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Engineered self-healing single-cavity microcapsules for pulsatile release of drug delivery

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Particuology 2023年第9期80卷 53-60页

作者： Tong Ye Lingjiao Zou Yishu Wang Guanghui Ma State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Division of Molecular Science Graduate School of Science and TechnologyGunma University1-5-1Tenjin-choKiryu376-8515Japan Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing100190China

A wide range of polymer-based drug delivery systems have been reported for the treatment of ***,the dosing regimen of many drugs,such as stimulator of interferon genes agonists,programmed cell death protein-1 antibodies,and coronavirus disease 2019 vaccines,consists of repeatedintratumoral or intramuscular *** repeated administrations may lead to poor adherence,thus resulting in compromised therapeutic outcomes and increased financial ***,we developed a multidose drug delivery platform by engineering polylactic-co-glycolic acid(PLGA)with differentmolecular weights into self-healing single-cavity microcapsules(SSM).This approach showed a flexiblecollocation strategy to achieve customized pulsatile drug release and was fully degradable with ***,this single-injection delivery system contains only PLGA,holding great promise forclinical translation.

关键词： Drug delivery Single-cavity microcapsule Pulsatile release Self-healing microparticle

Preparation and adsorption behavior for metal ions and humic acid of chitosan derivatives crosslinked by irradiation

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Nuclear Science and Techniques 2007年第1期18卷 42-49页

作者： ZHAO Long Jaroslaw M. WASIKIEWICZ Hiroshi MITOMO Naotsugu NAGASAWA Fumio YOSHII Department of Biological and Chemical Engineering Gunma University Tenjin-cho Kiryu Gunma 376-8515 Japan Advanced Materials Research Center R ＆D Laboratories Nissin Electric Co.Ltd Umezutakase-cho Ukyo-ku Kyoto 615-8686 Japan Takasaki Radiation Chemistry Research Establishment Japan Atomic Energy Research Institute Watanuki-machi Takasaki Gunma370-1292 Japan

Th/s article deals with the determination of the adsorption properties of metal ions and humic acid in wa- ter on crosslinked chitosan derivatives (carboxymethylchitosan) which were formed using the irradiation technique without any *** solubility test of these crosslinked materials were investigated in acidic,alkaline media, distilled water,and certain organic *** electron microscopic (SEM) images showed that the crosslinked chitosan derivatives possessed a porous morphological *** characteristic analyses demon- strated typically pH-dependent properties of the crosslinked *** adsorption studies were carried out by the batch method at room *** of heavy metal ions (such as Cu^(2+),Cd^(2+)) and humic acid onto crosslinked samples was found to be strongly *** kinetic studies indicated the rapid removal of metal ions,and humic acid from the aqueous ***,isothermal adsorption data revealed that Cu^(2+),Cd^(2+), and humic acid were removed by these crosslinked materials with high *** isothermal data were interpreted well by the Langmuir *** crosslinked carboxymethylated chitosan derivatives indicate favor- able adsorption of metal ions and humic acid.

关键词：金属离子腐殖酸壳聚糖衍生物辐射处理交联

Efficacy of the revised Vienna Classification for diagnosing colorectal epithelial neoplasias

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World Journal of Gastroenterology 2009年第19期15卷 2351-2356页

作者： Kenji Tominaga Sumio Fujinuma Takuro Endo Yoshihisa Saida Kei Takahashi Iruru Maetani Division of Gastroenterology Department of Internal MedicineToho University Ohashi Medical Center2-17-6 OhashiMeguro-kuTokyo 153-8515Japan Third Department of Surgery Toho University Ohashi Medical Center2-17-6 OhashiMeguro-kuTokyo 153-8515Japan Department of Surgical Pathology Toho University Ohashi Medical Center2-17-6 OhashiMeguro-kuTokyo 153-8515Japan

