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Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4194-4208页

作者： Ming He Ye Qi Ze-Mao Zheng Min Sha Xiang Zhao Yu-Rao Chen Zheng-Hai Chen Rong-Yu Qian Juan Yao Zheng-Dong Yang Department of radiation Oncology Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina Department of Nursing Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina institute of Clinical medicine Taizhou People's Hospital Affiliated of Nantong University of MedicineTaizhou 225300Zhejiang ProvinceChina Department of Thoracic Surgery Huai’an Hospital of Huai’anHuai’an 223299Jiangsu ProvinceChina

BACKGROUND The clinical effects and detailed roles of long non-coding RNA(LncRNA)steroid receptor RNA activator 1(SRA1)in esophageal squamous cell carcinoma(ESCC)remain *** the present study,the complementary sites between lncRNA SRA1,miRNA-363-5p,and phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)predicted via bioinformatics analysis stimulated us to hypothesize that miRNA-363-5p/LHPP axis might be required for SRA1-mediated ESCC *** To investigate the molecular events of SRA1 in the malignant behavior in *** Thirty-eight ESCC tissues and paired adjacent normal tissues were ***1 expression was detected in ESCC tissues and cell lines using quantitative reverse transcription-polymerase chain *** counting Kit-8 assay,transwell invasion assay,glycolysis assay,and xenograft tumor model were performed to address the malignant biological behaviors of ESCC cells after the introduction of *** t-test and theχ2 test were used for comparison between *** curve analysis was performed using the Kaplan-Meier *** SRA1 downregulation was identified in *** patients exhibiting a low SRA1 expression faced shorter overall survival than those with a high SRA1 *** introduction of SRA1 inhibited cell proliferation,glucose uptake,and lactate production in *** vivo,the growth of ESCC was hindered by SRA1 ***,SRA1 overexpresses the LHPP by inhibiting ***,the introduction of small interfering RNA si-LHPP or miRNA-363-5p mimic could abrogate the inhibition roles triggered by *** SRA1 inhibits the oncogenicity of ESCC via miRNA-363-5p/LHPP *** SRA1/miRNA-363-5p/LHPP pathway may be a therapeutic target for ESCC.

关键词： Steroid receptor RNA activator 1 Esophageal squamous cell carcinoma Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Cancer therapy MicroRNA Long non-coding RNA

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Ferulic acid reduces inflammatory response induced by radiation through Sirt1-NLRP3 pathway

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Acupuncture and Herbal medicine 2024年第3期4卷 367-374页

作者： Yao Nie Mingyue Huang Tingyu Yang Yu Mei Huiting Zhang Xue Wei Yue Gao Zengchun Ma Beijing institute of radiation medicine BeijingChina Anhui Zhifei Longcom Biopharmaceutical Co. Ltd.HefeiChina Tianjin University of Traditional Chinese medicine TianjinChina School of Traditional Chinese medicine Guangdong Pharmaceutical UniversityGuangzhouChina

Objective:A model of inflammatory damage was induced by radiation to investigate whether ferulic acid(FA)can reduce the inflammatory response through the Sirt1-NLRP3 inflammatory *** will help discover radiation-protective drugs and elucidate the molecular mechanisms related to radiation-induced inflammatory ***:A mouse model of radiation-induced immunoinflammatory injury was established to verify the anti-inflammatory effects of FA in vivo.C57BL/6J mice were randomly divided into six groups,and 5 Gy whole-body irradiation was used for *** were administered a gastric solvent,amifostine,or 25,50,or 100 mg/kg FA daily for 12 days,consecutively,before *** serum of mice was collected 24 hour after irradiation to observe the content of inflammatory factors interleukin(IL)-1β,IL-18,IL-6,and tumor necrosis factor(TNF)-α.The spleen and thymus tissues of mice were weighed and the organ index was calculated for pathological testing and immunofluorescence ***:FA reduced the radiation-induced decrease in the spleen and thymus *** significantly reduced the secretion of inflammatory factors in the serum and reversed the radiation-induced reduction in lymphocytes in the spleen and thymus of *** activated Sirt1 and inhibited the expression of the NLRP3 inflammasome to alleviate the inflammatory ***:FA reduced radiation-induced inflammation in animals,possibly by activating Sirt1 and reducing nucleotide oligomerization domain(NOD)-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome expression,thereby reducing the secretion of inflammatory factors.

