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Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1469-1476页

作者： Wei Zhou Hui Zhou Yuan-Yuan Liu Meng-Xuan Li Xiao-Han Wu Jiao Liang Jing Hao Sheng-Nan Liu Chun-Jie Jin Department of Ophthalmology Tianjin Medical University General HospitalTianjin 300052China Department of Ophthalmology Shanxi Yuncheng Tongde HospitalYuncheng 044000Shanxi ProvinceChina Department of Information Tianjin Medical University General HospitalTianjin 300052China

AIM:To describe the multimodal imaging features,treatment,and outcomes of patients diagnosed with adultonset Coats ***:This retrospective study included patients first diagnosed with Coats disease at≥18 years of age between September 2017 and September *** patients received anti-vascular endothelial growth factor(VEGF)therapy(conbercept,0.5 mg)as the initial treatment,which was combined with laser photocoagulation as *** the patients underwent best corrected visual acuity(BCVA)and intraocular pressure examinations,fundus color photography,spontaneous fluorescence tests,fundus fluorescein angiography,optical coherence tomography(OCT),OCT angiography,and other *** alterations and multimodal image findings in the affected eyes following treatment were compared and the prognostic factors were ***:The study included 15 patients who were aged 24-72(57.33±12.61)y at *** hypertension was the most common associated systemic condition,occurring in 13(86.7%)*** BCVA ranged from 2.0 to 5.0(4.0±1.1),which showed improvement following treatment(4.2±1.0).Multimodal imaging revealed retinal telangiectasis in 13 patients(86.7%),patchy hemorrhage in 5 patients(33.3%),and stage 2B disease(Shield’s staging criteria)in 11 patients(73.3%).OCT revealed that the baseline central macular thickness(CMT)ranged from 129 to 964μm(473.0±230.1μm),with 13 patients(86.7%)exhibiting a baseline CMT exceeding 250μ***,8 patients(53.3%)presented with an epiretinal membrane at baseline or during ***-reflective scars were observed on OCT in five patients(33.3%)with poor visual *** deteriorated in one patient who did not receive *** vision was stable in three patients who received laser treatment,whereas improvement was observed in one of two patients who received anti-VEGF therapy *** addition,8 of 9 patients(88.9%)who received laser treatment and conbercept exhibited sta

关键词： adult-onset Coats disease multimodal imaging anti-vascular endothelial growth factor conbercept

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ROLE OF B LYMPHOCYTE AND ITS SUBPOPULATIONS IN PATHOGENESIS OF IMMUNORELATED PANCYTOPENIA

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Chinese Medical Sciences Journal 2007年第3期22卷 199-202页

作者： Rong Fu Zong-hong Shao Hong Liu Yu-hong Wu Hua-quan Wang Li-min Xing Department of Hematology and Oncology General Hospital of Tianjin Medical University Tianjin 300052

Objective To measure the quantities and apoptosis-related protein levels of B lymphocyte in the patients with immunorelated pancytopenia （IRP） and explore the action of B lymphocyte in the pathogenic mechanism of IRP. Methods Quantifies of whole B lymphocytes and CD5^＋ B lymphocytes as well as the expressions of Fas and Bcl-2 in B lymphocytes in 35 patients with untreated IRP, 15 IRP patients in complete remission （CR）, and 10 normal controls were assayed by flow cytometry. The percentages of B lymphocyte and CD5^＋ B lymphocyte were significantly higher in untreated IRP patients than in CR IRP patients and normal controls （ P 〈 0. 05 ）, and there was no significant difference between the latter two groups （ P 〉 0. 05 ）. There was no significant difference of Fas expression in B lymphocyte among three groups （ P 〉 0. 05）. The expression of Bcl-2 in B lymphocyte was significantly higher in untreated patients than in CR patients or normal controls （ P 〈 0. 01 ）, and significantly higher in CR patients than in normal controls （ P 〈 0. 01 ）. The apoptosis. related index was significantly lower in untreated patients than in CR patients or normal controls （ P 〈 0. 05 ）, and signif. icantly lower in CR patients than in normal controls （ P 〈 0. 05 ）. The percentage of B lymphocyte was positively correlated with post-treated response time （ r = 0. 53, P 〈 0. 01 ）. Conclusion The production of auto-antibodies in IRP patients probably has some relationship with the abnormal quantifies of B lymphocyte and its subpopulations as well as with the inhibition of B lymphocyte apoptosis.

