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Review The Recent Studies on Treatment of the Damaged Intestinal Mucosa

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Journal of Traditional Chinese Medicine 2003年第4期23卷 299-304页

作者：陈艳芬陈蔚文毛树章 DepartmentofChineseMateriaMedica GuangzhouSchoolofPharmaceuticalScience510224 不详

Intestinal mucosa serves as an important defencebarrier of the organism because the damaged mucosamay cause a variety of pathogenic changes.

关键词：肠内粘膜损害中医药疗法研究进展免疫调节微循环组织修复

呼出气挥发性有机物的采集及分析方法研究进展

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环境与职业医学 2024年第6期41卷 707-712页

作者：何雅珍高汭吴智君樊晶光丁春光广东药科大学公共卫生学院广东广州510224 国家卫生健康委职业安全卫生研究中心北京102308 中国疾病预防控制中心职业卫生与中毒控制所北京102308

呼出气中挥发性有机物(VOCs)的组成和浓度与人体健康状态密切相关,通过采集人体呼出气分析VOCs已广泛应用于疾病的监测研究中。本文通过对呼出气VOCs的采集、富集和检测方法进行综述,为后续研究选择合适的技术提供参考。呼出气采集装置... 详细信息

呼出气中挥发性有机物(VOCs)的组成和浓度与人体健康状态密切相关,通过采集人体呼出气分析VOCs已广泛应用于疾病的监测研究中。本文通过对呼出气VOCs的采集、富集和检测方法进行综述,为后续研究选择合适的技术提供参考。呼出气采集装置主要有采集混合呼出气常用的采气袋和采集肺泡气常用的生物挥发性有机化合物呼吸(Bio-VOC)采样器。预富集设备包括热解吸仪或热脱附仪(TD)、固相微萃取装置(SPME)、针刺捕集装置(NTD)。呼出气VOCs的检测方法包括气相色谱质谱(GC-MS)、质子转移反应质谱(PTR-MS)、选择离子流管质谱法(SIFT-MS)、电子鼻等。目前呼出气的采集和富集技术尚未成熟,对呼出气检测结果的影响缺乏评估,未来应加强呼出气采集和富集技术的研究,进一步推动呼出气在疾病监测研究中的应用。

关键词：呼出气挥发性有机物采集富集检测

基于热解吸-气相色谱质谱法测定呼出气中27种挥发性有机物浓度

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环境与职业医学 2024年第1期41卷 96-102页

作者：高汭彭方达何雅珍冯洁刘武宾于丽佳陈青松丁春光广东药科大学公共卫生学院广东广州510224 国家卫生健康委职业安全卫生研究中心/粉尘危害工程防护重点实验室北京102308 国家卫生健康委尘肺病重点实验室山西太原030001

[背景]呼出气中的挥发性有机物(VOCs)与呼吸系统疾病密切相关,与体内多种代谢反应存在联系,建立其分析方法可为疾病中VOCs的研究提供技术支持。[目的]建立呼出气中27种VOCs的热解吸-气相色谱质谱(TD-GC-MS)检测方法。[方法]呼出气中VOC... 详细信息

[背景]呼出气中的挥发性有机物(VOCs)与呼吸系统疾病密切相关,与体内多种代谢反应存在联系,建立其分析方法可为疾病中VOCs的研究提供技术支持。[目的]建立呼出气中27种VOCs的热解吸-气相色谱质谱(TD-GC-MS)检测方法。[方法]呼出气中VOCs使用Bio-VOC呼出气采样器进行采集,随后用Tenax TA热解吸管富集后进行TD-GC-MS分析。使用Tenax TA 60/80热解吸管采集标准气,对TD-GC-MS检测方法的热解吸条件和色谱、质谱条件进行优化:通过优化升温程序实现27种VOCs的分离,通过优化定量离子提高灵敏度,通过对热解吸时间和温度的优化提高VOCs解吸效率。采用空白气袋加标的方式对方法的检出限、定量限、准确度、精密度及稳定性进行检测,并采集20名健康志愿者呼出气样品进行方法的应用考察。[结果]本研究热解吸温度为280℃,解吸时间为6 min,选择VF-624ms色谱柱进行VOCs的分离,色谱柱升温程序:初始温度35℃,保持1 min;以3℃·min^(-1)升至100℃保持1 min;以28℃·min^(-1)升至210℃并保持5 min,选择单离子检测扫描(SIM)模式进行27种VOCs的定量分析。此检测条件下,27种VOCs在各自测定范围内线性良好,相关系数均>0.9990,方法检出限范围为0.01~0.13 nmol·mol^(-1),定量限范围为0.02~0.44 nmol·mol^(-1),方法加标回收率范围为80.1%~120.5%,批内、批间精密度分别≤18.8%、17.9%,所有VOCs在常温(23~28℃)条件下可保存7 d,在4℃条件下可保存14 d。应用本法对20名受试者呼出气样本进行检测,检出率≥80%(除反式-2-戊烯和癸烷),检出浓度范围为0.00~465.50 nmol·mol^(-1)。[结论]本研究建立的呼出气中挥发性有机物TD-GC-MS定量法,具有灵敏度高、准确度好的特点,适用于呼出气中VOCs的定量检测,可为呼出气VOCs研究提供技术支持。

