检索结果-南通市图书馆

Pretreatment with a modified ***'solution in patients with severe upper limb injuries:Four case reports

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第20期11卷 4926-4931页

作者： Zhong-Yang Sun Li-Yi Li Jian-Xin Xing Liang-Cheng Tong Ying Li Department of Orthopedics Air Force Hospital of Eastern TheaterNanjing 210002Jiangsu ProvinceChina

BACKGROUND This study aims to describe the application of a modified ***'solution in patients with severe limb *** SUMMARY Four patients who sustained a high-energy trauma and underwent complete upper limb amputation were pretreated with a modified ***'solution before upper limb *** the perfusion solution stopped flowing from the blood vessel,the amputated upper limb amputation was *** patients were instructed to perform functional rehabilitation training after the *** 4 patients were followed up for 5 *** the severed upper limbs *** re-examination after the operation showed that the function of the affected limb was *** the patients were satisfied with the sensory and functional recovery of the affected *** The modified ***'solution can effectively improve the success rate of limb salvage surgery and the recovery of limb function in patients with a severe limb injury.

关键词： Severe upper limb injury Preperfusion Modified St.Thomas'solution Case report

INTRANASAL DELIVERY OF NERVE GROWTH FACTOR TO PROTECT THE CENTRAL NERVOUS SYSTEM AGAINST ACUTE CEREBRAL INFARCTION

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 2004年第4期19卷 257-261页

作者： Hong-meiZhao Xin-fengLiu Xiao-weiMao Chun-fuChen DepartmentofNeurology JinlingHospitalMedicalCollegeofNanjingUniversityNanjing210002 TraumaticCenterandEmergencyDepartment EastHospitalShanghai200120

Objective To confirmed reliability and feasibility of intranasal nerve growth factor (NGF) bypassing the blood-brain barrier and its potential neuroprotective effects on acute cerebral ischemia. Methods (1) To assay NGF concentrations in different brain regions after middle cerebral artery occlusion (MCAO).Rats were randomly divided into intranasal (IN) NGF, intravenous (IV) NGF, and untreated group (n= 4). The concentra-tions of NGF of different brain regions in the three groups after MCAO were measured by ELISA. (2) To observe neuro-protective action of NGF on focal cerebral ischemic damage. Rats were randomly assigned to 4 groups: IN vehicle, IN NGF, IV vehicle, IV NGF (n= 8). Treatment was initiated 30 minutes after onset of MCAO and given again 24 hours later. Three neurologic behavioral tests were performed 24 and 48 hours following onset of MCAO. Corrected infarct volumes were determined 48 hours after onset of MCAO. Results The olfactory bulb in IN NGF group obtained the highest concentration (3252 pg/g) of NGF among all regions, followed by the hippocampus. The NGF concentrations in the olfactory bulb and hippocampus in IN NGF group were markedly higher than that in IV NGF and control groups. The infarct volume in IN NGF group was markedly reduced by 38.8% compared with IN vehicle group. IN NGF group vestibulum function markedly improved compared with IN vehicle group at 24 and 48 hours after onset of MCAO (P 24 h = 0.02 and P 48 h = 0.04, respectively). Conclusion Intranasal NGF could pass through the blood-brain barrier, reach the central nervous system, reduce infarct volume, and improve neurologic function in rats following MCAO. Intranasal delivery of NGF may be a promising treat-ment for stroke.

关键词： nerve growth factor middle cerebral artery occlusion intranasal delivery cerebral ischemia

The research of myelinization of normal fetal brain with magnetic resonance imaging

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 1998年第1期111卷 71-74页

作者：王中秋陈君坤秦志宏张建敏 China 210002 China 200003

OBJECTIVE: To investigate the growth and development of myelin of sheath fetal brain. METHODS: Forty-four cases of pregnant women were imaged with magnetic resonance (MR) at 0.35 T (tesla). The signal changes of the main structures of fetal brain were analysed. RESULTS: The signal intensity of cerebral (except basal ganglia) and cerebellar matter was hypo-signal on the T1WI (T1 weighted spin-echo image), iso-signal of the PDWI (Proton density weighted image) and hyper-signal on the T2WI (T2 weighted spin-echo image). As to the brain stem and basal ganglia, their signal intensities showed difference in different gestational weeks on T1WI. The intensities were of slight hypo-signal before and iso-signal after the 29th week. However, their signal intensities on PDWI and T2WI were the same as those of the cerebral and cerebellar matter. CONCLUSIONS: There was no myelinization of fetal cerebral (except basal ganglia) and cerebellar matter during pregnant period. The myelin sheath was formed in the brain stem and basal ganglia after 29 gestational weeks. The process of myelinization began from brain stem to basal ganglia.

