检索结果-南通市图书馆

Targeting TrkB–PSd-95 coupling to mitigate neurological disorders

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang John Marshall department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanical Property Prediction of Commercially Pure Titanium Welds with Artificial Neural Network

引用

Journal of Materials Science & Technology 2005年第3期21卷 403-407页

作者： YanhongWEI K.K.d.H.Bhadeshia T.Sourmail StateKeyLaboratoryofAdvancedWeldingProductionTechnology HarbinInstituteofTechnologyHarbin150001China departmentofMaterialsScienceandMetallurgy UniversityofCambridgeCambridgeCB23QZUK

Factors that affect weld mechanical properties of commercially pure titanium have been investigated using artificial neural networks. Input data were obtained from mechanical testing of single-pass, autogenous welds, and neural network models were used to predict the ultimate tensile strength, yield strength, elongation, reduction of area, Vickers hardness and Rockwell B hardness. The results show that both oxygen and nitrogen have the most significant effects on the strength while hydrogen has the least effect over the range investigated. Predictions of the mechanical properties are shown and agree well with those obtained using the 'oxygen equivalent' (OE) equations.

关键词： Commercially pure titanium Artificial neural networks Mechanical properties Weld

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

double-skin façade simulation with computational fluid dynamics:A review of simulation trends,validation methods and research gaps

引用

Building Simulation 2023年第12期16卷 2307-2331页

作者： Simon Pommerencke Melgaard Ivan Titov Nikolaisson Chen Zhang Hicham Johra Olena Kalyanova Larsen department of the Built Environment Aalborg UniversityDenmarkThomas Manns Vej 239220 AalborgDenmark

dynamic simulation of a double-skin façade(dSF)with computational fluid dynamics(CFd)can be challenging due to the lack of validated models and benchmarking ***,there is a lack of consensus in the scientific community on what constitutes a successfully validated dSF *** present review study identifies simulation trends and research gaps for dSFs simulated with ***,this article presents a series of CFd simulations in which key aspects of the dSF modelling are varied:2d or 3d modelling approaches,turbulence viscosity models(TVMs),radiation models,and wall *** simulation results are compared to the empirical data(both temperature and velocity fields)of a benchmark test with laboratory-controlled boundary *** analysis shows that using the k-εRNG model with enhanced wall treatment and surface-to-surface(S2S)radiation model yields the best results for the 2d case of natural convection ***,it is shown that accounting for the velocity field in the validation process is essential to ensure the suitability of a ***,the authors advocate for the use of selected dimensionless numbers to improve the comparability of the different dSF scientific *** would also help to identify relevant experimental datasets for validation and suitable CFd simulation settings for specific dSF cases.

关键词： double-skin facade ventilated cavity computational fluid dynamics empirical validation modelling parameters dimensionless numbers convection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Scaling granular material with polygonal particles in discrete element modeling

引用

Particuology 2023年第4期75卷 151-164页

作者： Alireza Ahmadi Stefan Larsson Carl Wersall KTH Royal Institute of Technology Division of Soil and Rock MechanicsBrinellvagen 2310044StockholmSweden

despite advancements in computational resources,the discrete element method(dEM)still requires considerable computational time to solve detailed problems,especially when it comes to the large-scale *** addition to the geometry scale of the problem,the particle shape has a dramatic effect on the computational cost of ***,many studies have been performed with simplified spherical particles or *** scaling is an approach to increase the particle size to reduce the number of particles in the *** several particle scaling methods have been introduced,there are still some disagreements regarding their applicability to certain aspects of *** this study,the effect of particle scalping on the shear behavior of granular material is *** granular particles were scanned and imported as polygonal particles in the direct shear *** effect of particle size distri-bution,particle angularity,and the amount of scalping were *** results show that particle scalping can simulate the correct shear behavior of the model with significant improvement in computational ***,the accuracy of the scalping method depends on the particle angularity and particle size range.

关键词： Particle scaling direct shear test discrete element method PFC Polygonal shape Granular material

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of ribavirin dose on retreatment of chronic hepatitis C patients

引用

World Journal of Gastroenterology 2012年第23期18卷 2966-2972页

作者： Christiane Stern Michelle Martinot-Peignoux Marie Pierre Ripault Nathalie Boyer Corinne Castelnau dominique Valla Patrick Marcellin Service d'Hépatologie and INSERM U773-CRB3 H pital Beaujon University Paris-Diderot

AIM: To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis C (CHC) relapsing patients. METHOdS: Out of 1228 CHC patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV), 165 (13%) had a relapse. Among these, 62 patients were retreated with PEG-IFN-2a or-2b and RBV. Clinical, biological, virological and histological data were collected. Initial doses and treatment modifications were recorded. The efficacy of retreatment and predictive factors for SVR were analyzed. RESULTS: An SVR was achieved in 42% of patients. SVR was higher in young (d patients (27%) (P = 0.007), and in genotype 2 or 3 (57%) than in genotype 1 or 4 (28%) patients (P = 0.023). Prolonging therapy for at least 24 wk more than the previous course was associated with higher SVR rates (53% vs 28%, P = 0.04). Also, a better SVR rate was observed with RBV dose/body weight > 15.2 mg/kg per day (70% vs 35%, P = 0.04). In logistic regression, predictors of a response were age (P = 0.018), genotype (P = 0.048) and initial RBV dose/body weight (P = 0.022). None of the patients without a complete early virological response achieved an SVR (negative predictive value = 100%). CONCLUSION: Retreatment with PEG-IFN/RBV is effective in genotype 2 or 3 relapsers, especially in young patients. A high dose of RBV seems to be important for the retreatment response.

