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Epidemiology of Sexual dysfunction in Asia compared to the rest of the world

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Asian Journal of Andrology 2011年第1期13卷 152-158页

作者： Ronald W Lewis Section of Urology Medical College of Georgia Augusta GA 30912 USA

There have been a limited number of epidemiological studies published on sexual disorders in persons from Asia. This paper aims to assess the reports of sexual dysfunction epidemiological studies published in the English language that involved Asian countries. Key points are summarized in this paper from nine epidemiological papers on sexual dysfunction from Asia that were published in the English language. Seven met the criteria for evidence-based studies reaching a Prins score of at least 10 or more. Papers included in this report came from national and regional representative studies in peer review journals. These results for sexual dysfunction in the nine papers are summarized for various sexual dysfunctions in men and women in Asian countries. In three of these, worldwide data were presented in the same paper allowing comparisons with Asian data on prevalence rates. Detailed descriptions from each of these studies are presented in paragraph form. More detailed data on erectile dysfunction （ED） is presented in a tabular form. Collectively, there seems to be a need for country- and population-specific further descriptive and analytical epidemiological studies in all of the sexual disorders from Asia. This critical review paper should help guide these studies for reachinj[ evidence-based literature standards.

关键词： descriptive epidemiology male and female dysfunction male ED premature ejaculation

Engineering T cells for immunotherapy of primary human hepatocellular carcinoma

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Journal of Genetics and Genomics 2020年第1期47卷 1-15页

作者： Leidy DCaraballo Galva Lun Cai Yanxia Shao Yukai He Georgia Cancer Center.Medical College of Georgia Augusta University.AugustaGA.30912USA Department of Medicine.Medical College of Georgia Augusta UniversityAugustaGA30912USA

Liver cancers, majority of which are primary hepatocellular carcinoma(HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over the last few years,immunotherapies, especially the checkpoint blockades and adoptive cell therapies of engineered T cells,have demonstrated a great potential for treating malignant tumors including HCC. In this review, we summarize the current ongoing research of antigen-specific immunotherapies including cancer vaccines and adoptive cell therapies for HCC. We briefly discuss the HCC cancer vaccine and then focus on the antigen-specific T cells genetically engineered with the T cell receptor genes(TCRTs) and the chimeric antigen receptor genes(CARTs). We first review the current options of TCRTs and CARTs immunotherapies for HCC, and then analyze the factors and parameters that may help to improve the design of TCRTs and CARTs to enhance their antitumor efficacy and safety. Our goals are to render readers a panoramic view of the current stand of HCC immunotherapies and provide some strategies to design better TCRTs and CARTs to achieve more effective and durable antitumor effects.

关键词： Immunotherapy Hepatocellular carcinoma T cell receptor Chimeric antigen receptor T cell engineering Gene transfer

Effects of castration and testosterone replacement on veno-occlusion during penile erection in the rat

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Asian Journal of Andrology 1999年第1期1卷 53-59页

作者： Yu-TianDAI VivienneStopper RonaldLewis ThomasMills DepartmentofSurgeryUrologySection DepartmentofPhysiologyandEndoerinologyMedicalCollegeofGeorgia AugustaGA30912-3000USA

Aim: To determine if androgens directly regulate veno-occlusion or if androgens act indirectly to maintain the penilestructures which control outflow. Methods: Using CASTRATE and TESTO rats, measurement was made of meanarterial pressure (MAP), intracavernosal pressure (CCP), and intracavernosal flow (CCF) during erection resultingfrom stimulation of the autonomic innervation of the penis. CCP and CCF were also measured during saline infusioninto the cavernosal sinuses before and after treatment with sodium nitroprusside (SNP, a nitric oxide donor drag) tofully relax cavernosal smooth muscle. Penile tissue was also collected to measure the content of α actin and proline andhydroxyproline to determine if brief withdrawal of androgenic support led to changes in the number of smooth musclecells or the collagen content of the tissue. Results: Infusion of saline into the cavernosal sinuses demonstrated thatveno-occlusion was defective in CASTRATE rats while reno-occlusion was fully functional in TESTO ***, veno-occlusion could be induced in CASTRATE rats if they were first treated with SNP. Thisobservation suggests that failure of veno-occlusion in the CASTRATE rats is due to a deficiency in the production of NOresulting in a reduction in the degree of relaxation of the penile smooth muscle. The measurements of smooth muscleα actin and proline and hydroxyproline content of collagen showed that both were unaffected by castration and that thebasic structure of the penis did not degenerate after one week without androgenic support. Conclusion: Theseresults can be interpreted to mean that androgens control the veno-occlusive mechanism indirectly via a NO dependentmechanism and not by maintaining the structures of the penis which are essential to reno-occlusion.

