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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Role of surgery and transplantation in the treatment of hepatic metastases from neuroendocrine tumor

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World Journal of Gastroenterology 2014年第39期20卷 14348-14358页

作者： Sayee Sundar Alagusundaramoorthy Roberto Gedaly Division of transplantation Department of Surgery University of Kentucky College of Medicine Lexington KY 40536 United States

Neuroendocrine tumors(NET) are a heterogeneous group of cancers, with indolent behavior. The most common primary origin is the gastro-intestinal tract but can also appear in the lungs, kidneys, adrenals, ovaries and other organs. In general, NET is usually discovered in the metastatic phase(40%-80%). The liver is the most common organ involved when metastases occur(40%-93%), followed by bone(12%-20%) and lung(8%-10%).A number of different therapeutic options are available for the treatment of hepatic metastases including surgical resection, transplantation, ablation, trans-arterial chemoembolization, chemotherapy and somatostatin analogues. Recently, molecular targeted therapies have been used, usually in combination with other treatment options, to improve outcomes in patients with metastases. This article emphasizes on the role of surgery in the treatment of liver metastases from NET.

关键词： Neuroendocrine tumors Liver metastases Hepatectomy Liver transplantation

Multimodal treatment of hepatocellular carcinoma on cirrhosis: An update

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World Journal of Gastroenterology 2013年第42期19卷 7316-7326页

作者： Marco Vivarelli Roberto Montalti Andrea Risaliti Hepatobiliary and abdominal transplantation surgery Department of Gastroenterology and TransplantationPolytechnic University of Marche60129 AnconaItaly Department of surgery and transplantation University of Udine33100 UdineItaly

Hepatocellular carcinoma(HCC)is the most frequent primary liver tumor,and overall,it is one of the most frequent *** association of HCC with chronic liver disease,and cirrhosis in particular,is well known,making treatment complex and *** treatment of HCC must take into account the presence and stage of chronic liver disease,with the aim of preserving hepatic function that is often already impaired,the stage of HCC and the clinical condition of the *** different treatment options include surgical resection,transplantation,local ablation,chemoembolization,radioembolization and molecular targeted therapies;these treatments can be combined in various ways to achieve different ***,liver transplantation is best treatment for early stage HCC on cirrhosis because it removes both the tumor and the chronic disease that produced it;however,the application of this powerful tool is limited by the scarcity of *** and bridging are different strategies for the management of HCC patients who will undergo liver *** professionals,including gastroenterologists,radiologists and surgeons,are involved in the choice of the most appropriate treatment for a single case,and a multidisciplinary approach is necessary to optimize the *** purpose of this review is to provide a comprehensive description of the current treatment options for patients with HCC by analyzing the advantages,disadvantages and rationale for their use.

关键词： Hepatocellular carcinoma Multimodal treatment Locoregional treatments Molecular targeted therapies Liver resection Liver transplantation

Liver transplantation for colorectal metastasis: a stepwise approach

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Hepatobiliary surgery and Nutrition 2020年第3期9卷 336-338页

作者： Axel Andres Christian Toso abdominal surgery and transplantation Geneva University Hospital Geneva Switzerland

Six years after publishing their first results on liver transplantation for colorectal liver metastases(SECA-I)(1),Dueland et al.

关键词： colorectal metastasis al.

Using old liver grafts for liver transplantation: Where are the limits?

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World Journal of Gastroenterology 2014年第31期20卷 10691-10702页

作者： Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero Iago Justo Alonso Cristina Alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González Service of General and Digestive surgery and abdominal Organ transplantation "Doce de Octubre" University Hospital

The scarcity of ideal liver grafts for orthotopic liver transplantation (OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts.