关键词： Adult Brain Female Fetus Gestational Age Humans Magnetic Resonance Imaging Myelin Sheath Pregnancy

Current status of novel biologics and small molecule drugs in the individualized treatment of inflammatory bowel disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第48期28卷 6888-6899页

作者： Yi-Han Xu Wei-Ming Zhu Zhen Guo Department of General Surgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina

Treatment strategies for inflammatory bowel disease(IBD)are rapidly evolving with the development of biologics and small molecule drugs(SMDs).However,these drugs are not guaranteed to be effective in all patients,and a“ceiling effect”of biologic monotherapy may *** issue highlights an unmet need for optimizing the use of biologics and predicting therapeutic ***,the development of new drugs with novel mechanisms of action is urgently needed for patients with primary nonresponse and secondary loss of response to conventional biologics and *** addition,combining different biologics or SMDs has been proposed as a novel strategy to enhance treatment efficacy in IBD,which theoretically has multidimensional anti-inflammatory *** on the current evidence available for IBD,dual targeted therapy may be a promising strategy for refractory IBD patients who have failed in multiple biologic treatments or who have extraintestinal ***,identifying the subgroup of IBD patients who are responding to biological combination therapies is also equally important in stable disease *** this review,we summarize the newly developed biologics and SMDs and the current status of biologics/SMDs to highlight the development of individualized treatment in IBD.

关键词： Inflammatory bowel diseases Biologic Dual targeted therapy Therapeutic drug monitoring Bispecific antibodies

Pancreaticoduodenal transplantation with portal venous and enteric drainage in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第6期6卷 914-916页

作者： Gu YP Gu JY Li JS Nanjing Univ Nanjing Gen Hosp Sch Med Transplantat Ctr Nanjing 210002 Jiangsu Provinc Peoples R China

INTRODUCTIONThe use of combined pancreatic and renaltransplantation in patients with diabetes and end-stage renal failure has gained widespreadrecognition as an acceptable treatment *** method used for transplantation... 详细信息

关键词： pancreaticoduodenal transplantation kidney transplantation portal venous drainage enteric drainage postoperative complications rats

GNAS mutations suppress cell invasion by activating MEG3 in growth hormone–secreting pituitary adenoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第6期32卷 1079-1091页

作者： CHAO TANG CHUNYU ZHONG JUNHAO ZHU FENG YUAN JIN YANG YONG XU CHIYUAN MA Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing210002China Department of Neurosurgery Children’s Hospital of Nanjing Medical UniversityNanjing210019China Affiliated Eye Hospital Nanjing Medical UniversityNanjing210029China Department of Neurosurgery Jinling HospitalSouthern Medical UniversityNanjing210002China Department of Neurosurgery Jinling HospitalNanjing Medical UniversityNanjing210002China

Approximately 30%–40%of growth hormone–secreting pituitary adenomas(GHPAs)harbor somatic activating mutations in GNAS(αsubunit of stimulatory G protein).Mutations in GNAS are associated with clinical features of smaller and less invasive ***,the role of GNAS mutations in the invasiveness of GHPAs is *** mutations were detected in GHPAs using a standard polymerase chain reaction(PCR)sequencing *** expression of mutation-associated maternally expressed gene 3(MEG3)was evaluated with ***3 was manipulated in GH3 cells using a lentiviral expression *** invasion ability was measured using a Transwell assay,and epithelial–mesenchymal transition(EMT)-associated proteins were quantified by immunofluorescence and western ***,a tumor cell xenograft mouse model was used to verify the effect of MEG3 on tumor growth and *** invasiveness of GHPAs was significantly decreased in mice with mutated GNAS compared with that in mice with wild-type ***,the invasiveness of mutant GNASexpressing GH3 cells ***3 is uniquely expressed at high levels in GHPAs harboring mutated ***,MEG3 upregulation inhibited tumor cell invasion,and conversely,MEG3 downregulation increased tumor cell ***,GNAS mutations inhibit EMT in ***3 in mutated GNAS cells prevented cell invasion through the inactivation of the Wnt/β-catenin signaling pathway,which was further validated in *** data suggest that GNAS mutations may suppress cell invasion in GHPAs by regulating EMT through the activation of the MEG3/Wnt/β-catenin signaling pathway.

