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上海中医药杂志 2025年第1期59卷 20-23页

作者：冯俊涛尹磊淼牛瑞超胡新月蒋媛媛罗丽莎唐欢王宇李晓照中南大学湘雅医院湖南长沙410008 上海市针灸经络研究所上海200030

针灸学理论认为,腧穴位于体表,具有诊断与治疗的双重作用。基于临床,发现“气管隆脊”具有与体表腧穴相似的诊断与治疗的双重作用;因此提出“腔内腧穴”与“腔内(介入)针灸学”的概念。该假说有待进一步临床验证与理论构建。

关键词：腧穴腔内腧穴针灸腔内(介入)针灸学临床应用创新理论

Influence of sperm morphology on pregnancy outcome and offspring in in vitro fertilization and intracytoplasmic sperm injection:a matched case-control study

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Asian Journal of Andrology 2021年第4期23卷 421-428页

作者： Wen-Jun Zhou Chuan Huang Su-Hua Jiang Xi-Ren Ji Fei Gong Li-Qing Fan Wen-Bing Zhu Institute of Reproductive and Stem Cell Engineering Basic Medicine CollegeCentral South UniversityChangsha 410008China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410008China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410008China

Sperm morphology was once believed as one of the most predictive indicators of pregnancy outcome in assisted reproductive technology(ART).However,the impact of teratozoospermia on in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)outcomes and its offspring remains *** order to evaluate the influence of teratozoospermia on pregnancy outcome and newborn status after IVF and ICSI,a retrospective study was *** was a matched case-control study that included 2202 IVF cycles and 2574 ICSI cycles and was conducted at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha,China,from June 2013 to June *** were divided into two groups based on sperm morphology:teratozoospermia and normal sperm *** pregnancy outcome and newborn outcome were *** results indicated that couples with teratozoospermia had a significantly lower optimal embryo rate compared to those with normal sperm morphology in IVF(P=0.007),while there were no statistically significant differences between the two groups in terms of the fertilization rate,cleavage rate,implantation rate,and pregnancy rate(all P>0.05).Additionally,teratozoospermia was associated with lower infant birth weight in multiple births after *** regard to ICSI,there was no significant difference in both pregnancy outcome and newborn outcome between the teratozoospermia and normal groups(both P>0.05).Furthermore,no increase in the risk of birth defects occurred in the teratozoospermia group after IVF/***,we believe that teratozoospermia has limited predictive value for pregnancy outcomes in IVF/ICSI,and has little impact on the resulting offspring if multiple pregnancy is avoided.

关键词： in vitro fertilization intracytoplasmic sperm injection newborn outcome pregnancy outcome teratozoospermia

Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1637-1650页

作者： Yuanliang Yan Shangjun Zhou Xi Chen Qiaoli Yi Songshan Feng Zijin Zhao Yuanhong Liu Qiuju Liang Zhijie Xu Zhi Li Lunquan Sun Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008China Xiangya Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Molecular Radiation Oncology Hunan Province Changsha 410008China institute of Cancer Research National Clinical Research Center for Geriatric Disorders(Xiangya)Xiangya HospitalCentral South UniversityChangsha 410008China

Temozolomide(TMZ)represents a standard-of-care chemotherapeutic agent in glioblastoma(GBM).However,the development of drug resistance constitutes a significant hurdle in the treatment of malignant *** specific innovative approaches,such as immunotherapy,have shown favorable clinical outcomes,the inherent invasiveness of most gliomas continues to make them challenging to ***,there is an urgent need to identify effective therapeutic targets for gliomas to overcome chemoresistance and facilitate drug *** investigation used mass spectrometry to examine the proteomic profiles of six pairs of GBM patients who underwent standard-of-care treatment and surgery for both primary and recurrent tumors.A total of 648 proteins exhibiting significant differential expression were *** Set Enrichment Analysis(GSEA)unveiled notable alterations in pathways related to METABOLISM_OF_LIPIDS and BIOLOGICAL_OXIDATIONS between the primary and recurrent *** through glioma tissue arrays and the Xiangya cohort confirmed substantial upregulation of inositol 1,4,5-triphosphate(IP3)kinase B(ITPKB)in the recurrence group,correlating with poor survival in glioma *** TMZ-resistant cells,the depletion of ITPKB led to an increase in reactive oxygen species(ROS)related to NADPH oxidase(NOX)activity and restored cell sensitivity to ***,the decreased phosphorylation of the E3 ligase Trim25 at the S100 position in recurrent GBM samples accounted for the weakened ITPKB ***,in turn,elevated ITPKB stability and impaired ROS ***,ITPKB depletion or the ITPKB inhibitor GNF362 effectively overcome TMZ chemoresistance in a glioma xenograft mouse *** findings reveal a novel mechanism underlying TMZ resistance and propose ITPKB as a promising therapeutic target forTMZ-resistant GBM.

