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Progress in Natural Science:materials International 2015年第5期25卷 392-398页

作者： T.Sivaraman v.Narasimman v.S.Nagarethinam A.R.Balu PG and Research Department of Physics A.V.V.M Sri Pushpam College

CdS and chlorine doped CdS(CdS:Cl) thin films with different Cl-doping levels(0,2,4,6 and 8 at%) have been deposited on glass substrates by a spray pyrolysis technique using a perfume *** effect of Cl doping on the structural,morphological,optical and electrical properties of the films was *** patterns revealed that all the films exhibit hexagonal crystal structure with a preferential orientation along the(0 0 2) plane irrespective of the Cl doping *** particle size value decreases from 22.03 nm to 18.12 nm with increase in Cl *** band gap is blue-shifted from 2.48 ev to 2.73 ev with increase in Cl doping *** the films have resistivity in the order of 10～4 Ω *** obtained results confirm that chlorine as an anionic dopant material can enhance the physical properties of CdS thin films to a large extent.

关键词： X-ray diffraction Crystal structure Preferential orientation Thin films Optical band gap

Characteristic analysis on the physical properties of nanostructured mg-doped CdO thin films—Doping concentration effect

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Progress in Natural Science:materials International 2015年第3期25卷 251-257页

作者： K.Usharani A.R.Balu v.S.Nagarethinam m.Suganya PG and Research Department of Physics A.V.V.M Sri Pushpam College

Highly conductive and transparent magnesium-doped cadmium oxide(CdO :mg) thin films have been deposited on suitably cleaned glass substrates maintained at 375℃ by spray pyrolysis technique using perfume atomizer. The magnesium content in the films is varied from 0 to 8 at%in steps of 2 at%. The effect of mg doping on the structural, morphological, optical and electrical properties of the CdO thin films has been *** the films exhibited cubic structure with a preferential orientation along the(1 1 1) plane irrespective of the mg doping level. SEm analysis showed that the film morphology modifies from spherical shaped grains to closely packed cauliflower shaped nanostructures with mg *** for the film coated with 2 at% mg dopant, all the other doped films exhibited a blue shift in the optical band gap. Electrical studies revealed that the Cd O:mg film coated with 8 at% mg dopant had a minimum resistivity of 0.0853*10～1Ω-cm.

关键词： X-ray diffraction Texture coefficient Thin films Optical band gap Electrical properties

Anti-diabetic activity of quercetin extracted from Phyllanthus emblica ***: In silico and in vivo approaches

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Journal of Pharmaceutical Analysis 2018年第2期8卷 109-118页

作者： Prabhu srinivasan S.vijayakumar Swaminathan Kothandaraman manogar Palani Computational Phytochemistry Lab PG and Research Department of Botany and Microbiology A. V. V. M Sri Pushpam College (Autonomous) Department of Physics RKM Vivekananda College (Autonomous)

In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies.

关键词： Bioactive molecules Glycogen phosphorylase molecular docking Phyllanthus emblica Quercetin Albino Wister male rats

In silico prediction of monovalent and chimeric tetravalent vaccines for prevention and treatment of dengue fever

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The Journal of Biomedical Research 2018年第3期32卷 222-236页

作者： vijayakumar Subramaniyan Ramesh venkatachalam Prabhu srinivasan manogar Palani Computational Phytochemistry Laboratory P.G. and Research Department of Botany and microbiology A.V.V.M. Sri Pushpam College (Autonomous)

Reverse vaccinology method was used to predict the monovalent peptide vaccine candidate to produce antibodies for therapeutic purpose and to predict tetravalent vaccine candidate to act as a common vaccine to cover all the dengue virus serotypes. Envelope（E）-proteins of DENv-1-4 serotypes were used for vaccine prediction using NCBI,Uniprot/Swissprot, Swiss-prot viewer, vaxiJen v2.0, TmHmm, BCPREDS, Propred-1, Propred and mHC Pred. Eproteins of DENv-1-4 serotypes were identified as antigen from which T cell epitopes, through B cell epitopes, were predicted to act as peptide vaccine candidates. Each selected T cell epitope of E-protein was confirmed to act as vaccine and to induce complementary antibody against particular serotype of dengue virus. Chimeric tetravalent vaccine was formed by the conjugation of four vaccines, each from four dengue serotypes to act as a common vaccine candidate for all the four dengue serotypes. It can be justifiably concluded that the monovalent 9-mer T cell epitope for each DENv serotype can be used to produce specific antibody against dengue virus and a chimeric common tetravalent vaccine candidate to yield a comparative vaccine to cover any of the four dengue virus serotype. This vaccine is expected to be highly immunogenic against dengue fever.