关键词： Old liver donors Liver transplantation Aging liver Liver graft Liver disease Aging Donor management Septuagenarian donors Octogenarian donors

Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma-a multicenter study under the aegis of the French Association of Hepato-Biliary surgery and liver transplantation

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Hepatobiliary surgery and Nutrition 2023年第2期12卷 192-204,I0002-I0004页

作者： Charlotte Maulat Stéphanie Truant Christian Hobeika Louise Barbier Astrid Herrero Alexandre Doussot Johan Gagnière Édouard Girard Hadrien Tranchart Jean-Marc Regimbeau David Fuks François Cauchy Mathieu Prodeau Antoine Notte Cyprien Toubert Ephrem Salamé Mehdi El Amrani Sandrine Andrieu Fabrice Muscari Jason Shourick Bertrand Suc Department of Digestive surgery Hepatobiliary and Pancreatic Surgery and Liver Transplantation UnitToulouse University HospitalToulouseFrance Department of Digestive surgery and transplantation Claude-HuriezHospitalCHRU LilleLilleFrance CANTHER laboratory“Cancer Heterogeneity Plasticity and Resistance to Therapies”Inserm UMR-S1277 Teams“MucinsCancer and Drug Resistance”LilleFrance Department of Hepato-bilio-pancreatic surgery and Liver transplantation Beaujon HospitalAPHPClichyFrance Department of Digestive surgery and Liver transplantation Trousseau HospitalTours University HospitalToursFrance Department of Digestive surgery and Liver transplantation Saint Eloi HospitalMontpellier University HospitalMontpellierFrance Department of Digestive surgery and Liver transplantation Besançon University HospitalBesançonFrance Department of Digestive and Hepatobiliary surgery University Hospital of Clermont-FerrandClermont-FerrandFrance U1071 Inserm/UniversitéClermont-Auvergne Clermont-FerrandFrance Department of Digestive surgery and Emergency CHU Grenoble-AlpesGrenobleFrance Department of Mini-invasive surgery Antoine Béclère HospitalAPHPClamartFrance Department of Digestive surgery Amiens Picardie University Hospital and Picardie Jules Verne UniversityAmiensFrance Department of Digestive surgery Institut Mutualiste MontsourisParisFrance Department of Epidemiology Toulouse University HospitalToulouseFrance

Background:Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma(HCC).Few data exist concerning the prognosis of patients resected for non-cirrhotic *** objectives of this study were to determine the prognostic factors of recurrence-free survival(RFS)and overall survival(OS)and to develop a prognostication algorithm for non-cirrhotic ***:French multicenter retrospective study including HCC patients with non-cirrhotic liver without underlying viral hepatitis:F0,F1 or F2 ***:A total of 467 patients were included in 11 centers from 2010 to ***-cirrhotic liver had a fibrosis score of F0(n=237,50.7%),F1(n=127,27.2%)or F2(n=103,22.1%).OS and RFS at 5 years were 59.2%and 34.5%,*** multivariate analysis,microvascular invasion and HCC differentiation were prognostic factors of OS and RFS and the number and size were prognostic factors of RFS(P10 cm(n=176,Group 2);>2 HCC regardless of size Conclusions:We developed a prognostication algorithm based on the number(≤or>2)and size(≤or>10 cm),which could be used as a treatment decision support concerning the need for perioperative *** case of bifocal HCC,surgery should not be a contraindication.

关键词： Hepatocellular carcinoma(HCC) non-cirrhotic liver prognostic factors recurrence-free survival(RFS) prognostication algorithm

Uses of a dedicated 3D reconstruction software with augmented and mixed reality in planning and performing advanced liver surgery and living donor liver transplantation(with videos)

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 455-461页

作者： Deniz Balci Elvan Onur Kirimker Dimitri Aristotle Raptis Yujia Gao Alfred Wei Chieh Kow Department of surgery Medical Park Goztepe Hastanesi Organ Nakli Merkezi Nisan SokBahce se hir UniversityNo.23 Merdivenkoy KadıkoyIstanbulTurkiye Department of surgery Ankara UniversityAnkaraTurkiye Clinical Service of HPB surgery and Liver transplantation NHS Foundation TrustRoyal Free London HospitalLondonUK Division of surgery&Interventional Science University College LondonLondonUK Division of Hepatobiliary&Pancreatic surgery Department of SurgeryNational University of SingaporeSingapore Liver Transplant Program National University Center for Organ Transplantation(NUCOT)National University Health SystemSingapore

The development of digital intelligent diagnostic and treatment technology has opened countless new opportunities for liver surgery from the era of digital anatomy to a new era of digital diagnostics,virtual surgery simulation and using the created scenarios in real-time surgery using mixed *** this article,we described our experience on developing a dedicated 3 dimensional visualization and reconstruction software for surgeons to be used in advanced liver surgery and living donor liver ***,we shared the recent developments in the field by explaining the outreach of the software from virtual reality to augmented reality and mixed reality.

