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HD-03对实验性肝硬化的抑制(英文)

Acta Pharmacologica Sinica 2000年第9期21卷 11-15页

作者： S K MITRA,U VENKATESH UDUPA,S J SHESHADRI,M V VENKATARANGANNA,S GOPUMADHAVAN,S D ANTURLIKAR R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India R&D Centre The Himalaya Drug Company Bangalore-562 123 India

AIM; To investigate the protective effect of HD-03 in experimental cirrhosis following chronic intoxication with thioacetamide (TAA). METHODS; The effect of HD-03 (750 mg/kg po) was studied in rats following TAA-induced intoxication (50 mg/kg po) for a period of 90 d. HD-03 was administered as an aqueous suspen-sion . Levels of biochemical markers indicative of hepa-totoxicity were assessed in serum and liver. Histopatho-logical evaluation of liver was also carried out to find out the protective effect of HD-03 following TAA-induced chronic intoxication. RESULTS; Administration of TAA at a dose of 50 mg/kg po for 90 d resulted in a sig-nificant derangement of serum [ serum glutamic pyruvate transaminase ( SGPT), serum glutamic oxaloacetate transaminase (SGOT) , alkaline phosphatase (ALP), al-bumin and bilirubin] and hepatic (triglycerides, protein, hydroxyproline, collagen and glycogen) biochemical pa-rameters. Histopathological evaluation of liver sections following TAA-intoxication showed necrosis and

关键词：草药医学 HD-03 肝硬化

NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS

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World Journal of Gastroenterology 2007年第7期13卷 1103-1107页

作者： MV Venkataranganna Md Rafiq S Gopumadhavan Ghouse Peer UV Babu SK Mitra R&D Center The Himalaya Drug Company Bangalore-562 123 India

AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats. METHODS: Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg *** p.o. for 10 d. Sulfasalazine at a dose of 100 mg/kg *** for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase (MPO), lipid peroxidation (LPO) and alkaline phosphatase (ALP) activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFκ-B and iNOS expression. RESULTS: NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg ***., which was almost equipotent to 100 mg/kg ***. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg ***. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and d

关键词：姜黄色素 NCB-02 保护作用二硝基氯苯大肠炎

PRESENT STRESS STATE NEAR MEILING ARCUATE FAULTS

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Science in China,Ser.B 1985年第1期28卷 82-91页

作者：孙叶王宗杰沈士贞杨建华师继承田洪清程伟雪张景寿 562 Comprehensive Geological Brigade Chinese Academy of Geological Sciences

In this paper an analysis of the present stress field near the Meiling arcuate faults in Beijing area is made. Based on the in situ stress measurements, petrofabric analysis and model experiments, it has been found that this local stress field is a rotational shear stress field. It has been active from the late Yenshanian up to the present with the outer side rotating clockwise. The features of the local stress field are different from those of the present regional stress field characteristic of the Neocathaysian system. The trajectories of the maximum principal compressive stresses of the former show an arcuate pattern converging towards SE and diverging towards NW. However, those of the latter extend approximately in the NWW direction.

关键词： PRESENT STRESS STATE NEAR MEILING ARCUATE FAULTS

Protective effect of Prostane in experimental prostatic hyperplasia in rats

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Asian Journal of Andrology 1999年第4期1卷 175-179页

作者： S.K.Mitra R.Sundaram A.R.Mohan S.Gopumadhavan M.V.Venkataranganna Udupa Venkatesha S.J.Seshadri S.D.Autrulikar R&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 India

Aim: Prostane, a polyherbal formulation, was evaluated for its efficacy on 5α-reductase inhibition, α-adrenergic anta-gonistic activity and testosterone-induced prostatic hyperplasia. Methods: 5α-reductase inhibition was evaluated usingrat prostate homogenate as an enzyme source. Adrenergic antagonistic activity was evaluated using isolated rat vas def-erens. Experimental prostatic hyperplasia was induced in rats by giving testosterone 3 rog/kg sc for 21 days. Re-sults: Prostane dose-dependently inhibited 5α-reductase activity and exhibited α-adrenergic antagonistic activity. Treat-ment with Prostane at 250, 500 and 750 mg/kg body wt, po for 21 days significantly reduced the prostatic weight, theepithelial height and the stromal proliferation in experimental prostatic hypertrophy. Conclusion: Prostane is effectivein the treatment of experimental prostatic hypertrophy in rats and may be passed on to clinical trials on benign prostatichypertrophy after necessary toxicological evaluations. (Asian J Androl 1999 Dec; 1: 175-179)

关键词： Prostane BPH oxidoreductases adrenergic alpha-antagonists enzyme inhibitors prostate hyperplasia

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DISCUSSION ON PALEOBIOMIGRATION AND ASSOCIATED PROBLEMS

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中国科学B辑(英文版) 1985年第7期28卷 772-784页

作者：徐炳川 562 Comprehensive Geological Brigade Chinese Academy of Geological Sciences Yanjiao Sanhe Hebei Province

This paper is based on the Carboniferous materials of China and its neighbouring regions. It summarizes and points out interrelated phenomena associated with the organic evolution, the environmental change and the change of the lowest stratigraphic horizon of biota between high and low latitudes, through the stratigraphic and biologic time correlation. It infers a possible trend in the Carboniferous biomigration based on some events, showing the interrelationship between the biomigration and the environmental change since the Mesozoic Era. It briefly discusses the relations among biomigration, environment and organic evolution, the approaches to the study of biomigration, the non-synchroneity of biotic spatial distribution, the provenance of biota and the significance of dividing the biota into euryhabitat and stenohabitat ones.