关键词： TMZ homeostasis impaired

Signaling pathways and targeted therapies for psoriasis

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5835-5872页

作者： Jia Guo Hanyi Zhang Wenrui Lin Lixia Lu Juan Su Xiang Chen Department of Dermatology Xiangya HospitalCentral South UniversityNo.87 Xiangya RoadChangsha 410008 HunanChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha 410008 HunanChina Hunan Key Laboratory of Skin Cancer and Psoriasis Changsha 410008 HunanChina Hunan Engineering Research Center of Skin Health and Disease Changsha 410008 HunanChina

Psoriasis is a common,chronic,and inflammatory skin disease with a high burden on individuals,health systems,and society *** the immunological pathologies and pathogenesis of psoriasis becoming gradually revealed,the therapeutic approaches for this disease have gained revolutionary ***,the mechanisms of less common forms of psoriasis remain ***,severe adverse effects and the recurrence of disease upon treatment cessation should be noted and addressed during the treatment,which,however,has been rarely explored with the integration of preliminary ***,it is crucial to have a comprehensive understanding of the mechanisms behind psoriasis pathogenesis,which might offer new insights for research and lead to more substantive progress in therapeutic approaches and expand clinical options for psoriasis *** this review,we looked to briefly introduce the epidemiology,clinical subtypes,pathophysiology,and comorbidities of psoriasis and systematically discuss the signaling pathways involving extracellular cytokines and intracellular transmission,as well as the cross-talk between *** the discussion,we also paid more attention to the potential metabolic and epigenetic mechanisms of psoriasis and the molecular mechanistic cascades related to its *** review also outlined current treatment for psoriasis,especially targeted therapies and novel therapeutic strategies,as well as the potential mechanism of disease recurrence.

关键词： psoriasis epidemiology treatment

lncRNA cytoskeleton regulator RNA(CYTOR):Diverse functions in metabolism,inflammation and tumorigenesis,and potential applications in precision oncology

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Genes & Diseases 2023年第2期10卷 415-429页

作者： Chunlin Ou Xiaoyun He Yong Liu Xin Zhang Department of Otolaryngology Head and Neck Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Pathology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Departments of Ultrasound Imaging Xiangya HospitalCentral South UniversityChangshaHunan 410008China Otolaryngology Major Disease Research Key Laboratory of Hunan ProvinceChangshaHunan 410008China Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province ChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders (Xiangya Hospital) ChangshaHunan 410008China

Long non-coding RNAs(lncRNAs)are a novel class of non-coding RNA(ncRNA),that have been studied extensively in the field of tumor research in recent *** the case of tumor-associated lncRNAs,lncRNA cytoskeleton regulator RNA(CYTOR)displays extensive functions in tumorigenesis,including invasion,metastasis,malignant proliferation,glycolysis,and inflammatory ***,the dysregulation of CYTOR is closely related to clinicopathological characteristics,such as tumor stage,lymph node metastasis and infiltration,and poor prognosis of tumor *** this review,we provide a novel strategy to summarize the biological functions and clinical value of CYTOR in tumors through an overview of the literature combined with gene set enrichment analysis.A deeper understanding of the role of CYTOR in tumorigenesis may provide new diagnostic,prognostic and therapeutic markers for human tumors.

