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Small cell lung cancer with peripheral neuropathy as the first symptom:Two case reports

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World Journal of Clinical Cases 2025年第9期13卷 30-40页

作者： Man Luo Xiao-Xi Lu Dan-Yang Meng Jin Hu Department of Neurology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Information Technology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Small cell lung cancer(SCLC)is the most malignant type of lung *** in the latent period and early stage of the tumor,SCLC is prone to produce distant metastases with complex and diverse clinical *** is most closely related to paraneoplastic syndrome,and some cases present as paraneoplastic peripheral neuropathy(PPN).PPN in SCLC appears early,lacks specificity,and often occurs before diagnosis of the primary *** is easy to be misdiagnosed as a primary disease of the nervous system,leading to missed diagnosis and delayed diagnosis and *** SUMMARY This paper reports two cases of SCLC with limb weakness as the first *** first symptoms of one patient were rash,limb weakness,and abnormal *** patient was repeatedly referred to the hospital for limb weakness and rash for>1 year,during which time,treatment with hormones and immunosuppressants did not lead to significant improvement,and the condition gradually *** patient was later diagnosed with SCLC,and the dyskinesia did not worsen as the dermatomyositis improved after antineoplastic and hormone *** second case presented with limb numbness and weakness as the first symptom,but the patient did not pay attention to ***,the patient was diagnosed with SCLC after facial edema caused by tumor thrombus invading the ***,he was diagnosed with extensive SCLC and died 1 year after *** The two cases had PPN and abnormal electromyography,highlighting its correlation with early clinical indicators of SCLC.

关键词： Paraneoplastic peripheral neuropathy Small cell lung cancer Peripheral neuropathy Electromyography Dermatomyositis Case report

Non-alcoholic Wernicke encephalopathy in an esophageal cancer patient receiving radiotherapy:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5810-5815页

作者： Ye Zhang Lei Wang Jin Jiang Wen-Yu Chen Department of General Practice The Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Oncology The Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Respiration The Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND, Wernicke encephalopathy is a rare but potentially fatal adverse event caused by thiamine deficiency. Reports of non-alcoholic Wernicke encephalopathy due to malignancy are scarce in the literature, with those reported mainly being on haematological cancer, followed by gastrointestinal cancer. As a result, there is considerable under-recognition and delay in the diagnosis and treatment of Wernicke encephalopathy in oncology departments. To our knowledge, there has been no report of Wernicke encephalopathy in a patient with esophageal cancer while receiving *** SUMMARY A 64-year-old man presented to the oncology outpatient clinic with a history of dysphagia for 2 mo, and was diagnosed with locally advanced esophageal squamous cell carcinoma(stage ⅢB). Radiotherapy was initiated to alleviate dysphagia due to malignant esophageal stenosis;however, the patient exhibited consciousness disturbances starting on day 10 of radiotherapy. Brain magnetic resonance imaging indicated the development of Wernicke encephalopathy. Subsequent treatment with thiamine led to rapid improvement in the patient’s neurological *** Wernicke encephalopathy may develop in non-alcoholic patients undergoing radiotherapy for esophageal cancer. Early diagnosis and sufficient thiamine supplementation during radiotherapy are essential.

关键词： Wernicke encephalopathy Thiamine deficiency Esophageal cancer Radiotherapy Consciousness disturbance Case report

Mortality in patients with COVID-19 requiring extracorporeal membrane oxygenation:A meta-analysis

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World Journal of Clinical Cases 2022年第8期10卷 2457-2467页

作者： Ye Zhang Lei Wang Zhi-Xian Fang Jing Chen Jia-Lian Zheng Ming Yao Wen-Yu Chen Department of General Practice Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Respiration Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Oncology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pain Medicine Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)has become a worldwide pandemic and significant public health *** effectiveness of extracorporeal membrane oxygenation(ECMO)in treating COVID-19 patients has been called into *** To conduct a meta-analysis on the mortality of COVID-19 patients who require *** This analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes 2020(PRISMA)and has been registered at the International Prospective Register of Systematic Reviews(number CRD42020227414).A quality assessment for all the included articles was performed by the Newcastle-Ottawa Scale(NOS).Studies with tenor more COVID-19 patients undergoing ECMO were *** random-effects model was used to obtain the pooled incidence of mortality in COVID-19 patients receiving *** source of heterogeneity was investigated using subgroup and sensitivity *** We identified 18 articles with 1494 COVID-19 patients who were receiving *** score of the quality assessment ranged from 5 to 8 on the *** majority of patients received veno-venous ECMO(93.7%).Overall mortality was estimated to be 0.31[95%confidence interval(CI):0.24-0.39;I2=84.8%]based on random-effect pooled *** were significant differences in mortality between location groups(33.0%vs 55.0%vs 37.0%vs 18.0%,P<0.001),setting groups(28.0%vs 34.0%,P<0.001),sample size(37.0%vs 31.0%,P<0.001),and NOS groups(39.0%vs 19.0%,P<0.001).However,both subgroup analyses based on location,setting,and sample size,and sensitivity analysis failed to identify the source of *** funnel plot indicated no evident asymmetry,and the Egger’s(P=0.95)and Begg’s(P=0.14)tests also revealed no significant publication *** With more resource assessment and risk-benefit analysis,our data reveal that ECMO might be a feasible and effective treatment for COVID-19 patients.