关键词： Carboniferous stratigraphic horizon Mesozoic migration migrate Tertiary sedimentary briefly biologic

Frontal and oblique tectonics in the Brazilian Shield

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Episodes 2004年第4期27卷 255-259页

作者： GinaldoA.daC.Campanha BenjamimBleydeBritoNeves InstitutodeGeociěnciasdaUniversidadedeSāoPaulo Brazil.Address：RuadoLago562-CidadeUniversitáriaSāoPaulo-SPBrazilCEP

The Brazilian shield was assembled from a few Archean and Paleoproterozoic cratonic nuclei surrounded by Pan-African-Brasiliano mobile belts of Neoproterozoic age. While some of these mobile belts display a typical frontal collision tectonic style, others are dominated by transcurrent regimes, clearly indicating oblique collisional systems. This paper is an attempt to determine the mean orientation of the principal horizontal compressive stresses for each mobile belt, considering either the frontal or oblique convergence character. From these general observations a scheme with WNW - ESE to NWSE trends of the main compressive stress is proposed. We suggest that this trend represents the mean displacement vectors, according to a coherent kinematic picture for the amalgamation of the West Gondwana during the final stages of convergence of the Brasiliano belts, where WNW-ESE to NW-SE are the main directions of final closure.

关键词：巴西大陆地盾倾斜构造太古代克拉通板块原生代

中国主要油气盆地的地温特征及其与油气资源关系的初步探讨

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中国主要油气盆地的地温特征及其与油气资源关系的初步探讨

Trace element geochemistry and Sr-Nd characteristics of Mesoproterozoic mafic intrusive rocks from Rondonia, Brazil, SW Amazonian Craton： Petrogenetic and tectonic inferences

作者：张业成胡景江刘春凤 562综合大队 562综合大队 562综合大队

本文总结了中国主要油气盆地的地温特征,认为其地温值高于全球地温值,与世界上一般油气盆地大致相等,在全国范围内,从西向东,自北而南,盆地地温呈阶梯状升高,在盆地内,地温具高低相间,按一定方向呈带状分布。在地温条件控制下,不同时代...

本文总结了中国主要油气盆地的地温特征,认为其地温值高于全球地温值,与世界上一般油气盆地大致相等,在全国范围内,从西向东,自北而南,盆地地温呈阶梯状升高,在盆地内,地温具高低相间,按一定方向呈带状分布。在地温条件控制下,不同时代、不同区域和不同深度的生油岩的热演化程度不同、一般是西部低、东部高。我国主要石油产层集中在白垩纪和第三纪,并对找油工作提出了建议。

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Episodes 2008年第4期31卷 392-400页

作者： Girardi, V.A. V. Teixeira, W. Bettencourt, J.S. Andrade, S. Navarro, M.S. Sato, K. Instituto de Geociencias Universidade de Sao Paulo Rua do Lago 562. CEP 05508-080 Cidade Universitada S. Paulo Brazil

The Amazonian Craton comprises an Archean domain surrounded by four successively younger Proterozoic tectonic provinces. Within the Rio-Negro-Juruena province the Serra da Providência Intrusive Suite (1.60 and 1.53 Ga) consists of A-type rapakivi granites, charnockites and mangerites genetically associated with diabase dikes, gabbros and amphibolites. The original mafic melts were derived from a depleted mantle source (εNd(T) +2.5 to +2.8; εSr(T) -12.1). Underplated mafic magma induced melting of a short-lived felsic crust, thus originating coeval felsic-mafic magmatism in a continental intraplate setting. The Colorado Complex, assigned to the Rondonian-San Ignacio province, comprises 1.35-1.36 Ga intrusive bimodal magmatism represented by monzonite gneisses associated with amphibolite, gabbro and metadiabase dikes intercalated with metasediments with detrital zircon that yield U-Pb ages of 1.35 to 1.42 Ga. Mafic samples display juvenile signatures (εNd(T) 0.0 to +5.2; εSr(T) -5.0 to -30.7) and are less contaminated than the Serra da Previdência and Nova Brasilândia ones. The generation of the basaltic magma is related to the subduction of an oceanic slab below the peridotite wedge (intraoceanic arc setting). Fluids and/or small melts from the slab impregnated the mantle. The Nova Brasilândia Sequence (Sunsas-Aguapeí province) comprises a metasedimentary sequence intruded by 1.10-1.02 Ga metadiabases, gabbros, meta-gabbros, and amphibolites associated with granitic plutons (bimodal magmatism). The original tholeiitic magmas, derived from a depleted source (εNd(T) = +3.1 to +5.0), in a proto-oceanic setting, underwent subsequent contamination by the host rocks, as indicated by the isotopic and trace element data.

关键词：亚马逊河流域巴西 Sr-Nd特性地球化学

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云南昆明盆地泥炭聚集特征

云南昆明盆地泥炭聚集特征