关键词： dengue serotypes dengue virus vaccine E-proteins mHC Ⅰ and Ⅱ

Antimicrobial and antiproliferative prospective of kosinostatin-a secondary metabolite isolated from Streptomyces sp.

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Journal of Pharmaceutical Analysis 2015年第6期5卷 378-382页

作者： vinayagam Rambabu Subramaniyan Suba Suburamaniyan vijayakumar P.G. and Research Department of Botany and microbiology A.V.V.M. Sri Pushpam College (Autonomous) K.K Biotec Lab Service

Cancer is a communal health hazard worldwide. The present investigation attempts to evaluate anti- microbial and anticancer potential of kosinostatin on mammary carcinoma cell line （mCF-7）. The anticancer and antiproliferative activities of kosinostatin were analyzed on mCF cell line by mTT assay and cytotoxicity assays like lactate dehydrogenase （LDH） and glutathione （GSH）. The secondary metabolite kosinostatin exhibited its apoptotic nature by expressing p53 protein. Collectively, the results acquired from this study promise that kosinostatin shows the potent anticancer activity.

关键词： Kosinostatin Secondary metabolite Streptomyces sp. Cytotoxic activity mCF-7

Prevalence of various pathological conditions in female buffaloes (Bubalus bubalis)

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Asian pacific Journal of Reproduction 2017年第2期6卷 58-67页

作者： Perumal Ponraj Sukkum Chang Nakulan v Rajesh muthusamy veeraselvam Kalpana Devi Rajesh ICAR-National Research Centre on mithun MedziphemaNagaland-797 106India TANUvAS-veterinary University Training and Research Centre Ramanathapuram-623 503India TANUvAS-veterinary college and Research Institute OrathanaduThanjavur-614 625India a.v.v.m.sri pushpam college Thanjavur-613 503India

The present review article has described the prevalence of various pathological conditions of reproductive system of female buffaloes starting from ovary to vulva and vagina. various pathological conditions were analyzed and tabulated as the total number of animal examined, number of the animals showed pathological lesions, percentage of animal showed various pathological lesions and percentage of individual pathological lesion in different parts of reproductive system of female buffaloes. The incidence of disorders of female genital organs of buffaloes has been reported by various authors at various percentages in different countries. The incidence of pathological conditions was recorded in clinically infertile cows after slaughtering or from apparently healthy buffaloes slaughtered for human consumption and/or based on postmortem examination. This review is comprehensively covering pathological conditions of female buffalo hitherto which was not previously described at one place. This review will provide a comprehensive knowledge about the prevalence of different pathological condition of different parts of reproductive tract of female buffaloes. The review has six numbers of tables described about the various pathological conditions from ovary to vulva and vagina in female buffaloes. The present review article will be very useful to the buffalo farmers, buffalo breeders and researchers are working in buffalo reproduction & breeding and pathology.

关键词： Female buffaloes Reproductive system Pathological conditions Infertility Incidence/Percentage

Simultaneous Enhancement of Transparent and Antibacterial Properties of ZnO Films by Suitable F Doping

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Journal of materials Science & Technology 2015年第7期31卷 759-765页

作者： S.Snega K.Ravichandran m.Baneto S.vijayakumar Post Graduate & Research Department of Physics AVVM Sri Pushpam College(Autonomous) CUER-UL Universite de LomeFaculte Des Sciences Post Graduate & Research Department of Botany and microbiology AVVM Sri Pushpam College(Autonomous)