关键词： Chronic hepatitis C Relapse Retreatment Ribavirin Pegylated interferon

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fractional-Linear Transformations of Operator Balls;Applications to dynamical Systems

引用

Acta Mathematica Sinica,English Series 2006年第6期22卷 1687-1694页

作者： V.A.KHATSKEVICH V.A.SENdEROV Braude College College Campus P.O 23-2-156 Pyatnitskoe highway

The operator sets, which are the subject of this paper, have been studied in many papers where, under different restrictions on the generating operators, convexity, compactness in the weak operator topology, and nonemptiness were proved for sets of different classes under study. Then the results obtained were used in these papers to solve several applied problems. Namely, they played the key role in establishing the dichotomy of nonautonomous dynamical systems, with either continuous or discrete time. In the present paper, we generalize and sharpen the already known criteria and obtain several new criteria for convexity, compactness, and nonemptiness of several special operator sets. Then, using the assertions obtained, we construct examples of sets of the form under study which are nonconvex, noncompact in the weak operator topology, as well as empty, and are generated by ＂smooth＂ operators of a special class. The existence problem for such sets remained open until the authors of this paper announced some of its results.

关键词： Compactness Convexity Linear fractional relation Operator ball Krein space

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PMd and Cd Characterization of Chirped FBG Using Microwave Photonic Technique

引用

光学学报 2003年第S1期23卷 133-134页

作者： Xiaoke Yi, Chao Lu, Fang Wei, Yixin Wang, Wende Zhong Network Technology Research Center (S2-B3c-23), Nanyang Technological University. Singapore 639798 Institute for Communications Research, Singapore Network Technology Research Center S2-B3c-23 Nanyang Technological University Singapore 639798 Institute for Communications Research Singapore

We present and demonstrate experimentally a new method for measuring the polarization-mode-dispersion(PMd) of a Chirped Fiber Bragg Grating. The technique has also been applied to accurate chromatic dispersion evaluat... 详细信息

关键词： PMd and Cd Characterization of Chirped FBG Using Microwave Photonic Technique on in CFBG of Cd

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corrosion Behavior of AZ31 Magnesium Alloy in Highly Alkaline Environment

引用

Acta Metallurgica Sinica(English Letters) 2017年第4期30卷 367-375页

作者： Somi doja Lukas Bichler Simon Fan School of Engineering University of British ColumbiaOkanagan 3333 University Way Kelowna BC V1V 1VTCanada ZincNyx Energy solutions Vancouver BC V6P 6T3 Canada

Industrial components made with a magnesium-aluminum alloy AZ31 are often used in diverse engineering applications where component weight, strength, and durability are critical. Similarly as other Mg alloys, however, the AZ31 is susceptible to corrosion in alkaline environments. In this work, corrosion of commercial grade AZ31 alloy plate was examined in potassium hydroxide （KOH） using immersion and potentiodynamic studies. The results suggest that the concentration of A1 and Mn in the alloy may govern the kinetics of micro-galvanic corrosion and the initiation of corrosion pits. Further, trace amounts of Ni in the AZ31 alloy were seen to enable formation of Ni（OH）2 surface layer, which may have further accelerated alloy corrosion due to its cracking and void coalescence. The effect of pH on the corrosion behavior of AZ31 was studied with reference to Pourbaix diagrams.

关键词： Magnesium alloy AZ31 KOH

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HOM study and parameter calculation of the TESLA cavity model

引用

Chinese Physics C 2010年第1期34卷 99-102页

作者：曾日华 SCHUH Marcel GERIGK Frank WEGNER Rolf 潘卫民王光伟刘熔 Institute of High Energy Physics CAS CERN CH-1211 Geneva 23 Switzerland

The Superconducting Proton Linac （SPL） is the project for a superconducting, high current Haccelerator at CERN. To find dangerous higher order modes （HOMs） in the SPL superconducting cavities, simulation and analysis for the cavity model using simulation tools are necessary. The existing TESLA 9-cell cavity geometry data have been used for the initial construction of the models in HFSS. Monopole, dipole and quadrupole modes have been obtained by applying different symmetry boundaries on various cavity models. In calculation, scripting language in HFSS was used to create scripts to automatically calculate the parameters of modes in these cavity models （these scripts are also available in other cavities with different cell numbers and geometric structures）. The results calculated automatically are then compared with the values given in the TESLA paper. The optimized cavity model with the minimum error will be taken as the base for further simulation of the SPL cavities.

关键词： TESLA 9-cell cavity superconducting proton linac higher order modes HFSS scripts

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Patterns of Ips cembrae(Herr)infestation on trap and standing trees of European larch(Larix decidua Mill.)

引用

Journal of Forestry Research 2023年第6期34卷 2041-2050页

作者： Jakub Špoula Emanuel Kula Faculty of Forestry and Wood Technology Department of Forest Protection and Wildlife ManagementMendel University in BrnoZemědělská3Brno 61300Czech Republic

The large larch beetle,Ips cembrae,is a significant pest causing the death of *** 2020,the attack density of *** on larch trap trees and standing trees was evaluated using sample sections placed along the *** a defensive measure against ***,trap trees were highly effective in both spring and *** attack density increased with increasing trap tree surface area/*** were established evenly throughout the entire trunk including the thin upper *** the number of trap trees was low and their capacity full,a continual aggregation of adults occurred due to pheromone communication,leading to attacks on healthy standing trees in the immediate *** was found that *** attacked standing trees from the trunk base,with a continual colonization of the stem up to 70%of the tree height in a time-differentiated progression of development *** attack density of *** on standing trees was up to 40%lower than on the trap trees.

关键词： Forest protection Ips cembrae Larix decidua Stem infestation Trap tree

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：