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Particuology 2024年第7期90卷 189-198页

作者： Bina gidwani Vishal Jain Veenu Joshi ravindra Kumar Pandey Shiv Shankar Shukla Amber Vyas Columbia institute of pharmacy Raipur(C.G.)India University institute of pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 rPM, 8000 rPM, and 12000 rPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit rS 100 Nanoparticles hyperlipidemia

Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine Life Science & Technology 2024年第1期6卷 84-92页

作者： Yuna Jung Chaesun Kwon Taeyeon Kim Jin Woo Lee Min-Kyoo Shin Sang hee Shim Natural Products research institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea college of pharmacy and research institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea college of pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMr,and *** configurations were established on the basis of 1h coupling constants,rOESY correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,Sh-SY5Y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/L of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

CuInS_(2)quantum-dot-modified g-C_(3)N_(4)S-scheme heterojunction photocatalyst for hydrogen production and tetracycline degradation

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Journal of Materials Science & Technology 2024年第5期172卷 145-155页

作者： Jingjing Zhang Yue Zhao Kezhen Qi Shu-yuan Liu college of pharmacy Dali UniversityDali 671000China Department of Pharmacology Shenyang Medical CollegeShenyang 110034China

CuInS_(2)quantum-dot(CIS QD)-modified g-C_(3)N_(4)(CN)catalysts(CIS/CN)were prepared with the aid of an in-situ growth *** as-obtained photocatalysts were explored by measuring their crystallinity,surface morphology,binding energy and light absorption *** photocatalytic efficiency of the pho-tocatalysts was evaluated through photocatalytic water splitting for hydrogen production and tetracycline(TC)antibiotic degradation under the simulated solar light and visible light *** optimized sample(10CIS/CN)showed the best photocatalytic activity:producing 102.4μmol g^(-1)h^(-1)of hydrogen in 1 h,or degrading 52.16%of TC in 120 min,which were respectively 48 or 3.4 times higher than the photocatalytic activity of CN *** enhancement in the efficiency of the composite system was prin-cipally accredited to the enlargement of light absorption,the more effective in charge transfer and the dropping of the charge ca.r.er pa.r.recombination through a formed S-scheme heterojunctional *** work is an effort to adjust CN-based polysulfide QD for speedy *** enriched photo-catalytic activity grants a new sense for adjusting the optical properties of CN.

关键词： CuInS_(2)QDs g-C_(3)N_(4) Photocatalysis hydrogen production S-scheme heterojunction

Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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Food Science and human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi Chun-hsu Pan hui-Yu huang Chieh-hsi Wu Program in Clinical Drug Development from herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of pharmacy Taipei Medical UniversityTaipei 11031China graduate institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a.r.t model of restenosis and its underlying mechanisms in ma.r.phages and vascular smooth muscle cells(vSMCs).16S rrNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in ma.r.phages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in ma.r.phages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rrNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT restenosis Ma.r.phage Vascular smooth muscle cells gut microbiota

Mapping COVID-19 in India:Southern states at the forefront of new JN.1 variant

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 1-3页

作者： rabin Debnath Arshdeep Singh Kushal Seni Anjali Sharma Viney Chawla Pooja A Chawla Department of Pharmaceutical Chemistry ISF College of PharmacyG.T RoadGhal KalanMogaPunjab142001India Department of Pharmaceutical Analysis ISF College of PharmacyG.T RoadGhal KalanMogaPunjab142001India University institute of Pharmaceutical Sciences and research Baba Farid University of Health SciencesFaridkotPunjabIndia

A new variant,JN.1,stemming from the omicron subvariant BA.2.86,garnered the attention of the World health Organization(WhO)as a"variant of interest."Despite its rapid global spread,especially in the US,Canada,France,Singapore,Sweden[1],and the UK,JN.1 is considered to pose minimal *** vaccinations are believed to remain effective against *** WhO underscores the importance of maintaining immunization records amid co-occurring respiratory illnesses,and epidemiologists recommend monitoring hospitalizations,particularly in areas with low vaccination rates.

