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Prevalence of Dyslipidemia among Patients Received at the Biochemistry Unit of the charles de Gaulle Pediatric University Hospital in Ouagadougou

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Advances in Biological Chemistry 2024年第1期14卷 16-26页

作者： Fabienne Marie Soudre Arnaud Kouraogo Alice Kiba Ollo Da Mahutin Benoîte Hounhoui Diema Nadia Karama Seraphine Mano Denis Claude Drabo Augustin Kyetega Raoul Karfo Elie Kabre Jean Sakande Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso charles de Gaulle Pediatric University Hospital Ouagadougou Burkina Faso Health Sciences Institute Nazi BONI University Bobo Dioulasso Burkina Faso Biochemistry Unit Sourou Sanou University Hospital Bobo Dioulasso Burkina Faso Tengandogo University Hospital Ouagadougou Burkina Faso Faculty of Health Sciences Saint Thomas d’Aquin University Ouagadougou Burkina Faso Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso National Agency for Environmental Food Labor and Health Product Safety Ouagadougou Burkina Faso

Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the prevalence of dyslipidemia in the biochemistry unit of the charles De Gaulle Pediatric University Hospital (CHUP-CDG) in Ouagadougou. Material and Methods: This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients of all ages who performed a lipid panel in the CHUP-CDG biochemistry unit during the study period have been included. Results: A total of 2872 patients have been included. The mean age of the study population was 27.72 ± 19.51 years and the M/F sex ratio was 0.81. Among the patients, 22.84% had at least one dyslipidemia. The prevalences of hypercholesterolemia, hypo-HDL cholesterolemia and hyper-LDL cholesterolemia were 11.57%, 49.19% and 57.50% respectively. Hypertriglyceridemia and mixed hyperlipidemia were present in 9.04% and 2.08% of patients. Hypercholesterolemia was significantly more frequent in the female sex (p = 0.0077);hyper-LDL cholesterolemia (p = 0.0255) and mixed hyperlipidemia (p Conclusion: The relatively high prevalence of dyslipidemia in the study indicates a worrying situation. It would therefore appear essential to extend the search for risk factors nationwide, particularly those that can be modified, in order to reduce morbidity and mortality linked to cardiovascular disease.

关键词： Dyslipidemia Lipid Profile Lipid Abnormalities Prevalence Burkina Faso

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Proteomic-based evidence for adult neurogenesis in birds and mammals as indicated from cerebrospinal fluid

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Neural Regeneration Research 2022年第12期17卷 2576-2581页

作者： Eleni Voukali Michal Vinkler Department of Zoology Faculty of ScienceCharles UniversityPragueCzech Republic

Adult neurogenesis is the life-long process of neural stem cell proliferation,differentiation into neurons,migration,and incorporation into the existing neuronal *** decades of research,it is now widely accepted that mammals and birds retain the capacity to regenerate neurons even after their subadult *** fluid participates in the regulation of the neurogenic niches of the vertebrate brain through signaling pathways not fully *** studies of cerebrospinal fluid have the potential to allow the in-depth characterization of its molecular *** studies help to delineate those pathways that are universally critical for the regulation of neurogenesis in *** this review,we performed literature-based data mining in studies using liquid chromatography-tandem mass spectroscopy that analyzed cerebrospinal fluid samples from healthy adult humans(Homo sapiens);mice(Mus musculus);sheep(Ovis aries);chickens(Gallus gallus);and two parrot species,the budgerigar(Melopsittacus undulatus)and cockatiel(Nymphicus hollandicus).We identified up to 911 proteins represented in cerebrospinal fluid,involved in various pathways regulating adult ***,only 196 proteins were common across humans,mice,and *** components involved in nervous system development,cell migration,and axonal guidance were commonly evident in all species investigated so *** bioinformatic analysis revealed that the universally over-represented pathways involved L1 cell adhesion molecule protein interactions,cell-adhesion molecules,signals regulating extracellular matrix remodeling,regulation of insulin growth factor signaling,axonal guidance,programmed cell death,immune signaling,and post-translational *** of the reported proteins are part of extracellular vesicles enriched in cerebrospinal ***,the information presently available is still highly fragmentary,and far more questions persist than

关键词： adult neurogenesis birds cerebrospinal fluid chicken comparative proteomics human mammals mass spectrometry parrots

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Should we resect colorectal cancer in patients over the age of 85?