关键词：呼出气挥发性有机物热解吸气相色谱-质谱

Effect of manganese on the brain extrapyramidal development of rat offspring

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Biomedical and Environmental Sciences 1999年第4期12卷 310-311页

作者： ZHANGDexing GuangdongCollegeofPharmacy Guangzhou510224

Study on Microbes and Their Effects on Rare Earth Extraction in Weathering Crust of Granite

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Journal of Rare Earths 2001年第3期19卷 161-167页

作者：陈炳辉毋福海刘琥琥 Zhongshan Univ Dept Earth Sci Guangzhou 510275 Peoples R China Guangdong Pharmaceut Coll Guangzhou 510224 Peoples R China

Microbes were cultured from the samples at various depths in a weathering profile of RE-bearing granite in Gonghe RE mine, Guangdong Province. The cultured microbes, existing at a depth of 0.2 similar to 12 in and being more plentiful within 3 in in the profile, include bacteria ( Bacillus, Enterobacter, Escherichia, Alkaligenes, Neisseria, Staphylococcus and anaerobic bacteria such as Clostridium), fungi ( Aspergillus niger, Aspergillus flavus, Penicillium, Mucor and Saccharomycete) and actinomyces. Experiments were made under room temperature by using solutions of the cultured microbes and their metabolites, compared with distilled water and the culture solution without microbes, to leach RE from the sample of the weathering crust. The results are shown by the experiments: (1) The mixed microbes cultured from the profile and their metabolites increase the quantity of RE leached from the sample and reduce the pH of the solutions. (2) The ability to leach RE from the sample varies with various microbes, decreasing in a sequence of fungi ( Mucor, saccharomycete, Aspegillus and Penicillium), zymotic bacilli (Enterobacter, Escherichia etc.), Staphylococcus, zymotic Bacillus, actinomyces and Alkaligenes. (3) The RE leached with bacteria is mainly related to the pH value of the solutions influenced by the metabolites of the bacteria; whereas that leached with fungi is mainly related to the adsorption and imbibition of RE by the fungi and the complexing of RE with their metabolites. (4) Compared with that leached with ammonium sulfate, the fractionation of the RE leached with microbes is characterized by higher delta (Ce), lower delta (Eu) and lower ratios of N-La/Sm and N-Gd/Yb . The result of the fractionation of RE accords with the distribution of RE in the various layers of a profile of weathering crust of granite in South China. The experimental results indicate that microbes and their metabolites should play a positive role in the mobilization, migration and fractio

关键词： rare earths microbes weathering crust granite

Organic Metallogeny of Weathering Crust RE Deposit

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Journal of Rare Earths 1998年第1期16卷 60-68页

作者：陈志澄俞受 符群策陈炳辉张丽洁 Guangdong College of Pharmacy Guangzhou 510224 China Department of Earth Sciences Zhongshan University Guangzhou 510275 China Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

A series of experimental geochemical studies have been done to confirm the organic metallogenic mechanism of weathering crust RE deposits. It has been concluded that: (1) Rich REbearing weathering crusts contain abundant organisms such as monoacids, diacids and nonacid compounds. Varieties and quantities of the organisms decrease from the upper to the lower of the profile. Humic acids are mainly fulvic acids, which are characterized by containing conjugated π system, carboxylic group, hydroxyl group and only a few nitrogenous groups. No obvious benzene ring has been found. (2) The upper part of the weathering crust contains a great deal of microorganisms, of which the varieties and quantities decrease from the upper to the lower of the profile. No microorganism has been found in the deep part of the profile. The microorganisms and their metabolites such as aminoacids, shortchain acids and organic compounds with small molecular weights can form water soluble RE complexes, which accelerate the RE transportation from original rocks and precipitation states to watersoluble states and thus provide prerequisites for retransportation and reaccumulation of RE. (3) Medium and longchain acids can form REnAm(OH)x(H2O)y type mixedligand polynuclear RE complexes, which devoted to the RE accumulation, whereas shortchain acids and aminoacids can form not only mixedligand complexes with RE, but also water soluble complex ions, which also devoted to the transport and accumulation of RE. (4) The fulvic acids are very soluble in water. They are apt to be mobile in the weathering crust and are able to form soluble complex ions and insoluble mixedligand polynuclear complexes with RE at normal temperature and atmospheric pressure and pH4～6. The composition of these complexes varies with different conditions of the weathering crust. (5) All the organic acids, fulvic acids and microorgaisms have contributed to keeping constant pH condition of the weathering crust.