关键词： CYTOR GSEA Inflammation LncRNAs Therapy Tumorigenesis

CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability

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Cancer Biology & Medicine 2020年第2期17卷 328-342页

作者： Danmin Ou Lin Chen Jiang He Zhuoxian Rong Jie Gao Liyu Liu Feiyu Tang Jiang Li Yuezhen Deng Lunquan Sun Department of Oncology Center for Molecular MedicineXiangya HospitalCentral South UniversityChangsha 410008China international Cooperation Base of Cancer Precision Therapy Department of Science and Technology of Hunan ProvinceChangsha 410008China Key Laboratory of Molecular Radiation Oncology of Hunan Province Changsha 410008China National Clinical Research Center for Geriatric Disorders Changsha 410008China

Objectives:Improper activation of Wnt/β-catenin signaling has been implicated in human *** the well-studied glycogen synthase kinase 3p(GSK3p)and casein kinase 1(CK1),other kinases affecting Wnt/β-catenin signaling remain to be ***:To identify the kinases that modulate Wnt/β-catenin signaling,we applied a kinase small interfering RNA(siRNA)library screen *** assays,immunoblotting,and real-time polymerase chain reaction(PCR)were performed to confirm the regulation o f the Wnt/β-catenin signaling pathway by cyclin-dependent kinase 11(CDK11)and to investigate the underlying *** immunofluorescence,coimmunoprecipitation(co-IP),and scratch wound assays were used to demonstrate colocalization,detect protein interactions,and explore the function of ***:CDK11 was found to be a significant candidate kinase participating in the negative control of Wnt/P-catenin ***-regulation of CDK11 led to the accumulation of Wnt/β-catenin signaling receptor complexes,in a manner dependent on intact adenomatosis polyposis coli(APC)*** analysis showed that CDK11 modulation of Wnt/P-catenin signaling engaged the endolysosomal machinery,and CDK11 knockdown enhanced the colocalization of Wnt/β-catenin signaling receptor complexes with early endosomes and decreased colocalization with ***,CDK11 was found to function in Wnt/β-catenin signaling by regulating microtubule *** of CDK11 down-regulated ***,co-IP assays demonstrated that CDK11 interacts with the a-tubulin deacetylase SIRT2,whereas SIRT2 down-regulation in CDK11-depleted cells reversed the accumulation of Wnt/(3-catenin signaling receptor ***11 was found to suppress cell migration through altered W nt/β-catenin ***:CDK11 is a negative modulator of Wnt/β-catenin signaling that stabilizes microtubules,thus resulting in the dysregulation of receptor complex trafficking

关键词： Wnt/β-catenin signaling CDK11 endosome microtubule SIRT2

Parkinson’s disease and gut microbiota:from clinical to mechanistic and therapeutic studies

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Translational Neurodegeneration 2023年第1期12卷 1-30页

作者： Xuxiang Zhang Beisha Tang Jifeng Guo Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Engineering Research Center of Hunan Province in Cognitive Impairment Disorders Central South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China

Parkinson’s disease(PD)is one of the most prevalent neurodegenerative *** typical symptomatology of PD includes motor symptoms;however,a range of nonmotor symptoms,such as intestinal issues,usually occur before the motor *** microorganisms inhabiting the gastrointestinal tract can profoundly influence the physiopathology of the central nervous system through neurological,endocrine,and immune system pathways involved in the microbiota-gut-brain *** addition,extensive evidence suggests that the gut microbiota is strongly associated with *** review summarizes the latest findings on microbial changes in PD and their clinical relevance,describes the underlying mechanisms through which intestinal bacteria may mediate PD,and discusses the correlations between gut microbes and anti-PD *** addition,this review outlines the status of research on microbial therapies for PD and the future directions of PD-gut microbiota research.

