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Sustained release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA

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生物物理学报 2009年第S1期25卷 297-298页

作者： Hirokazu Miyoshi Radioisotope Research Center The University of Tokushima Kuramoto-cho 3-18-15 Tokushima 770-8503 Japan

The use of nanotechnology in drug delivery is a rapidly expanding field. Biodegradable or nontoxic nanomaterials have the most promising application potentials in nanomedicine.

关键词： Sustained release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA SiO

Preparation, characterization and release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA

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Chinese Science Bulletin 2010年第3期55卷 263-267页

作者： YANG Hong MIYOSHI Hirokazu LOU ChangChun REN ZhengLong LIU YiYao Department of Biophysics School of Life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 China Radioisotope Research Center University of Tokushima Kuramoto-cho 3-18-15 Tokushima 770-8503 Japan

The use of nanotechnology in drug delivery is a rapidly expanding field. Biodegradable or nontoxic nanomaterials have the most promising application potentials in nanomedicine. Herein, we report a novel core-shell nanoparticle with double shell coatings (silica and poly(D,L-lactide-co-glycolide) (PLGA)) with the total shell thickness of (8.7 ± 1.3) nm. The outer shell of PLGA is biodegradable and used for controlled and sustained release, and the inner shell of silica is mesoporous for the preservation of the chemical radiation therapeutic of methyl viologen (MV), an oxidant that produces reactive oxygen species during cancer radiation therapy. The dissolution time course data and transmission electron microscopy images showed that the novel nanoparticles (Au@SiO2&PLGA) have been successfully prepared, and silica and PLGA coated well the gold (Au) template surfaces. Nano- capsules (MV@SiO2&PLGA) were obtained after the gold templates were dissolved using sodium cyanide. The sustained release property was characterized through detecting fluorescence quenching time course of fluorescent isothiocyanate after mixing with MV@SiO2&PLGA nanocapsules that encapsulate MV molecules. The sustained release of MV molecules could be extended to approximately four weeks. This novel delivery system has high potential in future application for the delivery of therapeutic drugs, particularly for the treatment of cancer by radiation therapy.

关键词：二氧化硅纳米粒子甲基紫精输送系统 PLGA 双壳透射电子显微镜可生物降解

Corneal topographic changes and surgically induced astigmatism following combined phacoemulsification and 25-gauge vitrectomy

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 72-76页

作者： Khulood Mohammed Sayed Mahmoud M.Farouk Takashi Katome Toshihiko Nagasawa Takeshi Naito Yoshinori MitamurA Department of Ophthalmology and Visual Neuroscience Instituteof Health BiosciencesUniversity of Tokushima GraduateSchool3-18-15 Kuramoto-choTokushima 770-8503Japan Department of Ophthalmology Sohag Faculty of MedicineSohag University82524 SohagEgypt

AIM： To evaluate corneal topographic changes and surgically induced astigmatism （SIA） after combined phacoemulsification and 25-gauge transconjunctival sutureless vitrectomy （25-G TSV）.METHODS： A retrospective study on 96 eyes of 87 patients who underwent combined phacoemulsification and 25-G TSV. The different topographic parameters and SIA were analyzed pre- and ***： There was no significant changes in corneal topographic parameters at different follow up periods. Only surface regularity index changed significantly in the 2nd postoperative week and then returned to baseline values thereafter. Mean SIA gradually decreased to reach 0.12 D by the 6th postoperative ***： Corneal surface and astigmatic changes are insignificant in either early or late postoperative periods following combined phacoemulsification and 25-G TSV. The SIA was the minimum among previous reports on sutureless vitrectomy alone or combined with phacoemulsification. Improvement of SIA did not stop at the 3rd postoperative month but it continued till the 6th month postoperatively.

关键词： Corneal topographic indices surgicallyinduced astigmatism 25-gauge sutureless vitrectomy phacoemulsification

Isolation and characterization of fission yeast mutants which mutations are related to γ-tubulin function.

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Isolation and characterization of fission yeast mutants whic...

