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Pain and chronic pancreatitis: A complex interplay of multiple mechanisms

World Journal of Gastroenterology 2013年第42期19卷 7282-7291页

作者： Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Mech-Sense Department of Gastroenterology and HepatologyAalborg University HospitalDK-9000 AalborgDenmark Mech-Sense Department of RadiologyAalborg University HospitalDK-9000 AalborgDenmark Center for Sensory-Motor Interactions (SMI) Department of Health Science and TechnologyAalborg UniversityDK-9000 AalborgDenmark

Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for *** theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial *** observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often *** underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain *** other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain ***,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of *** review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic ***,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment.

关键词： Chronic pancreatitis Abdominal pain Pain mechanisms Neuropathy Sensitization

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Space-time description of transverse photons: near-field aspects

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Science China(Physics,Mechanics & Astronomy) 2012年第8期55卷 1389-1393页

作者： KELLER O. Institute of Physics and Nanotechnology Aalborg University

A mean position state based on the gauge invariant transverse vector potential is used to convert single-photon states in Hilbert space to photon wave packets in direct space. The resulting photon wave-mechanical description leads to scalar products which relate to covariant integration on the light cone. A new correlation matrix displays the spatial localization problem for single photons in an explicit manner in space-time. The correlation matrix essentially is the projection of the time-ordered Feynman photon propagator onto the transverse photon subspace. The present photon wave-mechanical formalism is generalized to two-photon dynamics. In the diamagnetic limit the transverse photon becomes massive in its interaction with matter, and the correlation matrix for massivephoton interaction, which can be used in studies of evanescent-photon mediated couplings, is analyzed. On the basis of the present formalism the existence of a dynamical near-field Aharonov-Bohm effect is predicted.

关键词： one-photon wave mechanics near-field optics correlation matrix transverse photon mass

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Abc-frame complex-coefficient filter and controller based current harmonic elimination strategy for three-phase grid connected inverter

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Journal of Modern Power Systems and Clean Energy 2016年第1期4卷 87-93页

作者： Xiaoqiang GUO Josep M.GUERRERO Department of Electrical Engineering Yanshan UniversityQinhuangdao 066004China Department of Energy Technology Aalborg University9220 AalborgDenmark

Current quality is one of the most important issues for operating three-phase grid-connected inverter in distributed generation systems. In practice, the grid current quality is degraded in case of non-ideal utility voltage. A new control strategy is proposed for the three-phase gridconnected inverter. Different from the traditional method,our proposal utilizes the unique abc-frame complex-coefficient filter and controller to achieve the balanced, sinusoidal grid current. The main feature of the proposed method is simple and easy to implement without any frame transformation. The theoretical analysis and experimental test are presented. The experimental results verify the effectiveness of the proposed control strategy.

关键词： Grid-connected inverter Current control Complex-coefficient filter Complex-coefficient controller

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Fault protection method of single-phase break for distribution network considering the influence of neutral grounding modes

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Protection and Control of Modern Power Systems 2020年第1期5卷 111-123页

作者： Yang Xiao Jinxin Ouyang Xiaofu Xiong Yutong Wang Yongjie Luo School of Electrical Engineering Chongqing UniversityChongqingChina North China Electric Power university BeijingChina aalborg university AalborgDenmark

With the rapid development of modern distribution network and the access of distributed generation,the network structure is becoming increasingly *** single-phase break faults have seriously affected equipment and personal safety and stable operation of the power ***,with the development and application of the composite neutral grounding modes,the protection of single-phase break fault is facing new *** paper proposes a protection method of single-phase break fault for distribution network considering the influence of neutral grounding *** characteristics of neutral voltage and sequence current are analyzed under normal operation and single-phase break fault with different grounding *** this,the protection criterion based on neutral voltage and sequence current variation is *** protection method of singlephase break fault for distribution network is proposed,which is applicable for various neutral grounding *** analysis and simulation results show that the protection method is less affected by system asymmetry,fault location and load *** method has higher sensitivity,reliability and adaptability.

