检索结果-南通市图书馆

Pathophysiology of severe gallstone pancreatitis:A new paradigm

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第7期30卷 614-623页

作者： Masatoshi Isogai Department of Surgery Nawa HospitalOgaki 503-0893GifuJapan

Severe gallstone pancreatitis(GSP)refractory to maximum conservative therapy has wide clinical variations,and its pathophysiology remains *** Editorial aimed to investigate the pathophysiology of severe disease based on Opie’s theories of obstruction,the common channel,and duodenal reflux and describe its *** GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis(biliary type)and necrotizing pancreatitis uncomplicated with biliary tract disease(pancreatic type),in which hepatobiliary and pancreatic lesion severity is inversely related to the presence or absence of impacted ampullary *** GSP is caused by stones that are persistently impacted at the ampulla with biliopancreatic obstruction(biliary type),and probably,stones that are either temporarily lodged at the duodenal orifice or passed into the duodenum,thereby permitting reflux of bile or possible duodenal contents into the pancreas(pancreas type).When the status of the stones and the presence or absence of impacted ampullary stones with biliopancreatic obstruction are determined,the clinical course and outcome can be *** represent the main cause of acute pancreatitis globally,and clinicians are expected to encounter GSP more *** of the etiology and pathogenesis of severe disease is mandatory.

关键词： Gallstone pancreatitis Biliary pancreatitis Gallstone hepatitis Acute cholangitis Necrotizing pancreatitis Pathophysiology

Dendritic Learning-Incorporated Vision Transformer for Image Recognition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 539-541页

作者： Zhiming Zhang Zhenyu Lei Masaaki Omura Hideyuki Hasegawa Shangce Gao Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan IEEE

Dear Editor,This letter proposes to integrate dendritic learnable network architecture with Vision Transformer to improve the accuracy of image *** this study,based on the theory of dendritic neurons in neuroscience,we design a network that is more practical for engineering to classify visual *** on this,we propose a dendritic learning-incorporated vision Transformer(DVT),which out-performs other state-of-the-art methods on three image recognition benchmarks.

关键词： Image network image

Hydrogen Permeation Characteristics of Pd-CuMembrane in Plasma Membrane Reactor

在线全文

学校读者我要写书评

暂无评论

Energy Engineering 2024年第2期121卷 259-272页

作者： Muhd Hadi Iskandar Abd Razak Motoki Tsuda YukioHayakawa Shinji Kambara Graduate School of Engineering Gifu UniversityGifu501-1193Japan

Hydrogen is an alternative energy source that has the potential to replace fossil *** of the hydrogen applications is as a material for Polymer Electrolyte Membrane Fuel Cells(PEMFC)in fuel cell ***-purity hydrogen can be obtained using a hydrogen separation membrane to prevent unwanted contaminants from potentially harming the PEMFC *** this study,we fabricated a plasma membrane reactor and investigated the permeation performance of a hydrogen separation membrane in a plasma membrane reactor utilizing atmospheric pressure *** result showed the hydrogen permeation rate increasing with time as reactor temperature is increased through joule *** decreasing the gap length of the reactor from 2 to 1 mm,the hydrogen permeation rate increases by up to 40%.The hydrogen permeation rate increases by 30%when pressure is applied to the plasma membrane reactor by up to 100 kPa.

关键词： Hydrogen energy hydrogen separation membrane atmospheric pressure plasma

Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第28期30卷 3428-3446页

作者： Aritoshi Koizumi Kosuke Kaji Norihisa Nishimura Shohei Asada Takuya Matsuda Misako Tanaka Nobuyuki Yorioka Yuki Tsuji Koh Kitagawa Shinya Sato Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji Department of Gastroenterology Nara Medical UniversityKashihara 634-8521Japan

