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Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages

Signal Transduction and Targeted Therapy 2024年第1期9卷 40-43页

作者： Huili Chen Shengyang Fu Xiangyu Li Meng Shi Jiazhen Qian Shu Zhao Ping Yuan Lu Ding Xiaohuan Xia Jialin C.Zheng Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of Medicine200065 ShanghaiChina Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Translational research institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital affiliated to Tongji University School of Medicine200434 ShanghaiChina

Dear Editor,Major depressive disorder(MDD)is one of the most common psychiatric illnesses that significantly increase the risk of suicide.1 Stress-triggered dysfunctions of microglia have been identified as a commonly occurred pathological feature of MDD.1–3 Microglial dysfunction contributes to the pathogenesis of MDD via immunoresponses/neuroinflammation-mediated neural damage and pathological synapse loss-mediated neural circuit disruption.1 Although the involvement of microglia in MDD has been widely investigated,the molecular mechanisms underlying microglial dysfunction remain largely ***,we identified glutaminase 1(Gls1)as one key protein that participates in microglial dysfunction.4.6 Gls1 catalyzes the hydrolysis of glutamine to produce glutamate in the brain.4.Besides its well-known role in excitatory neurotoxicity,we found Gls1 up-regulation in microglia in animal models of Alzheimer’s disease and ischemic stroke.4.7 Gls1 activates microglia to overproduce cytokines and release inflammatory extracellular vesicles,therefore leading to neuroinflammation in animal models of Alzheimer’s disease and ischemic stroke.4.6 More importantly,Gls1 has been found to be up-regulated in the brains of MDD patients,and microglial Gls1 deficiency mitigated LPS-induced depression-like behaviors.8 However,LPS exposure is not an appropriate model to mimic MDD phenotypes,leaving the involvement of Gls1 in MDD an undetermined question.

关键词： involvement inflammation media

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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome institutes(shanghai) ShanghaiChina Human Phenome institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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On-chip ultrafast stackable dielectric laser positron accelerator

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Chinese Physics B 2024年第3期33卷 350-354页

作者：孙斌何阳帆潘晨浩樊思劼王度王少义赵宗清 Department of Plasma Physics and Fusion Engineering School of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026China National Key Laboratory of Plasma Physics Research Center of Laser FusionChina Academy of Engineering PhysicsMianyang 621900China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of High Field Laser Physics and Chinese Academy of Sciences Center for Excellence in Ultra-Intense Laser Science Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Department of Engineering Physics Tsinghua UniversityBeijing 100084China The institute of Technological Sciences Wuhan UniversityWuhan 430072China

We present a first on-chip positron accelerator based on dielectric laser *** innovative approach significantly reduces the physical dimensions of the positron acceleration apparatus,enhancing its feasibility for diverse *** utilizing a stacked acceleration structure and far-infrared laser technology,we are able to achieve a seven-stage acceleration structure that surpasses the distance and energy gain of using the previous dielectric laser acceleration ***,we are able to compress the positron beam to an ultrafast sub-femtosecond scale during the acceleration process,compared with the traditional methods,the positron beam is compressed to a greater *** also demonstrate the robustness of the stacked acceleration structure through the successful acceleration of the positron beam.

关键词： dielectric laser accelerator positron accelerator high gradient accelerator inverse Cherenkov effect

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Emerging hierarchical mesoporous materials of covalent organic frameworks

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Science China Chemistry 2024年第9期67卷 2796-2802页

作者： Lingyan Huang Wenda Li Hongyi Zhang Shanzhe Ke Hao Chen Jianwei Fu Chengbin Jing Jiangong Cheng Shaohua Liu State Key Laboratory of Precision Spectroscopy/Engineering research Center of Nanophotonics&Advanced Instrument(Ministry of Education) School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450052China State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China

Benefiting from abundant exposed active sites,minimized diffusion resistance of guest molecules,facilitated mass transfer process and enhanced storage capacity,covalent organic frameworks(COFs)have gained widespread scientific attention[1–4..Further construction of mesopores regarding pore engineering(pore size,pore geometry,pore volume,and framework compositions)in COFs can improve mass transport,accessibility as well as size-selectivity of the special guest moieties,thus exhibiting potential in catalysis,energy storage and separation and so on[5,6].

