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Efficient Noninvasive FHB Estimation using RGB Images from a Novel Multiyear,Multirater Dataset

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Plant Phenomics 2023年第3期5卷 533-545页

作者： DominikRößle LukasPrey LudwigRamgraber AnjaHanemann DanielCremers Patrick OleNoack TorstenSchön aimotion bavaria Technische Hochschule IngolstadtIngolstadtGermany Hochschule Weihenstephan-Triesdorf WeidenbachGermany Saatzucht Josef Breun GmbH and Co.KG HerzogenaurachGermany Technical University of Munich MunichGermany

Fusarium head blight(FHB)is one of the most prevalent wheat diseases,causing substantial yield losses and health *** phenotyping of FHB is crucial for accelerating resistance breeding,but currently used methods are time-consuming and *** present article suggests a noninvasive classification model for FHB severity estimation using red–green–blue(RGB)images,without requiring extensive *** model accepts images taken from consumer-grade,low-cost RGB cameras and classifies the FHB severity into 6 ordinal *** addition,we introduce a novel dataset consisting of around 3,000 images from 3 different years(2020,2021,and 2022)and 2 FHB severity assessments per image from independent *** used a pretrained EfficientNet(size b0),redesigned as a regression *** results demonstrate that the interrater reliability(Cohen’s kappa,κ)is substantially lower than the achieved individual network-to-rater results,e.g.,0.68 and 0.76 for the data captured in 2020,*** model shows a generalization effect when trained with data from multiple years and tested on data from an independent ***,using the images from 2020 and 2021 for training and 2022 for testing,we improved the F_(1)^(w) score by 0.14,the accuracy by 0.11,κ by 0.12,and reduced the root mean squared error by 0.5 compared to the best network trained only on a single year’s *** proposed lightweight model and methods could be deployed on mobile devices to automatically and objectively assess FHB severity with images from low-cost RGB *** source code and the dataset are available at https://***/cvims/FHB_classification.

关键词： network consuming breeding

Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Shenghan Wang Carmen Mota Reyes Ibrahim Halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of Surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General Surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

Task sharing in psychotherapy as a viable global mental health approach in resource-poor countries and also in high-resource settings

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Global Health Journal 2021年第3期5卷 120-127页

作者： Klaus W.Lange Institute of Psychology Urtiversiiy of RegensburgRegensburgBavaria 93040Germany

A global disparity exists between the burden of mental ill-health and the resources available to address this *** mental disorders,such as mild-to-moderate depression,anxiety disorders and post-traumatic stress disorder,are associated with a significant decline in health and functioning and contribute significantly to the overall burden of *** view of a shortage of mental health professionals in most low-and middle-income countries,task sharing(task shifting)can make an important contribution to improving access to mental health *** sharing involves non-specialists in the delivery of health *** use of lay health workers is premised on the assumption that the shorter training required for non professionals will allow an increase in the provision of required care without the need for an increase in resources and will strengthen and scale-up sustainable health *** need for low-tech support in the management of conunon mental disorders is widespread,and the core resource is humans trained to identify and treat those requiring mental health *** is a strong evidence base for the effectiveness of task sharing in psychotherapy,and talk therapies,*** behavioral therapy,can easily be delegated to non-specialists,including non-specialist health workers,peer helpers and lay people.A(cost-)effective model of mental health care in low-resource settings as well as in high-income countries may include the medical school-based training of some psychiatrists and clinical psychologists in the treatment of referred patients with serious mental *** professional mental health specialists would also be trainers and supervisors of non-specialist health workers who would identify common mental health disorders and provide psychotherapy to people with these conditions in a community-based ***-based generalism including task sharing rather than centralized specialism may be capable of preventing and treating many

关键词： Mental health care Poor-resource settings Task sharing Psychotherapy Cognitive behavioral therapy

Gut Phage Database: phage mining in the cave of wonders

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1632-1633页

作者： Magdalena Unterer Mohammadali Khan Mirzaei Li Deng Institute of Virology Helmholtz Center Munich and Technical University of MunichNeuherbergBavariaGermany

The diversity of the viruses in the human gut remains mostly unexplored To shed some light on this known unknown,Camarillo-Guerrero et al.1 developed the Gut Phage Database(GPD),which includes 142,809 non-redundant gut phages obtained from analyzing 28,060 shotgun metagenome *** human intestinal tract is one of the most diverse microhabitats known,harboring billions of microorganisms including bacteria,viruses,fungi and archaea.

