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Immunohistochemical Study of EGF in Submandibular Gland During Healing of Gastric Ulcer in Rat

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Chinese Science Bulletin 1994年第11期39卷 960-964页

作者：赵培林李肇特 department of histology and Embryology Shanghai Medical UniversityShanghai 200032PRC. department of histology and Embryology Beijing Medical University Beijing 100083 PRC

The fact that organism can fully recover itself from certain visceral diseases sug-gests the existence of a natural disease-resistant mechanism, which mainly involvesneuro-endocrin regulation including the biological active peptides. Epidermalgrowth factor (EGF), which is a single-chain polypeptide consisting of 53 aminoacids, may be an important factor in this mechanism. EGF is synthesized

关键词： GCT cell EGF immunohistochemistry experimental gastric ulcer rat.

Protective effect of basic fibroblast growth factor on laser induced retinopathy

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 744-751页

作者： Unal Kartal Emel Koptagel H.Eray Bulut Haydar Erdogan department of histology and Embryology Faculty of MedicineCumhuriyet University department of Ophtalmology Faculty of MedicineCumhuriyet University

AIM:To investigate the side effects of the commonly used laser treatment along with testing the neuroprotective effect of bFGF on a potential retinal ***:To do this,30 chinchilla pigmented adult male rabbits were divided into the control and experimental *** control and experimental groups underwent both laser application and bFGF *** retinal tissue impairment and its renewal rate were tested under the light and electron microscopical ***:The focal laser application on rabbit eyes caused morphological alterations both in the application region and in the neighbouring *** the damaged areas,the outer nuclear layer of the neural retina was almost disappeared,retina pigment epithelium was interrupted,the retina pigment epithelium migrated intraretinally,and the damaged region along with neighbouring areas seemed to be not *** application just after the laser photocoagulation,revealed better results in application ***:It could be suggested that the bFGF application following laser photocoagulation might have protective,repairing and wound healing effects on the retina.

关键词： retina bFGF laser photocoagulation rabbit light microscopy electron microscopy

Immunocytochemical localization of serotonin and its receptor on the rat hepatoma cell line

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Chinese Science Bulletin 1995年第15期40卷 1287-1290页

作者：黄晓峰黄威权孙岚补永安 department of histology and Fmbryology Fourth Military Medical University. Xi'an 710032 China

It has been found in recent years that neuropeptides and neurotransmitters do notexclusively occur in classical neuroendocrine cell tumors but also in many other tumortypes. Serotonin (5-hydroxytryptamine, 5-HT) has been detected in some cells of certain co-lon carcinomas. It has been proved that 5-HT stimulates cell proliferation of the

关键词： 5-hydroxytryptamine receptors immunocytochemistry cells cultured liver ncoplasma.

Ultrastructural effect of sildenafil citrate on corpus cavernosum and other genital organs in female rats

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Asian Journal of Andrology 2003年第1期5卷 37-41页

作者： K.Kilinc M.I.Gündüz B.H.Gümüs S.Vatansever F.Kaymaz department of Urology University of Celal Bayar 45010 Manisa TurkeyDepartment of Urology University of Celal Bayar 45010 Manisa TurkeyDepartment of Urology University of Celal Bayar 45010 Manisa TurkeyDepartment of Histology University of Celal Bayar 45010 Manisa TurkeyDepartment of Histology University of Hacettepe Turkey

Aim: To determine the ultrastructural effects of sildenafil on the female genital organs. Methods: Twenty female cycling Wistar albino rats weighing 250±20 g were randomly divided into two groups of 10 each. Rats of one group were gavaged with 0.5 mg·kg-1·d-1 of sildenafil 3 days in a week for 4 weeks and the other served as the controls. After cessation of treatment animals were sacrificed by cervical dislocation under methoxyflurane anaesthesia. The clitoris, vagina, uterus and bartholin glands were taken at the estrous and were fixed with 10 % formalin solution for light microscopy and 2.5 % glutaraldehyde and osmic acid for electron microscopy. Results: Under the light microscope, the fibrocollageous tissue was found increased, the capillaries enlarged and the connecting tissue elements increased in the corpus cavernosum in the treated group. On electron microscopy, increased connective tissue, fibroblasts with notched nucleus, shorten immature collagen fibers without striation were seen. Abundant foldings and penetration with collagen bundles were observed in the basal membrane. Large connection complexes, especially gap junctions among the wide capillary endothelial cells were observed. Conclusion: There are evident histological changes due to sildenafil citrate in female rat corpus cavernosum. The clitoris and bartholin glands were the most effected organs. While the histopathological changes of clitoral tissue could be expected, an increase in the mass of bartholin gland was surprised.

关键词： sildenafil female clitoris histopathologic effects

Somatostatin involved in transmission of nociceptive information induced by substance P in the spinal cord

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Chinese Science Bulletin 1997年第5期42卷 426-429页

作者： Ruan, HZ Li, XC Cai, WQ department of Physiology China department of histology and Embryology Third Military Medical College Chongqing China

SUBSTANCE P (SP) and somatostatin (SOM), which were believed to have relation with the transmission of nociceptive information, were distributed commonly in the spinal cord. In the previous study, we observed that SP mainly functioned as an algogenesia in spinal cord and could enhance noxious stimulus-evoked pain response. It was reported that SOM was also

关键词： somatostatin substance P in situ hybridization immunohistochemistry spinal cord.