关键词： gained catalysis separation

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NF-κB in biology and targeted therapy:new insights and translational implications

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1322-1358页

作者： Qing Guo Yizi Jin Xinyu Chen Xiaomin Ye Xin Shen Mingxi Lin Cheng Zeng Teng Zhou Jian Zhang Department of Medical Oncology Fudan University Shanghai Cancer CenterNo.270Dong'an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina State Key Laboratory of Oncogenes and Related Genes Renj-Med-X Stem Cell Research CenterShanghai Cancer Institute&Department of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127PR China Department of Cardiology the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan 2nd RoadGuangzhou 510080China Department of Neurology Rujin HospitalShanghai JiaoTong University Schoolof MedicineShanghaiChina

NF-κB signaling has been discovered for nearly 4. ***,NF-κB signaling was identified as a pivotal pathway in mediating inflammatory ***,with extensive and in-depth investigations,researchers have discovered that its role can be expanded to a variety of signaling mechanisms,biological processes,human diseases,and treatment *** this review,we first scrutinize the research process of NF-κB signaling,and summarize the composition,activation,and regulatory mechanism of NF-κB *** investigate the interaction of NF-κB signaling with other important pathways,including PI3K/AKT,MAPK,JAK-STAT,TGF-β,Wnt,Notch,Hedgehog,and TLR *** physiological and pathological states of NF-κB signaling,as well as its intricate involvement in inflammation,immune regulation,and tumor microenvironment,are also ***,we illustrate how NF-κB signaling is involved in a variety of human diseases,including cancers,inflammatory and autoimmune diseases,cardiovascular diseases,metabolic diseases,neurological diseases,and ***,we discuss the therapeutic approaches targeting NF-κB signaling,including IKK inhibitors,monoclonal antibodies,proteasome inhibitors,nuclear translocation inhibitors,DNA binding inhibitors,TKls,non-coding RNAs,immunotherapy,and ***,we provide an outlook for research in the field of NF-κB *** hope to present a stereoscopic,comprehensive NF-κB signaling that will inform future research and clinical practice.

关键词： PI3K/AKT diseases involvement

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Engineering the Interface Between Au Nanoparticles and CoO-Ov to Enhance the Catalytic Performance of 5-Hydroxymethylfurfural(HMF)to 2,5-Dimethylfuran(DMF)

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Chemical research in Chinese Universities 2024年第1期40卷 47-54页

作者： XIANG Shuang GUO Yong LIU Xiaohui WANG Yanqin Key Laboratory for Advanced Materials and Joint International research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterResearch Institute of Industrial CatalysisSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237P.R.China

The interface between Au and support has attracted extensive interest because of its unique catalytic ability for hydrogen activation in catalytic hydrogenation/hydrogenolysis ***,we create the Au-CoO-OV interface in the 1.0%Au/Co3O4.Rod-250 catalyst,which could dissociate H2 via the heterolytic way to yield rich hydride species and achieve excellent catalytic performance in the hydrogenolysis of biomass-derived 5-hydroxymethylfurfural(HMF)to 2,5-dimethylfuran(DMF).The XRD and HRTEM analyses show that Au nanoparticles are uniformly dispersed on CoO-OV surface and in situ DRIFTS spectra show the enhancement of heterolytic dissociation of hydrogen(signals of Au-D and O-D vibration)compared with bare CoO(Co3O4.Rod-250).This work provides insights for fabricating highly active Au-support catalysts for catalytic hydrogenation/hydrogenolysis reactions.

