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World Journal of Clinical Cases 2022年第32期10卷 11929-11935页

作者： Jian-Hua Zhai Shi-Xin Li Ge Jin Yuan-Yuan Zhang Wei-Long Zhong Yan-Fen Chai Bang-Mao Wang Department of Emergency Medicine Tianjin Medical University General HospitalTianjin 300052China Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin 300052China Department of Radiology Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Blue rubber bleb nevus syndrome is a rare vascular malformation syndrome with unclear etiopathogenesis and noncurative *** is characterized by multiple vascular malformations of the skin,gastrointestinal tract,and other visceral *** most common symptoms are intermittent gastrointestinal bleeding and secondary iron deficiency anemia,thus requiring repeated blood transfusions and *** is easily missed and misdiagnosed,and there is no specific *** SUMMARY We report a case of blue rubber bleb nevus syndrome combined with disseminated intravascular coagulation and efficacy of treatment with argon plasma coagulation under enteroscopy and sirolimus.A 56-year-old female patient was admitted to the hospital with 3-year history of fatigue and dizziness that had aggravated over the past 10 d with *** patient had a history of repeated melena and multiple venous hemangiomas from *** treatment with argon plasma coagulation combined with sirolimus for nearly 8 wk,the patient’s serum hemoglobin increased to 100 g/*** the 12-mo follow-up,the patient was well with stable hemoglobin(102 g/L)and no recurrent intestinal *** Argon plasma coagulation and sirolimus may be an efficacious and safe treatment for blue rubber bleb nevus syndrome,which currently has no recommended treatments.

关键词： GI bleeding Disseminated intravascular coagulation Argon plasma coagulation Sirolimus

Mendelian Randomization Analysis to Analyze the Effect of Emergency Caesarean Section on Different Allergic Diseases and Related Blood Markers

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Biomedical and Environmental Sciences 2023年第11期36卷 1084-1089页

作者： LI Yu Jian KAN Xuan Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin 300052China

Caesarean section is a well-established surgical procedure that allows for maximum fetal rescue under special circumstances,such as intrauterine distress and intrauterine hypoxia,and minimizes injuries to pregnant women who cannot tolerate vaginal *** caesarean section is a special type of caesarean section that plays an important role in protecting the lives of pregnant mothers and fetuses[1].

关键词： Blood injuries Emergency

Selective Aberrant Functional–Structural Coupling of Multiscale Brain Networks in Subcortical Vascular Mild Cognitive Impairment

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Neuroscience Bulletin 2021年第3期37卷 287-297页

作者： Juanwei Ma Feng Liu Bingbing Yang Kaizhong Xue Pinxiao Wang Jian Zhou Yang Wang Yali Niu Jing Zhang Department of Radiology and Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General HospitalTianjin 300052China Department of Rehabilitation Tianjin Medical University General HospitalTianjin 300052China

Subcortical vascular mild cognitive impairment(svMCI)is a common prodromal stage of vascular *** mounting evidence has suggested abnormalities in several single brain network metrics,few studies have explored the consistency between functional and structural connectivity networks in ***,we constructed such networks using resting-state f MRI for functional connectivity and diffusion tensor imaging for structural connectivity in 30 patients with svMCI and 30 normal *** functional networks were then parcellated into topological modules,corresponding to several well-defined functional *** coupling between the functional and structural networks was finally estimated and compared at the multiscale network level(whole brain and modular level).We found no significant intergroup differences in the functional–structural coupling within the whole brain;however,there was significantly increased functional–structural coupling within the dorsal attention module and decreased functional–structural coupling within the ventral attention module in the svMCI *** addition,the svMCI patients demonstrated decreased intramodular connectivity strength in the visual,somatomotor,and dorsal attention modules as well as decreased intermodular connectivity strength between several modules in the functional network,mainly linking the visual,somatomotor,dorsal attention,ventral attention,and frontoparietal control *** was no significant correlation between the altered module-level functional–structural coupling and cognitive performance in patients with *** findings demonstrate for the first time that svMCI is reflected in a selective aberrant topological organization in multiscale brain networks and may improve our understanding of the pathophysiological mechanisms underlying svMCI.

关键词： Resting-state fMRI Diffusion tensor imaging Functional–structural coupling Modular architecture Subcortical vascular mild cognitive impairment

Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice

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Cellular & Molecular Immunology 2017年第8期14卷 702-711页

作者： Xiangda Meng Sijie Fang Zhuhong Zhang Yang Wang Caiyun You Jingkai Zhang Hua Yan Department of Ophthalmology Tianjin Medical University General HospitalTianjin 300052China

