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TEA domain transcription factor 1(TEAD1)induces cardiac fibroblasts cells remodeling through BRD4.Wnt4.pathway

Signal Transduction and Targeted Therapy 2024年第3期9卷 1209-1220页

作者： Shuai Song Xiaokai Zhang Zihang Huang Yongchao Zhao Shuyang Lu Linqi Zeng Fengze Cai Tongyao Wang Zhiqiang Pei Xinyu Weng Wei Luo Hao Lu Zilun Wei Jian Wu Peng Yu Li Shen Xiaochun Zhang Aijun Sun Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghaiChina State Key Laboratory of Cardiology Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Viral Heart Diseases National Health CommissionShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghaiChina National Clinical research Center for Interventional Medicine ShanghaiChina Department of cardiac surgery Zhongshan HospitalFudan UniversityShanghaiChina institutes of Biomedical Sciences Fudan UniversityShanghaiChina shanghai institute of Hypertension Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Cardiac fibroblasts(CFs)are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure(HF).TEAD1 has been shown to be essential for heart development and ***,fibroblast endogenous TEAD1 in cardiac remodeling remains incompletely *** analyses revealed consistently upregulated cardiac TEAD1 expression in mice 4.weeks after transverse aortic constriction(TAC)and Ang-l *** investigation revealed that CFs were the primary cell type expressing elevated TEAD1 levels in response to pressure *** TEAD1 knockout was achieved by crossing TEAD1-floxed mice with CFs-and myofibroblasts-specific Cre *** and histological analyses demonstrated that CFs-and myofibroblasts-specific TEAD1 deficiency and treatment with TEAD1 inhibitor,VT103,ameliorated TAC-induced cardiac ***,RNA-seq and ChiP-seq analysis identified Wnt4.as a novel TEAD1 ***1 has been shown to promote the fibroblast-to-myofibroblast transition through the Wnt signalling pathway,and genetic Wnt4.knockdown inhibited the pro-transformation phenotype in CFs with TEAD1 ***,coimmunoprecipitation combined with mass spectrometry,chromatin immunoprecipitation,and luciferase assays demonstrated interaction between TEAD1 and BET protein BRD4.leading to the binding and activation of the Wnt4.*** conclusion,TEAD1 is an essential regulator of the pro-fibrotic CFs phenotype associated with pathological cardiac remodeling via the BRD4.Wnt4.signallingpathway.

关键词： TEAD1 expression Wnt4

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A new idea of dipole moments in the tau lepton in ultra-peripheral heavy ion collisions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 14-14页

作者： Yu-Gang Ma Key Laboratory of nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China shanghai research Center for Theoretical nuclear Physics NSFC and Fudan UniversityShanghai 200438China

Precise measurements of the anomalous magnetic(MDM) and electric dipole moments(EDM) of leptons are essential for exploring potential new physics beyond the Standard ***,a major challenge is posed by the short lifetime of the tau lepton,which makes it impossible to measure its MDM and EDM directly using techniques similar to those used for the electron and muon.

关键词： dipole lepton moments

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Construction and performance test of charged particle detector array for MATE

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nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑Hui Ru Zhi‑Chao Zhang Bing‑Feng Lv Ning‑Tao Zhang Jin‑Long Zhang Chen‑Gui Lu Bing‑Shui Gao Jun‑Bing Ma Fu‑Shuai Shi Satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑Wei Xu Yan‑Yun Yang Hooi‑Jin Ong Xiao‑Dong Tang institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China research Center for nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14.N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4.He and 5%CO_(2) at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

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Confined Mn^(2+) enables effective aerobic oxidation catalysis

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Science China Chemistry 2024年第5期67卷 1545-1553页

作者： Desheng Yuan Sicong Ma Xiao Kong Chi Zhang Lin Chen Chengsheng Yang Lihua Wang Zhen Liu Lin Ye Yongmei Liu Rui Ma Zhi-Pan Liu Yifeng Zhu Yong Cao Xinhe Bao Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China institute of Advanced Fluorine-Containing Materials Zhejiang Normal UniversityJinhua 321004China State Key Laboratory of Catalysis National Laboratory for Clean EnergyCollaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Effective and mild activation of O_(2) is essential but challenging for aerobic oxidation. In heterogeneous catalysis, high-valence manganese oxide(e.g., +4. is known to be active for the oxidation, whereas divalent MnO is ineffective due to its limited capacity to supply surface oxygen and its thermodynamically unstable structure when binding O_(2) in reaction conditions. Inspired by natural enzymes that rely on divalent Mn^(2+), we discovered that confining Mn^(2+) onto the Mn_(2)O_(3) surface through a dedicated calcination process creates highly active catalysts for the aerobic oxidation of 5-hydroxymethylfurfural, benzyl alcohol, and *** Mn_(2)O_(3)-confined Mn^(2+) is undercoordinated and efficiently mediates O_(2) activation, resulting in 2–3 orders of magnitude higher activity than Mn_(2)O_(3) alone. Through low-temperature infrared spectroscopy, we distinguished low-content Mn^(2+) sites at Mn_(2)O_(3) surface, which are difficult to be differentiated by X-ray photoelectron spectroscopy. The combination of in-situ energydispersive X-ray absorption spectroscopy and X-ray diffraction further provides insights into the formation of the newly identified active Mn^(2+) sites. By optimizing the calcination step, we were able to increase the catalytic activity threefold *** finding offers promising frontiers for exploring active oxidation catalysts by utilizing the confinement of Mn^(2+)and oftenignored calcination skills.