关键词： Ferulic acid NLRP3 inflammasome radiation inflammation Sirt1

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Radical radiotherapy without surgical tumor resection for rectal cancer

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World Journal of Clinical Oncology 2024年第11期15卷 1390-1393页

作者： Takashi Ono Masashi Koto Department of radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

In this editorial,I would like to comment on the article,recently published in the World Journal of Clinical *** article focuses on non-surgical treatments for locally recurrent rectal cancer,including the watch-and-wait(WW)strategy after total neoadjuvant therapy(TNT)and particle beam *** treatment options for rectal cancer continue to evolve,the high complete response rate achieved with TNT has led to the development of a new non-surgical approach:*** followed by consolidation chemotherapy,in particular,has a low rate of tumor growth and is a treatment aimed at achieving a cure without ***,the risk of recurrence within two years is significant,necessitating careful *** standardized follow-up methods that can be implemented by many physicians is *** ion radiotherapy has demonstrated high local control with a low incidence of severe late toxicities,even after previous pelvic *** these new non-surgical curative treatments for rectal cancer require further investigation,future advancements in this field are anticipated.

关键词： Rectal cancer Locally recurrent rectal cancer Total neoadjuvant therapy Watch-and-wait Carbon ion radiotherapy Proton beam therapy

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Diabetic cardiomyopathy:Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis

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World Journal of Diabetes 2024年第8期15卷 1659-1662页

作者： Lu Cai Yi Tan Md Shahidul Islam Michael Horowitz Kupper A Wintergerst Pediatric Research institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Department of medicine University of AdelaideAdelaide 5005Australia Pediatric Research institute Division of EndocrinologyDepartment of PediatricsWendy Novak Diabetes InstituteNorton Children’s HospitalUniversity of LouisvilleLouisvilleKY 40202United States

Recently,the roles of pyroptosis,a form of cell death induced by activated NODlike receptor protein 3(NLRP3)inflammasome,in the pathogenesis of diabetic cardiomyopathy(DCM)have been extensively ***,most studies have focused mainly on whether diabetes increases the NLRP3 inflammasome and associated pyroptosis in the heart of type 1 or type 2 diabetic rodent models,and whether various medications and natural products prevent the development of DCM,associated with decreased levels of cardiac NLRP3 inflammasome and *** direct link of NLRP3 inflammasome and associated pyroptosis to the pathogenesis of DCM remains unclear based on the limited evidence derived from the available studies,with the approaches of NLRP3 gene silencing or pharmaceutical application of NLRP3 specific *** thus emphasize the requirement for more systematic studies that are designed to provide direct evidence to support the link,given that several studies have provided both direct and indirect evidence under specific *** editorial emphasizes that the current investigation should be circumspect in its conclusion,i.e.,not overemphasizing its role in the pathogenesis of DCM with the fact of only significantly increased expression or activation of NLRP3 inflammasome and pyroptosis in the heart of diabetic rodent *** clear-cut evidence-based causative roles of NLRP3 inflammasome and pyroptosis in the pathogenesis of DCM can help to develop effective and safe medications for the clinical management of DCM,targeting these biomarkers.

