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QuaPra: Efficient transcript assembly and quantification using quadratic programming with Apriori algorithm

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Science China(Life Sciences) 2019年第7期62卷 937-946页

作者： Xiangjun Ji Weida Tong Baitang Ning Christopher E. Mason David P. Kreil Pawel P. Labaj Geng Chen Tieliu Shi The Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China National Center for Toxicological Research U.S. Food and Drug Administration3900 NCTR RDJefferson AR 72079USA Department of Physiology and Biophysics Weill Cornell MedicineNew York 10065USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10021USA Feil Family Brain & Mind Research Institute New York 10065USA Chair of Bioinformatics Research Group Boku UniversityVienna A-1190Austria Malopolska Centre of Biotechnology Jagiellonian UniversityKrakow 30-387Poland apart fellow Austrian Academy of ScienceVienna A-1190Austria National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China

RNA sequencing(RNA-seq) has greatly facilitated the exploring of transcriptome landscape for diverse ***,transcriptome reconstruction is still challenging due to various limitations of current tools and sequencing ***,we introduce an efficient tool,QuaPra(Quadratic Programming combined with Apriori),for accurate transcriptome assembly and *** could detect at least 26.5% more low abundance(0.1–1 FPKM) transcripts with over 2.7% increase of sensitivity and precision on simulated data compared to other currently popular ***,around one-quarter more known transcripts were correctly assembled by QuaPra than other assemblers on real sequencing *** is freely available at http://***/QuaPra/.

关键词： RNA-Seq transcriptome reconstruction transcript assembly transcript quantification

Will Brexit Matter： A Probe into Its Reasons, Influences and Tendencies

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China International Studies 2016年第5期36卷 66-85页

作者： Jin Ling Associate Research fellow at the Department for European Studies China Institute ofInternational Studies (CIIS).

In a referendum held on June 23, 51.9 percent of the UK citizens voted to leave the European Union. Although surprising, the result is understandable. Brexit is the result of a number of complicated historical and other factors, the United Kingdom＇s sense of exceptionalism. After the referendum, the future of the United Kingdom＇s domestic politics, UK-EU relations and the European Union itself are uncertain. But no matter how things go, the referendum result is a turning point in the history of European integration and even international politics. The influence of Brexit will extend far beyond the United Kingdom and the European Union as it will have an impact on the transformation of the international structure.

关键词：英国原因物质国际政治欧洲联盟一体化欧盟

Features and effects of some acid-saline groundwaters of southern Australia

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Chinese Journal Of Geochemistry 2006年第B8期25卷 227-227页

作者： Bruce Dickson Angela Giblin Dickson Research Pty Ltd Sydney Australia CSIRO Honorary Research fellow Sydney Australia