关键词： COVID-19 Extracorporeal membrane oxygenation SARS-CoV-2 Meta-analysis Veno-venous extracorporeal membrane oxygenation Mortality

Synchronous primary duodenal papillary adenocarcinoma and gallbladder carcinoma:A case report and review of literature

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World Journal of Clinical Cases 2022年第27期10卷 9790-9797页

作者： Jing Chen Ming-Yuan Zhu Yan-Hua Huang Zhong-Cheng Zhou Yi-Yu Shen Quan Zhou Ming-Jian Fei Fan-Chuang Kong Department of General Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Synchronous primary cancers(SPCs) have become increasingly frequent over the past ***,the coexistence of duodenal papillary and gallbladder cancers is rare,and such cases have not been previously reported in the English ***,we describe an SPC case with duodenal papilla and gallbladder cancers and its diagnosis and successful *** SUMMARY A 68-year-old Chinese man was admitted to our hospital with the chief complaint of dyspepsia for the past ***-enhanced computed tomography of the abdomen performed at the local hospital revealed dilatation of the bile and pancreatic ducts and a space-occupying lesion in the duodenal *** revealed a tumor protruding from the duodenal *** findings for the biopsied tissue revealed tubular villous growth with moderate heterogeneous *** treatment was *** examination of this surgical specimen revealed a 2-cm papillary tumor and another tumor protruding by 0.5 cm in the gallbladder neck *** rapid pathology identified adenocarcinoma in the gallbladder neck duct and tubular villous adenoma with high-grade intraepithelial neoplasia and local canceration in the duodenal *** an uneventful postoperative recovery,the patient was discharged without *** It is essential for clinicians and pathologists to maintain a high degree of suspicion while evaluating such synchronous cancers.

关键词： Synchronous primary cancers Gallbladder carcinoma Duodenal papillary adenocarcinoma Surgical treatment Case report

Adult rhabdomyosarcoma originating in the temporal muscle,invading the skull and meninges:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4866-4872页

作者： Geng-Huan Wang He-Ping Shen Zheng-Min Chu Jian Shen Department of Neurosurgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Neurology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Rhabdomyosarcoma(RMS)is a rare malignant tumor of mesenchymal origin that mainly affects *** cell/sclerosing RMS(SSRMS)is even *** is a new subtype that was added to the World Health Organization disease classification in *** the best of our knowledge,this is the first reported case of adult SSRMS disease classification originating in the temporal *** SUMMARY SSRMS originating in the temporal muscle of a male adult enlarged rapidly,destroyed the skull,and invaded the *** tumor was completely removed,and the postoperative pathological diagnosis was *** recovery was good and chemotherapy and radiotherapy were given after the *** up for 3 mo,no tumor *** RMS is one of the differential diagnoses for head soft tissue tumors with shortterm enlargement and skull *** computed tomography or magnetic resonance imaging is necessary for early detection of tumor invasion of the skull and brain tissue.

关键词： Rhabdomyosarcoma Temporal Muscle Skull Dura Mater Adult Case report

Undifferentiated high-grade pleomorphic sarcoma of the common bile duct:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2253-2260页

作者： Li-Ping Zheng Wen-Yan Shen Chun-Dong Hu Chun-Hua Wang Xu-Jian Chen Jing Wang Yi-Yu Shen Department of General Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Undifferentiated pleomorphic sarcoma(UPS)is a rare malignant mesenchymal tumor with a poor *** mainly occurs in the extremities,trunk,head and neck,and retroperitoneum *** to the lack of specific clinical manifestations and imaging features,UPS diagnosis mainly depends on pathological and immunohistochemical examinations for exclusive *** we report an extremely rare case of high-grade UPS in the common bile duct(CBD).There are limited available data on such *** SUMMARY A 70-year-old woman was admitted to our department with yellow eyes and urine accompanied by upper abdominal distending pain for 2 *** laboratory data suggested significantly elevated hepatorenal function *** imaging data revealed calculous cholecystitis,intrahepatic and extrahepatic bile duct dilation with extrahepatic bile duct calculi,and a space-occupying lesion at the distal *** endoscopic biliary stenting and symptomatic support therapy,CBD exploration and biopsy were *** frozen section indicated malignant spindle cell tumor of the CBD mass,and further radical pancreaticoduodenectomy was ***,the neoplasm was diagnosed as a high-grade UPS combined with the light-microscopic morphology and immunohistochemical *** This extremely rare case highlighted the need for increasing physicians'vigilance,reducing the odds of misdiagnosis,and providing appropriate treatment strategies.