Uveitis is a common cause of blindness *** autoimmune uveitis(EAU)is an animal model of noninfectious ***(5,7-dihydroxyflavone)is a member of the flavonoid family and has anti-inflammatory *** immunized C57BL/6J mice with human interphotoreceptor retinoid-binding protein peptide 1–20 to induce *** was administered intragastrically at 25 mg/kg daily to the chrysin-treated mice from 3 days before immunization to 21 days after *** was administered to the mice in the control group according to the same *** clinical and histopathological scores,increased integrity of the blood–retinal barrier(BRB)and higher expression of tight junction proteins were observed in the chrysin-treated *** significantly decreased the proportions of Th1,Th17 and CD4^(+)CD3^(+)CD62L^(+)Th0 cells,and increased the proportion of Treg *** macrophage infiltration and the expression of inducible nitric oxide synthase in the retina were efficiently inhibited by chrysin *** chrysin-treated mice,the expression of interferon-γ,interleukin(IL)-17A,IL-6,IL-1βand tumor necrosis factor-αwas reduced in the retina,whereas higher levels of transforming growth factor-βwere ***,NF-κBp65 was downregulated after chrysin *** conclusion,as an anti-inflammatory molecule,chrysin exerts a preventive effect on EAU by modulating the balance among helper T-cell subsets and suppressing ocular inflammation,thereby maintaining the integrity of the BRB.

关键词： blood-retinal barrier chrysin experimental autoimmune uveitis NF-κB T helper-cell subsets

A Modified Chitosan Adsorbent for Selective Removal of Low Density Lipoprotein

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Chinese Chemical Letters 2004年第3期15卷 347-349页

作者： GuoQiFU KeYuSHI ZhiYUAN WenQiangNIU BingLinHE BinLIU BinSHEN YanLIU InstituteofPolymerChemistry TheStateKeyLaboratoryofFunctionalPolymerMaterialsforAdsorptionandSeparationNankaiUniversityTianjin300071 TianjinMedicalCollege Tianjin300052

A modified chitosan adsorbent was synthesized through a simple preparation procedure, and it demonstrated good adsorption performance for selective removal of low density lipoprotein in human plasma. Phase inversion technique was employed to form chitosan beads, to which epoxy groups were then introduced by reacting with ethyleneglycol diglycidylether, and tryptophan was subsequently coupled to the epoxy-activated beads.

关键词： Chitosan bead low density lipoprotein cholesterol adsorption tryptophan.

Preparation and Adsorption Properties of PAM Based Adsorbents for Plasma Lipoproteins

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Chinese Chemical Letters 2004年第4期15卷 449-452页

作者： HaiTaoLI ZhiYUAN XinFuCHEN BinLIU BinSHEN BingLinHE TheStateKeyLaboratoryofFunctionalPolymerMaterialsforAdsorptionandSeparation InstituteofPolymerChemistryNankaiUniversityTianjin300071 TianjinMedicalCollege Tianjin300052

Crosslinked macroporous polyacrylamide (PAM) was prepared with inverse phase suspension polymerization technique. After treatment with hydrazine, the polymer was functionalized with chloroacetic acid, trifluoroacetic acid diethylenetriaminepentaacetic acid (DEPAA), and maleic acid, respectively, and PAM based adsorbents bearing carboxyl functional groups for low density lipoprotein (LDL) apheresis use were obtained. The blood compatibility and the adsorption properties for plasma lipoproteins of PAM based adsorbents were investigated.

关键词： Macroporous polyacrylamide blood compatibility adsorption LDL apheresis.

Application of hybrid operating rooms for treating spinal dural arteriovenous fistula

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World Journal of Clinical Cases 2020年第6期8卷 1056-1064页

作者： Nai Zhang Wen-Qiang Xin Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND A hybrid operating room(hybrid-OR)is a surgical space that combines a conventional operating room with advanced medical imaging *** To explore and summarize the technical features and effectiveness of the application of a hybrid-OR in dealing with spinal dural arteriovenous fistulas(SDAVFs).METHODS Eleven patients with SDAVFs were treated with the use of a hybrid-OR at the Department of Neurosurgery of our hospital between January 2015 and December *** dual-marker localization technique was used in the hybrid-OR to locate the SDAVFs and skin incision,and the interoperative digital subtraction angiography(DSA)technique was used before and after microsurgical ligation of the fistulae in the hybrid-OR to verify the accuracy of *** patients were followed for an average of 2 years after the operation,and the preoperative American Spinal Cord Injury Association(ASIA)score and postoperative ASIA score at 6 mo after the operation were *** The location and skin incision of the SDAVFs were accurately obtained by using the dual-marker localization technique in the hybrid-OR in all patients,and there were no cases that required expansion of the range of the bone window in order to expose the *** error obliteration occurred and was identified in two patients by using the intraoperative DSA technique;therefore,the findings provided by the intraoperative DSA system significantly changed the surgical procedure in these two *** the assistance of the hybrid-OR,the feeding artery was correctly ligated in all cases,and the intraoperative error obliteration rate decreased from 18.2%(2/11)to 0%.All 11 patients were followed for an average of 2 *** ASIA score at 6 mo after the operation was significantly improved compared with the preoperative ASIA score,and there were no patients with late recurrence during the *** Compared with intra-arterial embolization for the treatment of SDAVFs,hyb