关键词： Au-CoO-OV interface Hydride species Heterolytic dissociation 5-Hydroxymethylfurfural(HMF) 2 5-Dimethylfuran(DMF)

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Organic ligand nanoarchitectonics for BiVO_(4. photoanodes surface passivation and cocatalyst grafting

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Nano research 2024年第5期17卷 3667-3674页

作者： Jingyi Lin Xin Li Zhiliang Wang Runlu Liu Hui Pan Yixin Zhao Lingti Kong Yao Li Shenmin Zhu Lianzhou Wang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Nanomaterials Centre School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnologythe University of QueenslandQLD 4072Australia School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Wuhan Institute of TechnologyWuhan 430205China

Bismuth vanadate(BiVO_(4.)is a promising photoanode material for efficient photoelectrochemical(PEC)water splitting,whereas its performance is inhibited by detrimental surface *** solve the problem,herein,a low-cost organic molecule 1,3,5-benzenetricarboxylic acid(BTC)is selected for surface passivation of BiVO_(4. photoanodes(BVOs),which also provides bonding sites for Co^(2+)to anchor,resulting in a Co-BTC-BVO *** to its strong coordination with metal ions,BTC not only passivates surface states of BVO,but also provides bonding between BVO and catalytic active sites(Co^(2+))to form a molecular *** study and interfacial charge kinetic investigation reveal that chemical bonding formed at the interface greatly suppresses charge recombination and accelerates charge *** obtained Co-BTC-BVO photoanode exhibits a photocurrent density of 4.82 mA/cm^(2) at 1.23 V *** hydrogen electrode(RHE)and a low onset potential of 0.22 VRHE under AM 1.5 G illumination,which ranks among the best photoanodes coupled with Co-based *** work presents a novel selection of passivation layers and emphasizes the significance of interfacial chemical bonding for the construction of efficient photoanodes.

关键词： bismuth vanadate photoanode water splitting surface passivation bridging ligands

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A dual-RPA based lateral flow strip for sensitive,on-site detection of CP4.EPSPS and Cry1Ab/Ac genes in genetically modified crops

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Food Science and Human Wellness 2024年第1期13卷 183-190页

作者： Jinbin Wang Yu Wang Xiuwen Hu Yifan Chen Wei Jiang Xiaofeng Liu Juan Liu Lemei Zhu Haijuan Zeng Hua Liu Key Laboratory of Agricultural Genetics and Breeding Institute of Biotechnology ResearchShanghai Academy of Agricultural SciencesShanghai 201106China Crops Ecological Environment Security Inspection and Supervision Center(shanghai) Ministry of Agriculture and Rural AffairsShanghai 201106China School of Life Science and Engineering Lanzhou University of TechnologyLanzhou 730050China School of Public Health Changsha Medical UniversityChangsha 410219China Academician Workstation Changsha Medical UniversityChangsha 410219China

Traditional transgenic detection methods require high test conditions and struggle to be both sensitive and *** this study,a one-tube dual recombinase polymerase amplification(RPA)reaction system for CP4.EPSPS and Cry1Ab/Ac was proposed and combined with a lateral flow immunochromatographic assay,named“Dual-RPA-LFD”,to visualize the dual detection of genetically modified(GM)*** which,the herbicide tolerance gene CP4.EPSPS and the insect resistance gene Cry1Ab/Ac were selected as targets taking into account the current status of the most widespread application of insect resistance and herbicide tolerance traits and their stacked *** diluted plasmids,transgenic standards,and actual samples were used as templates to conduct sensitivity,specificity,and practicality assays,*** constructed method achieved the visual detection of plasmid at levels as low as 100 copies,demonstrating its high *** addition,good applicability to transgenic samples was observed,with no cross-interference between two test lines and no influence from other *** conclusion,this strategy achieved the expected purpose of simultaneous detection of the two popular targets in GM crops within 20 min at 37°C in a rapid,equipmentfree field manner,providing a new alternative for rapid screening for transgenic assays in the field.

关键词： Genetically modifi ed crops On-site detection Lateral fl ow test strips Dual recombinase polymerase amplification (RPA)

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Waveform simulation in PandaX-4.