AIM： To prospectively investigate the efficacy of the revised Vienna Classification for diagnosing colorectal epithelial neoplastic lesions in cold biopsy ***： Patients were selected for inclusion if they had colorectal epithelial lesions that were not considered suitable for direct endoscopic resection,These included colorectal polyps ≥ 10 mm and lesions suspected of being carcinomas capable of invading the colorectal submucosa or beyond, including strictures, based on the cold biopsies obtained from each lesion prior to resection. We investigated the relationship between diagnoses based on cold biopsy samples using the revised Vienna Classification and resected specimens of the same lesions, and the therapeutic implications of diagnoses made using the revised Vienna Classification. The same cold biopsy specimens were also examined using the Japanese Group Classification guidelines, and compared with the resected specimens of the same lesions for ***： A total of 179 lesions were identified. The sensitivity, specificity, positive and negativepredictive values of the revised Vienna Classification for distinguishing between intramucosal lesions and submucosal invasive carcinomas in cold biopsy specimens was 22.2%, 100%, 100%, and 71.4%,respectively, and for distinguishing between intramucosal lesions and those invading the submucosa or beyond was 59.7%, 100%, 100%, and 37.6%,respectively. The sensitivity, specificity, positive and negative predictive values of the Japanese Group Classification for distinguishing between intramucosal lesions and submucosal invasive carcinomas in cold biopsy specimens was 83.3%, 91.4%, 83.3%. and 91.4%, respectively, and for distinguishing between intramucosal lesions and those invading the submucosa or beyond was 95.1%, 91.4%, 97.9%, and 82.1%, respectively. A total of 137 of 144 carcinomas that had invaded the submucosa or beyond and three high-grade intraepithelial neoplasias were diagnosed as ＂carcinoma＂

关键词： Biopsy Cancer Colonoscopy Colorectalepithelial neoplasia Revised Vienna Classification

Reduction of radiative heating due to a SiC ablation layer

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Reduction of radiative heating due to a SiC ablation layer

直喷汽油机压电晶体控制外开轴针式喷油器喷雾场速度特性

The 24th International Symposium on Shock Waves

作者： M.Funatsu H.Shirai Department of Mechanical System Engineering School of Engineering Gunma University 1-5-1 Tenjin-cho Kiryu Gunma 376-8515 Japan

The effectiveness of SiC ablation layer was investigated numerically for the radiative heating from the high-temperature shock layer to a wall surface using a very simplified shock layer with the wall-surface reflectance. Considering the entry into the atmosphere of the planet Jupiter, it was assumed that the shock layer consisted only of the chemical species originated from the atmosphere and the ablation layer from the SiC heat shield. In the calculation of the radiative heat flux with the incident angle, molecular bands, atomic lines, and continuum emission were all included. It was found that SiC ablation material was effective in reducing the radiative heat flux to the wall surface, to the same extent as carbon/carbon material.

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内燃机学报 2012年第6期30卷 531-537页

作者：董全隆武强田江平石間経章川岛久宜大连理工大学内燃机研究所辽宁大连116024 群马大学大学院日本群马376-8515

应用粒子图像测速技术(PIV)对定容弹内多种试验条件下压电晶体控制的外开轴针式喷油器的喷雾场速度特性进行测量与分析.试验结果表明,油嘴附近的大尺度气体涡流A和涡流B不仅对油气掺混和喷雾雾化起到关键作用,对于点火时刻火花塞附近的... 详细信息

应用粒子图像测速技术(PIV)对定容弹内多种试验条件下压电晶体控制的外开轴针式喷油器的喷雾场速度特性进行测量与分析.试验结果表明,油嘴附近的大尺度气体涡流A和涡流B不仅对油气掺混和喷雾雾化起到关键作用,对于点火时刻火花塞附近的混合气特性也具有重要影响.将喷射压力、环境压力、轴针升程及轴针座锥角对喷雾场内涡流运动的影响作为重点进行分析.结果表明,环境压力增加促进了涡流A和涡流B的增长,同时使涡流的位置更加靠近喷油器.轴针座锥角的变化显著改变了喷雾场内的气流运动特征,94°轴针座锥角的喷雾出现了明显的冲向油嘴的气体回流.通过对喷雾场各节点的速度结果进行标准差计算,得到了喷雾场的速度标准偏差.以此为基础,对喷雾场内涡流的运动特性及其对混合气分布的影响做了进一步的分析.

关键词：外开轴针式粒子图像测速技术涡流速度特性

直喷汽油机压电晶体控制外开轴针式喷油器的喷雾场粒子特性

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内燃机学报 2013年第2期31卷 126-132页

作者：董全隆武强田江平石間経章川岛久宜大连理工大学内燃机研究所辽宁大连116024 群马大学大学院日本群马376-8515

应用相位多普勒测量技术(PDA)对压电晶体控制的外开轴针式喷油器的喷雾场内粒子速度及直径大小进行测量与分析.结果表明,常压条件下,喷雾路径上的粒子速度和粒径都要明显大于喷雾外侧相邻的测量点.环境压力变化影响了气体回流进入喷雾... 详细信息

