy was assessed by a panel of tests, including New York Heart Association functional class, 6-minute walking distance, and echocardiographic and hemodynamic parameters. results: Mean 6-minute walking distance increased from 362± 105 to 434± 68 m(P=.001). New York Heart Association class also improved significantly(3.1 to 2.4, P=.0001). This was associated with slight trends in improvements of transcutaneous oxygen saturation(86% ± 7% to 88% ± 7% , P=.13) and maximum oxygen uptake(13.2± 4.0 to 14.9± 2.5, P=.18). right ventricular systolic pressure measured by echocardiographic decreased from 111± 32 to 106± 22 mm Hg(P=.001). Bosentan treatment was well tolerated by all patients. Conclusions: Long-term bosentan treatment in adult patients with PAH-CHD was well tolerated and improved functional status as well as exercise capacity. These findings have to be corroborated by controlled studies that are presently ongoing.

关键词：肺动脉特发性肺动脉高压先天性心脏病心脏先天畸形 bosentan 成年患者

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用组织多普勒应变成像检测法洛四联症修补术后右束支传导阻滞患者的左心室不同步

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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 60-60页

作者： Abd El rahman M.Y. Hui W. Yigitbasi M. H. Abdul-Khaliq 吴波 Dr.Klin. f. angeborene herzfehler/K. Deutsches Herzzentrum Berlin D-13353 Berlin Germany

OBJECTIVES: We aimed to investigate whether patients after tetralogy of fallot(TOf) repair with right bundle branch block have left ventricular(LV) asynchrony and to assess the influence of ventricular asynchrony on regional and global LV function. BACKGrOUND: Patients after TOf repair usually have right bundle branch block. However, no data regarding LV asynchrony in this group are available. METHODS: Twenty-five patients after TOf repair and 25 age-matched healthy control subjects were studied. The regional myocardial deformation of the interventricular septum(IVS) and the LV lateral wall were examined using tissue-Doppler-derived strain. The time interval between the onset of QrS complex and the peak strain was measured for each wall. According to the difference between LV and septum time intervals among the normal subjects, a normal range(mean±2 SD) was plotted, and TOf patients in whom the difference was beyond the normal range were considered to have LV asynchrony. The Tei index was used to assess global LV function. rESULTS: Thirteen(52%) of the examined patients after TOf repair had LV asynchrony. Patients after TOf repair with LV asynchrony had a significantly reduced regional septal systolic strain(pficantly elevated Tei index(pred with those without. CONCLUSIONS: Left ventricular asynchrony may exist in patients after TOf repair with right bundle branch block. This LV asynchrony is associated with a reduction of both regional and global LV function.

关键词：法洛四联症组织多普勒右束支传导阻滞左心室波群室间隔时间间隔指数评价收缩应变

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