关键词： immunorelated pancytopenia B lymphocyte quantifies apoptosis

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Gestational diabetes mellitus combined with fulminant type 1 diabetes mellitus, four cases of double diabetes: A case report

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World Journal of Clinical Cases 2024年第4期12卷 787-794页

作者： Hui Li Yun Chai Wei-Hong Guo Yu-Meng Huang Xiao-Na Zhang Wen-Li Feng Qing He Jin Cui Ming Liu Department of Endocrinology and Metabolism Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose ***,we present four patients who developed FT1DM during treatment but were first diagnosed with gestational diabetes mellitus(GDM).CASE SUMMARY The clinical data of four patients with GDM combined with FT1DM admitted to our hospital between July 2018 and April 2021 were collected,and the patients and their infants were followed *** patients were diagnosed with GDM during the second trimester and were *** blood glucose level elevated suddenly during the third trimester and then were diagnosed with *** patients had an insulin allergy,and two had symptoms of upper respiratory tract infection before *** patient developed ketoacidosis,and three developed *** patients had cesarean section deliveries,and two had vaginal *** growth and development of the infants were normal.C-peptide levels were lower than those at onset,suggesting progressive impairment of islet *** frequencies of the DRB109:01,DQB103:03,DQA103:02,DPA101:03,DPA102:02,DPB105:01,DRB401:03,G 01:01,and G 01:04 human leukocyte antigen(HLA)-G alleles were high in the present *** In comparison with pregnancy-associated FT1DM(PF),patients with GDM combined with FT1DM had an older age of onset,higher body mass index,slower onset,fewer prodromal symptoms,and less *** pathogenesis may be due to various factors affecting the already fragileβ-cells of GDM patients with genetically susceptible class II HLA *** speculate that GDM combined with FT1DM during pregnancy,referred to as“double diabetes,”is a subtype of PF with its own unique characteristics that should be investigated further.

关键词： Fulminant type 1 diabetes mellitus Gestational diabetes mellitus Pregnancy-related fulminant type 1 diabetes mellitus Double diabetes Case report

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Preparation of tryptophan modified chitosan beads and their adsorption of low density lipoprotein

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Chinese Science Bulletin 2003年第21期48卷 2303-2307页

作者： FUGuoqi SHIKeyu YUANZhi HEBinglin LIUBin SHENBin WANGQishun InstituteofPolymerChemistry TheStateKeyLaboratoryofFunctionalPolymerMaterialsforAdsorptionandSeparationNankaiUniversityTianjin300071China TianjinMedicalCollege Tianjin300052China

An adsorbent with good adsorption perform-ance for binding low density lipoprotein (LDL) was synthe-sized through a simple preparation procedure. The phase-inversion technique was employed to form macropor-ous chitosan beads, which were then simultaneously acti-vated, cross-linked and connected with a long spacer arm via the reaction with ethyleneglycol diglycidylether (EGDE). Tryptophan (Trp) was subsequently coupled to the ep-oxy-activated beads. This adsorbent demonstrated satisfac-tory adsorption capacity and selectivity for LDL, and it also exhibited excellent blood compatibility. The effect of spacer arms with different length on the adsorption selectivity was investigated experimentally, and the mechanism was ana-lyzed.

关键词：色氨酸壳聚糖低密度脂蛋白吸附剂心血管疾病

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Gastrointestinal bleeding caused by jejunal angiosarcoma: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4565-4571页

作者： Yang-Yang Hui Lan-Ping Zhu Bo Yang Zi-Yue Zhang Yu-Jie Zhang Xin Chen Bang-Mao Wang Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin 300052China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Department of Pathology Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Angiosarcoma is a rare disease with a poor *** occurrence in the small intestine is low,and gastrointestinal bleeding caused by small intestinal angiosarcoma is *** SUMMARY Here,we report the case of a 57-year-old man who presented with hematochezia for 1 *** patient had a medical history of chronic viral hepatitis B for 15 *** causes of gastrointestinal bleeding were initially diagnosed as esophagogastric variceal bleeding or portal hypertensive gastropathy before ***,after a complicated diagnostic and therapeutic process,including gastroendoscopy,colonoscopy,contrast-enhanced computed tomographic(CT),positron emission computed tomography/CT,capsule endoscopy,and pathological and immunohistochemical examinations,small intestinal angiosarcoma was *** of bleeding was achieved after surgical ***,the patient had lung cancer with bone and adrenal *** the follow-up 10 mo after the operation,the patient was *** Gastroenterologists should maintain strong vigilance to small intestinal angiosarcoma,which is necessary for the early identification of this infrequent but fatal disease.