关键词： Diabetic cardiomyopathy Nucleotide oligomerization domain NOD-like receptor protein 3 inflammasome Cardiac cell death Pyroptosis

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Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation:a multi-institutional,retrospective study

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Stroke & Vascular Neurology 2024年第3期9卷 221-229,I0130,I0131页

作者： Chloe Dumot Georgios Mantziaris Sam Dayawansa Zhiyuan Xu Stylianos Pikis Selcuk Peker Yavuz Samanci Gokce D Ardor Ahmed M Nabeel Wael A Reda Sameh R Tawadros Khaled Abdelkarim Amr M N El-Shehaby Reem M Emad Eldin Ahmed H Elazzazi Nuria Martínez Moreno Roberto MartínezÁlvarez Roman Liscak Jaromir May David Mathieu Jean-Nicolas Tourigny Manjul Tripathi Akshay Rajput Narendra Kumar Rupinder Kaur Piero Picozzi Andrea Franzini Herwin Speckter Wenceslao Hernandez Anderson Brito Ronald E Warnick Juan Alzate Douglas Kondziolka Greg N Bowden Samir Patel Jason Sheehan Department of Neurological Surgery Hospices Civils de LyonLyonFrance Department of Neurological Surgery University of VirginiaCharlottesvilleVirginiaUSA Department of Neurosurgery Koc University School of MedicineIstanbulTurkey Gamma-knife Center Nasser institute HospitalCairoEgypt Neurosurgery Department Benha UniversityBenhaEgypt Departments of Neurosurgery Ain Shams UniversityCairoEgypt Department of Clinical Oncology Ain Shams UniversityCairoEgypt Department of radiation Oncology National Cancer InstituteCairo UniversityGizaEgypt Faculty of medicine Extended Modular ProgramAin Shams UniversityCairoEgypt Department of Radiosurgery Rúber Internacional HospitalMadridSpain Department of Stereotactic and radiation Neurosurgery Na Homolce HospitalPragueCzech Republic Neurosurgery Centre de recherche du CHUSUniversitéde SherbrookeSherbrookeQuebecCanada Neurosurgery PGIMERChandigarhChandigarhIndia radiation Therapy PGIMERChandigarhChandigarhIndia Neurosurgery IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Dominican Gamma Knife Center and Radiology Department CEDIMATSanto DomingoDominican Republic Gamma Knife Center Mayfield ClinicThe Jewish Hospital-Mercy HealthCincinnatiOhioUSA Neurosurgery NYU Langone HealthNew YorkNew YorkUSA Neurosurgery University of AlbertaEdmontonAlbertaCanada Division of radiation Oncology Department of OncologyUniversity of AlbertaEdmontonAlbertaCanada

Background Cerebral cavernous malformations(CCMs)frequently manifest with *** radiosurgery(SRS)has been employed for CCM not suitable for *** effect on reducing haemorrhage risk is still *** aim of this study was to expand on the safety and efficacy of SRS for haemorrhagic *** This retrospective multicentric study included CCM with at least one haemorrhage treated with single-session *** annual haemorrhagic rate(AHR)was calculated before and after *** event analysis and Cox regression were used to evaluate factors associated with *** radiation effects(AREs)and occurrence of new neurological deficits were *** The study included 381 patients (median age:37.5 years(Q1–Q3:25.8–51.9))with 414 *** AHR from diagnosis to SRS excluding the first haemorrhage was 11.08 per 100 CCM-years and was reduced to 2.7 per 100 CCM-years after *** recurrent event analysis,SRS,HR 0.27(95%CI 0.17 to 0.44),p2.40),p=*** cumulative risk of first haemorrhage after SRS was 9.4%(95%CI 6%to 12.6%)at 5 years and 15.6%(95%CI%9 to 21.8%)at 10 *** doses>13 Gy,HR 2.27(95%CI 1.20 to 4.32),p=0.012 and the presence of DVA,HR 2.08(95%CI 1.00 to 4.31),p=0.049 were factors associated with higher probability of post-SRS ***-SRS haemorrhage was symptomatic in 22 out of 381(5.8%)patients,presenting with transient(15/381)or permanent(7/381)neurological *** occurred in 11.1%(46/414)CCM and was responsible for transient neurological deficit in 3.9%(15/381)of the patients and permanent deficit in 1.1%(4/381)of the *** doses>13 Gy and CCM volume>0.7 cc were associated with increased risk of ARE.

