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Novel berberine derivatives as adjuvants in the battle against Acinetobacter baumannii: A promising strategy for combating multi-drug resistance

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Chinese Chemical Letters 2024年第10期35卷 334-340页

作者： Liping Zhao Xixi Guo Zhimeng Zhang Xi Lu Qingxuan Zeng Tianyun Fan Xintong Zhang Fenbei Chen Mengyi Xu Min Yuan Zhenjun Li Jiandong Jiang Jing Pang Xuefu You Yanxiang Wang Danqing Song Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China State Key Laboratory for Infectious diseases prevention and control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

The development of resistance against most of the available antibiotics has made Acinetobacter baumannii(***)a pathogen of high *** this study,thirty novel berberine derivatives are rationally designed,synthesized,and evaluated for their synergistic antibacterial activities against *** them,compound 2d shows the most potent synergetic effect to aztreonam against ***,including carbapenem-resistant and extended-spectrumβ-lactamases-producing ***,synergistic effects were observed for the combinations of 2d and different antibacterial used in clinical practices,indicating its potent broad-spectrum antibiotic-sensitizing effects against *** combination of 2d and aztreonam significantly improves the survival rates of *** larvae compared with aztreonam treatment *** studies indicate that 2d inhibits the drug efflux and iron acquisition of the bacteria by targeting the AdeB transporter protein,thus achieving a synergistic antimicrobial efficacy with different antibacterial ***,berberine derivatives represent a new family of antimicrobial adjuvants against ***,with the advantage of dual-function antibacterial effect,and are worthy of further investigation.

关键词： Acinetobacter baumannii Berberine derivatives Rational design Synergistic effect Eflux Ironacquisition

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Molecular Evolution of Protein Sequences and Codon Usage in Monkeypox Viruses

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 89-97页

作者： Ke-Jia Shan Changcheng Wu Xiaolu Tang Roujian Lu Yaling Hu Wenjie Tan Jian Lu State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Sinovac Biotech Ltd. Beijing 100085China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100052China

The monkeypox virus(mpox virus,MPXV)epidemic in 2022 has posed a significant public health ***,the evolutionary principles of MPXV remain largely ***,we examined the evolutionary patterns of protein sequences and codon usage in *** first demonstrated the signal of positive selection in OPG027,specifically in the CladeⅠlineage of ***,we discovered accelerated protein sequence evolution over time in the variants responsible for the 2022 ***,we showed strong epistasis between amino acid substitutions located in different *** codon adaptation index(CAI)analysis revealed that MPXV genes tended to use more non-preferred codons compared to human genes,and the CAI decreased over time and diverged between clades,with CladeⅠ>Ⅱa andⅡb-A>Ⅱ*** the decrease in fatality rate among the three groups aligned with the CAI pattern,it remains unclear whether this correlation was coincidental or if the deoptimization of codon usage in MPXV led to a reduction in fatality *** study sheds new light on the mechanisms that govern the evolution of MPXV in human populations.

关键词： Mpox virus Positive selection OPG027 Accelerated evolution Codon usage bias

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Epidemiological Characteristics of Dengue Fever-China,2005–2023

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China CDC weekly 2024年第41期6卷 1045-1048页

作者： Zhuowei Li Xiaoxia Huang Aqian Li Shanshan Du Guangxue He Jiandong Li National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases NHC Key Laboratory of BiosafetyNHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Diseases Control and PreventionBeijingChina

Introduction:The global incidence of dengue fever has increased significantly over the past two decades,and China faces a significant upward trend in dengue control ***:Data were obtained from China’s NNDRS from 2005 to *** regression software was used to analyze temporal trends,while SaTScan software was used to analyze spatial,seasonal,and spatiotemporal *** software was used to visualize ***:A total of 117,892 dengue cases were reported from 2005 to 2023.with significant fluctuation in annual reported *** was not endemic in *** outbreaks most likely occurred in the southwestern,southeastern coastal,and inland areas of *** outbreaks have occurred between June and November,generally peaking in September or October,around epidemiological week(EW)***:Dengue challenges in China are *** case monitoring,proactive control interventions,and staff mobilization should be implemented before June to ensure a timely response to autochthonous outbreaks.