关键词： Rare earths Organic matter Metallogeny Weathering crust RE deposit

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Biomedical and Environmental Sciences 2004年第4期17卷 410-417页

作者： YIYANG KONG-LAIZHANG DepartmentofEpidemiology FacultyofPreventiveMediuineGuangdongPharmaceuticalCollegeNo.40GuanghanZhijieBaogangHaizhuDistrictGuangzhou510224GuangdongChina DepartmentofEpidemiology InstituteofBasicMedicalSciencesChineseAcademyofMedicalSciencesSchoolofBasicMedicinePekingUnionMedicalCollegeBeijing100005China

Objective In order to explore the features of discrimination against people with HIV/AIDS in rural areas, a community-based intervention was carried out in two pilot communities of X County of Shanxi Province from September 2002 to October 2003. Methods Data were collected using qualitative methods (in-depth interview and focus group discussion) and anonymously structured questionnaires. Results (1) Severe discrimination against people infected with HIV/AIDS was revealed in the target communities. However, the response to HIV/AIDS was different in each community. (2) People were reluctant to disclose their HIV status or get tested for HIV, which endangered their sexual partners to contract HIV through unprotected sexual intercourses. (3) Attitudes towards people infected with HIV/AIDS varied. (4) Public education promoted a better understanding of HIV/AIDS which in turn improved community attitudes and behaviors towards people with HIV/AIDS. Conclusion HIV/AIDS-related discrimination undermines both individuals and communities responses to HIV/AIDS and may be a serious obstacle towards effective HIV/AIDS prevention and control.

关键词： HIV/AIDS Discrimination Rural area Intervention

应用时间序列统计方法分析广东省1984～1993年乙型脑炎季节性分布特性

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中华流行病学杂志 1998年第2期19卷 103-106页

作者：李廷杰陈秀山李燕芬广东药学院广州510224

对构成双向有序列联表时间序列数据的广东 1984～ 1993年 10年乙型脑炎 (乙脑 )逐月发病资料 ,应用游程检验和有序对数比检验两种不同统计方法进行季节性分布分析 ,获一致的统计结论 ,乙脑发病呈明显的一年一峰 ( 6月或 7月 )季节性周... 详细信息

对构成双向有序列联表时间序列数据的广东 1984～ 1993年 10年乙型脑炎 (乙脑 )逐月发病资料 ,应用游程检验和有序对数比检验两种不同统计方法进行季节性分布分析 ,获一致的统计结论 ,乙脑发病呈明显的一年一峰 ( 6月或 7月 )季节性周期 ,这对流行病学工作者掌握两种统计方法的基本原理和方法有一定帮助。

关键词：流行性乙型脑炎游程检验有序对数比检验

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不同采收期海南广藿香挥发油成分分析

中药材 2002年第1期25卷 21-23页

作者：罗集鹏郭晓玲冯毅凡广东药学院广州510224

目的:分析海南省万宁市不同采收期的广藿香挥发油成分。方法:GC/MS联用技术。结果:从茎油中分离出47个色谱峰,鉴定出28个化合物,占总量的81.92％;从叶油中分离出34个色谱峰,鉴定出18个化合物,占总量的74.94％。主要是单萜烯、倍半萜烯... 详细信息

目的:分析海南省万宁市不同采收期的广藿香挥发油成分。方法:GC/MS联用技术。结果:从茎油中分离出47个色谱峰,鉴定出28个化合物,占总量的81.92％;从叶油中分离出34个色谱峰,鉴定出18个化合物,占总量的74.94％。主要是单萜烯、倍半萜烯、醇类、酮类、醛类与烷酸类。含量超过1％的有10个化合物,以广藿香醇含量最高(茎油中含36.06％,叶油中占37.74％);茎油中含广藿香酮17.08％,而叶油中含量甚微(0.85％)。6～8月,含油率分别为0.8％、0.7％和0.6％,广藿香醇含量以7月最高(42.62％),6月稍低(40.84％),8月最低(31.40％);广藿香酮含量则以8月最高(5.13％),7月和6月相近(分别为2.19％和1.36％)。结论:海南产广藿香挥发油成分与广东湛江地区产的相似,以7月和6月采收较为合适。

关键词：海南广藿香挥发油成分分析采收期