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Development of CaP nanocomposites as photothermal actuators for doxorubicin delivery to enhance breast cancer treatment

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Journal of Materials Science & Technology 2021年第4期63卷 73-80页

作者： Jie Liu Li Li Run Zhang Zhi Ping Xu australian institute for bioengineering and nanotechnology The University of QueenslandSt LuciaQLD4072Australia

Breast cancer is the most common one in women worldwide and doxorubicin(Dox)is one of the most commonly used and effective drugs for breast cancer ***,Dox-based chemotherapy faces irreversible cardiotoxicity and unsatisfactory therapy *** is desirable to devise Dox nanoformulations with less adverse effects and greater therapeutic efficacy for this cancer *** this work,a multifunctional calcium phosphate nanoformulation(ICG-Dox/DNA@CaP)was developed by co-loading Dox/DNA complexes and indocyanine green(ICG)molecules for photothermal therapy(PTT)-enhanced *** this nanocomposite,using DNA as Dox carrier facilitated Dox loading into the CaP matrix,and significantly reduced Dox leakage as well as cytotoxicity in comparison with that of free Dox in physiological medium(pH 7.4).In specific,ICG-Dox/DNA@CaP only released Dox in a weakly acidic nuclease-containing environment,such as tumor microenvironment and endosome/***,Dox/DNA complexes exhibited synergistic interactions with ICG-based photothermal effect on tumor cell apoptosis in this ICG-Dox/DNA@CaP *** work has demonstrated a new strategy to combine FDA-approved therapeutics(Dox and ICG)in CaP-based nanomaterials for reduced cytotoxicity and enhanced therapeutic effect,and provided a new way to engineer CaP carriers as multifunctional delivery systems for clinical anti-cancer therapy.

关键词： chemotherapy doxorubicin breast

Nanoemulsions for drug delivery

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Particuology 2022年第5期20卷 85-97页

作者： Russell J.Wilson Yang Li Guangze Yang Chun-Xia Zhao australian institute for bioengineering and nanotechnology The University of QueenslandSt Lucia Queensland 4072Australia

Emulsions are liquid-liquid dispersions with one liquid phase dispersed in the other liquid phase as small *** are nano-sized emulsions with sizes ranging from tens to hundreds of nanometers,and have great potential applications in pharmaceutics,foods and cosmetics due to their attractive properties,such as small sizes,high surface area per unit volume,improved dispersion of active hydrophobic components and enhanced *** article provides an overview of nanoemulsions for drug delivery,starting with an introduction of emulsion types,nanoemulsion preparation and nanoemulsion *** play critical roles in producing and stabilizing *** types of surfactants are summarized including small molecule surfactants,particle surfactants,phospholipids,peptide and protein *** the applications of nanoemulsions as nanomedicine in drug delivery are ***,clinical applications of nanoemulsions are discussed.

关键词： Nanoemulsions Surfactants Drug delivery Nanomedicine Peptide surfactant

Ligand engineering of perovskite quantum dots for efficient and stable solar cells

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Journal of Energy Chemistry 2022年第6期31卷 626-648,I0018页

作者： Shanshan Ding Mengmeng Hao Tongen Lin Yang Bai Lianzhou Wang School of Chemical Engineering and australian institute of bioengineering and nanotechnology The University of QueenslandBrisbaneQLD 4072Australia

Lead halide perovskite quantum dots(PQDs) have recently emerged as promising light absorbers for photovoltaic application due to their extraordinary optoelectronic properties. Surface ligands are of utmost importance for the colloidal stability and property tuning of PQDs, while their highly dynamic binding nature not only impedes further efficiency improvement of PQD-based solar cells but also induces intrinsic instability. Tremendous efforts have been made in ligand engineering with good hopes to solve such challenging issues in the past few years. In this review, we first present a fundamental understanding of the role of surface ligands in PQDs, followed by a brief discussion and classification of various ligands that have the potential for improving the electronic coupling and stability of PQD solids. We then provide a critical overview of recent advances in ligand engineering including the strategies of in-situ ligand engineering, postsynthesis/-deposition ligand-exchange, and interfacial engineering, and discuss their impacts on changing the efficiency and stability of perovskite QD solar cells(QDSCs). Finally, we give our perspectives on the future directions of ligand engineering towards more efficient and stable perovskite QDSCs.

关键词： Perovskite quantum dots Ligand engineering Defect passivation Solar cells Stability

Confined growth of ZIF-8 in dendritic mesoporous organosilica nanoparticles as bioregulators for enhanced mRNA delivery in vivo

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National Science Review 2021年第8期8卷 198-207页

作者： Yue Wang Hao Song Chao Liu Ye Zhang Yueqi Kong Jie Tang Yannan Yang Chengzhong Yu australian institute for bioengineering and nanotechnology The University of Queensland School of Chemistry and Molecular Engineering East China Normal University

Zeolitic imidazolate framework-8(ZIF-8) and its composites have diverse applications. However,ZIF-8-based nanocomposites are mainly used as carriers in biomolecular delivery, with the functions of metal ions and ligands rarely used to modulate the biofunctions. In this work, dendritic mesoporous organosilica nanoparticles(DMONs) with tetrasulfide bond were used to confine ZIF-8 growth partially inside mesopores as a novel nanocomposite for m RNA delivery. Each component in the resultant DMONs-ZIF-8 contributed to m RNA delivery applications, including high loading benefitting from positively charged ZIF-8 and large mesopores of DMONs, endosomal escape promoted by the imidazole ring of ZIF-8, and long-term glutathione depletion mediated by both zinc ions and tetrasulfide *** together, DMONs-ZIF-8 demonstrated enhanced m RNA translation and better transfection efficiency than commercial products and toxic polymer-modified DMONs in vitro and in vivo.