关键词： Small intestine Angiosarcoma Gastrointestinal bleeding Case report Diagnosis Prognosis

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Clinical outcome and prognostic factors of T4N0M0 colon cancer after R0 resection:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1869-1877页

作者： Bang Liu Zhao-Xiong Zhang Xin-Yang Nie Wei-Lin Sun Yong-Jia Yan Wei-Hua Fu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China

BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this *** To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these *** Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation *** between the training and validation groups were *** training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram *** The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,***(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was *** Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon *** nomogram model exhibited good agreement and accuracy.

关键词： T4N0M0 colon cancer Prognosis Multivariate analysis Nomogram Colon cancer

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Role of Dicer on tumorigenesis in glioma cells

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Neural Regeneration Research 2010年第17期5卷 1324-1329页

作者： Anling Zhang Lei Han Guangxiu Wang Zhifan Jia Peiyu Pu Chunsheng Kang Department of Neurosurgery Tianjin Medical University General Hospital and Laboratory of Neuro-OncologyTianjin Neurological InstituteTianjin 300052China

Micro RNAs（miRNAs）are non-coding,single-stranded RNAs that regulate target gene expression by repressing translation or promoting RNA *** studies show that miRNA expression is globally decreased in some human *** is an essential component of the miRNA processing *** determine whether global reduction of miRNA effects tumorigenesis,small interfering RNA were designed to target Dicer to restrain whole miRNA expression in the glioblastoma cell *** effective knock-down of Dicer,tumor cells were invasive and proliferative,and globally impaired miRNA processing enhanced proliferation and invasiveness of glioma cells in *** of Dicer expression resulted in a more aggressive glioma phenotype,which suggests that global reduction of miRNA expression could have an oncogenic role in glioblastoma cells.

关键词： Dicer glioma tumorigenesis small interfering RNA micro RNAs

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Synaptic development in the injured spinal cord cavity following co-transplantation of fetal spinal cord cells and autologous activated Schwann cells

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Neural Regeneration Research 2010年第19期5卷 1445-1450页

作者： Wendong Ruan Yuan Xue Ninghua Li Xiaotao Zhao Huajian Zhao Peng Li Department of Orthopedics Tianjin Medical University Genemal Hospital Tianjin 300052 China Beijing Hospital Ministry of Health Beijing 100730 China

Transplantation of activated transgenic Schwann cells or a fetal spinal cord cell suspension has been widely used to treat spinal cord injury. However, little is known regarding the effects of co-transplantation. In the present study, autologous Schwann cells in combination with a fetal spinal cord cell suspension were transplanted into adult Wistar rats with spinal cord injury, and newly generated axonal connections were observed ultrastructurally. Transmission electron microscopic observations showed that the neuroblast first presented cytoplasmic processes, followed by pre- and postsynaptic membranes with low electron density forming a dense projection. The number and types of synaptic vesicles were increased. Synaptic connections developed from single cell body-dendritic synapses into multiple cell body-dendritic and dendrite-dendritic synapses. In addition, the cell organs of the transplanted neuroblast, oligodendroblast and astroblast matured gradually. The blood-brain barrier appeared subsequently. Moreover, neurofilament, histamine, calcitonin-gene-related peptides, and glial fibrillary acidic protein positive fibers were observed in the transplant region. These findings demonstrate that fetal spinal cord cells in the presence of autologous activated Schwann cells can develop into mature synapses in the cavity of injured spinal cords, suggesting the possibility of information exchange through the reconstructed synapse between fetal spinal cord cells and the host.