关键词： Distribution network Single-phase break fault Protection Neutral grounding

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Pathophysiology of chronic pancreatitis

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World Journal of Gastroenterology 2013年第42期19卷 7231-7240页

作者： Christina Brock Lecia Mφller Nielsen Dina Lelic Asbjφrn Mohr Drewes Department of Gastroenterology and Hepatology Aalborg University HospitalDK-9000 AalborgDenmark Center for Sensory-Motor Interactions (SMI) Department of Health Science and TechnologyAalborg UniversityDK-9220 AalborgDenmark

Chronic pancreatitis(CP)is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic secretory *** the heterogeneity in pathogenesis and involved risk factors,processes such as necrosis/apoptosis,inflammation or duct obstruction are *** fibrosing process ultimately leads to progressive loss of the lobular morphology and structure of the pancreas,deformation of the large ducts and severe changes in the arrangement and composition of the *** conditions lead to irreversible morphological and structural changes resulting in impairment of both exocrine and endocrine *** prevalence of the disease is largely dependent on culture and *** etiological risk-factors associated with CP are multiple and involve both genetic and environmental *** this review the M-ANNHEIM classification system will be used,comprising a detailed description of risk factors such as:alcohol-consumption,nicotineconsumption,nutritional factors,hereditary factors,efferent duct factors,immunological factors and miscellaneous and rare metabolic *** knowledge of the different etiological factors may encourage the use of further advanced diagnostic tools,which potentially will help clinicians to diagnose CP at an earlier ***,in view of the multi factorial disease and the complex clinical picture,it is not surprising that treatment of patients with CP is challenging and often unsuccessful.

关键词： Chronic pancreatitis Pathogenesis Risk factors Etiology

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Supporting integrative maritime spatial planning by operationalising SEANERGY – a tool to study cross-sectoral synergies and conflicts

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International Journal of Digital Earth 2021年第6期14卷 678-695页

作者： Ida Maria Bonnevie Henning Sten Hansen Lise Schrøder Department of Planning Aalborg UniversityCopenhagenDenmark

With growing pressures on marine ecosystems and on marine space,an increasingly needed strategy to optimise the use of marine space is to co-locate synergic marine human uses in close spatial–temporal proximity while separating conflicting marine human *** ArcMap toolbox SEANERGY is a new,cross-sectoral spatial decision support tool(DST)that enables maritime spatial planners to consider synergies and conflicts between marine uses to support assessments of co-location ***-sectoral approaches are important to reach more integrative maritime spatial planning(MSP)*** this article demonstrates through a Baltic Sea analysis,SEANERGY presents a crosssectoral use catalogue for MSP through enabling the tool users to answer important specific questions to spatially and/or numerically weight potential synergies/conflicts between marine *** article discusses to what degree such a cross-sectoral perspective can support integrative MSP *** MSP integrative challenges still exist,SEANERGY enables MSP processes to move towards developing shared goals and initiate discussions built on best available knowledge regarding potential use-use synergies and use-use conflicts for whole sea basins at once.

关键词： Coexistence integrative maritime spatial planning(MSP) SEANERGY spatial decision support tools(DSTs) use-use interactions

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Wearable sensors for activity monitoring and motion control:A review

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Biomimetic Intelligence & Robotics 2023年第1期3卷 1-10页

作者： Xiaoming Wang Hongliu Yu Soren Kold Ole Rahbek Shaoping Bai Department of Materials and Production Aalborg UniversityAalborg 9220Denmark Rehabilitation Engineering and Technology Institute University of Shanghai for Science and TechnologyShanghai 200093China Department of Orthopedic Surgery Aalborg University HospitalAalborg 9220Denmark

Wearable sensors for activity monitoring currently are being designed and developed,driven by an increasing demand in health care for noninvasive patient monitoring and rehabilitation *** article reviews state-of-the-art wearable sensors for activity monitoring and motion *** technologies,including electromechanical,bioelectrical,and biomechanical sensors,are reviewed,along with their broad ***,an overview of existing commercial wearable products and the computation methods for motion analysis are *** research issues are identified and discussed.