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World Journal of Gastrointestinal Oncology 2021年第3期13卷 185-196页

作者： David E Flynn Derek Mao stephanie Yerkovich Robert Franz Harish Iswariah Andrew Hughes Ian Shaw Diana Tam Manju Chandrasegaram Department of General Surgery The Prince Charles HospitalChermside 4032QueenslandAustralia Department of General Surgery The Prince Charles HospitalBrisbane 4032QueenslandAustralia The Common Good Foundation The Prince Charles HospitalBrisbane 4032QueenslandAustralia

BACKGROUND The prevalence of colorectal cancer in the elderly is rising,with increasing numbers of older patients undergoing ***,there is a paucity of information on the surgical outcomes and operative techniques used in this *** To evaluate the post-operative outcomes for patients≥85 years old following colorectal cancer resection as well as evaluating the outcomes of laparoscopic resection of colorectal cancer in patients over *** Patients who underwent colorectal cancer resection at our institution between January 2010 and December 2018 were *** study was divided into two *** part one,patients were divided into two groups based on age:Those age≥85 years old(n=48)and those aged 75-84 years old(n=136).Short term surgical outcomes and clinicopathological features were compared using appropriate parametric and non-parametric *** part two,patient’s over 85 years old were divided into two groups based upon operative technique:Laparoscopic(n=37)vs open(n=11)colorectal ***-term postoperative outcomes of each approach were *** The median length of stay between patients over 85 and those aged 75-85 was eight days,with no statistically significant difference between the groups(P=0.29).No significant difference was identified between the older and younger groups with regards to severity of complications(P=0.93),American Society of Anaesthesiologists grading(P=0.43)or 30-d mortality(2%vs 2%,P=0.96).Patients over 85 who underwent laparoscopic colorectal resection were compared to those who underwent an open *** median length of stay between the groups was similar(8 vs 9 d respectively)with no significant difference in length of stay(P=0.18).There was no significant difference in 30-d mortality rates(0%vs 9%,P=0.063)or severity of complication grades(P=0.46)between the laparoscopic and open surgical *** No significant short term surgical differences were identified in patients≥

关键词： Aged Colorectal neoplasms General surgery Open abdomen techniques Laparoscopy Colorectal surgery

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Administration of pre/probiotics with conventional drug treatment in Alzheimer’s disease

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Neural Regeneration Research 2020年第3期15卷 448-449页

作者： Jakub Hort Martin Valis Francesco Angelucci Memory Clinic Department of Neurology2nd Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic International Clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic Department of Neurology University Hospital Hradec KraloveCharles University in PragueFaculty of Medicine in Hradec KraloveCzech Republic

Alzheimer’s disease(AD)is a neurodegenerative disease with long preclinical phase,typically followed by a slow decline in memory,thinking and reasoning *** underlying pathological processes are not yet fully elucidated,although two main disease hallmarks have been associated with AD pathology:amyloid beta species and neurofibrillary *** plaques are deposits of a protein fragment called beta-amyloid(Aβ),which accumulates in the spaces between *** are twisted fibers of the tau protein,which accumulates inside the cells.

关键词： Alzheimer amyloid clinical

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维生素A加用二十二碳六烯酸治疗视网膜色素变性患者的临床试验研究

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 16-17页

作者： Berson E.L. Rosner B. Sandberg M.A. 张磊 Berman-Gund Labo ratory 243 Charles St Boston MA 02114 United States Dr.

Objective: To determine whether a therapeutic dose of docosahexaenoic acid (DH A), an ω-3 fatty acid, will slow the course of retinal degeneration in adult p atients with retinitis pigmentosa who are also receiving vitamin A. Design: Rand omized, controlled, double-masked trial of 221 patients, aged 18 to 55 years, e valuated over a 4-year interval. Patients were given either 1200 mg/d of docosa hexaenoic acid or control capsules. All were given 15000 IU/d of vitamin A (give n as retinyl palmitate). Randomization considered genetic type and baseline diet ary ω-3 fatty acid intake. Main Outcome Measures: The primary outcome measure was the total point score for the 30-2 program of the Humphrey field analyzer; secondary outcome measures were the total point score for the 30-2 and 30/60-1 programs combined, 30-Hz electroretinogram amplitude, and Early Treatment Diab etic Rentinopathy study visual acuity. Results: No significant differences in de cline in ocular function were found between the docosahexaenoic acid plus vitami n A (DHA +A) group and control plus vitamin A (control +A)-group over a 4-ye ar interval among all 221 randomized patients or among the 208 patients who comp leted all 4 follow-up visits. The mean annual rate of loss of sensitivity for the Humphrey Field Analyzer 30-2 programwas 37 dB for the DHA +A group and 38 dB for the control +A group (P=0.88). For the Humphrey Field Analyzer 30-2 and 30/60-1 programs combined, the mean annual rates of loss of field sensitivity were 57 dB for the DHA +A group and 60 dB (P=0.73) for contro l +A group. No toxic adverse effects were observed. No significant differences by treatment group assignment were observed within genetic types or within the c ategory of baseline ω-3 fatty acid intake. Conclusion: In patients assigned to receive 15000 IU/d of vitamin A, this randomized trial showed that 1200 mg/d of docosahexaenoic acid supplementation over a 4-year interval did not, on averag e, slow the course of disease i