关键词： mesoporous organosilica nanoparticles metal-organic framework mRNA transfection cellular delivery bioregulator

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek W.Wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Performance improvement of hybrid polymer membranes for wastewater treatment by introduction of micro reaction locations

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Progress in Natural Science:Materials International 2018年第2期28卷 148-159页

作者： Ying Wang Ming Yong Song Wei Yuqing Zhang Wei Liu Zhiping Xu School of Chemical Engineering and Technology Tianjin University australian institute for bioengineering and nanotechnology University of Queensland

This article reviews the progresses on polymer membranes embedded with novel inorganic nanomaterials to provide micro reaction locations(MRLs) in the polymer matrices for wastewater treatment. Ultrafiltration(UF)membranes, especially polyvinylidene fluoride(PVDF) and polysulfone(PSF) membranes, are broadly applied in wastewater treatment. The strategy of embedding functional nanomaterials into the polymer matrices has been extensively investigated to enhance the integrated properties of polymer membrane. Nevertheless, the performance enhancement just comes from physical interactions between nanomaterials and wastes, while the chemical interactions are not involved, thus limiting further improvements. In order to further enhance the integrated properties of polymer membranes, functional inorganic nanomaterials that can chemically react with the wastes are proposed and embedded into the polymer membranes to form many MRLs. In this paper, the strategies for embedding functional nanomaterials such as sulfated TiO2deposited SiO2nanotubes, solid superacid porous ZrO2shell/void/TiO2core particles and porous YxFeyZr1-x-yO2coated TiO2solid superacid nanoparticles in polymer membranes were presented and the enhancement effect of MRLs on their integrated properties for wastewater treatments was discussed. Therefore, polymer membranes embedded with functional inorganic nanomaterials with MRLs are potentially applied in various wastewater treatments.

关键词： Nanomaterials Micro reaction locations Polymer membrane Ultrafiltration Wastewater treatment

Highly efficient nitrogen fixation over S-scheme heterojunction photocatalysts with enhanced active hydrogen supply

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National Science Review 2024年第5期11卷 315-325页

作者： Tong Bao Yamin Xi Chaoqi Zhang Peiyang Du Yitong Xiang Jiaxin Li Ling Yuan Chengzhong Yu Chao Liu School of Chemistry and Molecular Engineering East China Normal University australian institute for bioengineering and nanotechnology The University of Queensland

Photocatalytic N2fixation is a promising strategy for ammonia（NH3） synthesis;however,it suffers from relatively low ammonia yield due to the difficulty in the design of photocatalysts with both high charge transfer efficiency and desirable N2adsorption/activation ***,an S-scheme CoSx/ZnS heterojunction with dual active sites is designed as an efficient N2fixation *** CoSx/ZnS heterojunction exhibits a unique pocket-like nanostructure with small ZnS nanocrystals adhered on a single-hole CoSxhollow *** the heterojunction,the ele ctronic interaction between ZnS and CoSxcreates electron-deficient Zn sites with enhanced N2chemisorption and electron-sufficient Co sites with active hydrogen supply for N2hydrogenation,cooperatively reducing the energy barrier for *** combination with the promoted photogenerated electron-hole separation of the S-scheme heterojunction and facilitated mass transfer by the pocket-like nanostructure,an excellent N2fixation performance with a high NH3yield of 1175.37 μmol g-1h-1is *** study provides new insights into the design of hetero junction photocatalysts for N2fixation.

关键词： photocatalysis nitrogen fixation S-scheme heterojunction active hydrogen ammonia

Noble-metal-free MoS2/Ta3N5 heterostructure photocatalyst for hydrogen generation

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Progress in Natural Science:Materials International 2018年第2期28卷 189-193页

作者： Mu Xiao Bin Luo Supphasin Thaweesak Lianzhou Wang Nanomaterials Centre School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology the University of Queensland

A noble-metal-free heterostructure composed of Ta3N5nanosheets and MoS2co-catalyst was developed as an efficient photocatalyst for hydrogen production. In special, the MoS2/Ta3N5heterostructure with 5.2 wt% of MoS2exhibits a H2generation rate of 119.4 μmol h-1g-1, which is comparable to that of Ta3N5nanosheets with Pt as co-catalyst. The efficient H2 generation for MoS2/Ta3N5 heterostructure is resulted from the short diffusion distance of photo-excited charge carriers in Ta3 N5 nanosheets, efficient transfer of electrons from Ta3 N5 nanosheets to MoS2surface, and reduced overpotential for water reduction. Furthermore, the stability of the MoS2/Ta3N5heterostructured photocatalysts are evaluated for the photocatalytic H2generation.

关键词： MoS2 Ta3N5 nanosheets Heterostructure Photocatalysis Hydrogen evolution

Perovskite solar modules hit new efficiency record

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Science Bulletin 2017年第19期62卷 1293-1294页

作者： Yang Bai Lianzhou Wang Nanomaterials Centre Australian Institute for Bioengineering and Nanotechnology and School of Chemical EngineeringThe University of Queensland

The last few years witnessed exceptional advancement of organohalide perovskite photovoltaics owing to their intriguing optoelectronic *** power conversion efficiency(PCE)of the state-of-art lab-scale perovskite solar... 详细信息

关键词：太阳能电池钙钛矿组件功率转换效率实验室规模光电特性 PSCs 孔面积