The Historical Fate of Lu Xun in Today＇s China

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Tetsuya Horio Aya Takeoka Masayuki Yamato Department of Food Microbiology School of MedicineThe University of Tokushima 3-18-15 KuramotoTokushima 770-8503Japan

γ-Tubulin is a member of tubulin superfamily and is essential for microtubule nucleation and, thus, plays a key role in organization of microtubules in the cell. We have designed a mutant screening procedure which can concentrate mutants of γ-tubulin related factors. One of authors reported previously that human γ-tubulin can be

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2013年第4期7卷 529-540页

作者： Lu Xun His Legacy Institute of Chinese Studies Delhi lndia 15-18 November 2012

＂The historical fate of Lu Xun in today＇s China＂ is an enormous topic, and a discussion of this question can also encompass important questions of Chinese society, thought, and culture. I have not performed special...

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Virus-induced gene silencing and virusinduced flowering in strawberry(Fragaria×ananassa)using apple latent spherical virus vectors

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Horticulture Research 2019年第1期6卷 1428-1437页

作者： Chunjiang Li Noriko Yamagishi Ichiro Kasajima Nobuyuki Yoshikawa Faculty of Agriculture Iwate UniversityMorioka 3-18-8Iwate 020-8550Japan Agri-Innovation Research Center Iwate UniversityMorioka 3-18-8Iwate 020-8550Japan

Apple latent spherical virus(ALSV)vector is a convenient alternative to genetic transformation in horticultural plants,especially in species recalcitrant to genetic ***,an RNA virus,can infect a wide variety of plant species including major horticultural plants without inducing ***,methodologies were developed for infection of ALSV vectors to strawberry seedlings and plantlets cultured in vitro.A seed-propagated F1 hybrid strawberry cultivar'Yotsuboshi'was aseptically grown on half-strength Murashige–Skoog medium for 1 month and true leaves were inoculated with an ALSV RNA preparation by particle *** vector infection rates varied from 58 to 100%according to the insertion sequences,in‘Yotsuboshi’***(‘Dover’)propagated in vitro could also be infected with ALSV vector at a similar infection *** virus-induced gene silencing(VIGS),we prepared an ALSV vector carrying a 201 nucleotide segment of the strawberry phytoene desaturase gene.‘Yotsuboshi’and‘Dover’plants infected by this vector generated completely white leaves at fifth or sixth true leaves and *** virus-induced flowering(VIF),we used an ALSV vector expressing the Arabidopsis thaliana flowering locus T *** seedlings infected by this vector started to flower from about 2 months post inoculation and bore fruits with viable *** ALSV vector was no longer detected in any of the seedlings from early-flowered ***,the ALSV vector may be beneficial for examination of gene functions by VIGS in strawberry,and VIF using ALSV vector constitutes an effective new plant breeding technique for the promotion of cross-breeding in strawberry.

关键词： straw breeding Fragaria

Mechanisms Modeling the Double Rotation of the Elytra in Beetles （Coleoptera）

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Journal of Bionic Engineering 2011年第4期8卷 395-405页

作者： Leonid Frantsevich Schmalhausen-Institute of Zoology B. Chmielnicki str. 15 Kiev-3 O 01601 Ukraine

We recorded transient movements, i.e. opening and closing, of beetle elytra. The beetles were tethered from below and filmed under a skew mirror; two markers were glued on each elytron at the apex and at the base. Body-fixed 3D traces of the apical and basal markers were reconstructed. The trace of the basal marker was, as a rule, non-parallel to the apical trace. The costal edge of the elytron uniformly supinated in the course of adduction of the apical marker. We found two essential attributes of double rotation：（1） the elytron to body articulation is approximately a spherical mechanism; （2） transient opening and closing possess single degree of freedom. The double rotation was modeled with two mechanisms：（1） a flexagon model of the Haas and Wootton＇s type simulated the elytral movement relative to the movement of one facet of the flexagon; （2） a screw and nut model provided traces as two sectors of a helical thread, one sector was phase shifted with respect to other one. Screw guideways in a spherical mechanism give rise to discrepancies. Exact solution for a spherical mechanism with two guideways was proposed. The modeling revealed the attribute （3）： the elytron is actuated by two linked but differently directed drives. Experimental investigations on the elytron to body articulation may be oriented at search of those mechanisms.

