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Effect of poly(3-hydroxyalkanoates) as natural polymers on mesenchymal stem cells

World Journal of Stem Cells 2019年第10期11卷 764-786页

作者： Vera Voinova Garina Bonartseva Anton Bonartsev Faculty of Biology M.V.Lomonosov Moscow State UniversityMoscow 119234Russia A.N.Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of SciencesMoscow 119071Russia

Mesenchymal stem cells(MSCs)are stromal multipotent stem cells that can differentiate into multiple cell types,including fibroblasts,osteoblasts,chondrocytes,adipocytes,and myoblasts,thus allowing them to contribute to the regeneration of various tissues,especially bone tissue.MSCs are now considered one of the most promising cell types in the field of tissue engineering.Traditional petri dish-based culture of MSCs generate heterogeneity,which leads to inconsistent efficacy of MSC applications.Biodegradable and biocompatible polymers,poly(3-hydroxyalkanoates)(PHAs),are actively used for the manufacture of scaffolds that serve as carriers for MSC growth.The growth and differentiation of MSCs grown on PHA scaffolds depend on the physicochemical properties of the polymers,the 3D and surface microstructure of the scaffolds,and the biological activity of PHAs,which was discovered in a series of investigations.The mechanisms of the biological activity of PHAs in relation to MSCs remain insufficiently studied.We suggest that this effect on MSCs could be associated with the natural properties of bacteria-derived PHAs,especially the most widespread representative poly(3-hydroxybutyrate)(PHB).This biopolymer is present in the bacteria of mammalian microbiota,whereas endogenous poly(3-hydroxybutyrate)is found in mammalian tissues.The possible association of PHA effects on MSCs with various biological functions of poly(3-hydroxybutyrate)in bacteria and eukaryotes,including in humans,is discussed in this paper.

关键词： Mesenchymal stem cells Polyhydroxyalkanoates Poly(3-hydroxybutyrate) Tissue engineering Differentiation natural functions Microbiota Bone Intestine

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Laser speckle contrast imaging for monitoring of acutepancreatitis at ischemia-reperfusion injury of thepancreas in rats

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 90-102页

作者： P.A.Dyachenko(Timoshina) A.n.Bashkatov D.A.Alexandrov V.I.Kochubey V.V.Tuchin Saratov State University SaratovRussia Laboratories of Biophotonics and Laser Molecular Imaging and Machine Learning national Research Tomsk State University TomskRussia Saratov State Medical University SaratovRussia institute of Precision Mechanics and Control Russian Academy of SciencesRussia A.N.Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of Sciences MoscowRussia

The influence of ischemia-reperfusion(I/R)action on pancreatic blood flow(PBF)and the development of acute pancreatitis(AP)in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging(LSCI).Additionally,the optical properties in norm and under condition of AP in rats were assessed using a modied integrating sphere spectrometer and inverse Monte Carlo(IMC)software.The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented.The data obtained conrm the fact that local ischemia and changes in the blood°ow velocity of the main vessels cause and provoke acute pancreatitis.

关键词： Laser speckles contrast of speckle images adaptive algorithm microcirculation blood flow acute pancreatitis pancreas rats optical properties integrating sphere spectroscopy

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Introduction to the special issue on celebrating the 15th anniversary of JIOHS and the 70th anniversary of HUST

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Journal of Innovative Optical Health Sciences 2023年第1期16卷 1-4页

作者： Qingming Luo Valery V.Tuchin Lihong Wang Hainan University P.R.China Wuhan NationalLabforOptoelectronics HUSTP.R.China institute of Precision Mechanics and Control FRC SSC RASRussia A.N.Bach Institute of Biochemistry FRC Fundamentals of Biotechnology RAS Russia California institute of Technology USA

Since launching in 2008,Journal of Innovative Optical Health Sciences(JIOHS)has been published for 15 years umtil 2022.Supported by the founding advisor Prof.Britton Chance and other founding Editorial Members,JIOHS was quickly embraced by the biomedical optics community,especially in Asia.Authors submitted some of their high quality papers to JIOHS,which led to a constant Impact Factor(IF)increase frcom the first IF 0.632 to IF 2396(Journal Citation Report 2021).