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Chinese Physics C 2024年第7期48卷 1-13页

作者：李家富阿卜杜萨拉姆薄子豪陈葳谌勋程晨成赵侃崔祥仪樊英杰方德清耿立升 Karl Giboni 郭绪元韩晨成韩柯何昶达何金荣黄迪黄俊挺黄周侯汝全侯钰季向东巨永林李晨翔李名川李帅杰李涛林箐刘江来陆聪聪芦晓盈罗棱尹罗云阳马文博马余刚冒亚军孟月宁旭阳庞彬宇祁宁春钱志成任祥祥 Nasir Shaheed 尚晓凤邵熙元申国防司琳孙文良谈安迪陶奕王安庆王萌王秋红王少博王思广王为王秀丽王旭王舟魏月环武蒙蒙邬维浩吴渊肖梦姣肖翔燕斌斌阎玺宇杨勇喻纯旭袁影苑哲运有辉曾鑫宁张敏桢张鹏张世博张澍张涛张威张洋张瀛心张园园赵力周济芳周宁周小朋周永周钰博周知震 School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Beihang UniversityBeijing 102206China International research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Physics Peking UniversityBeijing 100871China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China Department of Physics University of MarylandCollege ParkMaryland 20742USA Tsung-Dao Lee institute Shanghai Jiao Tong UniversityShanghai200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French institute of nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China shanghai Jiao Tong University Sichuan research institute Chengdu 610213China SJTU Paris Elite institute of Technology Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics Yantai UniversityYantai 264005Ch

Signal reconstruction through software processing is a crucial component of the background and signal models in the PandaX-4. experiment,which is a multi-tonne dark matter direct search *** accuracy of signal reconstruction is influenced by various detector artifacts,including noise,dark count of photomultiplier,photoionization of impurities in the detector,and other relevant *** this study,we presented a detailed description of a semi-data-driven approach designed to simulate a signal *** work provides a reliable model for the efficiency and bias of the signal reconstruction in the data analysis of *** comparing critical variables that relate to the temporal shape and hit pattern of the signals,we found good agreement between the simulation and data.

关键词： dark matter time projection chamber simulation

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Anisotropic magnetism and band evolution induced by ferromagnetic phase transition in titanium-based kagome ferromagnet SmTi_3Bi_4

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 137-145页

作者： Zhe Zheng Long Chen Xuecong Ji Ying Zhou Gexing Qu Mingzhe Hu Yaobo Huang Hongming Weng Tian Qian Gang Wang Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Physics and Engineering Henan University of Science and TechnologyLuoyang 471023China shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Songshan Lake Materials Laboratory Dongguan 523808China CAS Center for Excellence in Topological Quantum Computation Chinese Academy of SciencesBeijing 100190China

Kagome magnets with diverse topological quantum responses are crucial for next-generation topological *** anisotropic magnetism and band evolution induced by ferromagnetic phase transition(FMPT)is reported in a newly discovered titanium-based kagome ferromagnet Sm Ti3Bi4.which features a distorted Ti kagome lattice and Sm atomic zig-zag ***-dependent resistivity,heat capacity,and magnetic susceptibility reveal a ferromagnetic ordering temperature Tc of23.2 K.A large magnetic anisotropy,observed by applying the magnetic field along three crystallographic axes,identifies the b axis as the easy ***-resolved photoemission spectroscopy with first-principles calculations unveils the characteristic kagome motif,including the Dirac point at the Fermi level and multiple van Hove ***,a band splitting and gap closing attributed to FMPT is observed,originating from the exchange coupling between Sm 4.f local moments and itinerant electrons of the kagome Ti atoms,as well as the time-reversal symmetry breaking induced by the long-range ferromagnetic *** the large in-plane magnetization and the evolution of electronic structure under the influence of ferromagnetic ordering,such materials promise to be a new platform for exploring the intricate electronic properties and magnetic phases based on the kagome lattice.

关键词： kagome lattice anisotropic magnetism band splitting ferromagnetic phase transition ARPES

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