检索结果-南通市图书馆

Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing

引用

World Journal of Gastroenterology 2019年第32期25卷 4629-4660页

作者： Daniel Pohl Peter M Keller Valentine Bordier Karoline Wagner Division of Gastroenterology University Hospital of ZurichZurich 8006Switzerland Institute for Infectious Diseases University of BernBern 3010Switzerland Institute of Medical Microbiology University of ZurichZurich 8006Switzerland

Helicobacter pylori(***)infection is highly prevalent in the human population and may lead to severe gastrointestinal pathology including gastric and duodenal ulcers,mucosa associated tissue lymphoma and gastric *** recent years,an alarming increase in antimicrobial resistance and subsequently failing empiric *** eradication therapies have been noted worldwide,also in many European ***,rapid and accurate determination of ***’s antibiotic susceptibility prior to the administration of eradication regimens becomes ever more ***,detection of *** and its antimicrobial resistance is done by culture and phenotypic drug susceptibility testing that are cumbersome with a long *** advances in diagnostics provide new tools,like real-time polymerase chain reaction(PCR)and line probe assays,to diagnose *** infection and antimicrobial resistance to certain antibiotics,directly from clinical ***,high-throughput whole genome sequencing technologies allow the rapid analysis of the pathogen’s genome,thereby allowing identification of resistance mutations and associated antibiotic *** the first part of this review,we will give an overview on currently available diagnostic methods for detection of *** and its drug resistance and their implementation in *** *** second part of the review focusses on the use of next generation sequencing technology in *** *** this end,we conducted a literature search for original research articles in English using the terms“Helicobacter”,“transcriptomic”,“transcriptome”,“next generation sequencing”and“whole genome sequencing”.This review is aimed to bridge the gap between current diagnostic practice(histology,rapid urease test,*** culture,PCR and line probe assays)and new sequencing technologies and their potential implementation in diagnostic laboratory settings in order to complement the currently

关键词： Helicobacter pylori Advances in diagnostics Next generation sequencing Whole genome sequencing Clinical management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于双估计强化学习结合前向预测控制的自动驾驶运动控制研究

引用

汽车工程 2024年第4期46卷 564-576页

作者：杜国栋邹渊张旭东孙文景孙巍北京理工大学机械与车辆学院北京100081 苏黎世联邦理工大学动态系统与控制系苏黎世8006

运动控制研究是实现自动驾驶目标的重要组成部分,针对传统强化学习算法在求解中因单步决策局限而导致控制序列次优的问题,提出了一种基于双估计强化学习算法及前向预测控制方法结合的运动控制框架(DEQL-FPC)。在该框架中引入双估计器以... 详细信息

运动控制研究是实现自动驾驶目标的重要组成部分,针对传统强化学习算法在求解中因单步决策局限而导致控制序列次优的问题,提出了一种基于双估计强化学习算法及前向预测控制方法结合的运动控制框架(DEQL-FPC)。在该框架中引入双估计器以解决传统强化学习方法动作值过估计问题并提高训练优化的速度,设计前向预测多步决策方法替代传统强化学习的单步决策,以有效提高全局控制策略的性能。通过虚拟驾驶环境仿真,证明了该控制框架应用在自动驾驶汽车的路径跟踪以及安全避障的优越性,保证了运动控制中的精确性、安全性、快速性以及舒适性。

关键词：自动驾驶汽车运动控制优化双估计强化学习算法前向预测控制方法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The state of mountain research in Canada

引用

Journal of Mountain Science 2022年第10期19卷 3013-3025页

作者： Graham MCDOWELL Katherine HANLY Department of Geography University of CalgaryCalgaryABT2NiN4Canada Department of Geography University of ZurichCH-8006 ZurichSwitzerland

Nearly a quarter of Canada’s landmass is covered by mountainous terrain,making mountains an important aspect of the physical and human geography of the *** areas in Canada have motivated a great deal of research activity,yet the state of mountain research in the country has never been systematically characterized,precluding a detailed understanding of what is being studied,when,where,how,and by *** response,we conducted a systematic scoping review to rigorously identify,collate,and critically examine existing peer-reviewed articles related to mountains in Canada.2,888 articles were included in our review,which reveals strong biases towards work in the natural sciences and in the mountain west,with little work to date in the social and health sciences or in other mountainous regions of the *** results demonstrate that Canada is among the most productive contributors to mountain research globally,but that topical and geographical biases in existing research effort leave important gaps that must be addressed to successfully navigate challenges and opportunities facing mountain areas in *** provide a roadmap to guide future mountain-focused research activities in the country.