BACKGROUND Alcohol-associated liver disease(ALD)is a leading cause of liver-related morbidity and mortality,but there are no therapeutic targets and modalities to prevent ALD-related liver *** proliferator activated receptor(PPAR)α and δ play a key role in lipid metabolism and intestinal barrier homeostasis,which are major contributors to the pathological progression of ***,elafibranor(EFN),which is a dual PPARαand PPARδagonist,has reached a phase III clinical trial for the treatment of metabolic dysfunctionassociated steatotic liver disease and primary biliary ***,the benefits of EFN for ALD treatment is *** To evaluate the inhibitory effects of EFN on liver fibrosis and gut-intestinal barrier dysfunction in an ALD mouse *** ALD-related liver fibrosis was induced in female C57BL/6J mice by feeding a 2.5% ethanol(EtOH)-containing Lieber-DeCarli liquid diet and intraperitoneally injecting carbon tetrachloride thrice weekly(1 mL/kg)for 8 ***(3 and 10 mg/kg/day)was orally administered during the experimental *** and molecular analyses were performed to assess the effect of EFN on steatohepatitis,fibrosis,and intestinal barrier *** EFN effects on HepG2 lipotoxicity and Caco-2 barrier function were evaluated by cell-based *** The hepatic steatosis,apoptosis,and fibrosis in the ALD mice model were significantly attenuated by EFN *** promoted lipolysis and β-oxidation and enhanced autophagic and antioxidant capacities in EtOH-stimulated HepG2 cells,primarily through PPARα***,EFN inhibited the Kupffer cell-mediated inflammatory response,with blunted hepatic exposure to lipopolysaccharide(LPS)and toll like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)*** improved intestinal hyperpermeability by restoring tight junction proteins and autophagy and by inhibiting apoptosis and proinflammatory *** protective effect on intestinal bar

关键词： Liver fibrosis Ethanol Gut barrier function Apoptosis Autophagy Peroxisome proliferator activated receptor

Step-over of strike-slip faults and overpressure fluid favor occurrence of foreshocks:Insights from the 1975 Haicheng fore-main-aftershock sequence,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Research Advances 2024年第1期4卷 36-46页

作者： Xinglin Lei Zhiwei Wang Shengli Ma Changrong He Geological Survey of japan AISTTsukuba305-8567Japan State Key Laboratory of Earthquake Dynamics Institute of GeologyCEABeijing100029 China

This study analyzed and summarized in detail the spatial and temporal distributions of earthquakes,tidal responses,focal mechanisms,and stress field characteristics for the M 7.3 Haicheng earthquake sequence in February *** foreshocks are related to the main fault and the conjugate faults surrounding the extension step-over in the *** initiation timing of the foreshock clusters and the original time of the mainshock were clearly modulated by the Earth's tidal force and coincided with the peak of dilational volumetric tidal *** a plausible and testable hypothesis,we proposed a fluid-driven foreshock model,by which all observed seismicity features can be more reasonably interpreted with respect to the results of existing *** with some other known examples,the widely existing step-over along strike-slip faults and associated conjugate faults,especially for extensional ones in the presence of deep fluids,favor the occurrence of short-term *** clustered seismicity with characteristics similar to those of the studied case is not a sufficient and necessary condition for large earthquakes to occur under similar tectonic conditions,it undoubtedly has a warning significance for the criticality of the main *** testing would require quantification of true/false positives/negatives.

关键词： Haicheng earthquake Seismogenic fault ETAS Foreshock Deep fluid

Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 557-562页

作者： Toshiaki Tsurui Yuya Hirasawa Yutaro Kubota Kiyoshi Yoshimura Takuya Tsunoda Department of Medical Oncology Showa UniversityTokyo 1428555Japan Department of Clinical Immuno Oncology Clinical Research Institute of Clinical Pharmacology and TherapeuticsShowa UniversityTokyo 1578577Japan

BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,owing to the liver’s diffuse metastatic ***,an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently *** SUMMARY The patient,a man in his 50s,presented with progressive fatigue and severe *** tomography revealed multiple hepatic masses with thick-ened walls in the sigmoid colon,which was pathologically confirmed as a well-differentiated *** RAS or BRAF mutations were *** Eastern Cooperative Oncology Group(ECOG)performance status(PS)score was *** drainage was impossible due to the absence of a dilated bile duct,and panitumumab monotherapy was promptly ***,the bilirubin level decreased and then normalized,and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse *** Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.