关键词： confinement catalysis manganese oxide aerobic oxidation divalent Mn^(2+) operando spectroscopies

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Suppression of host plant defense by bacterial small RNAs packaged in outer membrane vesicles

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Plant Communications 2024年第4期5卷 252-254页

作者： Yan Wu Sai Wang Peihong Wang Wenhan Nie Iftikhar Ahmad Panagiotis F.Sarris Gongyou Chen Bo Zhu shanghai Yangtze River Delta Eco-Environmental Change and Management Observation and research Station Shanghai Cooperative Innovation Center for Modern Seed Industry School of Agriculture and Biology Shanghai Jiao Tong University Shanghai China Department of Environmental Sciences COMSATS University Islamabad Vehari-Campus Vehari 61100 Pakistan Department of Biology University of Crete 714 09 Heraklion Crete Greece shanghai Jiao Tong University Chongqing research institute Shanghai China

(Plant Communications 5,100817;April 82024.After a careful,in-depth examination,the authors found some additional errors in the published *** revision,the authors created a mutant DXosr001(in which the full-length Xosr001 was deleted)and a mutant DXosr001’(in which the predicted binding motif of Xosr001 was deleted)as shown in Figure S4.of the original *** RNA-FISH assays,Xosr001 transcript could not be detected in leaves inoculated with DXosr001-OMVs,while leaves inoculated with WT-and DXosr001’-OMVs could emit green fluorescence.

关键词： deleted Figure outer

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Rapid Fabrication of Electrodes for Symmetrical Solid Oxide Cells by Extreme Heat Treatment

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Energy & Environmental Materials 2024年第05期7卷 353-360页

作者： Weiwei Fan Zhu Sun Manxi Wang Manxian Li Yuming Chen Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and Environment Southeast University Department of nuclear Science and Engineering Massachusetts Institute of Technology Cambridge School of Materials Science and Engineering Shanghai Jiao Tong University Zhangjiang institute for Advanced Study (ZIAS) Shanghai Jiao Tong University College of Environmental Science and Engineering and College of Physics and Energy Fujian Normal University

Symmetrical solid oxide cells （SSOCs） are very useful for energy generation and conversion. To fabricate the electrode of SSOC, it is very time-consuming to use the conventional approach. In this work, we design and develop a novel method, extreme heat treatment （EHT）, to rapidly fabricate electrodes for SSOC. We show that by using the EHT method, the electrode can be fabricated in seconds （the fastest method to date）, benefiting from enhanced reaction kinetics. The EHT-fabricated electrode presents a porous structure and good adhesion with the electrolyte. In contrast, tens of hours are needed to prepare the electrode by the conventional approach, and the prepared electrode exhibits a dense structure with a larger particle size due to the lengthy treatment. The EHT-fabricated electrode shows desirable electrochemical performance. Moreover, we show that the electrocatalytic activity of the perovskite electrode can be tuned by the vigorous approach of fast exsolution,deriving from the increased active sites for enhancing the electrochemical reactions. At 900℃, a promising peak power density of 966mWcm-2is reached. Our work exploits a new territory to fabricate and develop advanced electrodes for SSOCs in a rapid and high-throughput manner.

关键词： electrochemical performance extreme heat treatment perovskite electrode symmetrical solid oxide cells

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Understand the Temperature Sensing Behavior of Solid-state Polymerized PEDOT Hybrid Based on X-ray Scattering Studies

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Chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： Zhen-Hang He Guang-Feng Liu Ze-Kun Zhou Zhen Liu Yi-Shu Zeng Peng Zhang School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China shanghai Advanced research institute(Zhangjiang Laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4.ethylenedioxythiophene)(PEDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PEDOT hybrids consisting of PEDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PEO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PEDOT:PSS/PEO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PEDOT:PSS/PEO hybrid. It demonstrated that PEDOT formed conductive paths in the hybrids, which were not destroyed by the PEO crystallization. As temperature increased, the PEO crystals' melting and the accompanying reorganization of PEDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1 ℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PEDOT hybrid Structure-property correlation X-ray scattering

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Prospect of ultrahigh-resolution fast neutron absorption spectroscopy based on a laser plasma electron accelerator

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High Power Laser Science and Engineering 2024年第1期12卷 108-115页