关键词： Canada Mountains Systematic scoping review Research

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HUANAN ALPS, NOT SOUTH CHINA PLATFORM

引用

Science in China,Ser.B 1988年第1期31卷 109-119页

作者：许靖华孙枢李继亮 Geological Institute Swiss Federal Institute of Technology 8006 zurich Switzerland Institute of Geology Academia Sinica Beijing

The notion that South China was a post-Caledonian platform is clearly proven incorrect by the ev-idence of Mesozoic deformation and igneous activities. Reinterpretation of map patterns suggested the pres-ence of Mesozoic orogenic belt comparable to Southern Appalachians in dimension and in style of de-formation. Field work in 1985 led to the discovery of possible flysch and rigid basement nappes, whichhave been thrust onto carbonate platform. A suture zone has been identified. The Huanan Alps owed itsorigin to Indosinian Orogeny, which eliminated a Paleo Tethyan Seaway, the Xiangganzhe （Hunan-Ji-angxi-Zhejiang） Ocean between the Yangtze and Huanan Terranes.

关键词： HUANAN ALPS NOT SOUTH CHINA PLATFORM

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Liver transplantation for malignant liver tumors

引用

iLIVER 2022年第1期1卷 3-11页

作者： Richard X.Sousa Da Silva Beat Muellhaupt Philipp Dutkowski Pierre-Alain Clavien Department of Surgery and Transplantation Swiss Hepato-Pancreato-Biliary(HPB)and Transplant CenterUniversity Hospital ZurichRaemistrasse 1008091 ZurichSwitzerland Wyss zurich ETH ZurichUniversity of ZurichWeinbergstrasse 358006 ZurichSwitzerland Department of Gastroenterology and Hepatology University Hospital ZurichRaemistrasse 1008091 ZurichSwitzerland

Liver transplantation is a highly effective treatment not only for acute or chronic liver failure but also for primary liver cancer such as hepatocellular carcinoma,perihilar cholangiocarcinoma,intrahepatic cholangiocarcinoma,and metastatic tumors such as from neuroendocrine or colorectal liver *** success strongly relies on strict adherence to stringent selection criteria,which lead to excellent outcomes,while previously regarded as contraindication for liver *** impressive results are,however,mostly achieved with a combination of pretreatment strategies and convincing control of the tumor growth prior to transplantation,as well as minimizing long-term *** this emergence of oncologic liver transplantation,we expect an increasing need of grafts,and therefore included in this report strategies to improve the number of available grafts by maximizing liver utilization *** machine liver perfusion approaches may play in this respect an important role.

关键词： Liver transplantation Selection criteria Malignant tumor Machine perfusion Tumor recurrence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New Catalysts for ROMP

引用

复旦学报(自然科学版) 2005年第5期44卷 625-626页

作者： H.Berke C.Frech A.Lhamazares O.Blacque H.W.Schmalle C.Adlhart P.Chen University of zurich Institute of Inorganic ChemistryWinterthurerstr.190CH-8057 ZürichSwitzeland Swiss Federal Institute of Technology zurich(ETH) Rmistrasse 101CH-8006 ZürichSwitzeland

1 Introduction Ring Opening Metathesis Polymerization(ROMP)is based on the olefin metathesis reaction,which requires transition metal *** molybdenum,tungsten and ruthenium based catalysts have up to now been ***“in-between”metal rhenium was only rarely applied in olefin metathesis reactions,and not at all in ROMP *** have found that cationic phosphine substituted dinitrosyl rhenium complexes 1a and 1b effectively catalyze ROMP of norbonene,dicyclopentadiene and of *** Fig.1.

关键词： ROMP rhenium morbene DFT

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Global boundary Stratotype Section and Point （GSSP） of the Ladinian Stage （Middle Triassic） at Bagolino （Southern Alps, Northern Italy） and its implications for the Triassic time scale

引用

Episodes 2005年第4期28卷 233-244页

作者： Peter Brack Hans Riebe Alda Nicora Roland Mundil Departement Erdwissenschaften ETH-Zentrum CH-8092 Zurich Switzerland. Palaontologisches Instituit Universitat ZurichCH-8006ZurichSwitzerland. Dipartimento di Scienze della Terra Universita di Milano Via Mangiagaiii 341-20133 Milano Italy. Berkeley Geochronology Center 2455 Ridge Road Berkeley CA 94709 USA

The Global boundary Stratotype Section and Point （GSSP） for the base of the Ladinian Stage （Middle Triassic） is defined in the Caffaro river bed （45°49＇09.5＂N, 10°28＇15.5＂E）, south of the village of Bagolino （Province of Brescia, northern Italy）, at the base of a 15-20-cm-thick limestone bed overlying a distinct groove （＂Chiesense groove ＂） of limestone nodules in a shaly matrix, located about 5 m above the base of the Buchenstein Formation. The lower surface of the thick limestone bed has the lowest occurrence of the ammonoid Eoprotrachyceras curionii （base of the E. curionii Zone; onset of the Trachyceratidae ammonoid family）. Secondary global markers in the uppermost Anisian include the lowest occurrence of conodont Neogondolella praehungafica and a brief normal-polarity magnetic zone recognized in closely correlated sections including the principal auxiliary section at Seceda in the Dolomites. The GSSP-level is bracketed by U-Pb single zircon age data from volcaniclastic horizons, indicating a boundary age of ca 241 Ma.