关键词： al. mostly harbor

Coronavirus disease 2019 (COVID-19) and global mental health

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Global Health Journal 2021年第1期5卷 31-36页

作者： Klaus W.Lange Institute of Psychology University of RegensburgRegensburgBavaria 93040Germany

The mental health effects of the coronavirus disease 2019(COVID-19)pandemic may shape population health for many years to *** to address the mental health issues stemming from the pandemic is likely to prolong its *** COVID-19 pandemic has created a significant global challenge and,in lower-income countries,even a disruption of mental health *** our experience with previous pandemics,the present COVID-19 crisis can be expected to cause psychological trauma,and steps are needed to address this issue *** focusing on the long-term mental health consequences of COVID-19 may equal the importance of those currently seeking to mitigate its physical *** implications of the GOVID-19 pandemic for mental health call for a greater focus on the needs of those with mental disorders and on mental health issues affecting health care workers and the general *** preventive and therapeutic mental health care is essential in addressing the psychosocial needs of populations exposed to the *** addition to specialist care,"task-shifting"and digital technologies may provide cost-effective means of providing mental health care in lower-income countries worldwide as well as in higher-income countries with mental health services overwhelmed by the effects of the COVID-19 *** view of the ever-increasing pressure on global health systems resulting from the COVID-19 pandemic,adopting and adapting"task-shifting",i.e.,the delegation of psychotherapeutic interventions to trained non-specialists,as an element of the provision of mental health services,is *** technologies can be used to enhance social support and facilitate resilience to the detrimental mental health effects of the pandemic;they may also offer an efficient and cost-effective way to provide easy access to mentalhealth care.

关键词： Coronavirus disease 2019(COVID-19) Mental health Prevention Treatment Task shifting Digital technology

Burned-out testicular seminoma with retroperitoneal metastasis and contralateral sertoli cell-only syndrome

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Asian Journal of Urology 2022年第3期9卷 343-345页

作者： Fiona-Sofia Siokou Stefan Schweyer Christiane Tympner Christoph Walz Roman Ganzer Department of Urology Asklepios Hospital Bad TölzTeaching Hospital of Ludwig-Maximilians-University(LMU)Bad TölzBavariaGermany Pathology Starnberg StarnbergBavariaGermany Institute of Pathology Ludwig-Maximilians-University(LMU)MunichBavariaGermany

Dear editor,Spontaneous regression of testicular cancer is a rare phenomenon,which has not been completely *** so-called burned-out tumors typically present at metastatic stage with no testicular symptoms or clinical evidence of a primary testicular lesion and can be mistaken for primary extragonadal *** is the most likely to regress without treatment,whereas a burnedout seminoma is uncommon[1].Gonadal function is often impaired in men with testicular *** 25%of these men experience spermatogenic failure,such as a Sertoli cell-only syndrome with azoospermia[2].We present the case of a patient with burned-out testicular seminoma and contralateral Sertoli cell-only *** consent to procedures and publication was obtained from the patient before presentation of this case report.