关键词： founding optics OHS

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A pilot study of the dynamics of tissue oxygenation in vivo using time-resolved phosphorescence imaging

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 15-24页

作者： natalia Kazachkina Julia Lymar Vladislav Shcheslavskiy Alexander Savitsky A.N.Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of Sciences Moscow 119071Russian Federation institute of Experimental Oncology and Biomedical Technologies Privolzhsky Research Medical University Sq Minin and Pozharsky10/1603005 Nizhny Novgorod Russian Federation Becker and Hickl GmbH nunsdorfer Ring 7-912277 BerlinGermany

Oxygenation of tissues plays an important role in the development and progression of tumor to treatment effects.Method of metalloporphyrines phosphorescence quenching by oxygen is one of the ways to measure dynamics of the oxygen concentration in the tissues by phosphorescence lifetime imaging of meso-tetra(sulfophenyl)tetrabenzoporphyrin Pd(Ⅱ)(TBP)using the time-correlated single photon counting(TCSPC)method.It has been shown that phosphorescence lifetime of the sensor in S37 tumor in vivo varied in the range of 130 to 290μs after both topical and intravenous administration of TBP.It indicates that oxygen level in tumors was lower compared to normal tissues where TBP phosphorescence has not been detected.Phosphorescence lifetimes of TBP increased in the solid tumor and in the muscle after photodynamic therapy of solid tumor that demonstrates oxygen consumption during treatment and possibly stopping the blood flow and hence the oxygen supply to the tissues.

关键词： Phosphorescence oxygen sensor metalloporphyrines TCSPC

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Laser speckle contrast imaging for monitoring of acute pancreatitis at ischemia-reperfusion injury of the pancreas in rats

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创新光学健康科学杂志(英文) 2023年第5期16卷 147-147页

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手性药物与生物大分子相互作用中对映选择性的表征方法研究进展

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分析科学学报 2016年第4期32卷 569-574页

作者：卢蓝蓝陈佳虹刘英菊肖治理张炽坚 Sergei A Eremin 孙远明雷红涛华南农业大学食品学院广东省食品质量安全重点实验室广东广州510642 华南农业大学理学院生物材料研究所广东广州510642 A.N.Bach Institute of Biochemistry Russian Academy of SciencesMoscowRussia 119071

手性药物在临床上有着重要的影响,已成为人们关注的一个重点问题。本文对手性药物小分子与生物大分子间相互作用中对映选择性分析方法的研究进展作了概述,重点介绍了分子光谱分析法、等温滴定量热法、手性传感器、原子力显微镜、分子对... 详细信息

手性药物在临床上有着重要的影响,已成为人们关注的一个重点问题。本文对手性药物小分子与生物大分子间相互作用中对映选择性分析方法的研究进展作了概述,重点介绍了分子光谱分析法、等温滴定量热法、手性传感器、原子力显微镜、分子对接模拟等方法在手性药物小分子与生物大分子间对映选择性相互作用表征方法中的应用与进展。

关键词：手性药物生物大分子对映选择性

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Integrated binary hologram to monitor cargo release from a drug-eluting film

Light(Advanced Manufacturing)

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Light(Advanced Manufacturing) 2022年第3期3卷 93-102页

作者： Arkady S.Abdurashitov Pavel IProshin Valery V.Tuchin Gleb B.Sukhorukov Center for neurobiology and Brain Restoration Skolkovo Institute of Science and TechnologyMoscow 121205Russia Science Medical Center Saratov State UniversitySaratov 410012Russia A.N.Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of SciencesMoscow119071Russia School of Engineering and Materials Science Queen Mary University of LondonLondon E14NSUnited Kingdom Siberian State Medical University Moskovskiy Trakt2Tomsk 634050Russia

nowadays,holography translates from a pure technical tool for recording the phase and amplitude of the light wave to a widely applicable research-based method.Holographic devices are used for security enhancement,entertainment,3D display technologies and augmented reality.Binary computer-generated holograms(amplitude or phase-based)are of specific interest.They are easy to compute and their manufacturing methods are fast and robust.In this work,a method of manufacturing amplitude-only binary holograms out of biopolymers films is proposed.Opaque cargo bits made out of different bioactive substances(antibiotics,dyes,etc.)absorb or scatter specific parts of the incoming light wave.Cargo release was conducted by submerging the produced holograms into the aqueous solution at specific pH and temperature levels.Drug elution from the film was traced out by the numerical analysis of the far-field diffraction pattern,which otherwise could only be measured post-factum using sophisticated spectroscopic or chromatography devices.This approach broadens the application of general holography over to the field of biomedical research relevant to quantitative monitoring of the drug elution.