应用相位多普勒测量技术(PDA)对压电晶体控制的外开轴针式喷油器的喷雾场内粒子速度及直径大小进行测量与分析.结果表明,常压条件下,喷雾路径上的粒子速度和粒径都要明显大于喷雾外侧相邻的测量点.环境压力变化影响了气体回流进入喷雾内部的位置,从而使Z=16,mm上的所有测点在两个背压条件下得到了速度方向完全相反的结果.喷油结束后,气体回流不仅使喷雾内部的粒子具有较高的速度,也使喷雾内部的粒子平均粒径明显大于喷雾外侧的粒子平均粒径.采用时间分割法将喷雾划分为4个区域进行分开比较.在喷射过程中,喷雾前端粒子速度较高,粒径较大,但随着喷油结束,喷雾场内的粒子速度接近于零,粒子算数平均直径(AMD)和索特平均直径(SMD)也分别达到了稳定水平.

关键词：汽油机外开轴针式时间分割法

Treatment of Dye Wastewater by Hybrid Gas/Liquid Pulsed Discharge Plasma Reactor using Porous Ceramic Tube

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Treatment of Dye Wastewater by Hybrid Gas/Liquid Pulsed Disc...

直喷汽油机压电晶体控制外开轴针式喷油器的喷雾可视化研究

第十五届全国等离子体科学技术会议

作者： Masayuki Sato Department of Chemical & Environmental Engineering Faculty of EngineeringGunma UniversityKiryuTenjin-cho 1-5-1376-8515Japan

The rapid development of textile industry has led to increasing production of dye wastewater,which has caused serious environmental *** plasma technique is regarded as a promising alternative for dye wastewater treatment due to its large amounts of chemically active species(including O,OH,O and HO) of high oxidation *** the present study,the discharge electrode was placed in the center of porous ceramic tube and a stainless steel mesh was tightly attached to the

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内燃机学报 2012年第5期30卷 415-422页

作者：董全隆武强田江平石間経章川岛久宜小林義幸大连理工大学内燃机研究所辽宁大连116024 群马大学大学院工学研究科日本群马376-8515

对新型压电晶体控制的外开轴针式喷油器在不同边界条件下实现的圆锥状喷雾的基本特征,包括喷雾锥角、喷雾轴向贯穿距及每循环喷油量进行了分析与研究,并在此基础上提出了针对这种外开轴针式喷油器的喷雾轴向贯穿距经验公式.为了能够对... 详细信息

对新型压电晶体控制的外开轴针式喷油器在不同边界条件下实现的圆锥状喷雾的基本特征,包括喷雾锥角、喷雾轴向贯穿距及每循环喷油量进行了分析与研究,并在此基础上提出了针对这种外开轴针式喷油器的喷雾轴向贯穿距经验公式.为了能够对喷雾的空间分布能力及油气混合特性进行定性分析,提出了喷雾体积放大倍率的概念.采用超高速摄影相机获得的可视化结果表明,这种喷油器形成的空心圆锥状喷雾实际上是由许多直径较小的"油线"组成的.油线结构的发现为进一步分析及研究其喷雾特性提供了参考和依据.

关键词：外开轴针式可视化喷雾体积放大倍率油线

Spray characteristics and controlling mechanism of fuel containing CO2

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Frontiers in Energy 2012年第1期6卷 80-88页

作者： Zhen HUANG Jin XIAO Xinqi QIAO Gaozhi JIANG Yiming SHAO Seiichi SHIGA Yasuhiro DAISHO Key Laboratory for Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China Faculty of Engineering Depamnent of Mechanical System EngineeringGunma UniversityGunma 376-8515Japan Faculty of Transportation Engineering Chongqing Jiaotong UniversityChongqing 400074China Faculty of Science and Engineering Waseda UniversityTokyo169-8555Japan

This paper presents studies of spray characteristics and controlling mechanism of fuel containing CO2. Using diesel fuel containing CO2 gas, experiments were conducted on diesel hole-type nozzles and simple nozzles. The steady spray and transient spray characteristics were observed and measured by instantaneous shadowgraphy, high-speed photography, phase Doppler anemometry （PDA） and LDSA respectively. The effects of CO2 concentration in the fuel, the injection pressure, the nozzle L/D ratio, surrounding gas pressure and temperature on the atomization behavior and spray pattern were evaluated. The results show that the injection of fuel containing CO2 can greatly improve the atomization and produce a parabolic-shaped spray; and the CO2 gas concentration, surrounding gas pressure, temperature and nozzle config- uration have dominant influences on spray characteristics of the fuel containing CO2. New insight into the controlling mechanism of atomization of the fuel containing CO2 was provided.

关键词： spray characteristics fuel atomization fuelcontaining CO2