关键词： Wearable sensor Activity monitoring and tracking Intelligent motion control Human–machine interface

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Reverse Droop Control-based Smooth Transfer Strategy for Interface Converters in Hybrid AC/DC Distribution Networks

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CSEE Journal of Power and Energy Systems 2023年第1期9卷 122-134页

作者： Wenyuan Cao Minxiao Han Xiangkun Meng Wenqiang Xie Zmarrak Wali Khan Josep M.Guerrero Gibran David Agundis Tinajero School of Electric and Electronic Engineering North China Electric Power UniversityBeijing 102206China Department of Energy Technology Aalborg UniversityAalborg 9220Denmark

Hybrid AC/DC distribution networks are promising candidates for future applications due to their rapid advancement in power electronics *** use interface converters(IFCs)to link DC and AC distribution ***,the networks possess drawbacks with AC voltage and frequency offsets when transferring from grid-tied to islanding *** address these problems,this paper proposes a simple but effective strategy based on the reverse droop ***,the power balance equation of the distribution system is derived,which reveals that the cause of voltage and frequency offsets is the mismatch between the IFC output power and the rated load ***,the reverse droop control is introduced into the IFC *** using a voltage-active power/frequency-reactive power(U-P/f-Q)reverse droop loop,the IFC output power enables adaptive tracking of the rated load ***,the AC voltage offset and frequency offset are suppressed during the transfer process of operational *** addition,the universal parameter design method is discussed based on the stability limitations of the control system and the voltage quality requirements of AC critical ***,simulation and experimental results clearly validate the proposed control strategy and parameter design method.

关键词： Adaptive adjustment hybrid AC/DC distribution network interface converters parameter design method reverse droop control

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Neurological consequences of human calmodulin mutations

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Neural Regeneration Research 2024年第5期19卷 943-944页

作者： Helene H.Jensen Anders Olsen Medical Biotechnology Department of Chemistry and BiosciencesAalborg UniversityAalborgDenmark

When calcium ions enter the cytosol,it is a stimulatory signal for cellular *** calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction *** this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and *** is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CALM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell ***,throughout vertebrate evolution,the protein sequence has remained completely unchanged.

关键词： consequences unchanged calmodulin

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Scenario Generations for Renewable Energy Sources and Loads Based on Implicit Maximum Likelihood Estimations

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1563-1575页

作者： Wenlong Liao Birgitte Bak-Jensen Jayakrishnan Radhakrishna Pillai Zhe Yang Yusen Wang Kuangpu Liu AAU Energy Aalborg UniversityAalborgDenmark School of Electrical Engineering and Computer Science KTH Royal Institute of TechnologyStockholmSweden

Scenario generations for renewable energy sources and loads play an important role in the stable operation and risk assessment of integrated energy *** paper proposes a deep generative network based method to model time-series curves,e.g.,power generation curves and load curves,of renewable energy sources and loads based on implicit maximum likelihood estimations(IMLEs),which can generate realistic scenarios with similar patterns as real *** training the model,any number of new scenarios can be obtained by simply inputting Gaussian noises into the data generator of *** proposed approach does not require any model assumptions or prior knowledge of the form in the likelihood function being made during the training process,which leads to stronger applicability than explicit density model based *** extensive experiments show that the IMLEs accurately capture the complex shapes,frequency-domain characteristics,probability distributions,and correlations of renewable energy sources and ***,the proposed approach can be easily generalized to scenario generation tasks of various renewable energy sources and loads by fine-tuning parameters and structures.

关键词： Renewable energy source scenario generation implicit maximum likelihood estimation(IMLE) deep learning generative network

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