作者： Wen-Zhao Wang Jie Feng Xiao-Peng Zhang Yao-Jun Li Wei-Jun Zhou Wen-Chao Yan Guo-Qiang Zhang Chang-Bo Fu Li-Ming Chen Key Laboratory of Laser Plasma(MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghaiChina institute of High Energy Physics Chinese Academy of SciencesBeijingChina shanghai Advanced research institute Chinese Academy of SciencesShanghaiChina Key Laboratory of nuclear Physics and Ion-beam Application(MoE) Institute of Modern PhysicsFudan UniversityShanghaiChina

Fast neutron absorption spectroscopy is widely used in the study of nuclear structure and element analysis. However,due to the traditional neutron source pulse duration being of the order of nanoseconds, it is difficult to obtain a high-resolution absorption spectrum. Thus, we present a method of ultrahigh energy-resolution absorption spectroscopy via a high repetition rate, picosecond duration pulsed neutron source driven by a terawatt laser. The technology of single neutron count is used, which results in easily distinguishing the width of approximately 20 keV at 2 MeV and an asymmetric shape of the neutron absorption peak. The absorption spectroscopy based on a laser neutron source has one order of magnitude higher energy-resolution power than the state-of-the-art traditional neutron sources, which could be of benefit for precisely measuring nuclear structure data.

关键词： fast neutron absorption spectroscopy laser plasma accelerator photo-nuclear neutrons single neutron count

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Advances in magnesium-containing bioceramics for bone repair

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Biomaterials Translational 2024年第1期5卷 3-20页

作者： Lei Qi Tong Zhao Jinge Yan Weiwen Ge Weidong Jiang Jing Wang Mazaher Gholipourmalekabadi Kaili Lin Xiuhui Wang Lei Zhang Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghaiChina institute of Translational Medicine Shanghai UniversityOrganoid Research CenterShanghai UniversityShanghaiChina Department’s Education Deputy Department of Medical BiotechnologyIran University of Medical SciencesTehranIran

Reconstruction of bone defects or fractures caused by ageing,trauma and tumour resection is still a great challenge in clinical *** autologous bone graft is considered as gold standard,the source of natural bone is *** recent years,regenerative therapy based on bioactive materials has been proposed for bone ***,numerous studies have indicated that bioactive ceramics including silicate and phosphate bioceramics exhibit excellent osteoinductivity and osteoconductivity,further promote bone *** addition,magnesium(Mg)element,as an indispensable mineral element,plays a vital role in promoting bone mineralisation and *** this review,different types of Mg-containing bioceramics including Mg-containing calcium phosphate-based bioceramics(such as Mg-hydroxyapatite,Mg-biphasic calcium phosphate),Mg-containing calcium silicate-based bioceramics(such as Mg2SiO4.Ca2MgSi2O7 and Mg-doped bioglass),Mg-based biocements,Mg-containing metal/polymer-bioceramic composites were systematacially ***,the fabrication technologies and their materiobiological effects were deeply *** applications and perspectives of magnesium-containing bioceramics for bone repair are ***,Mg-containing bioceramics are regarded as regenerative therapy with their optimised ***,more in-depth two-way researches on their performance and structure are essential to satisfy their clinical needs.

关键词： bioactive ions bioceramics bone repair magnesium osteoconductivity

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High-resolution mid-infrared single-photon upconversion ranging

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Photonics research 2024年第6期12卷 1294-1302页

作者： SHUHONG JIANG KUN HUANG TINGTING YU JIANAN FANG BEN SUN YAN LIANG QIANG HAO E.WU MING YAN HEPING ZENG State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China School of Optical Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China shanghai research Center for Quantum Sciences Shanghai 201315China Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqing 400064China

Single-photon laser ranging has widespread applications in remote sensing and target ***,highly sensitive light detection and ranging(lidar)has long been restricted in the visible or near-infrared *** appealing quest is to extend the operation wavelength into the mid-infrared(MIR)region,which calls for an infrared photon-counting system at high detection sensitivity and precise temporal ***,we devise and demonstrate an MIR upconversion lidar based on nonlinear asynchronous optical ***,the infrared probe is interrogated in a nonlinear crystal by a train of pump pulses at a slightly different repetition rate,which favors temporal optical scanning at a picosecond timing resolution and a kilohertz refreshing rate ***,the cross-correlation upconversion trace is temporally stretched by a factor of 2×10^(4.,which can thus be recorded by a low-bandwidth silicon *** combination with the time-correlated photon-counting technique,the achieved effective resolution is about two orders of magnitude better than the timing jitter of the detector itself,which facilitates a ranging precision of 4.m under a low detected flux of 8×10^(−5) photons per *** presented MIR time-of-flight range finder is featured with single-photon sensitivity and high positioning resolution,which would be particularly useful in infrared sensing and imaging in photon-starved scenarios.

关键词： resolution lidar repetition

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