关键词： Colorectal neoplasms Panitumumab Chemotherapy Hyperbilirubinemia Jaundice Case report

In situ observation of the phase transformation kinetics of bismuth during shock release

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第4期33卷 586-592页

作者：李江涛王倩男徐亮柳雷张航 Sota Takagi Kouhei Ichiyanagi Ryo Fukaya Shunsuke Nozawa 胡建波 Laboratory for Shock Wave and Detonation Physics Research Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China State Key Laboratory for Environment-Friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China japan Society for the Promotion of Science Tokyo102-0083Japan Institute of Materials Structure Science High Energy Accelerator Research OrganizationIbaraki305-8572Japan

A time-resolved x-ray diffraction technique is employed to monitor the structural transformation of laser-shocked *** reveal a retarded transformation from the shock-induced Bi-Ⅴphase to a metastable Bi-Ⅳphase during the shock release,instead of the thermodynamically stable Bi-Ⅲ*** emergence of the metastable Bi-Ⅳphase is understood by the competitive interplay between two transformation pathways towards the Bi-Ⅳand Bi-Ⅲ,*** former is more rapid than the latter because the Bi-Ⅴto B-Ⅳtransformation is driven by interaction between the closest atoms while the Bi-Ⅴto B-Ⅲtransformation requires interaction between the second-closest *** nucleation time for the Bi-Ⅴto Bi-Ⅳtransformation is determined to be 5.1±0.9 ns according to a classical nucleation *** observation demonstrates the importance of the formation of the transient metastable phases,which can change the phase transformation pathway in a dynamic process.

关键词： phase transformation time-resolved x-ray diffraction(XRD) bismuth metastable phase nonequilibrium phase diagram

Controlling a peristaltic robot inspired by inchworms

在线全文

学校读者我要写书评

暂无评论

Biomimetic Intelligence & Robotics 2024年第1期4卷 88-96页

作者： Yanhong Peng Hiroyuki Nabae Yuki Funabora Koichi Suzumori Department of Information and Communication Engineering Graduate School of EngineeringNagoya UniversityNagoya 464-8601Japan Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan

This study presents an innovative approach in soft robotics,focusing on an inchworm-inspired robot designed for enhanced transport *** explore the impact of various parameters on the robot’s performance,including the number of activated sections,object size and material,supplied air pressure,and command execution *** a series of controlled experiments,we demonstrate that the robot can achieve a maximum transportation speed of 8.54 mm/s and handle loads exceeding 100 g,significantly outperforming existing models in both speed and load *** findings provide valuable insights into the optimization of soft robotic design for improved efficiency and adaptability in transport *** research not only contributes to the advancement of soft robotics but also opens new avenues for practical applications in areas requiring precise and efficient object *** study underscores the potential of biomimetic designs in robotics and sets a new benchmark for future developments in the field.

关键词： McKibben artificial muscles Bionics Soft robotics Soft actuator Bio-inspired robotics

Autohydrolysis treatment of bamboo and potassium oxalate(K_(2)C_(2)O_(4))activation of bamboo product for CO_(2) capture utilization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2024年第4期18卷 63-72页

作者： Dang Duc Viet Doan Thi Thao Khuong Duy Anh Toshiki Tsubota Department of Materials Science Faculty of EngineeringKyushu Institute of TechnologyFukuoka 804-8550Japan Vietnamese Academy of Forest Sciences Hanoi 10000Vietnam Collaborative Research Centre for Green Materials on Environmental Technology Kyushu Institute of TechnologyFukuoka 808-0196Japan

Typically,the hydroxide agents,such as sodium hydroxide and potassium hydroxide,which have corrosive properties,are used in the carbon activation *** this study,potassium oxalate(K_(2)C_(2)O_(4)),a less toxic and non-corrosive activating reagent,was used to synthesize activated carbon from the solid residue after autohydrolysis *** effect of the autohydrolysis treatment and the ratio of the K_(2)C_(2)O_(4)/solid residue are presented in this ***,the comparison between the activated carbon from bamboo and biochar from the solid residue are also *** resulting activated carbon from the solid residue exhibited a high surface area of up to 1432 m^(2)·g^(-1) and a total pore volume of up to 0.88 cm^(3)·g^(-1).The autohydrolysis treatment enhanced the microporosity properties compared to those without pretreatment of the activated *** microporosity of the activated carbon from the solid residue was dominated by the pore width at 0.7 nm,which is excellent for CO_(2) *** 25℃ and 1.013×10^(5) Pa,the CO_(2) captured reached up to 4.1 mmol·g^(-1).On the other hand,the ratio between K_(2)C_(2)O_(4) and the solid residue has not played a critical role in determining the porosity *** ratio of the K_(2)C_(2)O_(4)/solid residue of 2 could help the carbon material reach a highly microporous textural property that produces a high carbon capture *** finding proved the benefit of using the solid residue from the autohydrolysis treatment as a precursor material and offering a more friendly and sustainable activation carbon process.

关键词： activated carbon bamboo biochar CO_(2)capture potassium oxalate