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Effect of Zeolite on Small Intestine Microbiota of Broiler Chickens:A Case Study

Food and Nutrition Sciences 2017年第1期8卷 163-188页

作者： Sandrine Le Gall-David Vincent Meuric Gaelle Benzoni Sophie Valière Alain Guyonvarch Jacques Minet Martine Bonnaure-Mallet Microbiology Team EA 1254 Universitéde Rennes 1RennesFrance Hospital RennesFrance Invivo NSA Saint NolffFrance INRA UAR 1209Castanet-TolosanFrance INRA GeT-PlaGeGenotoulCastanet-TolosanFrance CNRS-IGDR-UMR 6290 RennesFrance amadeus platform-biosit RennesFrance

After ban of antibiotics growth promoters (AGP) in Europe in 2006, use of non-medicated gut microbiota regulators as feed additives has dramatically increased. This study aimed at describing the effects of a copper-exchanged zeolite on broiler growth performance, small intestine morphology and microbiota composition. Illumina Sequencing of the V3-V4 region of the 16S rRNA gene was employed to study the small intestine microbiota. This microbiota with copper-exchanged zeolite treated-chickens was significantly less diverse with an almost exclusive presence of Lactobacillus johnsonii and Lactobacillus reuteri. These Lactobacilli are correlated with increased diameter, length and weight of the three segments of the small intestine and decreased viscosity of the intestinal content, suggesting probiotic action. The tested copper-exchanged zeolite would act as a prebiotic, selecting a “favorable” flora for the healthy broilers development.

关键词： Microbiota Chicken Growth Promoting Zeolite Bacitracin

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Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa

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Asian Journal of Andrology 2019年第6期21卷 570-576页

作者： Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel Univ Rennes CHU RennesLaboratoire de Biologie de la Reproduction-CECOSInsermEH ESPIrset(Institut de recherche en santeenvironnement et travail)-UMR_S 1085Rennes F-35000France Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences194223 St-PetersburgRussia Univ Rennes Biosit Platform-MRICRennes 35000France Univ Rennes CHU RennesDepartment of Gynecology Obstetric and Human ReproductionRennes 35000France Univ Rennes CHU RennesDepartment of CytogeneticIrset(Institute for Environmental and Occupational Health)-UMR_S 1085Rennes 35000France Univ Rennes InsermEH ESPIrset(Institute for Environmental and Occupational Health)-UMR_S 1085Rennes F-35000France University of Poitiers-CHU Poitiers STIM ERL 7003 CNRSPoitiers 86021France

Autophagy is invoIved in spermatogenesis by regulating germ cell *** catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged *** is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in *** aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid *** samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron *** protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm ***3 was also detected in the midpiece of cryptorchid sperm *** substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid *** electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid *** degraded mitochondria were frequently discerned in autophagic *** conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to *** work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological ***,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men.

关键词： autophagy cryptorchidism mitophagy spermatozoa

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New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties

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International Journal of Organic Chemistry 2024年第3期14卷 107-122页

作者： Marwa Dhiabi Sirine Karoui Mehdi Fakhfakh Souhir Abid Emmanuelle Limanton Rémy Le Guével Thierry Charlier Ludovic Paquin Jean-Pierre Bazureau Houcine Ammar Laboratoire de Chimie Applique: Htrocycles Corps et Polymres Facult des Sciences de Sfax Universit de Sfax Sfax Tunisie Institut des Sciences Chimiques de Rennes Universit de Rennes Campus de Beaulieu Rennes Cedex France Department of Chemistry (Science and Arts): Al Qurayat Al-Jouf University Al Jawf Saudi Arabia S2Wave platform ScanMAT UAR CNRS Universit de Rennes Campus de Beaulieu Rennes Cedex France ImPACcell platform Biosit SFR UMS CNRS Inserm Campus de Villejean Rennes France Institut de Recherche en Sant Environnement et Travail IRSET Inserm UMR_S Rennes France

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

关键词： 2-Amino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-Amine Microwave Irradiation Tumoral Cell Line in Silico ADMET

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3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines

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International Journal of Organic Chemistry 2021年第1期11卷 24-34页

作者： Ali Bouattour Mehdi Fakhfakh Souhir Abid El-Gharbi Majdi Abid Ludovic Paquin Rémy Le Guevel Thierry Charlier Houcine Ammar Jean-Pierre Bazureau Laboratoire de Chimie Appliquée: Hétérocycles Corps Gras et Polymères Faculté des Sciences de Sfax Université de Sfax Sfax Tunisie Chemistry Department College of Science and Arts Jouf University Al Qurayyat Al Jawf KSA Institut des Sciences Chimiques de Rennes ISCR UMR CNRS 6226 Campus Beaulieu Université de Rennes 1 Bat. 10A Rennes Cedex France S2Wave platform ScanMAT UMS 2001 CNRS Campus Beaulieu Université de Rennes 1 Bat. 10A Rennes Cedex France ImPACcell platform SFR Biosit Bat. 8 Campus Villejean Rennes Cedex France

The first report of new 3-(tetrazol-5-yl)-2-iminocoumarin derivatives is described. The title compounds were prepared in two steps and were obtained in good yields (55-93%). They have been fully characterized by 1H, 13C NMR, FTIR, UV-Visible and HRMS. They were tested for their antiproliferative activities against six representative human tumor cell lines (Huh 7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and HaCat keratinocytes. Among them, compound 5e was active on HCT 116 (IC50 15 μM).

关键词： 2-Iminocoumarin Tetrazole Fluorescence Tumor Cell Lines HCT 116

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