关键词： Undifferentiated pleomorphic sarcoma Soft tissue sarcoma Common bile duct Extrahepatic bile duct Immunohistochemistry Case report

Delineation of a SMARCA4-specific competing endogenous RNA network and its function in hepatocellular carcinoma

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World Journal of Clinical Cases 2022年第29期10卷 10501-10515页

作者： Lei Zhang Ting Sun Xiao-Ye Wu Fa-Ming Fei Zhen-Zhen Gao Department of Clinical Oncology Jiaxing Second HospitalJiaxing 314000Zhejiang ProvinceChina Department of Clinical Oncology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a common malignancy worldwide,and the mortality rate continues to rise each ***4 expression has been associated with poor prognosis in various types of cancer;however,the specific mechanism of action of SMARCA4 in HCC needs to be fully *** To explore the specific mechanism of action of SMARCA4 in *** Herein,the expression level of SMARCA4 as well as its association with HCC prognosis were evaluated using transcriptome profiling and clinical data of 18 different types of cancer collected from The Cancer Genome Atlas ***,SMARCA4-high and-low groups were ***,gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to identify the function of SMARCA4,followed by construction of a SMARCA4-specific competing endogenous RNA(ceRNA)network using starBase *** role of SMARCA4 in immunotherapy and its association with immune cells were assessed using correlation *** It was observed that SMARCA4 was overexpressed and negatively correlated with prognosis in ***,SMARCA4 expression was positively associated with tumor mutational burden,microsatellite stability,and immunotherapy *** SNHG3/THUMP3-AS1-miR-139-5p-SMARCA4 ceRNA network was established and could be assumed to serve as a stimulatory mechanism in *** The findings of this study demonstrated that SMARCA4 plays a significant role in progression and immune infiltration in ***,a ceRNA network was detected,which was found to be correlated with poor prognosis in *** findings of this study could contribute towards the identification of predictive markers for immunotherapy and a novel mechanism of action for HCC treatment.

关键词： Hepatocellular carcinoma SMARCA4 Prognosis Immune infiltration Competing endogenous RNA

Surgically treating a rare and asymptomatic intraductal papillary neoplasm of the bile duct:A case report

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World Journal of Clinical Cases 2024年第2期12卷 367-373页

作者： Shen-Zhen Zhu Zhao-Feng Gao Xiao-Rong Liu Xiao-Guang Wang Fei Chen Department of General Surgery Jiaxing Second HospitalJiaxing 314000Zhejiang ProvinceChina Department of Hepatobiliary Surgery Jiaxing Second HospitalJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Intraductal papillary neoplasms of the bile duct(IPNBs)are rare and characterized by papillary growth within the bile duct *** is similar to obstructive biliary *** this report,we present an unexpected case of asymptomatic IPNB and consolidate our findings with the relevant literature to augment our understanding of this *** relevant literature contributes to a more comprehensive understanding of the *** SUMMARY A 66-year-old Chinese male patient was admitted to our hospital for surgical intervention after gallstones were discovered during a routine physical *** imaging revealed a lesion on the left side of the liver,which raised the suspicion of IPNB.A laparoscopic left hemihepatectomy was performed,and subsequent histopathological examination confirmed the diagnosis of *** the 3-mo postoperative follow-up,the patient reported good recovery and no *** can manifest both latently and *** surgical resection is the most effective treatment for *** Hepatic and biliary masses,should be considered to diagnose *** surgery and vigilant follow-up are crucial in determining prognosis.

关键词： Intraductal papillary neoplasm of the bile duct Tumor Surgical treatment Prognosis Case report

Breast-conserving surgery and sentinel lymph node biopsy for breast cancer and their correlation with the expression of polyligand proteoglycan-1

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World Journal of Clinical Cases 2022年第10期10卷 3113-3120页

作者： Fu-Ming Li Dan-Ying Xu Qi Xu Yan Yuan Department of Breast Surgery The Second Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Breast cancer is a malignant tumor with an unclear etiology and is the most common malignant tumor in *** is the main clinical treatment for breast *** traditional total mastectomy combined with axillary lymph node dissection is effective,it can result in shoulder dysfunction,especially in middle-aged and elderly patients with breast cancer with weak constitution and other underlying ***,the postoperative quality of life is *** To assess breast-conserving surgery and sentinel lymph node biopsy for breast cancer treatment and their correlation with polyligand *** Overall,80 patients with breast cancer treated in our hospital from January 2021 to July 2021 were retrospectively selected and divided into an observation group(n=44)and control group(n=36)according to the treatment *** observation group was treated with breast-conserving surgery and sentinel lymph node biopsy,and the control group was treated with total breast ***,immunohistochemical staining was used to detect the expression of syndecan-1(SDC-1)in the lesions,and its relationship with clinicopathological findings was *** Intraoperative blood loss,operation time,and hospital stay in the observation group were 65.51±9.94 m L,65.59±9.40 min,and 14.80±3.03 d,respectively,which were significantly lower than those in the control group(P0.05).The positive expression rate of SDC-1 in patients with American Joint Committee on Cancer(AJCC)stageⅡwas 14.29%,which was significantly lower than that in patients with AJCC stageⅠ(P<0.05).The positive expression of SDC-1 had no significant relationship with age,course of dise

关键词： Breast preservation Sentinel lymph node biopsy Breast cancer Clinical effectiveness Polyligand proteoglycan-1