Ultrastructural changes in embryoic neuroepithelial cells caused by passive smoking in golden hamsters at different periods of pregnancy: A randomized controlled trial

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Neural Regeneration Research 2007年第2期2卷 82-86页

作者： Dong Wang Xiangmin Yu Heng Cai department of histology and Embryology Binzhou Medical College Yantai 264000 Shandong Province China department of histology and Embryology Qingdao University Qingdao 266000 Shandong Province China

BACKGROUND： Tobacco smoke exposure is recognized as a health risk for pregnant women and it is increasingly evident that tobacco smoke affects the development of brain. Recently, associations between maternal smoking during pregnancy and subsequent mental health problems in offspring have been reported. OBJECTIVE： To observe the effect of passive smoking on the morphology of nerve tissues and the ultrastructure of neuroepithelial cells during embryogenesis in golden hamster at different pregnant period. DESIGN： A randomized control study. SETTING： department of histology and embryology, Qingdao University. MATERIALS： Adult golden hamsters, including 40 males and 40 females that had not delivered, weighing （105±5） g, were provided by Shenyang Changsheng Biotechnology, Co.,Ltd. At 20 ： 00 - 21 ： 00, one male and one female were matched in each cage, and their mating was observed. The vaginal swabs were examined the next day and the day of positive sperm was taken as embryonic day 1 （E1）. METHODS： The experiment was completed in the department of histology and Embryology of Qingdao University from September 2001 to September 2003. （1） Abnormality caused by smoking, grouping and model establishment： A total of 40 healthy pregnant golden hamsters were randomly divided into control group （n =20） and experimental group （n =20）. The hamsters in the experimental group were exposed to tobacco smoke from embryonic day 4 to 7, 3 times per day, continuously 1 hour per time, 1 cigarette per golden hamster, for 4 consecutive days in the self-made chamber. The animals in the control group were given the same conditions as those in the experimental group except exposure to smoke. （2） Observation with transmission electron microscope： According to different gestational ages, the experimental group and the control group were all divided 4 subgroups （Groups A, B, C and D） respectively, and 5 hamsters in each subgroup. The pregnant golden hamsters were anaesthetized with 1 g/L pentobarb

关键词： tobacco smoke neural tube defects embryo development mesocricetusek

ER stress and ER stress-induced apoptosis are activated in gastric SMCs in diabetic rats

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World Journal of Gastroenterology 2014年第25期20卷 8260-8267页

作者： Xia Chen Xiang-Sheng Fu Chang-Ping Li Hong-Xian Zhao department of Gastroenterology Affiliated Hospital of Luzhou Medical College department of histology and Embryology Lu-zhou Medical College

AIM: To investigate the gastric muscle injury caused by endoplasmic reticulum (ER) stress in rats with diabetic gastroparesis.

关键词： Diabetic gastroparesis Apoptosis Endoplasmic reticulum stress glucose-regulated protein 78 kD Caspase-12

Localization of somatostatin mRNA in early human placental villi by in situ hybridization histochemistry

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Chinese Science Bulletin 1996年第10期41卷 858-861页

作者：黄威权张荣庆唐美仪张崇理孙岚 department of histology and Embryology the Fourth Military Medical University Xi' an 710032 China

Previous immunohistochemical studies showed that the human placenta contained notonly many regulatory peptides, but also 5-HT and dopamine (DA) classicalneurotransmitters. These results made us suggest the following hypothesis: the human placentamight be a complex endocrine organ. In order to confirm this hypothesis, it must beunderstood whether these regulatory peptides and classical neurotransmitters can be pro-

关键词： somatostatin mRNA human placenta in situ hybridization.

AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 43-51页

作者： Qing-Qi Zhang Qian Chen Pan Cao Chun-Xia Shi Lu-Yi Zhang Lu-Wen Wang Zuo-Jiong Gong department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Background:Acute liver failure(ALF)is an unpredictable and life-threatening critical *** pathological characteristic of ALF is massive necrosis of hepatocytes and lots of inflammatory cells infiltration which may lead to multiple organ ***:Animals were divided into 3 groups,normal,thioacetamide(TAA,ALF model)and TAA+*** L02 cells were divided into 5 groups,normal,TAA,TAA+mitofusin 2(MFN2)-siRNA,TAA+AGK2,and TAA+AGK2+MFN2-siRNA *** liver histology was evaluated with hematoxylin and eosin staining,inositol-requiring enzyme 1(IRE1),activating transcription factor 6β(ATF6β),protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)and phosphorylated-PERK(p-PERK).C/EBP homologous protein(CHOP),reactive oxygen species(ROS),MFN2 and glutathione peroxidase 4(GPX4)were measured with Western blotting,and cell viability and liver chemistry were also *** endoplasmic reticulum membranes(MAMs)were measured by ***:The liver tissue in the ALF group had massive inflammatory cell infiltration and hepatocytes necrosis,which were reduced by AGK2 *** comparison to the normal group,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+in the TAA-induced ALF model group were significantly increased,which were decreased by AGK2 *** levels of MFN2 and GPX4 were decreased in TAA-induced mice compared with the normal group,which were enhanced by AGK2 *** with the TAA-induced L02 cell,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+were further increased and levels of MFN2 and GPX4 were decreased in the MFN2-siRNA ***2 pre-treatment decreased the apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+and enhanced the protein expression of MFN2 and GPX4 in MFN2-siRNA treated L02 *** observation showed that level of MAMs was promoted in the AGK2 pre-treatment group when compared with the TAA-induced gr

关键词： SIRT2 inhibitor AGK2 Acute liver failure MFN2 Ferroptosis