检索结果-南通市图书馆

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

Translational Neurodegeneration 2020年第1期9卷 39-54页

作者： Niccolo Candelise Matthias Schmitz Katrin Thüne Maria Cramm Alberto Rabano Saima Zafar Erik Stoops Hugo Vanderstichele Anna Villar-Pique Franc Llorens Inga Zerr Department of Neurology University Medicine Goettingen and the German Center for Neurodegenerative Diseases(DZNE)Robert-Koch-Stra?e 4037075 G?ttingenGermany Biomedical Engineering and Sciences Department School of Mechanical and Manufacturing Engineering(SMME)National University of Sciences and Technology(NUST)IslamabadPakistan Department of Experimental Diagnostic and Speciality MedicineUniversity of BolognaBolognaItaly Departamento de Neuropatología y Banco de Tejidos(BT-CIEN) Fundación CIENInstituto de Salud Carlos III Centro Alzheimer Fundación Reina SofíacValderrebollo n°528031 MadridSpain adx neurosciences Technologiepark 4GhentBelgium CIBERNED(Network center for biomedical research of neurodegenerative diseases) Institute Carlos IIIMadridSpain Bellvitge Biomedical Research Institute(IDIBELL) Hospitalet de LlobregatBarcelonaSpain

Background: α-Synuclein is a small soluble protein,whose physiological function in the healthy brain is poorly *** inclusions of α-synuclein,referred to as Lewy bodies(LBs),are pathological hallmarks ofαsynucleinopathies,such as Parkinson’s disease(PD)or dementia with Lewy bodies(DLB).Main body:Understanding of the molecular basis as well as the factors or conditions promoting α-synuclein misfolding and aggregation is an important step towards the comprehension of pathological mechanism ofαsynucleinopathies and for the development of efficient therapeutic *** on the conversion and aggregation mechanism of α-synuclein,novel diagnostic tests,such as protein misfolding seeded conversion assays,*** real-time quaking-induced conversion(RT-QuIC),had been *** diagnostics, α-synuclein RT-QuIC exhibits a specificity between 82 and 100%while the sensitivity varies between 70 and 100%among different *** addition,the α-synuclein RT-QuIC can be used to study the α-synuclein-seeding-characteristics of different α-synucleinopathies and to differentiate between DLB and ***:The variable diagnostic accuracy of current α-synuclein RT-QuIC occurs due to different protocols,cohorts and material etc..An impact of micro-environmental factors on the α-synuclein aggregation and conversion process and the occurrence and detection of differential misfolded α-synuclein types or strains might underpin the clinical heterogeneity of α-synucleinopathies.

关键词： RT-QuIC α-Synucleinopathies Protein misfolding Protein strains

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：