关键词： inland likely southwestern

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Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis:A Systematic Review

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Biomedical and Environmental Sciences 2024年第1期37卷 85-95页

作者： WANG Han Lin XUE Yan Feng CUI Bao Qiu LIU Hong SHEN Xin Xin Shandong Provincial Research Center for Bioinformatic Engineering and Technique School of Life SciencesShandong University of TechnologyZibo 255049ShandongChina Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013ShanxiChina State Key Laboratory of Infectious disease prevention and control National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective This study explored the potentially modifiable factors for depression and major depressive disorder(MDD)from the MR-Base database and further evaluated the associations between drug targets with *** We analyzed two-sample of Mendelian randomization(2SMR)using genetic variant depression(n=113.154)and MDD(n=208,811)from Genome-Wide Association Studies(GWAS).Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 *** MR analysis was performed by screening drug targets with MDD in the DrugBank database to explore the therapeutic targets for *** variance weighted(IVW),fixed-effect inverse variance weighted(FE-IVW),MR-Egger,weighted median,and weighted mode were used for complementary *** The potential causal relationship between modifiable risk factors and depression contained 459 results for depression and 424 for ***,the associations between drug targets and MDD showed that SLC6A4,GRIN2A,GRIN2C,SCN10A,and IL1B expression are associated with an increased risk of *** contrast,ADRB1,CHRNA3.HTR3.,GSTP1,and GABRG2 genes are candidate protective factors against *** This study identified the risk factors causally associated with depression and MDD,and estimated 10 drug targets with significant impact on MDD,providing essential information for formulating strategies to prevent and treat depression.

关键词： Risk factors Drug targets Depression Major depressive disorder Two-sample Mendelian randomization

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Infection and Genomic Characteristics of Campylobacter jejuni from a Patient Without Diarrhea—China,2018

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China CDC weekly 2024年第33期6卷 846-851,I0001-I0005页

作者： Xiangdong Yang Wen Wang Chajin Cui Binbin Yu Qing Zhang Yanhua Wang Ecological Medicine Research Center National Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Zoonotic disease control and prevention Yunnan Institute of Endemic Diseases Control&PreventionDali Bai Autonomous PrefectureYunnan ProvinceChina Medical Laboratory Department Yunnan Luxi County People’s HospitalHonghe Hani-Yi Autonomous PrefectureYunnan ProvinceChina

What is already known about this topic?A 20-month-old boy was admitted to the hospital with a maximum temperature of 40°C and a single ***,blood culture detected Francisella tularensis(***)using the VITEK 2 Compact *** is added by this report?After incubation of the patient’s blood for 48 hours,the cultured strain was identified as Campylobacter jejuni,named L8,excluding *** the genome sequence of L8,we found a novel Type VI Secretion System(T6SS),of which the conserved C-terminal VgrG domain from positions 561 to 884 showed significant *** are the implications for public health practice?It should be underscored that relying solely on automatic bacterial identification instruments for accurate strain identification is ***,our study suggests that the potential effect of T6SS should be considered when studying the genetic features of a patient’s clinical phenotypes.

关键词： Campylobacter admitted culture

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Prevalence and Influencing Factor Analysis of Typhoid/Paratyphoid Fever—China,2011-2020

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China CDC weekly 2024年第21期6卷 493-498页

作者： Shumei Huang Meiying Yan Biao Kan School of Public Health Shandong UniversityJinan CityShandong ProvinceChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:Over the last 12 years,there has been a consistent decline in the cases of typhoid/paratyphoid fever in *** the epidemiological patterns of these diseases in various provincial-level administrative divisions(PLADs)and examining potential influencing factors can provide crucial information for implementing successful control ***:In this study,we analyzed the cases and incidence rates of typhoid/paratyphoid fever reported in various PLADs of China from 2011 to 2022,along with exploring potential influencing *** initially studied spatial shifts in the incidence rates through centroid shift *** variations in typhoid/paratyphoid fever onset were examined using *** autocorrelation analysis was utilized to understand the spatial correlations among different *** assess potential factors,we utilized a generalized estimating equations model that integrated spatial lag effects and sequence comparison ***:The study identified significant geographical clustering of typhoid/paratyphoid fever cases in southwestern China.A decrease in incidence rates in the west resulted in a movement of the disease center towards the *** incidence occurred during warmer seasons,highlighting the seasonal pattern of the *** such as meteorological conditions and socioeconomic status were probable influencers of typhoid/paratyphoid ***:The geographical and temporal spread of typhoid/paratyphoid fever can be impacted by meteorological and socioeconomic *** economic conditions,particularly in regions with high disease prevalence,could aid in the prevention and management of these fevers.