Undoped and fluorine doped ZnO （ZnO：F） thin films were deposited onto glass substrates by employing a simplified spray pyrolysis technique using a perfume atomizer. The fluorine doping level in the starting solution was varied from 0 to 20 at.% in steps of 5 at.~g and the effects of fluorine doping level on the structural, optical, surface morphological properties along with their antibacterial activity against Escherichia coil （E. coli） and Bacillus subtilis （B. subtilis） bacteria were studied and reported. The X-ray diffraction studies revealed that despite the orientation ofcrystallites was strongly influenced by fluorine doping, the preferential orientation was retained in favor of （002） plane even at the highest doping level. The crystallite size decreased as the F doping level was increased and the reason for this variation has been explained on the basis of Zener pinning effect. The average optical transparency in the visible range was about 80%-90g for doped films and the optical band gap was found to be slightly increased with the F doping level. The antibacterial efficiency of the F doped ZnO films was found to be enhanced as the F doping level was increased. The antibacterial efficiency was more pronounced in the case of B. subtilis （Gram-positive） when compared with E. coil （Gram-negative）.

关键词： ZnO filmAntibacterial activitySpray pyrolysisDoping

Dielectric and Optical Characterization of Boron Doped Ammonium Dihydrogen Phosphate

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Journal of Crystallization Process and Technology 2013年第1期3卷 5-11页

作者： Delci Zion Shyamala Devarajan Thayumanavan Arunachalam Department of Physics A.V.V.M. Sri Pushpam College Thanjavur India. Department of Physics D.G.Vaishnav College Chennai India

Single crystals of pure and boron doped ammonium dihydrogen phosphate were grown from aqueous solution by slow solvent evaporation process. ICP studies were done to confirm the presence of the dopant boron in the parent crystal. The values of the lattice parameters were determined by single crystal X-ray diffraction. The pure and doped ADP crystals were found to have tetragonal structure. Complete optical characterizations of the crystals were done using the FTIR, Uv-vis and NLO studies. The presences of the various functional groups in the crystals were identified by FTIR spectrum. The band gap energies of the pure and doped crystals have been calculated at their cut off frequencies using the Uv-vis spectrum. The second harmonic generation efficiency of the crystals was determined. The electric properties of the grown crystal have been analyzed by studying the variation of dielectric constant and dielectric loss with frequency.

关键词： Solution Growth ADP Boric Acid Optical Transparency NLO Dielectric Constant

Growth, Thermal, mechanical and Dielectric Studies of Glycine Doped Potassium Acid Phthalate Single Crystals

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Journal of minerals and materials Characterization and Engineering 2011年第9期10卷 805-815页

作者： T. Baraniraj P. Philominathan Department of Physics A.V.V.M Sri Pushpam College (Autonomous) Poondi Thanjavur-613 503 India Department of Physics Roever college of Engineering & Technology Perambalur 621 212India

Single crystals of glycine doped potassium acid phthalate (KAP) have been grown from low temperature solution growth method by employing slow evaporation of the solvent at room temperature. The grown crystal was subjected to various studies such as X-ray diffraction (XRD), Fourier Transform Infrared (FTIR), Uv-visible and Second Harmonic Generation (SHG) studies. The thermal stability, mechanical strength and dielectric constant were also measured. The various studies revealed the influence of the glycine on KAP and the investigations indicated that glycine played an important role in the changes of the spectral, optical and mechanical properties of KAP crystals.

关键词： nonlinear optics growth from solution X-ray diffraction dielectric constant

Growth and Characterization of Gamma Glycine Single Crystals Grown from Alpha Glycine in the Presence of Sodium Acetate

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Journal of minerals and materials Characterization and Engineering 2011年第4期10卷 351-356页

作者： T. Baraniraj P. Philominathan Department of Physics A.V.V.M Sri Pushpam College (Autonomous) Poondi Thanjavur-613 503 India Department of Physics Roever College of Engineering & Technology Perambalur-621 212India

A nonlinear optical crystal of gamma glycine was grown by slow evaporation solution growth technique using deionized water and sodium acetate. The functional groups and vibrational frequencies were identified using FTIR spectral analysis. The cell parameters were determined from single crystal X-ray diffraction analysis. Thermogravimetric analysis (TGA) and differential thermal analysis (DTA) were used to study its thermal properties. The optical transmittance window and lower cutoff wavelength have been identified by Uv-absorption spectrum analysis. Second harmonic generation (SHG) efficiency measurement was carried out by powder Kurtz method.

关键词： Nonlinear optical crystal solution growth technique characterization technique second harmonic generation