关键词：三叠纪镧阿尔卑斯山意大利 GSSP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

医用脑机接口数据隐私的法律规制:国际比较与启示

引用

卫生法学 2024年第4期32卷 73-79页

作者：曾益四川师范大学法学院成都610068 苏黎世大学法学院苏黎世8006

随着医用脑机接口技术的不断发展,数据隐私问题日益凸显。脑机接口数据隐私具有自身的独特性:一方面因脑机接口直连大脑,因此数据隐私具有高度私密性;另一方面患者无法预筛、修正或删除脑机接口收集的信息,数据隐私面临更高的风险。相... 详细信息

随着医用脑机接口技术的不断发展,数据隐私问题日益凸显。脑机接口数据隐私具有自身的独特性:一方面因脑机接口直连大脑,因此数据隐私具有高度私密性;另一方面患者无法预筛、修正或删除脑机接口收集的信息,数据隐私面临更高的风险。相较于其他国家和地区,我国在脑机接口数据隐私方面的研究较为有限。为更好规制脑机接口数据隐私,有必要系统了解美国、日本、智利以及欧盟等地区的现行经验,结合我国实际情况完善相关措施,具体包括加强匿名化处理、强化第三方算法平台责任、明确神经权利法律地位和提高隐私保护意识4个方面的内容。

关键词：脑接机口 BCI 算法数据隐私医疗数据

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Late Cretaceous Foraminiferal Faunas from the Saiqu“mélange”in Southern Tibet

引用

Acta Geologica Sinica(English Edition) 2007年第6期81卷 917-924页

作者： LI Guobiao WAN Xiaoqiao JIANG Ganqing HU Xiumian GOUDEMAND Nicolas HAN Hongdou CHEN Xi Departmemt of Earth Sciences China University of Geosciences Xueyuan Lu 29 Beijing 100083 China Department of Geosciences Universi-ty ofNevada Las Vegas Las Vegas NV89154-4010 US Departmemt of Earth Sciences Nanjing University Nanjing 210093 China Insitute of Paleontology and Museum University of Zurich Karl Schmid-Strasse 4 Zurich CH-8006 Switzerland

As one of the mélanges in the southern side of the Yarlung-Zangbo suture zone, the Saiqu mélange in southern Tibet is important for understanding the evolution of the Neo-Tethys ocean. The age of the Saiqu mélange, however, has been debated due to the lack of reliable fossil evidence in matrix strata. Based on lithological similarities with platform strata in southern Tibet and limited fossils from exotic blocks, previous studies variously ascribed the Saiqu mélange to be Triassic in general, Late Triassic, or Late Cretaceous. Here we reported planktonic foraminiferal faunas from the matrix strata of the Saiqu mélange. The new fossils yield a Late Cretaceous age, which is so far the best age constraint for the mélange. Regional stratigraphic correlation indicates that the Cretaceous Oceanic Red Beds （CORBs） in Saiqu may be time equivalent to the CORBs of the Zongzhuo Formation in neighboring regions. Thus the Saiqu m^lange should be correlated to the Upper Cretaceous Zongzhuo Formation rather than the Triassic Xiukang Group, as previously suggested.

关键词： Saiqu Mélange Planktonic Foraminifera Late Cretaceous Red Beds Zongzhuo Formation Tibet

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Moment tensor and stress inversion solutions of acoustic emissions during compression and tensile fracturing in crystalline rocks

引用

Journal of Rock Mechanics and Geotechnical Engineering 2023年第10期15卷 2778-2786页

作者： Zihua Niu Bing Qiuyi Li Omid Moradian Department of Earth Sciences Swiss Federal Institute of Technology(ETH)Zurich8006Switzerland Department of Civil and Environmental Engineering Western UniversityLondonONN6A 3K7Canada Department of Civil and Environmental Engineering Colorado School of MinesGoldenCO80401USA

We investigate the accuracy and robustness of moment tensor(MT)and stress inversion solutions derived from acoustic emissions(AEs)during the laboratory fracturing of prismatic Barre granite ***-cut flaws in the specimens introduce a complex stress field,resulting in a spatial and temporal variation of focal ***,we consider two experimental setups:(1)where the rock is loaded in compression to generate primarily shear-type fractures and(2)where the material is loaded in indirect tension to generate predominantly tensile-type *** each test,we first decompose AE moment tensors into double-couple(DC)and non-DC terms and then derive unambiguous normal and slip vectors using k-means clustering and an unstructured damped stress inversion *** explore temporal and spatial distributions of DC and non-DC events at different loading *** majority of the DC and the tensile non-DC events cluster around the pre-cut flaws,where macro-cracks later *** of stress inversion are verified against the stress field from finite element(FE)modeling.A good agreement is found between the experimentally derived and numerically simulated stress *** the best of the authors’knowledge,this work presents the first case where stress inversion methodologies are validated by numerical simulations at laboratory scale and under highly heterogeneous stress distributions.

关键词： Induced seismicity Acoustic emission(AE) Moment tensor(MT)inversion Stress inversion Finite element(FE)modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：