关键词： prevention utilized meteorological

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Analysis of Epidemiological and Issues Encountered in Case Reports on Echinococcosis—China,2022

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China CDC weekly 2024年第6期6卷 100-104页

作者： Yan Kui Shuai Han Xiaojuan Zhang Guangzhong Shi Yale Yu Ruirui Li Peizheng Zhan Hongju Duan Wenbo Luo Benfu Li Shaoqi Ning Yalan Zhang Aiya Zhu Jingbo Xue National institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWorld Health Organization Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Gansu Provincial Center for disease control and prevention Lanzhou CityGansu ProvinceChina The Center for disease control and prevention of Xinjiang Uygur Autonomous Region Urumuqi CityXinjiang Uygur Autonomous RegionChina Xinjiang Production and Construction Corps Center for disease control and prevention Urumuqi CityXinjiang Uygur Autonomous RegionChina Sichuan Provincial Center for disease control and prevention Chengdu CitySichuan ProvinceChina Qinhai institute for Endemic disease control and {3. Xining CityQinghai ProvinceChina Ningxia Center for disease control and prevention Yinchuan CityNingxia Hui Autonomous RegionChina Inner Mongolia Autonomous Region Center for Comprehensive disease control and prevention Hohhot CityInner Mongolia AutonomousChina Yunnan institute of Parasitic diseases Puer CityYunnan ProvinceChina Shaanxi Provincial Center for disease control and prevention Xi'an CityShaanxi ProvinceChina Henan Provincial Center for disease control and prevention Zhengzhou CityHenan ProvinceChina Guizhou Provincial Center for disease control and prevention Guiyang CityGuizhou ProvinceChina

Summary What is already known about this topic?Echinococcosis is classified as a Class C infectious disease in *** is endemic in 3.0 counties located in the agricultural and pastoral regions of western *** is added by this report?This report provides a comprehensive overview of the cases of echinococcosis reported in China in *** a thorough evaluation conducted by provincial CDCs.

关键词： China Ech counties

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Characterization of a New HIV-1 Circulating Recombinant Form CRF142_BC—Yunnan,China,2015 and 2021

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China CDC weekly 2024年第42期6卷 1080-1085页

作者： Min Chen Huichao Chen Shouxiong Lei Jie Dai Yanling Ma Manhong Jia Yunnan Provincial Key Laboratory of Public Health and Biosafety&Health Laboratory Center Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina institute for AIDS/STD control and prevention Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina Division for AIDS/STD control and prevention Zhaotong Center for Disease Control and PreventionZhaotong CityYunnan ProvinceChina Yunnan Provincial Key Laboratory of Public Health and Biosafety&institute for AIDS/STD control and prevention Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina

What is already known about this topic?Recombinant strains dominate the human immunodeficiency virus 1(HIV-1)epidemic in *** Province was the first region in China to report HIV-1 infections in *** long-term HIV-1 epidemic led to the generation of various recombinant *** the 47 circulating recombinant forms(CRFs)reported in China,more than 20 were first identified in Yunnan *** is added by this report?This study reported a previously unrecognized HIV-1 CRF(CRF142_BC)characterized by the insertion of four short subtype B fragments into the subtype C ***142_BC was estimated to have emerged in the mid-1990s,close to the time of the emergence of most known CRF_BCs in *** are the implications for public health practice?The discovery of new CRFs will provide a basis for HIV-1 molecular tracing and intervention *** addition,HIV-1 recombination can alter viral biological *** study of HIV-1 gene variants needs to be intensified.

关键词： properties. China. intensified

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Hearing Loss and Depressive Symptoms Among Community-Dwelling Older Adults-Liaoning,Henan,and Guangdong Provinces,China,2019-2020

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China CDC weekly 2024年第32期6卷 811-815,I0002页

作者： Ran An Lu Cui Liyuan Yang Han Zhang Shige Qi Haoyan Guo National Center for Chronic and Noncommunicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina School of Public Health Capital Medical UniversityBeijingChina Chengnan Community Health Service Center of Changping District BeijingChina National institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?More than half of Chinese older adults over 60 are suffering from hearing loss(HL),which might increase the risk of depressive *** is added by this report?The results indicated a significant association between severe or profound HL and depressive symptoms,characterized by notable age and gender disparities,particularly among women aged 60–74 years *** are the implications for public health practice?Timely intervention and treatment for elderly individuals with HL,particularly younger female elders suffering from severe or profound HL,are pivotal in reducing depressive symptom rates and are key policy considerations.

关键词： younger policy suffering

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Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3./AKT Pathway-Induced Inflammation

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Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei ZHANG Heng Dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina institute of Occupational disease prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for disease prevention and control Suzhou 215004JiangsuChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293. cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3. protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3., AKT, and IL-6 ***, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3., AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3./AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN Occupational mercury exposure Occupational health PI3./AKT pathway 293. cell IL-6

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