关键词： insect flight insect thorax flexagon screw and nut joint

Solvent-Resistant Wearable Triboelectric Nanogenerator for Energy-Harvesting and Self-Powered Sensors

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Energy & Environmental Materials 2024年第5期7卷 376-386页

作者： Yongtao Yu Yuelin Yu Hongyi Wu Tianshuo Gao Yi Zhang Jiajia Wu Jiawei Yan Jian Shi Hideaki Morikawa Chunhong Zhu Graduate School of Medicine Science and TechnologyShinshu University3-15-1 TokidaUedaNagano 386-8567Japan Institute for Fiber Engineering(IFES) Interdisciplinary Cluster for Cutting Edge Research(ICCER)Shinshu University3-15-1 TokidaUedaNagano 386-8567Japan Faculty of Textile Science and Technology Shinshu University3-15-1 TokidaUedaNagano 386-8567Japan

Wearable triboelectric nanogenerators(TENGs)have attracted attention owing to their ability to harvest energy from the surrounding environment without ***,polyetherimide-Al_(2)O_(3)(PAl)and polyvinylidene fluoride-co-hexafluoropropylene(PVDF-HFP,PH)nanofiber membranes were used as tribo-positive and tribo-negative materials,*** acid-doped polyaniline(PANI)/cotton fabric(PPCF)and ethylenediamine(EDA)-crosslinked PAl(EPAl)nanofiber membranes were used as triboelectrode and triboencapsulation materials,*** result showed that when the PAl-PH-based TENG was shaped as a circle with a radius of 1 cm,under the pressure of 50 N,and the frequency of 0.5 Hz,the open-circuit voltage(V_(oc))and short-circuit current(I_(sc))reached the highest value of 66.6 V and-93.4 to 110.1 nA,***,the PH-based TENG could be used as a fabric sensor to detect fabric composition and as a sensor-inductive switch for light bulbs or beeping warning *** the PAl-PH-based TENG was shaped as a 5×5 cm^(2)rectangle,a 33 pF capacitor could be charged to 15 V in 28 ***,compared to PAl nanofiber membranes,EPAl nanofiber membranes exhibited good dyeing properties and excellent solvent *** PPCF exhibited<5%resistance change after washing,bending,and stretching.

关键词： energy-harvesting power supply sensors solvent-resistant wearable triboelectric nanogenerator

Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases

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Acta Pharmacologica Sinica 2004年第8期 3-11页

作者： Moe KYAW,Masanori YOSHIZUMI,Koichiro TSUCHIYA,Yuki IZAWA,Yasuhisa KANEMATSU,Toshiaki TAMAKI Department of Pharmacology Department of Pharmacology Department of Clinical Pharmacology Department of Pharmacology Department of Pharmacology Department of Pharmacology The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Pharmaceutical Sciences 3-18-15 kuramoto Tokushima 770-8503 Japan The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine The University of Tokushima Graduate School of Medicine

Reactive oxygen species (ROS) have been known to play an important role in the pathogenesis of atherosclerosis and several other cardiovascular diseases. It is now apparent that ROS induce endothelial cell damage and vascular smooth muscle cell (VSMC) growth and cardiac remodeling, which are associated with hypertension, atherosclerosis, heart failure, and restenosis. Several lines of evidence have indicated that ROS and mitogen activated protein (MAP) kinases were involved in vascular remodeling under various pathological conditions. Recently, it was also reported that MAP kinases were sensitive to oxidative stress. MAP kinases play an important role in cell differentiation, growth, apoptosis, and the regulation of a variety of transcription factors and gene expressions. Bioflavonoids and polyphenolic compounds are believed to be beneficial for the prevention and treatment of atherosclerosis and cardiovascular diseases. One of the most widely distributed bioflavonoids, 3,3',4',5,7-penta hydroxyflavone (

关键词： reactive oxygen species mitogen-activated protein kinase antioxidant vascular smooth muscle cell atherosclerosis