关键词： Canada Mapping spite

In silico identification of antiviral compounds for the treatment of chikungunya virus infection:qsar modelling and md simulation analysis

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Medicine in Novel Technology and Devices 2024年第2期22卷 102-114页

作者： hayder M Abdulhamza Muthanna S.Farhan Sara.S hassan hany Aqeel Al-hussainy Amjad Ibrahim Oriabi Department of pharmacy Kut University CollegeAlkutWasit52001Iraq Department of Pharmaceutical Chemistry College of PharmacyUniversity of BaghdadBaghdadIraq Al-Manara college for Medical Sciences Department of PharmacyIraq Department of pharmacy Hilla University CollegeBabylonIraq Dr hany Akeel institute Iraqi Medical Research CenterBaghdad10001Iraq

Chikungunya virus(ChIKV),transmitted by arthropods,has gained global recognition for its impact on public *** has expanded globally,including a.r.ca,Asia,and the Indian subcontinent,and has a helicase protein in its genome that is crucial for its ***,the study targeted the helicase protein of ChIKV with 745 antiviral compounds using an ML-based QSAr model and molecular *** binders(5279172,78161839,6474310,and 5330286)were selected for MD simulation based on the control(Silvestrol).All compounds had the highest binding scores,with 78161839 showing the most consistent rMSD and the least conformational variation,indicating high *** also showed the lowest binding free energy(Δg¼31.31 kcal/mol),indicating energetically favourable *** and FEL also depicted the stable complex confirmation of the protein and 78161839 complex during the 100 ns ***,this study aimed to identify helicase function antiviral binders that could be experimentally tested for treating ChIKV.

关键词： Chikungunya virus Machine learning based QSAr Molecular dynamic solution helicase

glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-geun Song Jae Woo Jung haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi hyun-Woo rhee Kwang-hyeon Liu Jung Weon Lee Department of pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea research institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUr Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea college of pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DrP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impa.r.d oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

Development of lithium-free P2-type high-sodium content cathode materials with enhanced cycle and a.r.stability for sodium-ion batteries

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rare Metals 2024年第1期43卷 113-123页

作者： Jin-Lv Tian Lin-rong Wu hai-Jun Zhao Shou-Dong Xu Liang Chen Ding Zhang Xiao-Chuan Duan college of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China college of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and pharmacy Wuhan Institute of TechnologyWuhan 430205China

The effect of partial substitution of Mg for Ni on a high-sodium and lithium-free layered P2-type Na_(45/54)Mg_(6)/_(54)Ni_(12/54)Mn_(34/54)O_(2) cathode with high initial Coulombic efficiency and excellent cyclic stability has been investigated in this *** on the crystal structural analysis,the Mg doping can retain the P2 structure up to 4.3 V,thus restraining the detrimental phase transformation of P2-02during the Na-ion intercalation/deintercalation ***,the obtained Mg-doped P2-type cathode exhibits a.r.versible specific capacity of 109 mAh·g^(-1) at 0.1C between 2.0 and 4.3 V and a.r.tention rate of 81.5% after 200cycles at *** addition,the full cell consisting of Mg-doped P2-type cathode and hard carbon anode shows a capacity retention rate of 85.6% after 100 *** study provides new insight into the development of durable cathode materials for sodium-ion batteries.

关键词： Sodium-ion batteries Cathode material high sodium content a.r.stability

Effects of Inoculation with Phosphate Solubilizing Bacteria on the Physiology,Biochemistry,and Expression of genes related to the Protective Enzyme System of Fritillaria taipaiensis ***

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 247-260页

作者： Zhifen Shi Fumei Pan Xiaotian Kong Jiaqi Lang Mingyan Ye Qian Wu guangzhi Wang Liang han Nong Zhou college of pharmacy Chengdu University of Traditional Chinese MedicineChengdu611130China college of pharmacy Dali UniversityDali671000China college of Food and Biological Engineering Chongqing Three Gorges UniversityChongqing404120China Diqing Tibetan Autonomous Prefecture institute of Plateau Biology Diqing674400China Chongqing institute of Medicinal Plant Cultivation Chongqing408435China