关键词： castration testosterone cavernous sinus penile erection nitric oxide androgens

Do cardiopulmonary resuscitation real-time audiovisual feedback devices improve patient outcomes? A systematic review and metaanalysis

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World Journal of Cardiology 2023年第10期15卷 531-541页

作者： Nitish Sood Anish Sangari Arnav Goyal Christina Sun Madison Horinek Joseph Andy Hauger Lane Perry Medical College of Georgia Augusta UniversityAugustaGA 30912United States Dental College of Georgia Augusta UniversityAugustaGA 30912United States Department of Chemistry and Physics Augusta UniversityAugustaGA 30912United States

BACKGROUND Cardiac arrest is a leading cause of mortality in America and has increased in the incidence of cases over the last several *** resuscitation(CPR)increases survival outcomes in cases of cardiac arrest;however,healthcare workers often do not perform CPR within recommended ***-time audiovisual feedback(RTAVF)devices improve the quality of CPR *** systematic review and meta-analysis aims to compare the effect of RTAVF-assisted CPR with conventional CPR and to evaluate whether the use of these devices improved outcomes in both in-hospital cardiac arrest(IHCA)and out-of-hospital cardiac arrest(OHCA)*** To identify the effect of RTAVF-assisted CPR on patient outcomes and CPR quality with in-and *** We searched PubMed,SCOPUS,the Cochrane Library,and EMBASE from inception to July 27,2020,for studies comparing patient outcomes and/or CPR quality metrics between RTAVF-assisted CPR and conventional CPR in cases of IHCA or *** primary outcomes of interest were return of spontaneous circulation(ROSC)and survival to hospital discharge(SHD),with secondary outcomes of chest compression rate and chest compression *** methodo-logical quality of the included studies was assessed using the Newcastle-Ottawa scale and Cochrane Collaboration’s“risk of bias”*** was analyzed using R statistical software *** were statistically significant if P<*** Thirteen studies(n=17600)were *** were on average 69±17.5 years old,with 7022(39.8%)female *** pooled ROSC in patients in this study was 37%(95%confidence interval=23%-54%).RTAVF-assisted CPR significantly improved ROSC,both overall[risk ratio(RR)1.17(1.001-1.362);P=0.048]and in cases of IHCA[RR 1.36(1.06-1.80);P=0.002].There was no significant improvement in ROSC for OHCA(RR 1.04;0.91-1.19;P=0.47).No significant effect was seen in SHD[RR 1.04(0.91-1.19);P=0.47]or chest compression rate[standardized mean difference(SM

关键词： Real-time audiovisual feedback Cardiopulmonary resuscitation Cardiac arrest Return of spontaneous circulation Survival to hospital discharge Cardiopulmonary resuscitation quality

Vasopressin Signaling Buffers Synaptic Metaplasticity in a Sex-specific Manner

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Neuroscience Bulletin 2021年第9期37卷 1377-1380页

作者： Luodan Yang Lorelei Tucker Quanguang Zhang Department of Neuroscience and Regenerative Medicine Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Social animals prefer to live in groups and transfer social signals to share their physical or psychological distress and seek comfort[1,2].During this process,social buffering is an essential concept in social *** refers to the phenomenon wherein the presence of social partners reduces the physiological stress response in a distressed animal[3].

关键词： Buffers networks. distress

MicroRNAs in treatment-induced neuroendocrine differentiation in prostate cancer

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Cancer Drug Resistance 2020年第4期3卷 804-818页

作者： Theresa Akoto Divya Bhagirath Sharanjot Saini Department of Cellular Biology and Anatomy Augusta UniversityAugustaGA 30912USA Department of Biochemistry and Molecular Biology Augusta UniversityAugustaGA 30912USA

Prostate cancer is a condition commonly associated with men *** deprivation therapy remains one of the targeted ***,after some years,there is biochemical recurrence and metastatic progression into castration-resistant prostate cancer(CRPC).CRPC cases are treated with second-line androgen deprivation therapy,after which,these CRPCs transdifferentiate to form neuroendocrine prostate cancer(NEPC),a highly aggressive variant of *** arises via a reversible transdifferentiation process,known as neuroendocrine differentiation(NED),which is associated with altered expression of lineage markers such as decreased expression of androgen receptor and increased expression of neuroendocrine lineage markers including enolase 2,chromogranin A and *** etiological factors and molecular basis for NED are poorly understood,contributing to a lack of adequate molecular biomarkers for its diagnosis and ***,there is a need to fully understand the underlying molecular basis for this *** studies have shown that microRNAs(miRNAs)play a key epigenetic role in driving therapy-induced NED in prostate *** this review,we briefly describe the role of miRNAs in prostate cancer and CRPCs,discuss some key players in NEPCs and elaborate on miRNA dysregulation as a key epigenetic process that accompanies therapy-induced NED in metastatic *** understanding will contribute to better clinical management of the disease.

