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Orbital pacing and secular evolution of lake-level changes reconstructed by sedimentary noise modeling during the Early Jurassic icehouses-(super)greenhouses

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Science China Earth sciences 2024年第1期67卷 252-267页

作者： Meng LI Xin LI Stephen P.HESSELBO Mingjie LI Wenjin LIU Wei WU Jienan PAN Ruizhen GAO school of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China Camborne school of Mines and Environment and sustainability institute University of ExeterPenryn TR109FEUnited Kingdom Qinghai No.105 Coal Geological Exploration Team Xining 810000China

Lake-level changes can significantly affect paleoenvironmental evolution,resource occurrence,terrestrial carbon budget,and biodiversity in continental *** is one of the most critical factors controlling lake-level *** of the Early Jurassic has been evidenced by oscillating icehouses to(super)greenhouses with interrupted intermittent extreme climatic events(hyperthermal and cooling),e.g.,the Toarcian oceanic anoxic event(~183 Ma)and the late Pliensbachian cooling event(~185 Ma).Lake-level evolution and hydrologic cycling on Earth’s surface during the Early Jurassic icehouses-to-(super)greenhouses are thus far poorly understood due to a lack of continuous high-resolution nonmarine *** we present a super-long nonmarine lake level record for this pivotal interval from the early Pliensbachian to Toarcian by sedimentary noise modeling,and construct a 16.7-Myr-long astronomical time scale(174.2 Ma to 190.9 Ma)based on cyclostratigraphy analysis of rock color datasets(CIE b*)of the Qaidam *** results document lake-level oscillations on a 5-to 10-million-year(Myr)scale which shows a pronounced correlation with long-term climate variation and extreme climatic events,and 1-to 2.5-Myr-scale lake-level changes that are prominently paced by the 2.4.Myr long-eccentricity forcing and the 1.2-Myr obliquity *** the Pliensbachian Stage,the 1.2-Myr-scale lake-level changes are in phase with the coeval sealevel *** forced growth and decay of the ephemeral or permanent ice sheets in polar regions are interpreted to control the synchronous ups-and-downs of continental lake level and global sea ***,during the Toarcian ice-free greenhouses to(super)greenhouses,the 1.2-Myr-scale lake-level variations show an anti-phase relationship with global sea level,indicating a‘seesaw’interaction between continental reservoirs(lakes and groundwater)and global *** 2.4.Myr longeccentricity cycles mainly regulate variation

关键词： Milankovitch cycles Orbital forcing Sedimentary noise model Lake level Continental basins

Protect the oceans from Japan's radioisotope dumping

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Environmental Science and Ecotechnology 2024年第4期20卷 16-17页

作者： Chengjun Li Huan Zhong Lingyu Meng Mengjie Wu Wenjing Ning Su Shiung Lam Jun Luo Christian Sonne institute of Environmental Research at Greater Bay Area Guangzhou UniversityGuangzhou 510006China school of Environment Nanjing UniversityNanjingChina Department of Civil Engineering Nagoya Institute of TechnologyJapan Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjingChina Universiti Malaysia Terengganu TerengganuMalaysia Center for global Health Research(CGHR) Saveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiIndia Aarhus University RoskildeDenmark sustainability Cluster School of EngineeringUniversity of Petroleum&Energy StudiesDehradunUttarakhandIndia

In August 2023,Japan started to dump its 1.3 million tons of radioactive wastewater into the oceans[1,2].Most radioisotopes are claimed to be removed from the wastewater except tritium,which needs further dilution before ***,this dilution does not effectively remove any tritium from the wastewater but serves as a measure to bring its abnormally high concentration down to meet emission *** most worrisome situation is that many more bioaccumulative long-lived radioisotopes(BLLRs),such as carbon-14.and cobalt-60,slip through the treatment *** are attempts to reduce the concentrations of BLLRs via repurification to meet the regulatory standards[3];however,even low levels of these BLLRs can undergo biomagnification of up to 50,000 folds in marine fish species[4..

