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A Reevaluation of Prazosin Pharmacokinetics in a Two-Compartment Model, the Apparent Volume of Distribution and Comparative Simulations in the One-Compartment Model

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Journal of Biosciences and Medicines 2022年第1期10卷 108-140页

作者： Michalakis Savva Xudong Yuan South University Savannah USA acon Pharmaceuticals Cranbury USA

Published clinical data of Prazosin were reevaluated pharmacokinetically using explicit solutions to drug concentration as a function of total time for IV bolus injection, intermittent intravenous infusion and oral routes of administration in an open two-compartment model. In a novel way, the apparent volume of distribution was estimated from a two-compartment model and found to be close to the total body water suggesting that Prazosin is distributed in all tissues both extracellularly and intracellularly. In addition, extracting the value of the apparent volume of distribution from a two-compartment model allowed comparative simulations in the one-compartment model. It is shown that dosage calculations of Prazosin intermittent infusion can be safely performed using the simpler one-compartment model equations. Lastly, several additional time-dependent pharmacokinetic parameters e.g., the peak time in the central and peripheral compartment and non-steady state and steady state peak concentration and AUC were determined using series equations for all three routes of administration, as a function of dose number and total time upon multiple drug administrations in the two-compartment model. It is also the first time that steady-state plasma drug concentration equations were derived in a two-compartment mammillary model.

关键词： Prazosin Pharmacokinetics Intravenous Bolus Intermittent Infusion Oral Dose Multiple Doses Compartment Model Apparent Volume of Distribution

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Mpox (monkeypox) knowledge, concern, willingness to change behaviour, and seek vaccination: Results of a national cross-sectional survey

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Sexual Health 2023年第5期20卷 403-410页

作者： Macgibbon J. Cornelisse V.J. Smith A.K.J. Broady T.R. Hammoud M.A. Bavinton B.R. Heath-Paynter D. Vaughan M. Wright E.J. Holt M. Centre for Social Research in Health UNSW Sydney Sydney NSW Australia Kirby Institute UNSW Sydney Sydney NSW Australia NSW Health Sydney NSW Australia Health Equity Matters Sydney NSW Australia acon Sydney NSW Australia Department of Infectious Diseases Alfred Hospital and Central Clinical School Monash University Melbourne VIC Australia Burnet Institute Melbourne VIC Australia The Peter Doherty Institute of Infection and Immunity Melbourne VIC Australia

Background: In mid-2022, a global mpox (formerly 'monkeypox') outbreak affecting predominantly gay and bisexual men emerged in non-endemic countries. Australia had never previously recorded mpox cases and there was no prior research on knowledge or attitudes to mpox among gay and bisexual men across Australia. Methods: We conducted a national, online cross-sectional survey between August 2022 and September 2022. Participants were recruited through community organisation promotions, online advertising, and direct email invitations. Eligible participants were gay, bisexual or queer; identified as male (cisgender or transgender) or non-binary; aged 16 years or older; and lived in Australia. The main outcome measures were: knowledge and concern about mpox; recognition of mpox symptoms and transmission routes; vaccination history; acceptability of behavioural changes to reduce mpox risk, and willingness to be vaccinated. Results: Of 2287 participants, most participants were male (2189/2287; 95.7%) and gay (1894/2287; 82.8%). Nearly all had heard about mpox (2255/2287; 98.6%), and the majority were concerned about acquiring it (1461/2287; 64.4%). Most of the 2268 participants not previously diagnosed with mpox correctly identified skin lesions (2087; 92%), rash (1977; 87.2%), and fever (1647; 72.6%) as potential symptoms, and prolonged and brief skin-To-skin contact as potential ways to acquire mpox (2124, 93.7%; and 1860, 82%, respectively). The most acceptable behavioural changes were reducing or avoiding attendance at sex parties (1494; 65.9%) and sex-on-premises venues (1503; 66.4%), and having fewer sexual partners (1466; 64.6%). Most unvaccinated and undiagnosed participants were willing to be vaccinated (1457/1733; 84.1%). Conclusions: People at risk of mpox should be supported to adopt acceptable risk reduction strategies during outbreaks and to seek vaccination. © 2023 CSIRO. All rights reserved.

关键词： attitudes Australia gay and bisexual men men who have sex with men monkeypox mpox sexual behaviour sexual practice sexually transmissible infection vaccination vaccine

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The innovations in China’s primary health care reform: Development and characteristics of the community health services in Hangzhou

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Family Medicine and Community Health 2015年第3期3卷 52-66页

作者： Feng Lin Qihong Sun Zhangping Peng Jun Cai Philip Geanacopoulos Lin Li Yun Zhao Xin Zhang Xiaoxiao Chen acon Primary Care Research Center 4F Tower BUnion PlazaNo.2 Zijinghua RoadHangzhouZhejiang 310023China Walter H.Shorenstein Asia-Pacific Research Center Freeman Spogli Institute for International StudiesStanford University616 Serra St.Encina Hall E311StanfordCA 94305USA

Objective:This study focuses on Hangzhou,a Chinese city with a population of nine million urban and rural residents,to examine the successful development and innovation experience of its primary health care service system during the new health reform in China since 2009 and then dis-seminate the findings through international third parties.Methods:Measures such as data analysis,study of documents and regulations,fieldwork,and expert discussions were used to systematically investigate primary health care in Hangzhou.The findings will have a profound practical impact on the health reform for nine million rural and urban residents throughout Hangzhou’s municipal boroughs.Results:Community health services in Hangzhou are characterized as follows:They are gov-ernment led;they are guaranteed with enough financing,personnel,facilities,and regulation;sup-ported by the unified information platform;general practitioners have been assigned the key role of health‘gatekeepers’;they provide primary care combined with basic public health services;there are integrated urban and rural health services and insurance coverage;and there is health care-pen-sion-nursing integration and general practitioner-contracted‘smart’services.Preliminary data collection and analysis indicate that the basic health status of Hangzhou residents is superior to that of residents of China as a whole,and some health indicators in Hangzhou are comparable to those in Western developed countries.Conclusion:It is reasonable to believe that the primary health care level in China,including Hangzhou,will be further developed and promoted with indexed performance evaluations and more effective implementation of additional measures.

关键词： Health care reforms community health services health status Hangzhou China

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