关键词： Living donor liver transplantation 3D reconstruction software 3D volumetry Precision medicine Augmented reality Mixed reality

Octogenarian liver grafts:Is their use for transplant currently justified?

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World Journal of Gastroenterology 2017年第17期23卷 3099-3110页

作者： Carlos Jiménez-Romero Felix Cambra Oscar Caso Alejandro Manrique Jorge Calvo Alejandro Marcacuzco Paula Rioja David Lora Iago Justo HPB surgery and abdominal Organ transplantation Unit University Hospital“Doce de Octubre” Department of surgery Facultad de Medicina

AIMTo analyse the impact of octogenarian donors in liver *** present a retrospective single-center study, performed between November 1996 and March 2015, that comprises a sample of 153 liver transplants. Recipients were divided into two groups according to liver donor age: recipients of donors ≤ 65 years (group A; n = 102), and recipients of donors ≥ 80 years (group B; n = 51). A comparative analysis between the groups was performed. Quantitative variables were expressed as mean values and SD, and qualitative variables as percentages. Differences in properties between qualitative variables were assessed by χ2 test. Comparison of quantitative variables was made by t-test. Graft and patient survivals were estimated using the Kaplan-Meier ***, 3 and 5-year overall patient survival was 87.3%, 84% and 75.2%, respectively, in recipients of younger grafts vs 88.2%, 84.1% and 66.4%, respectively, in recipients of octogenarian grafts (P = 0.748). One, 3 and 5-year overall graft survival was 84.3%, 83.1% and 74.2%, respectively, in recipients of younger grafts vs 84.3%, 79.4% and 64.2%, respectively, in recipients of octogenarian grafts (P = 0.524). After excluding the patients with hepatitis C virus cirrhosis (16 in group A and 10 in group B), the 1, 3 and 5-year patient (P = 0.657) and graft (P = 0.419) survivals were practically the same in both groups. Multivariate Cox regression analysis demonstrated that overall patient survival was adversely affected by cerebrovascular donor death, hepatocarcinoma, and recipient preoperative bilirubin, and overall graft survival was adversely influenced by cerebrovascular donor death, and recipient preoperative *** standard criteria for utilization of octogenarian liver grafts are: normal gross appearance and consistency, normal or almost normal liver tests, hemodynamic stability with use of < 10 μg/kg per minute of vasopressors before procurement, intensive care unit s

关键词： Older liver Donor age Marginal liver Liver transplant Aging liver

Current status and perspectives in split liver transplantation

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World Journal of Gastroenterology 2015年第39期21卷 11003-11015页

作者： Andrea Lauterio Stefano Di Sandro Giacomo Concone Riccardo De Carlis Alessandro Giacomoni Luciano De Carlis Transplant Center Department of General Surgery and Abdominal Transplantation Niguarda Cà Granda Hospital Department of General surgery University of Pavia Medical School

Growing experience with the liver splitting technique and favorable results equivalent to those of whole liver transplant have led to wider application of split liver transplantation(SLT) for adult and pediatric recipients in the last decade. Conversely, SLT for two adult recipients remains a challenging surgical procedure and outcomes have yet to improve. Differences in organ shortages together with religious and ethical issues related to cadaveric organ donation have had an impact on the worldwide distribution of SLT. Despite technical refinements and a better understanding of the complex liver anatomy, SLT remains a technically and logistically demanding surgical procedure. This article reviews the surgical and clinical advances in this field of liver transplantation focusing on the role of SLT and the issues that may lead a further expansion of this complex surgical procedure.

关键词： Liver transplantation Split liver Segmental liver