关键词： impaired metastasis clinical

Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome

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Cancer Communications 2023年第11期43卷 1280-1285页

作者： Elisabeth Naschberger Maximilian Fuchs Nicholas Dickel Meik Kunz Bernt Popp Charles Gwellem Anchang Richard Demmler Yanmin Lyu Steffen Uebe Arif Bülent Ekici Carol Immanuel Geppert Arndt Hartmann Christian Flierl Katja Petter Tobias Gass Simon Völkl Michael Scharl Andreas Ramming Claudia Günther Susanne Merkel Vera Simone Schellerer Michael Stürzl Division of Molecular and Experimental Surgery Translational Research CenterUniversitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN) ErlangenBavariaGermany Chair of Medical Informatics Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Fraunhofer Institute of Toxicology and Experimental Medicine Lower saxonyHannoverGermany Institute of Human Genetics Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Medicine 3 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Institute of Pathology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Internal Medicine 5 – Hematology and Oncology Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Gastroenterology and Hepatology University Hospital ZurichUniversity of ZurichCanton ZurichZurichSwitzerland Department of Medicine 1 Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany Department of Surgery Universitätsklinikum ErlangenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU)ErlangenBavariaGermany

Dear Editor,Tumor microenvironment(TME)-dependent stromal cell plasticity governs tumor development and therapy *** endothelial cells(TECs)are a major cellular component in this context[1].In colorectal carcinoma(CRC),the stromal cell-dependent impact of the TME is illustrated by an improved survival depending on an interferon(IFN)-γ-dominated Th1-like TME associated with high T-cell density[2]and suppressed angiogenesis[3,4].Cellular transcriptional memory is reported in cell lines after repeated exposure to IFN-γin vitro[5],suggesting that a Th1-like TME may also exert stable imprinting effects in ***,we investigated whether TME-dependent transcriptional imprinting in TECs from CRC patients can be exploited to retrieve clinically relevant signatures predicting outcomes.

关键词： imprinting colon interferon

Sport and physical exercise in sustainable mental health care of common mental disorders:Lessons from the COVID-19 pandemic

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Sports Medicine and Health Science 2023年第2期5卷 151-155页

作者： Klaus W.Lange Yukiko Nakamura Andreas Reissmann Faculty of Human Sciences(Psychology Education and Sport Science)University of RegensburgRegensburgBavariaGermany

The large-scale disruptions to physical activity during the coronavirus pandemic have been found to be a leading predictor of common mental *** addition,regular physical exercise has been found to alleviate anxiety,sadness and depression during the *** findings,together with numerous studies published before the pandemic on the effects of physical activity on mental health,should be considered in the provision of mental health care following the ***-sectional research has revealed that all types of exercise and sport are associated with a reduced mental health ***,the effectiveness of exercise and sport participation in sustainable mental health care as well as the causal relationship between exercise,psychosocial health and common mental disorders merit further *** activity and sport,with their global accessibility,significant and clinically meaningful efficacy as well as virtual absence of adverse effects,offer a promising option for the promotion of mental health,including the prevention and treatment of common mental *** exercise and sport are likely to become valuable public mental health resources in the future.

关键词： Anxiety Depression Mental health Physical exercise COVID-19

Landing in Ski Jumping: A Review About its Biomechanics and the Connected Injuries

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Journal of Science in Sport and Exercise 2021年第3期3卷 238-248页

作者： Veronica Bessone Ansgar Schwirtz Department of Biomechanics in Sports Faculty of Sport and Health SciencesTechnical University of MunichMunichBavariaGermany

The present review deals with the current scientific knowledge related with ski jump landing.A specific focus is given on the landing biomechanics,the methods utilized for its analysis and the injuries connected to the landing *** the demonstrated importance for the safety and the performance of ski jumpers,the landing and its preparation are rarely *** this paper,after having firstly described the execution of landing and its preparation and the reason why is impor-tant to analyze it,an overview of the current status of the research related to the landing biomechanics is reported(kinetics,kinematics,electromyographic activation,aerodynamics,computer simulation).The third part describes the methods and technologies utilized in literature to analyze the landing and its preparation(video cameras,inertial sensors,force insoles,wind tunnel and computer simulation).After that,an overview of the injuries related to landing is *** final section proposes future research in the field of biomechanics of ski jump landing in different fields,such as computer simulations,kinematic analysis,equipment development and biomechanics of female athletes.

关键词： Feedback Sensors Prevention Kinetics Kinematics Winter sports