关键词： fetal spinal cord cell suspension synapse development autologous activated Schwann cells spinal cord injury peripheral nerve injury neural regeneration

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m7G Methylation-Related Gene NUDT10 as novel prognostic biomarker and its ceRNA regulatory network in colorectal cancer

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Medical Data Mining 2023年第2期6卷 7-20页

作者： Yu-Jian Li Xuan Kan Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin 300052China

Background:Colorectal cancer(CRC)is a life-threatening malignant disease of the digestive system,which is still a leading cause of cancer death *** methylation,a fundamental process in epigenetic regulation,also plays an important role in tumor ***,the functional mechanisms of 7-methylguanosine(m7G)methylation-related gene in CRC are ***:The differential expression of m7G methylation-related gene between CRC tissues and normal tissues in UCSC XENA,TCGA and GTEx was verified using *** regression,Nomogram were used to construct corresponding prognostic models of ***-Meier analysis,receiver operating characteristic curve analysis,clinical correlation analysis and enrichment analysis were used to further investigate the correlation and functional mechanisms of m7G methylation-related gene with ***-infiltration was used to verify the relationship between nudix hydroxylase 10(NUDT10)and immune cells,while methylation analysis was used to study the promoter methylation of *** was used to analyze the protein expression between CRC tissues and normal *** ceRNA regulatory network was used to identify the mRNA-miRNA-lncRNA regulatory ***:The m7G methylation-related gene NUDT10 was lowly expressed in *** regression,Nomogram and calibration curve finally identified NUDT10 as the novel prognostic biomarker of CRC and constructed the corresponding prognostic *** results of immunohistochemistry showed that the protein expression levels of NUDT10 differed between CRC tissues and normal *** addition,NUDT10 had predictive power for CRC and the expression of NUDT10 in CRC was closely associated with immune *** Ontology,Kyoto Encyclopedia of Genes and Genomes and Gene Set Enrichment Analysis revealed that biological functions such as the regulation of angiogenesis,muscle contraction,transporter complex and gated channel activity,pathways such as heme metabo

关键词： 7-methylguanosine methylation colorectal cancer ceRNA prognostic biomarker immune infiltration

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siRNA epidermal growth factor receptor silencing in U251 glioma cells

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Neural Regeneration Research 2008年第6期3卷 652-655页

作者： Chunsheng Kang Zhiyong Zhang Zhifan Jia Qiang Huang Guangxlu Wang Mingzhe Qiu Peiyu Pu Department of Neurosurgery Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology Tianjin Neurological Institute Tianjin 300052 China

BACKGROUND： Dicer, a large multidomain ribonuclease, is responsible for processing double-stranded RNAs （dsRNAs） to 20-bp-long small interfering RNAs （siRNAs）, which act as effectors during RNA interference （RNAi）. OBJECTIVE： To observe the efficacy of siRNA cocktails generated by recombinant human Dicer on the down-regulation of epidermal growth factor receptor （EGFR） expression in human glioma cells. DESIGN, TIME AND SETTING： The following in vitro experiment was performed at the Department of Neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology, Tianjin Neurological Institute. MATERIALS： Mini-RNA isolation kit, human placenta complimentary DNA （cDNA） was produced by Tiangen Biotech （Beijing, China）, human glioblastoma U251-MG cells were produced by the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. METHODS： A PCR product from the human EGFR, which corresponded to the tyrosine kinase domain of the 3＇-end fragment, was used as the T7-promotor for in vitro transcription. siRNA cocktails were generated by in vitro dicing of double stranded RNA. A total of 500, 250 and 125 μg siRNA cocktails were transiently transfected into U251 glioma cells through the use of the GeneSilencer. MAIN OUTCOME MEASURE： Expression of EGFR was detected by real-time PCR. RESULTS： The total PCR product of the human EGFR, corresponding to the tyrosine kinase domain, is approximately 680 bp in length. The PCR transcriptants included GCC leader sequences and a T7 promoter sequence, with a fragment of EGFR cDNA at the center. The T7 promoter was prepared for in vitro transcription of dsRNA. After dicing for 24 hours, the 21-nt siRNA cocktails were verified by 4% agarose gel. The difference between threshold cycle of a sample assay and threshold cycle of the corresponding endogenous reference （ΔCt） among parental U251 cells and cells transfected with different doses of siRNA cocktails were determined to be 3.06, 7.35, and 10.31 cycl

关键词： siRNA epidermal growth factor receptor, glioma gene expression

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