关键词： wastewater Japan removed

Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4.and protects against sepsis in mice

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3068-3085页

作者： Dongping Li Rongjuan Wei Xianglong Zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin Li Meiling Chen Ruofan Liu Yantong Wan Yinghao Hong Zhenhua Zeng Peng Gu Zhang Wang Kutty Selva Nandakumar Yong Jiang Hongwei Zhou Peng Chen Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China Department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China institute of Ecological sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China Department of Environmental and Biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated with the disruption of gut ***,the modulatory mechanisms of gut microbiota operating during sepsis are still ***,we investigated how gut commensals impact sepsis development in a pre-clinical *** ligation and puncture(CLP)surgery was used to establish polymicrobial sepsis in *** depleted of gut microbiota by an antibiotic cocktail(ABX)exhibited a significantly higher level of mortality than *** determined by metabolomics analysis,ABX treatment has depleted many metabolites,and subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohydrate metabolite,exerted profound immunomodulatory properties with a significant enhancement in macrophage phagocytosis,which in turn improved organ damage and ***,rhamnose binds directly to and activates the solute carrier family 12(potassium-chloride symporter),member 4.SLC12A4.in macrophages and promotes phagocytosis by activating the small G-proteins,Ras-related C3 botulinum toxin substrate1(Rac1)and cell division control protein 4. homolog(Cdc4.).Interestingly,rhamnose has enhanced the phagocytosis capacity of macrophages from sepsis *** conclusion,by identifying SLC12A4.as the host interacting protein,we disclosed that the gut commensal metabolite rhamnose is a functional molecular that could promote the phagocytosis capacity of macrophages and protect the host against sepsis.

关键词： Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cdc4. Macrophage Phagocytosis

Uncovering the impact of alcohol on internal organs and reproductive health:Exploring TLR4.NF-kB and CYP2E1/ROS/Nrf2 pathways

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Animal Models and Experimental Medicine 2024年第4期7卷 444-459页

作者： Eason Qi Zheng Kong Vetriselvan Subramaniyan Natasha Sura Anak Lubau Pharmacology Unit Jeffrey Cheah School of Medicine and Health SciencesMonash University MalaysiaSubang JayaSelangorMalaysia Center for global Health Research Saveetha Medical CollegeSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia

This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health,elucidating the underlying mechanisms involving the Toll-like receptor 4.TLR4./Nuclear factor kappa light chain enhancer of activated B cells(NF-kB)pathway and the Cytochrome P4.02E1(CYP2E1)/reactive oxygen spe-cies(ROS)/nuclear factor erythroid 2-related factor 2(Nrf2)*** TLR4.NF-kB pathway,crucial for inflammatory and immune responses,triggers the production of pro-inflammatory agents and type-1 interferon,disrupting the balance between inflammatory and antioxidant responses when tissues are chronically exposed to ***-induced dysbiosis in gut microbes heightens gut wall permeability to pathogen-associated molecular patterns(PAMPs),leading to liver cell infection and subsequent ***,CYP2E1-mediated alcohol metabolism gen-erates ROS,causing oxidative stress and damaging cells,lipids,proteins,and deoxy-ribonucleic acid(DNA).To counteract this inflammatory imbalance,Nrf2 regulates gene expression,inhibiting inflammatory progression and promoting antioxidant *** alcohol intake results in elevated liver enzymes(ADH,CYP2E1,and catalase),ROS,NADH,acetaldehyde,and acetate,leading to damage in vital organs such as the heart,brain,and ***,alcohol negatively affects reproduc-tive health by inhibiting the hypothalamic-pituitary-gonadal axis,causing infertility in both men and *** findings underscore the profound health concerns associated with alcohol-induced damage,emphasizing the need for public awareness regarding the intricate interplay between immune responses and the multi-organ im-pacts of alcohol consumption.

关键词： alcohol health impact inflammation metabolism molecular pathways

Promoted surface charge density from interlayer Zn–N_(4. configuration in carbon nitride for enhanced CO_(2) photoreduction

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Nano Research 2024年第4期17卷 2400-2409页

作者： Xianjin Shi Yu Huang Gangqiang Zhu Wei Peng Meijuan Chen State Key Laboratory of Loess and Quaternary Geology(SKLLQG) Key Laboratory of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Center of Excellence in Quaternary Science and global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of sciences Beijing 100049China school of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China school of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China