关键词： Computer generated holograms Biopolymers Release monitoring Payload holograms

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SERS-based lateral flow immunoassay of troponin I by using gapenhanced Raman tags

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nano Research 2019年第2期12卷 413-420页

作者： Boris n. Khlebtsov Daniil n. Bratashov nadezhda A. Byzova Boris B. Dzantiev nikolai G. Khlebtsov institute of biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences Saratov 410049 Russia Saratov State University Saratov 410012 Russia A. n. bach institute of biochemistry Research Centre of Biotechnology Russian Academy of Sciences Moscow 119071 Russia

The lateral flow immuno assay (LFIA) has emerged as a powerful tool for rapid scree ning owing to its simplicity and flexibility for detection of various biomarkers. However, conventional LFIA strips have several disadvantages, including limits in quantitative analysis and low sensitivity. Here we developed a novel surface-e nhanced Rama n scatteri ng LFIA based on non spherical gap-e nhanced Raman tags (GERTs), with Raman molecules (RMs) embedded in a 1-nm gap between Au nanorod core and Au shell. Such tags have a strong and uniform surface-enhanced Rama n scattering (SERS) resp on se, an order of mag nitude higher than that of other comm on SERS tags such as Au nano rods, nano stars, Au nano shells with surface-adsorbed RMs, or spherical GERTs with embedded RMs. The feasibility of the tags was dem on strated by the semiqua ntitative and sen sitive detecti on of the heart disease biomarker cardiac tropo nin I (cTnI). GERTs were conjugated with mono clonal antibodies and used for LFIA in the same way as ordinary functionalized colloidal gold. The presenee of the target antigen, cTnI, was identified by Raman microscopy mapping of the test zone. With the SERS-based LFIA, the limit of cTnI detection was about 0.1 ng/mL. This value is within the diagnostic range of cTnI in the blood serum of patients with heart infarction and is 30 times lower than that of the colorimetric LFIA test using the same antibodies and either GERTs or colloidal gold as labels.

关键词： surface-enhanced Raman scattering (SERS) lateral flow immunoassay Au core/shell nanorods gap-enhanced Raman tags cardiac troponin I

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On the interaction of a donepezil-huprine hybrid with synthetic membrane models

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neural Regeneration Research 2023年第2期18卷 333-334页

作者： Pablo Zambrano Max Planck institute of biochemistry Cellular and Molecular BiophysicsMunichGermany

Alzheimer's disease is the most prevalent type of dementia today,discovered and described by Alois Alzheimer in 1907.According to the World Alzheimer Report 2021,75%of people with dementia worldwide are undiagnosed,equivalent to 41 million people(Gauthier et al.,2021).With each passing year,the number of people affected by these diseases is increasing,and the estimates of suffering from them in the future are growing.

关键词： Alzheimer diseases

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Developing molecular-level models for organic field-effect transistors

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national Science Review 2021年第4期8卷 167-180页

作者： Haoyuan Li Jean-Luc Brédas School of Chemistry and biochemistry and Center for Organic Photonics and Electronics Georgia Institute of Technology Department of Chemistry and biochemistry University of Arizona

Organic field-effect transistors(OFETs) are not only functional devices but also represent an important tool for measuring the charge-transport properties of organic semiconductors(OSs). Thus, efforts to understand the performance and characteristics of OFET devices are not only useful in helping achieve higher device efficiencies but also critical to ensuring accuracy in the evaluations of OS charge mobilities.These studies rely on OFET device models, which connect the measured current characteristics to the properties of the OSs. Developing such OFET models requires good knowledge of the charge-transport processes in OSs. In device active layers, the OS thin films are either amorphous(e.g. in organic light-emitting diodes and organic solar cells) or crystalline(e.g. those optimized for charge transport in OFETs). When the electronic couplings between adjacent OS molecules or polymer chain segments are weak, the charge-transport mechanism is dominated by hopping processes, which is the context in which we frame the discussion in this Review. Factors such as disorder, mobility anisotropy, traps, grain boundaries or film morphology all impact charge transport. To take these features fully into account in an OFET device model requires considering a nano-scale, molecular-level resolution. Here, we discuss the recent development of such molecular-resolution OFET models based on a kinetic Monte Carlo approach relevant to the hopping regime. We also briefly describe the applicability of these models to high-mobility OFETs,where we underline the need to extend them to incorporate aspects related to charge delocalization.

关键词： organic semiconductors charge transport kinetic Monte Carlo simulations mobility measurements gradual channel approximation

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