关键词： Spinal dural arteriovenous fistula Hybrid operating room Dual-marker localization technique Interoperative DSA technique Retrospective study

Application of hybrid operating rooms for clipping large or giant intracranial carotid-ophthalmic aneurysms

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World Journal of Clinical Cases 2020年第21期8卷 5149-5158页

作者： Nai Zhang Wen-Qiang Xin Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND A hybrid operating room(Hybrid-OR)is a surgical theatre that combines a conventional operating room with advanced medical imaging *** are still plenty of limitations when endovascular treatment or microsurgical treatment is used individually to treat large or giant carotid-ophthalmic *** To explore and summarize the technical features and effectiveness of the application of a Hybrid-OR in managing major intracranial carotid-ophthalmic *** The Department of Neurosurgery treated 12 cases of large or giant intracranial carotid-ophthalmic aneurysms between March 2013 and December 2019 in a *** cases were treated with clipping and parent vessel *** With the assistance of the Hybrid-OR,the rate of incomplete intraoperative aneurysm clipping decreased from 25%(3/12)to 0%,while the rate of vessel stenosis decreased from 16.7%(2/12)to 8.35%(1/12).In terms of thromboembolic events,ischemic infarction complication occurred in only one patient,and none of the patients experienced embolic infarction *** 12 patients were followed for an average of 3 years,and no aneurysms *** postoperative recovery was evaluated with the modified Rankin Scale(mRS):11 patients showed no symptoms(mRS=0),1 patient showed slight disability(mRS 1-2),and none of the patients had severe disability(mRS=5)or died(mRS=6).CONCLUSION The Hybrid-OR provides new ideas for the surgical clipping of large or giant intracranial carotid-ophthalmic aneurysms and decreases the rate of intraoperative vessel stenosis and unsuccessful clipping.

关键词： Balloon Microsurgical clipping Hybrid operating room Large or giant carotid-ophthalmic aneurysm

核素骨显象及计算机半定量分析在代射性骨病中的应用

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中华骨科杂志 1991年第2期11卷 110-113页

作者：高硕杨立昌 300052 300052

以往利用核素骨显象诊断代谢性骨病，主要是依靠对图象的直观判断，这不可避免地受相片质量及主观印象的影响。本文参考Kida在1987年提出的模式，并加以改进，在MCS-560计算机上建立了半定量分析软件。运用此方法，对16例代谢骨病患者... 详细信息

以往利用核素骨显象诊断代谢性骨病，主要是依靠对图象的直观判断，这不可避免地受相片质量及主观印象的影响。本文参考Kida在1987年提出的模式，并加以改进，在MCS-560计算机上建立了半定量分析软件。运用此方法，对16例代谢骨病患者进行了骨显象及X线检查对比观察。16例患者半定量分析均表现出全身骨代谢明显异常，X线检查13例出现了代谢骨病征象。核素骨显象可使全身骨一次成象，而X线检查往往根据症状确定摄相部位，本文有两例患者是经全身骨显象明确诊断的。5例患者治疗后半定量分析结果均有不同程度下降，经配对资料统计分析，t=4.4，P<0.01，而同期X线检查未见明显变化。核素骨显象及半定量分析对代谢骨病的诊断、鉴别诊断及疗效评价确有重要临床价值。

关键词：核素骨显象代谢性骨病半定量分析

Intestinal obstruction in pregnancy with reverse rotation of the midgut:A case report

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World Journal of Clinical Cases 2020年第16期8卷 3553-3559页

作者： Xin-Yu Zhao Xin Wang Chun-Qiang Li Qi Zhang An-Qi He Gang Liu epartment of General Surgery Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Reverse rotation of the midgut is a rare type of intestinal *** of the right colon or entire midgut,stenosis of the transverse colon and obstruction of the duodenojejunal junction are common complications of reverse *** this study,we report the first case of intestinal obstruction associated with reverse rotation in *** SUMMARY A 31-year-old woman at 362+wk gestation presented to the emergency department with progressive abdominal cramping,nausea and bilious *** ultrasound scanning showed dilatation of the *** tomography scanning revealed features of reverse rotation of the midgut with intestinal *** consultation with the obstetrician,the pregnancy was terminated and exploratory abdominal surgery was ***-operatively,it was found that the mesentery of the colon and small intestine was insufficiently *** right colon and the small intestinal mesentery was twisted,and intestinal necrosis was *** duodenum and duodenojejunal junction were curved in front of the transverse colon,and the transverse colon passed through the tunnel behind the mesenteric *** reverse rotation with volvulus was *** necrotic intestine was resected and small intestine mesenteric reconstruction was *** patient recovered after *** leaving the hospital,the patient and her daughter remained well during an 8-month follow-up *** We report the diagnosis,treatment and etiology of a pregnant patient with intestinal obstruction due to reverse rotation of the *** similar cases,appropriate diagnosis and treatment should be carried out according to the condition of the fetus and pregnant woman.

关键词： Congenital intestinal malrotation Volvulus Reverse rotation of the midgut Intestinal obstruction Pregnancy Case report