The solar-driven reduction of CO_(2) into valuable products is a promising method to alleviate global environmental problems and energy ***,the low surface charge density limits the photocatalytic conversion performance of CO_(2).Herein,a polymeric carbon nitride(PCN)photocatalyst with Zn single atoms(Zn1/CN)was designed and synthesized for CO_(2) *** results of the CO_(2) photoreduction studies show that the CO and CH_(4. yields of Zn1/CN increased fivefold,reaching 76.9 and 22.9μmol/(g·h),respectively,in contrast to the unmodified ***+plasma-etched X-ray photoelectron spectroscopy and synchrotron radiation-based X-ray absorption fine structure results reveal that Zn single atom is mainly present in the interlayer space of PCN in the Zn–N_(4. *** characterizations indicate that the interlayer Zn–N_(4. configuration can amplify light absorption and establish an interlayer charge transfer ***-assisted Kelvin probe force microscopy confirms that more photogenerated electrons are delivered to the catalyst surface through interlayer Zn–N_(4. configuration,which increases its surface charge ***,in-situ infrared spectroscopy combined with density functional theory calculation reveals that promoted surface charge density accelerates key intermediates(*COOH)conversion,thus achieving efficient CO_(2) *** work elucidates the role of internal single atoms in catalytic surface reactions,which provides important implications for the design of single-atom catalysts.

关键词： single-atom catalysts photocatalytic CO_(2)reduction interlayer modification charge transfer dynamics surface charge density

A likely paleo-autotetraploidization event shaped the high conservation of Nyssaceae genome

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Horticultural Plant Journal 2024年第3期10卷 911-930页

作者： Yishan Feng Zhenyi Wang Qimeng Xiao Jia Teng Jianyu Wang Zijian Yu Jiaqi Wang Qiang Xu Yan Zhang Shaoqi Shen Shoutong Bao Yu Li Zimo Yan Yue Ding Zihan Liu Yuxian Li Tianyu Lei Min Yuan Xiu-Qing Li Jinpeng Wang Department of Bioinformatics School of Life SciencesNorth China University of Science and TechnologyTangshanHebei 063000China Fredericton Research and Development Centre Agriculture and Agri-Food CanadaFrederictonNew Brunswick E3B 4Z7Canada State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of ScienceBeijing 100093China University of Chinese Academy of sciences Beijing 100049China

Scientific knowledge about the ancestral genome of core eudicot plant kingdom can potentially have profound impacts on both basic and applied research,including evolution,genetics,genomics,ecology,agriculture,forestry,and global *** investigate which plant conserves best the core eudicots common ancestor genome,we compared Arcto-Tertiary relict Nyssaceae and 30 other eudicot plant *** genomes of Davidia involucrata(a known living fossil),Camptotheca acuminata and Nyssa sinensis,one per existent genus of Nyssaceae,were performed comparative genomic *** found that Nyssaceae originated from a single Nyssaceae common tetraploidization event(NCT)-autotetraploidization 28-31 Mya after the core eudicot common hexaploidization(ECH).We identified Nyssaceae orthologous and paralogous genes,determined its chromosomal evolutionary trajectory,and reconstructed the Nyssaceae most recent ancestor *** genome contained the entire seven paleochromosomes and 17 ECH-generated eudicot common ancestor chromosomes and was the slowest in mutation among the analyzed 4. species of 31 plant *** both its high retention of paleochromosomes and its low mutation rate,*** provides the best case in conservation of the core eudicot paleogenome.

关键词： Nyssaceae Polyploidization Multigenome alignment Evolutionary rate Autotetraploidization Karyotype evolution

Impact of natural resource mining on sustainable economic development:The role of education and green innovation in China

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Geoscience Frontiers 2024年第3期15卷 346-357页

作者： Xing Li Lina Ma Asif M.Ruman Najaf Iqbal Wadim Strielkowski school of Media&Linguistics Anhui University of Finance&EconomicsBengbuAnhuiChina Graduate school of Management&Information Technology Hannan UniversityJapan school of Accounting Wuhan Textile UniversityWuhanHubeiChina Business school University of OuluOuluFinland school of Finance Anhui University of Finance and EconomicsBengbu 233030AnhuiChina Africa-Asia Centre for sustainability Business SchoolUniversity of AberdeenScotlandUK Department of Trade and Finance Faculty of Economics and ManagementCzech University of Life Sciences PragueKamycká129Prague 616500 PragueCzech Republic Centre for Energy Studies Cambridge Institute for Advanced StudiesKing str.23CB11AH CambridgeUK

