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Lyophilized recombinant human brain natriuretic peptide for chronic heart failure:Effects on cardiac function and inflammation

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World Journal of Clinical Cases 2023年第26期11卷 6066-6072页

作者： Feng Li Hao Li Rong Luo Jia-Bao Pei Xue-Ying Yu Department of Cardiovascular Internal Medicine People's Hospital of JieshouJieshou 236500Anhui ProvinceChina

BACKGROUND Chronic heart failure(CHF)is a serious and prevalent condition characterized by impaired cardiac function and *** therapy for CHF has limitations,prompting the exploration of alternative *** human brain natriuretic peptide(BNP)has emerged as a potential therapy,with evidence suggesting that it can improve cardiac function and reduce inflammation in patients with ***,further research is required to determine the efficacy and safety of lyophilized recombinant human BNP in CHF patients and its impact on microinflammatory *** study aimed to investigate the effects of lyophilized recombinant human BNP therapy on CHF patients’cardiac function and microinflammatory *** To investigate the effects of freeze-dried recombinant human BNP therapy on cardiac function and microinflammatory status in patients with *** In total,102 CHF patients admitted to our hospital from January 2021 to January 2022 were randomly assigned to control and observation groups(n=51 patients/group).The control patients were treated with standard HF therapy for 3 d,whereas the observational patients were injected with the recombinant human BNP for 3 *** efficacy,inflammatory factor levels,myocardial damage,cardiac function before and after the treatment,and adverse reactions during treatment were compared between the two *** The overall clinical efficacy was higher in the observation group than in the control *** with baseline,serum hypersensitive C-reactive protein,N-terminal proBNP,and troponin I level,and physical,emotional,social,and economic scores were lower in both groups after treatment,with greater reductions in levels and scores noted in the observation group than in the control *** overall incidence of adverse reactions in the observation group was not significantly different compared with that in the control group(P>0.05).CONCLUSION Freeze-dried recombinant human BNP therapy can

关键词： Chronic heart failure Lyophilized recombinant human brain natriuretic peptide Cardiac function Microinflammatory state

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探究2023年颍淮地区内非重症呼吸道感染者病原体流行特征及现况调查

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临床肺科杂志 2025年第1期30卷 46-51页

作者：李乔张萌萌卢家胜熊庆勇李佳遥谢琳娜陈烁文安徽中医药大学附属太和中医院安徽界首236500 安徽中医药大学安徽界首236500 界首市中医院安徽界首236500

目的回顾性分析颍淮地区内非重症呼吸道病原体感染情况的流行病学特征。方法纳入2023年1月—2023年12月界首市中医院、安徽中医药大学附属太和中医院1238例具有典型呼吸道感染症状的患者,通过20余种病原学检查,回顾性探究颍淮地区内... 详细信息

目的回顾性分析颍淮地区内非重症呼吸道病原体感染情况的流行病学特征。方法纳入2023年1月—2023年12月界首市中医院、安徽中医药大学附属太和中医院1238例具有典型呼吸道感染症状的患者,通过20余种病原学检查,回顾性探究颍淮地区内呼吸道感染患者流行病学特征及现况调查。结果呼吸道病原体总体检出阳性率为59.94%(742/1238),肺炎支原体检出阳性率为49.35%(611/1238),占阳性病例达82.35%(611/742);细菌阳性率为17.69%(219/1238),占29.51%(219/742);病毒阳性率为12.52%(155/1238),占比20.89%(155/742);在所有病原体种类里,排序前5类为肺炎支原体611例、甲型流感病毒109例、乙型流感病毒84例、肺炎克雷伯杆菌68例、铜绿假单胞菌68例;单一病原体感染占阳性病例的71.83%(533/742),混和感染有28.17%(209/742)。在11、3、10、12月检出率较高(P<0.05),实年组和老年组的检出率较低(P<0.05)。无序多分类Logistic回归模型分析结果提示年龄、性别、发病时间3个因素对感染数量均有不同程度的影响。结论 2023年1月-2023年12月颍淮地区内非重症呼吸道传染病感染病原体的阳性检出率较高,病原体感染以肺炎支原体为主,细菌及病毒感染情况减少,有部分患者存在混和感染情况。冬春季节病原体的阳性检出率较高,年长者检出率较低,且时间、年龄、性别会影响病原体混和感染率。

关键词：呼吸道感染病原体流行病学肺炎支原体病毒

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劳动教育:“难解”向“可解”的转化

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中学政治教学参考 2020年第27期 4-5页

作者：姚昌富安徽省界首中学 236500

劳动是个人身心健康发展的基础,是个人习得适应社会能力的重要途径,具有载德、增智、强体、育美的多重功效。因而,劳动教育始终是党和国家培养人才的重要要求,也是思政教育的重要内容。实践中,开展劳动教育仍存在缺乏合适教材等诸多难... 详细信息

劳动是个人身心健康发展的基础,是个人习得适应社会能力的重要途径,具有载德、增智、强体、育美的多重功效。因而,劳动教育始终是党和国家培养人才的重要要求,也是思政教育的重要内容。实践中,开展劳动教育仍存在缺乏合适教材等诸多难题。只有破解这些难题,思政教育才能更好地回归育人本质,回答好“怎样培养人”的问题。