关键词： doses haemorrhagic diagnosis

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Postmastectomy radiotherapy in breast reconstruction:Current controversies and trends

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Cancer Innovation 2024年第1期3卷 113-123页

作者： Honghong Zhang Dandan Song Liangxi Xie Ning Zhan Wenjia Xie Jianming Zhang Department of radiation Oncology Xiang'an Hospital of Xiamen UniversityCancer Research CenterSchool of MedicineXiamen UniversityXiang'anXiamenFujianChina Fujian Provincial Key Laboratory of Intelligent Identification and Control of Complex Dynamic System Quanzhou Institute of Equipment ManufacturingHaixi InstitutesChinese Academy of SciencesQuanzhouFujianChina

Breast cancer is the most common cancer among women *** radiotherapy(PMRT)is an essential component of combined therapy for early-stage,high-risk breast *** reconstruction(BR)is often considered for patients with breast cancer who have undergone *** has been a considerable amount of discussion about the optimal approach to combining PMRT with BR in the treatment of breast *** may increase the risk of complications and prevent good aesthetic results after BR,while BR may increase the complexity of PMRT and the radiation dose to surrounding normal *** purpose of this review is to give a broad overview and summary of the current controversies and trends in PMRT and BR in the context of the most recent literature available.

关键词： breast reconstruction postmastectomy radiotherapy radiotherapy techniques

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Metabolic cell death in cancer:ferroptosis,cuproptosis,disulfidptosis,and beyond

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Protein & Cell 2024年第9期15卷 642-660页

作者： Chao Mao Min Wang Li Zhuang Boyi Gan Department of Experimental radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Molecular and Cellular Biology Baylor College of MedicineHoustonTX 77030USA The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences HoustonTX 77030USA

Cell death resistance represents a hallmark of *** studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular *** review discusses the mechanisms of metabolic cell death—ferroptosis,cuproptosis,disulfidptosis,lysozincrosis,and alkaliptosis—and explores their potential in cancer *** review underscores the complexity of the metabolic cell death pathways and offers insights into innovative therapeutic avenues for cancer treatment.

关键词： cell death cancer treatment ferroptosis cuproptosis disulfidptosis

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Immune mediated support of metastasis:Implication for bone invasion

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Cancer Communications 2024年第9期44卷 967-991页

作者： Zengfeng Xin Luying Qin Yang Tang Siyu Guo Fangfang Li Yuan Fang Gege Li Yihan Yao Binbin Zheng Bicheng Zhang Dang Wu Jie Xiao Chao Ni Qichun Wei Ting Zhang Department of Orthopedic Surgery Second Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Cancer institute(Key Laboratory of Cancer Prevention and Intervention National Ministry of Education)Second Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Department of radiation Oncology Second Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Department of Respiratory medicine Ningbo Hangzhou Bay HospitalNingboZhejiangP.R.China Department of Orthopedic Surgery Second Affiliated Hospital(Jiande Branch)Zhejiang University School of MedicineHangzhouZhejiangP.R.China Department of Breast Surgery Second Affiliated HospitalZhejiang University School of MedicineZhejiang UniversityHangzhouZhejiangP.R.China

Bone is a common organ affected by metastasis in various advanced cancers,including lung,breast,prostate,colorectal,and *** a patient is diagnosed with bone metastasis,the patient’s quality of life and overall survival are significantly reduced owing to a wide range ofmorbidities and the increasing difficulty of *** studies have shown that bone metastasis is closely related to bone microenvironment,especially bone immune ***,the effects of various immune cells in the bone microenvironment on bone metastasis remain ***,we described the changes in various immune cells during bone metastasis and discussed their related ***,adipocytes,and other non-immune cells closely related to bone metastasis were also *** review also summarized the existing treatment methods and potential therapeutic targets,and provided insights for future studies of cancer bone metastasis.