As the extraction and usage of natural resources continue to be a double-edged sword-supporting economic growth but deteriorating the environment-we study the impact of natural resource mining on sustainable economic development in the largest(PPP)*** use province-level data from 2001 to 2020 and employ econometric panel techniques,such as fixed effects,two-stage least squares,and a battery of robustness *** further explore the potential effects of education and green innovation in mitigating/exacerbating the role of natural resources in the Chinese provincial *** results show that:(1)Natural resource mining hurts sustainable development,verifying the“resource curse”effect.(2)Green innovation and education restrain the negative impact of resource mining on sustainable development,turning the curse into a blessing.(3)A regional heterogeneity is observed in the impact of resource mining on sustainable development,showing more significant effects in the Western and low-urbanized regions.(4.Green innovation and education can assuage the curse effect of natural resources into gospel *** implications and recommendations are proposed in light of the findings to promote sustainable economic development in China.

关键词： Natural resource mining Sustainable economic growth Education Green innovation Resource curse China

The evolution and diurnal expression patterns of photosynthetic pathway genes of the invasive alien weed,Mikania micrantha

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Journal of Integrative Agriculture 2024年第2期23卷 590-604页

作者： Kangkang Wang Mengjiao Jin Jingjing Li Yesong Ren Zaiyuan Li Xinghai Ren Cong Huang Fanghao Wan Wanqiang Qian Bo Liu Shenzhen Branch Guangdong Laboratory of Lingnan Modern Agriculture/Genome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Shenzhen Research institute of Henan University Shenzhen 518000China

Mikania micrantha is a fast-growing global invasive weed species that causes severe damage to natural ecosystems and very large economic losses of forest and crop *** has advantages in photosynthesis,including a similar net photosynthetic rate as C4.plants and a higher carbon fixation *** used a combination of genomics and transcriptomics approaches to study the evolutionary mechanisms and circadian expression patterns of *** ***,16 positive selection genes focused on photoreaction and utilization of *** different tissues,98.1%of the genes associated with photoresponse had high expression in stems,and more than half of the genes of the C4.cycle had higher expression in stems than in *** stomatal opening and closing,2 genes of carbonic anhydrase(CAs)had higher expression at 18:00 than at 8:00,and the slow anion channel 1(SLAC1)and high-leaf-temperature 1 kinase(HT1)genes were expressed at low levels at 18:*** addition,genes associated with photosynthesis had higher expression levels at 7:00 and 17:*** hypothesized that *** may undergo photosynthesis in the stem and flower organs and that some stomata of the leaves were opening at night by CO_(2)*** addition,its evolution may attenuate photoinhibition at high light intensities,and enhance more efficient of photosynthesis during low light *** the tissue-specific photosynthetic types and different diurnal pattern of photosynthetic-related genes may contribute to its rapid colonization of new habitats of ***.

关键词： invasion plant Mikania micrantha photosynthesis stomata stem

Engagement of N^(6)-methyladenisine methylation of Gng4.mRNA in astrocyte dysfunction regulated by CircHECW2

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1644-1660页

作者： Ying Bai Di Chang Hui Ren Minzi Ju Yu Wang Biling Chen Han Li Xue Liu Daxing Li Xinchen Huo Xiaofei Guo Mengze Tong Ying Tan Honghong Yao Bing Han Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjing 210009China Department of Radiology Zhongda HospitalJiangsu Key Laboratory of Molecular and Functional ImagingMedical School of Southeast UniversityNanjing 210009China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China institute of life sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Center for global Health School of Public HealthNanjing Medical UniversityNanjing 211166China

The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target *** evidence has suggested that m6A methylation may be involved in the pathological process of major depressive disorder(MDD),a common neuropsychiatric disorder with an unclear ***,we found that the levels of the circular RNA HECW2(circHECW2)were significantly increased in the plasma of both MDD patients and the chronic unpredictable stress(CUS)mouse ***,the downregulation of circHECW2 attenuated astrocyte dysfunction and depression-like behaviors induced by ***,we demonstrated that the downregulation of circHECW2 increased the expression of the methylase WTAP,leading to an increase in Gng4.expression via m^(6)A *** findings provide functional insight into the correlation between circHECW2 and m^(6)A methylation,suggesting that circHECW2 may represent a potential target for MDD treatment.

关键词： N^(6)-Methyladenosine Depression circHECW2 Astrocyte WTAP Ubiquitination GNG4 Dysfunction