关键词：思政教育培养人才多重功效育人本质怎样培养育美适应社会能力

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项目化学习与议题式教学的关联互济

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中学政治教学参考 2022年第33期 47-49页

作者：杨登芳安徽省界首中学 236500

为进一步适应新课程改革的需要,探索教学策略背后的理论支撑,着力从教学实践中挖掘项目化学习与议题式教学内在联系,用项目化思维进一步优化议题式教学实施,积极探索新形势下思政课课堂改革。特别是在项目化学习背景下,通过构建项目与... 详细信息

为进一步适应新课程改革的需要,探索教学策略背后的理论支撑,着力从教学实践中挖掘项目化学习与议题式教学内在联系,用项目化思维进一步优化议题式教学实施,积极探索新形势下思政课课堂改革。特别是在项目化学习背景下,通过构建项目与场景、探究原委与意义、兼顾发现与创造、注重应用与反思等策略优化议题式教学,借鉴项目化评价完善评价标准、促进课程实践。

关键词：思政课议题式教学项目化学习核心素养

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Iridic oxide nanoparticles grown in situ on BCN nanotubes as highly efficient dual electrocatalyst for rechargeable lithium-O2 batteries

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Journal of Energy Chemistry 2020年第10期29卷 291-298页

作者： Xufang Li Yajun Zhao Jing Zhang Chaoxiong Li Shan Wu Qiufan Shi Dawei Zhang Qingchun Yang School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009AnhuiChina Anhui Province Key Laboratory of Power Battery Tianneng Battery Group(Anhui Company)Jieshou 236500AnhuiChina School of Materials Science and Technology Hefei University of TechnologyHefei 230009AnhuiChina

Oxygen cathode catalysts can significantly address the issues faced by Li-O2 *** this research,a composite of IrO2 nanoparticles grown in situ on BCN nanotubes(IrO2@BCNNTs)has been synthesized by facile hydrothermal method,which is initially fabricated as cathode catalyst for Li-O2 *** results indicate that IrO2@BCNNTs nanocomposite has a better effect on improving the actual discharge capacity,voltage gap and cyclability of Li-O2 *** addition,it is also demonstrated that the Ir O2@BCNNTs composite exhibits bifunctional characteristics for both the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)through rotating disk electrode(RDE)*** excellent performances of the synthesized catalyst may be attributed to the unique interconnected tubular structure and strong synergistic effect,which can provide more charged sites and defect sites and then facilitate reversible Li2 O2 formation and ***,it is promising for applying the rational design of the bifunctional catalyst to Li-O2 battery.

关键词： BCN nanotubes IrO2@BCNNTs composite Rechargeable Li-O2 batteries

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窖泥老化与防治

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酿酒 2001年第6期28卷 42-44页

作者：孙景明安徽沙河王酒厂安徽界首236500

窖泥是生产浓香型优质白酒的重要基础条件.窖泥中生长着种类繁多、功能各异的微生物,如球菌、梭菌、杆菌及其它菌群,其中代谢己酸的梭状芽胞杆菌,是产生浓香型白酒主体香气-己酸乙酯的重要菌种.因而生产浓香型白酒的厂家,都把培养窖泥... 详细信息

窖泥是生产浓香型优质白酒的重要基础条件.窖泥中生长着种类繁多、功能各异的微生物,如球菌、梭菌、杆菌及其它菌群,其中代谢己酸的梭状芽胞杆菌,是产生浓香型白酒主体香气-己酸乙酯的重要菌种.因而生产浓香型白酒的厂家,都把培养窖泥做为提高产品质量的重要措施;把已经成熟的老窖泥视为工厂的'命根子'.然而我们对于已经培养成熟的窖泥又如何防治其老化呢?本文将就这一问题进行探讨.

关键词：窖泥浓香型白酒老化防治微生物

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High-Throughput MicroRNA and mRNA Sequencing Reveals that MicroRNAs May Be Involved in Pectinesterase-Mediated Cold Resistance in Potato

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 561-586页

作者： Chongchong Yan Qianqian Wang Nan Zhang Jiajia Wang Xuexiang Ren Bingjie Xue Xiaojing Pu Zhihong Xu Huajun Liao Anhui Academy of Agricultural Sciences Hefei230031China Anhui Vocational College of City Management Hefei231635China Funan County Agricultural Technology Promotion Center Funan236300China Jieshou County Agricultural Technology Promotion Center Jieshou236500China

Since potato cultivars are sensitive to low temperature,cold injury severely affects the geographical distribution and yield of *** some miRNAs have been identified in response to cold stress in plants,there is no report about the role of miRNAs in the response to cold stress in ***,via high throughput sequencing,we described the profiling of cold stress response to miRNA and mRNA in *** small RNA and six mRNA libraries were constructed and sequenced.296 known and 211 novel miRNAs were identified,in which 34 miRNAs in Cold Group(CG)had the higher expression quantity than which in Normal Group(NG)and 32 in CG had lower expression quantity than which in NG.3068 differentially expressed genes were detected between NG and CG,in which 1400 genes were up-regulated and 1668 genes were *** metabolism pathway of starch and sucrose(ko00500)is the common KEGG pathway in differentially expressed miRNA and *** this pathway,StuPME21575 and StuPME42971 are pectinesterase which mainly catalyzes the pectin-forming pectate,which are controlled by stu-miR6023 and *** the potato suffering cold stress,these two miRNAs expression levels became higher,but their target genes expression levels were just opposite and this result is the same with qRT-PCR.

关键词： Potato microRNA RNA-Seq low-temperature stress pectinesterase

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