关键词：视网膜色素变性临床试验研究二十二碳六烯酸视网膜电图视野计棕榈酸视黄酯联合分析视功能视力检查下降值

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Updates on management of gliomas in the molecular age

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World Journal of Clinical Oncology 2024年第2期15卷 178-194页

作者： Ali Ahmed Mohamed Rakan Alshaibi steven Faragalla Youssef Mohamed Brandon Lucke-Wold charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Florida International UniversityMiamiFL 33199United States College of Osteopathic Medicine Kansas City UniversityJoplinMO 64804United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic *** developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular *** review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year *** adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and *** contrast,pediatric gliomas,due to their diversity,require a more tailored *** complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and ***-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be *** recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric *** review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.

关键词： Gliomas Chemotherapy Radiotherapy Isocitrate dehydrogenase type mutant Pediatric gliomas Astrocytoma Oligodendroglioma 1p/19q-codeleted

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对接受维生素A治疗的视网膜色素变性患者加用二十二碳六烯酸效果的进一步分析:亚群分析

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 17-18页

作者： Berson E.L. Rosner B. Sandberg M.A. 张磊 Berman-Gund Labo ratory 243 Charles St Boston MA 02114 United States Dr.

Objective: To determine whether docosahexaenoic acid will slow the course of r etinal degeneration in subgroups of patients with retinitis pigmentosa who are r eceiving vitamin A. Design: Acohort of 208 patients with retinitis pigmentosa, a ged 18 to 55 years, were randomly assigned to 1200 mg of docosahexaenoic acid pl us 15000 IU/d of vitamin A given as retinyl palmitate (DHA +A group) or control fatty acid plus 15000 IU/d of vitamin A (control +A group) and followed up ove r 4 years. Seventy percent of the patients in each group were taking vitamin A, 15000 IU/d, prior to entry. We compared rates of decline in ocular function in t he DHA +A vs control +A groups among the subgroups defined by use or nonuse of vitamin A prior to entry. We also determined whether decline in ocular function was related to red blood cell phosphatidylethanolamine docosahexaenoic acid lev el, dietary ω-3 fatty acid intake, or duration of vitamin A use. Main outcome measures were Humphrey Field Analyzer visual field sensitivity, 30-Hz electrore tinogram amplitude, and visual acuity. Results: Among patients not taking vitami n A prior to entry, those in the DHA +A group had a slower decline in field sen sitivity and electroretinogram amplitude than those in the control +A group ove r the first 2 years (P=.01 and P=.03, respectively); these differences were not observed in years 3 and 4 of follow-up or among patients taking vitamin A prior to entry. In the entire cohort, red blood cell phosphatidylethanolamine docosah exaenoic acid level was inversely related to rate of decline in total field sens itivity over 4 years (test for trend, P=0.05). This was particularly evident ove r the first 2 years among those not on vitamin A prior to entry (test for trend, P=0.003). In the entire control +A group, dietary ω-3 fatty acid intake was inversely related to loss of total field sensitivity over 4 years (intake,< 0.20 vs ≥0.20 g/d; P= 0.02). The duration of vitamin A supplementation prior to ent r

关键词：视网膜色素变性二十二碳六烯酸群分析视网膜电图视功能棕榈酸视黄酯磷脂酰乙醇胺负相关趋势检验队列研究

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An in vivo Evaluation of Ultra-fine Grained Titanium Implants

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Journal of Materials Science & Technology 2009年第4期25卷 556-560页