Fritillaria taipaiensis *** is a widely used medicinal herb in treating pulmonary *** recent years,its wild resources have become scarce,and the demand for efficient artificial cultivation has significantly *** article is the first to apply phosphate solubilizing bacteria isolated from the rhizosphere soil of *** *** to the cultivation process of *** *** aim is to identify suitable reference strains for the artificial cultivation and industrial development of *** *** by examining the effects of various phosphate solubilizing bacteria and their combinations on photosynthesis,physiological and biochemical properties,and gene expression related to the protective enzyme system in *** *** experiment,conducted in pots at room temperature,included a control group(CK)and groups inoculated with inorganic phosphorussolubilizing bacteria:W1(Bacillus cereus),W2(Serratia plymuthica),W12(Bacillus cereus and Serratia plymuthica),and groups inoculated with organophosphorus-solubilizing bacteria:Y1(Bacillus cereus),Y2(Bacillus cereus),Y12(Bacillus cereus and Bacillus cereus),totaling seven *** to CK,most growth indices in the bacterial addition groups showed significant differences,with W12 achieving the highest values in all indices except the leaf area *** content of photosynthetic pigments,photosynthetic parameters,and osmoregulatory substances increased variably in each bacterial treatment group.W12 exhibited the highest content of chlorophyll a and soluble protein,while W1 had the highest free proline *** activities of peroxidase(POD),superoxide dismutase(SOD),and catalase(CAT)in all inoculated groups were higher than in CK,with significant changes in SOD and CAT *** malondialdehyde(MDA)content in all inoculated groups was lower than in CK,with Y12 being the lowest,at approximately 30%of *** expression corresponding to these three enzymes also increased var

关键词： Fritillaria taipaiensis P.Y.Li phosphate solubiliozing bacteria photosynthesis physiology and biochemistry protective enzymes

Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-month follow-up questionna.r. study

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World Journal of Clinical Cases 2024年第15期12卷 2560-2567页

作者： Abdullah M Alhammad Namareq F Aldardeer Abdulaziz Alqahtani Mohammad h Aljawadi Bushra Alnefaie raghad Alonazi Mansour Almuqbil Abdulrahman Alsaadon rakan M Alqahtani rashid Alballaa Bader Alshehri Mohammed I Alarifi Fahad D Alosaimi Department of Clinical pharmacy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia Department of pharmacy Services King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate Department of pharmacy Services King Saud University Medical CityRiyadh 12372Saudi Arabia college of pharmacy King Saud UniversityRiyadh 12372Saudi Arabia Department of Critical Care Medicine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Psychia.r. College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKgrOUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological ***,few studies have examined those who recovered from coronavirus disease 2019(COVID-19).There is a paucity of data from the Middle East assessing the post-ICU discharge mental health status of patients who had *** To evaluate anxiety and depression among patients who had severe *** This is a prospective single-center follow-up questionna.r.-based study of adults who were admitted to the ICU or under ICU consultation for>24 h for *** patients were contacted via *** patient’s anxiety and depression six months after ICU discharge were assessed using the hospital Anxiety and Depression Scale(hADS).The primary outcome was the mean hADS *** secondary outcomes were risk factors of anxiety and/or *** Patients who were admitted to the ICU because of COVID-19 were screened(n=518).Of these,48 completed the *** mean age was 56.3±17.2 *** patients(62.5%)were *** main comorbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)*** mean overall hADS score for anxiety and depression at 6 months post-ICU discharge was 11.4(SD±8.5).A hADS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),*** from the multivariable ordered logistic regression demonstrated that vasopressor use was associated with the development of anxiety and depression[odds ratio(Or)39.06,95% confidence interval:1.309-1165.8;Phs after ICU discharge,30% of patients who had COVID-19 demonstrated a hADS score that confirmed anxiety and *** compare the psychological status of patients following an ICU admission(with vs without COVID-19),further studies are wa.r.nted.

关键词： COVID-19 Critically ill Anxiety Depression hADS Saudi Arabia