关键词： GHPAs GNAS mutation MEG3 β-catenin EMT

Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factor and tropomyosin-related kinase B in rat hippocampus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2012年第4期6卷 411-415页

作者： Chun Yang Xiaomin Li Nan Wang Shixia Xu Jianjun Yang Zhiqiang Zhou Department of Anesthesiology Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002China

Ketamine exerts rapid and robust antidepressant properties in both animal models and depressed patients and tramadol possesses potential antidepressant ***-derived neurotrophic factor(BDNF)is an important biomarker for mood disorders and tropomyosin-related kinase B(TrkB)is a high affinity catalytic receptor for *** hypothesized that tramadol pretreatment might reinforce ketamine-elicited antidepressant effects with significant changes in hippocampal BDNF and TrkB levels in *** time of rats receiving different treatment in the forced swimming test(FST)was *** of BDNF and TrkB in hippocampus were measured by enzyme linked immunosorbent *** showed that tramadol(5 mg/kg)administrated alone neither elicited antidepressant effects nor altered BDNF or TrkB ***,pretreatment with tramadol(5 mg/kg)enhanced the ketamine(10 mg/kg)-elicited antidepressant effects and upregulated the BDNF and TrkB levels in *** conclusion,tramadol pretreatment reinforces the ketamine-elicited antidepressant effects,which is associated with the increased levels of BDNF and TrkB in rat hippocampus.

关键词： tramadol ketamine antidepressant brain-derived neurotrophic factor tropomyosin-related kinase B

CLINICAL AND EXPERIMENTAL STUDIES ON THE TREATMENT OF SENILE CONSTIPATION WITH SHENSHEN WAN

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 1996年第3期16卷 182-185页

作者：张思佳常越萍王宁徐德宝刘昭景 Nanjing Hospital of the PLA Air Force Nanjing 210002

From August 1988 through February 1991, we have successfully treated 400 cases of senile constipation with self-made Shenshen Wan with a total effective rate of 98%. A group of patients taking Maren Wan served as controls. Clinical practice has proved that Shenshen Wan can not only relax the bowels, but also improve renal functioa Furthermore, no side effects whatever were observed after a prolonged administration of the pills.

关键词：益气养阴润燥肝肾阴虚养血润肠宣肺通腑滋肾气血补肾肾亏

ANALYSIS OF RISK FACTORS IN 3901 PATIENTS WITH STROKE

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 2005年第1期20卷 35-39,页

作者： Xin-FengLiu GuyvanMelle JulienBogousslavsky DepartmentofNeurology CentreHospitalierUniversitaireVaudoisUniversityofLausanneSwitzerland DepartmentofNeurology JinlingHospitalSchoolofMedicineNanjingUniveristyNanjing210002

Objective To estimate the frequency of various risk factors for overall stroke and to identify risk factors for cerebral infarction (CI) versus intracerebral hemorrhage (ICH) in a large hospital-based stroke registry. Methods Data from a total of 3901 patients, consisting of 3525 patients with CI and 376 patients with ICH were pros-pectively coded and entered into a computerized data bank. Results Hypertension and smoking were the most prominent factors affecting overall stroke followed by mild internal carotid artery stenosis (< 50%), hypercholesterolemia, transient ischemic attacks (TIAs), diabetes mellitus, and cardiac ischemia. Univariate analysis showed that factors in male significantly associated with CI versus ICH were old age, a family history of stroke, and intermittent claudication; whereas in female the factors were oral contraception and migraine. By multivariate analysis, in all patients, the factors significantly associated with CI as opposed to ICH were smoking, hyperch-olesterolemia, migraine, TIAs, atrial fibrillation, structural heart disease, and arterial disease. Hypertension was the only significant factor related with ICH versus *** The factors for ischemic and hemorrhagic stroke are not exactly the same. Cardiac and arterial disease are the most powerful factors associated with CI rather than ICH.

关键词： stroke registry heart disease arterial disease risk factors