关键词： bone metastasis bone microenvironment cancer immune cell therapy

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Radiotherapy enhances efficacy of PD-1 inhibitors in advanced hepatocellular carcinoma:A propensity-matched real-world study

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Chinese Medical Journal 2024年第11期137卷 1332-1342页

作者： Shujung Hsu Yencheng Chao Yong Hu Yang Zhang Weifeng Hong Yixing Chen Rongxin Chen Zhaochong Zeng Shisuo Du Department of radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pulmonary medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Liver Cancer institute Zhongshan HospitalFudan UniversityShanghai 200032China

Background:To address the need for immunotherapy in patients with advanced primary hepatocellular carcinoma(HCC),combination with radiotherapy(RT)has emerged as a promising *** preclinical studies,irradiated tumors released tumor antigens to synergistically increase the antitumor effect of ***,we investigated whether RT enhances the efficacy of anti-programmed death receptor-1(PD-1)inhibitors in advanced HCC in real-world ***:Between August 2018 and June 2021,172 patients with advanced primary HCC were enrolled in the tertiary center(Zhongshan Hospital of Fudan University);95 were treated with a combination of RT and the inhibitor of PD-1(RT-PD1 cohort),and 77 were administered anti-PD-1 therapy(PD1 cohort).The first cycle of PD-1 inhibitors was administered within 60 days or concurrently with *** score matching for bias reduction was used to evaluate the clinical ***:Among 71 propensity-matched pairs,median progression-free survival was 5.7 months in the RT-PD1 cohort vs.2.9 months in the PD1 cohort(P20.9 months in the RT-PD1 cohort vs.11.2 months in the PD1 cohort(P=0.018).Compared with patients in the PD1 cohort,patients in the RT-PD1 cohort had significantly higher objective response rates(40.8%,29/71 vs.19.7%,14/71,P=0.006)and disease control rates(62.0%,44/71 vs.31.0%,22/71,P<0.001).The incidences of toxic effects were not significantly different between the two ***:RT plus anti-PD-1 therapy is well *** enhances the efficacy of anti-PD-1 therapy in patients with advanced primary HCC by improving survival outcomes without increased toxic effects.

关键词： Radiotherapy Immune checkpoint inhibitor Programmed cell death receptor-1 Hepatocellular carcinoma Propensity score matching Treatment outcome Adverse effects

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Alzheimer's disease and low-dose radiation therapy:A new hope

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radiation medicine and Protection 2024年第1期5卷 1-6页

作者： Neal E.Dunlap Robert P.Friedland Lu Cai Department of radiation Oncology University of Louisville School of MedicineLouisvilleKY40202USA Department of Neurology The University of Louisville School of MedicineLouisvilleKY40202USA Pediatric Research institute Departments of PediatricsPharmacology and ToxicologyUniversity of Louisville School of MedicineLouisvilleKY40202USA

The concept of low-dose radiation(LDR)-induced hormetic responses was initially observed approximately 70 years ago and systematically reviewed along with the discovery of LDR-induced adaptive responses in a cytogenetic in vitro study in *** the end of the 1990s,discussions regarding the potential applications of LDRinduced hormesis and adaptive responses for preventing or treating chronic diseases,such as Alzheimer’s disease(AD)had taken *** 2016,reports on radiotherapy for the subjects with AD and for genetic AD model mice were ***,several preclinical studies with animal models of AD and clinical studies in AD subjects were conducted.A significant milestone was achieved with the online availability of a new Systematic Review based on qualified publications from these preclinical and clinical *** mini-review provides a concise historical introduction to LDR-induced hormesis and adaptive responses with discussion of AD radiotherapy with either LDR or relatively high dose *** of this Systematic Review cover promising outcomes,challenges,and new questions,followed by discussion of potential mechanisms.

关键词： Alzheimer’s disease Low-dose radiation radiation adaptive response radiation hormesis

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