作者： S. Bindu K.P. Sanosh K. Smetana A. Balakrishnan T.N. Kim Department of Life Science and Genetic Engineering Paichai University Department of Information and Electronic Materials Engineering Paichai University charles University 1st and 2nd Faculty of MedicineInstitute of Anatomy and Center of Cell Therapy and Tissue Repair

The present work focuses mainly on an in vivo evaluation of ultra fine grained titanium （UFG-Ti） obtained by severe plastic deformation （SPD）. The SPD on commercially produced Grade 2 titanium （Cp-Ti） resulted in the refinement of the grain size by several orders of magnitude. Polished surfaces having similar roughness from both UFG-Ti and Cp-Ti were prepared. In vitro test revealed the presence of fibronectin, which was involved in the attachment of the cells to the substrate. Phase contrast micrographs showed the highest signal of fibronectin in UFG-Ti, indicating that it is more cytocompatible than Cp-Ti. In vivo tests, by subcutaneous implantation of the metals in the rats showed the better biocompatibility of UFG-Ti over Cp-Ti. The improved biocompatibility of UFG-Ti was attributed to the presence of surface discontinuities （in the form of nano-defects）, surface energy, higher wettability, surface stress and stable TiO2 films, which increased the protein adsorption on the surface.

关键词： Surfaces Grain size Titanium In vivo Biocompatibility

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Only mothers feed mature offspring in European Ceratina bees

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Insect Science 2021年第5期28卷 1468-1481页

作者： Michael Mikat Jitka Waldhauserova Tereza Frankova Katerina Cermakova Vojtech Broz Simon Zeman Marcela Dokulilova Jakub straka Department of Zoology Faculty of ScienceCharles UniversityPragueCzech Republic Jihlava Grammar School JihlavaCzech Republic Department of Ecology Faculty of ScienceCharles UniversityPragueCzech Republic

Parental care directed to adult offspring is uncommon in *** parental care has been documented in Xylocopinae bees(Hymenoptera:Apidae).Moreover,some Ceratina bees(Xylocopinae)are known to feed mature siblings,and feeding of mature siblings is achieved by dwarf eldest daughters when mothers *** daughters are intentionally malnourished by mothers and usually originate from the first brood ***,we examined the pattern of care prov ided to young adults in three small European carpenter bees:Ceratina(Ceratina)cucurbitina,C.(Euceratina)chalybea,and C.(E.)*** of nest departures and arrivals were performed to study foraging *** detected intensive foraging behavior of mothers in all three studied ***,we did not observe regular foraging bchavior of daughters in any *** experimental removal of mothers in *** led to the emigration of young adults and did not initiate foraging activity in *** conclude that the feeding of siblings does not occur in these species unlike in the American species *** detected female-biased sex ratios in the first brood cell in *** and *** offspring in the first brood cell was smaller than other female offspring only in *** results show that a female-biased sex ratio and the small size of daughters in the first brood cell do not provide sufficient ev idence for demonstrating the existence of an altruistic daughter and also that the pattern of maternal investment is not exclusively shaped by social interactions.

关键词： foraging trip Hymenoptera maternal care provisioning sociality Xylocopinae

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Initial Error Growth and Predictability of Chaotic Low-dimensional Atmospheric Model

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International Journal of Automation and computing 2014年第3期11卷 256-264页

作者： Hynek Bednár Ale Raidl Jiri Mikovsk Department of Meteorology and Environment Protection Faculty of Mathematics and Physics Charles University in Prague

The growth of small errors in weather prediction is exponential on average. As an error becomes larger, its growth slows down and then stops with the magnitude of the error saturating at about the average distance between two states chosen *** paper studies the error growth in a low-dimensional atmospheric model before, during and after the initial exponential divergence occurs. We test cubic, quartic and logarithmic hypotheses by ensemble prediction method. Furthermore, the quadratic hypothesis suggested by Lorenz in 1969 is compared with the ensemble prediction method. The study shows that a small error growth is best modeled by the quadratic hypothesis. After the error exceeds about a half of the average value of variables, logarithmic approximation becomes superior. It is also shown that the time length of the exponential growth in the model data is a function of the size of small initial error and the largest Lyapunov exponent. We conclude that the size of the error at the least upper bound(supremum) of time length is equal to 1 and it is invariant to these variables. Predictability, as a time interval, where the model error is growing, is for small initial error, the sum of the least upper bound of time interval of exponential growth and predictability for the size of initial error equal to 1.

关键词： Chaos planetary atmospheres prediction methods error analysis modeling.

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