关键词： MicroRNAs neuroendocrine differentiation castration-resistant prostate cancer epigenetics oncomirs tumor suppressors androgen deprivation therapy

Effects of medically generated electromagnetic interference from medical devices on cardiac implantable electronic devices: A review

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World Journal of Cardiology 2022年第8期14卷 446-453页

作者： Walker Barmore Himax Patel Cassandra Voong Caroline Tarallo Joe B Calkins Jr Department of Cardiology Augusta University Medical CenterAugustaGA 30912United States Department of Internal Medicine Augusta University Medical CenterAugustaGA 30912United States Medical College of Georgia Medical College of GeorgiaAugustaGA 30912United States

As cardiac implantable electronic devices(CIED)become more prevalent,it is important to acknowledge potential electromagnetic interference(EMI)from other sources,such as internal and external electronic devices and procedures and its effect on these *** from other sources can potentially inhibit pacing and trigger shocks in permanent pacemakers(PPM)and implantable cardioverter defibrillators(ICD),*** review analyzes potential EMI amongst CIED and left ventricular assist device,deep brain stimulators,spinal cord stimulators,transcutaneous electrical nerve stimulators,and throughout an array of procedures,such as endoscopy,bronchoscopy,and procedures involving *** there is evidence to support EMI from internal and external devices and during procedures,there is a lack of large multicenter studies,and,as a result,current management guidelines are based primarily on expert opinion and anecdotal *** aim to provide a general overview of PPM/ICD function,review documented EMI effect on these devices,and acknowledge current management of CIED interference.

关键词： Electromagnetic interference Pacemaker Implantable cardioverter defibrillator Permanent pacemakers Cardiac implantable electronic devices Left ventricular assist device Endoscopy Bronchoscopy Electrocautery Capsule endoscopy Transcutaneous electrical nerve stimulators unit Spinal cord stimulator

Expanding beyond endoscopy: A review of non-invasive modalities in Barrett’s esophagus screening and surveillance

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World Journal of Gastroenterology 2022年第32期28卷 4516-4526页

作者： Dariush Shahsavari Praneeth Kudaravalli John Erikson L Yap Kenneth J Vega Division of Gastroenterology and Hepatology Augusta University-Medical College of GeorgiaAugustaGA 30912United States

Barrett’s esophagus(BE)is a condition that results from replacement of the damaged normal squamous esophageal mucosa to intestinal columnar mucosa and is the most significant predisposing factor for development of esophageal *** guidelines recommend endoscopic evaluation for screening and surveillance based on various risk factors which has limitations such as invasiveness,availability of a trained specialist,patient logistics and ***-nasal endoscopy is a less invasive modality but still has similar limitations such as limited availability of trained specialist and ***-endoscopic modalities,in comparison,require minimal intervention,can be done in an office visit and has the potential to be a more ideal choice for mass public screening and surveillance,particularly in patents at low risk for *** include newer generations of esophageal capsule endoscopy which provides direct visualization of BE,and tethered capsule endomicroscopy which can obtain high-resolution images of the *** cell collection devices coupled with biomarkers have been used for BE ***,in combination with TFF3,as well as EsophaCap and EsoCheck have shown promising results in various studies when used with various *** modalities including circulatory microRNAs and volatile organic compounds that have demonstrated favorable *** of these cell collection methods for BE surveillance is a potential area of future research.

关键词： Barrett’s esophagus Screening Surveillance Non-endoscopic Cytosponge Esophacap Esocheck

Takotsubo cardiomyopathy:A comprehensive review

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World Journal of Cardiology 2022年第6期14卷 355-362页

作者： Walker Barmore Himax Patel Sean Harrell Daniel Garcia Joe B Calkins Jr Department of Internal Medicine Augusta University Medical CenterAugustaGA 30912United States Department of Cardiovascular Medicine Augusta University Medical CenterAugustaGA 30912United States

Takotsubo cardiomyopathy(TCM),also known as stress cardiomyopathy,occurs in the setting of catecholamine surge from an acute *** cardiomyopathy mimics acute myocardial infarction in the absence of coronary *** classic feature of TCM is regional wall motion abnormalities with characteristic ballooning of the left *** etiology of the stressor is often physical or emotional stress,however iatrogenic causes of TCM have been reported in the *** our review,we discuss medications,primarily the exogenous administration of catecholamines,and a wide array of procedures with subsequent development of iatrogenic *** is unique in that it is transient and has favorable outcomes in most ***,beta-blockers and ACE-inhibitors have been prescribed in individuals with cardiomyopathy;however,unique to TCM,no specific treatment is required other than temporary supportive measures as this process is ***,no improvement in mortality or recurrence have been reported in patients on these *** aim of this review is to elucidate on the iatrogenic causes of TCM,allowing for prompt recognition and management by clinicians.

关键词： Takotsubo Cardiomyopathy Iatrogenic Heart Failure Myocardial Infarction