关键词： Gut microbiota Microbiota-gut-brain axis Mechanisms Alpha-synuclein Microbial therapy

Cancer stem cells: advances in knowledge and implications for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3242-3304页

作者： Xianjing Chu Wentao Tian Jiaoyang Ning Gang Xiao Yunqi Zhou Ziqi Wang Zhuofan Zhai Guilong Tanzhu Jie Yang Rongrong Zhou Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China xiangya Lung Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan Province 410008China

Cancer stem cells(CSCs),a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation,lead to tumorigenesis,metastasis,and maintain tumor *** continues to be a significant global disease *** the past,surgery,radiotherapy,and chemotherapy were the main cancer *** technology of cancer treatments continues to develop and advance,and the emergence of targeted therapy,and immunotherapy provides more options for patients to a certain ***,the limitations of efficacy and treatment resistance are still *** review begins with a brief introduction of the historical discoveries,original hypotheses,and pathways that regulate CSCs,such as WNT/β-Catenin,hedgehog,Notch,NFkB,JAK/STAT,TGF-β,PI3K/AKT,PPAR pathway,and their *** focus on the role of CSCs in various therapeutic outcomes and resistance,including how the treatments affect the content of CSCs and the alteration of related molecules,CSCs-mediated therapeutic resistance,and the clinical value of targeting CSCs in patients with refractory,progressed or advanced *** summary,CSCs affect therapeutic efficacy,and the treatment method of targeting CSCs is stll difficult to *** regulatory mechanisms and targeting biomarkers of CSCs is currently the mainstream idea.

关键词： Cancer maintain knowledge

Osteopontin(OPN)alleviates the progression of osteoarthritis by promoting the anabolism of chondrocytes

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Genes & Diseases 2023年第4期10卷 1714-1725页

作者： Wei Luo Zili Lin Yuhao Yuan Ziyi Wu Wei Zhong Qing Liu Department of Orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangshaHunan 410008China

Osteoarthritis(OA)is a chronic debilitating joint disease,characterized by degen-eration of the cartilage and loss of the cartilage matrix,and it is clinically manifested as joint ***(OPN)is a glycoprotein that is abnormally expressed in the bone and carti-lage tissues and plays a vital role in various pathological processes such as the osteoarthritic inflammatory response and endochondral *** focus of our study is to investigate the therapeutic potential and specific role of OPN in *** morphological comparisons,we found that the cartilage was severely worn-out and there was a significant loss of the cartilage matrix in ***,CD44,and hyaluronic acid(HA)synthase 1(HAS1)were highly expressed,and the anabolism of HA was significantly higher in the OA chondrocytes than in the control ***,we treated the OA chondrocytes with small interfering RNA(siRNA)targeting OPN,recombinant human OPN(rhOPN),and a combination of rhOPN and anti-CD44 ***,in vivo experiments were performed in *** found that OPN up-regulated the expression of downstream HAS1 and increased the anabolism of HA through CD44 protein expression in OA mice compared with those in control ***,intra-articular injection of OPN in mice with OA significantly inhibited OA *** summary,OPN ini-tiates an intracellular cascade via CD44 which results in an anabolic increase in HA levels,thereby inhibiting OA ***,OPN is a promising therapeutic agent in precision treatment of OA.

关键词： Cartilage degeneration CD44 Hyaluronic acid Osteoarthritis Osteopontin

Applications of nanomaterials in COVID-19 pandemic

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Rare Metals 2022年第1期41卷 1-13页

作者： Mei-Fang Xiao Chang Zeng Shao-Hui Li Fu-Lai Yuan Health Management Center Xiangya HospitalCentral South UniversityChangsha 410008China

The novel coronavirus 2019(COVID-19)pandemic represents one of the biggest global health threats in the last two decades,so researchers around the world are searching for solutions and treatments for *** the time of writing,there are no specific drugs that have demonstrated suitable effectiveness in treating *** current challenge involves designing tools for the prevention,rapid and accurate diagnosis,drug delivery,and effective treatment of this novel *** this short review,we discuss how nanotechnology offers new ways to combat COVID-19,and how nanomaterials can be applied to control the COVID-19 *** also summarize relevant studies regarding the use of nanomaterials for preventing viral spread,preparing vaccines,and diagnosing coronavirus,as well as studies that show how nanoparticles can be used as drug delivery systems for the treatment of viral *** on nanotechnology-based diagnosis,drug delivery,and antiviral therapy is currently in the early ***,the unique chemical properties of some nanomaterials highlight the broad prospect of nanomaterials in the future,and we propose that they will play an important role in the fight against COVID-19.

关键词： Coronaviruses COVID-19 Nanomaterials Viral control