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Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna E Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)

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Acta Pharmacologica Sinica 2002年第12期23卷 110-115页

作者： Susan Wai Sum LEUNG,Yaw Loong SIOW,Ricky Ying Keung MAN Department of Pharmacology Faculty of Medicine University of Hong Kong 21 Sassoon road Hong Kong China Department of Pharmacology Faculty of Medicine University of Hong Kong 21 Sassoon road Hong Kong China Department of Pharmacology Faculty of Medicine University of Hong Kong 21 Sassoon road Hong Kong China Department of Pharmacology University of Hong Kong 21 Sassoon road Hong Kong China

AIM: To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations. METHODS: Commercially available danshen crude drugs from different sources, as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected. The composition of these danshen samples was analyzed using HPLC. Specifically, the amounts of magnesium tanshinoate B (MTB), danshensu, isotanshinone IIA, and ctyptotanshinone were determined. In some of these samples, the content of MTB was further confirmed by liquid chromatography-tandem mass spectrometer (LC-MS)/MS method. RESULTS: There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study. The amount of MTB was the highest among the four components measured in the crude drugs. However, the amounts of MTB in all danshen preparations were much

关键词： Salvia miltiorrhiza magnesium tanshinoate B (MTB) high pressure liquid chromatography

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single Molecule FRET Study of DNAG Quadruplex

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Chemical Research in Chinese Universities 2002年第2期18卷 103-106页

作者： Jeremy Green Liming Ying David Klenerman Shankar Blasubramanian Department of Chemistry University of CambridgeLensfield RoadCambridge CB21EWUK

The DNA G quadruplex formed by the human telomeric sequence is a potential target for novel anticancer drugs. We have investigated an intramolecular DNA G quadruplex using single molecule fluorescence resonance energy transfer and shown that individual folded quadruplexes can be identified. The mean proximity ratio measured at the single molecule level was consistent with ensemble measurement

关键词： G quadruplex Fluorescence resonance energy transfer(FRET) Single molecule spectroscopy

Pollutant reduction effectiveness of low-impact development drainage system in a campus

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Frontiers of Environmental Science & Engineering 2017年第4期11卷 113-120页

作者： Shuhan Zhang Yingying Meng Jiao Pan Jiangang Chen Beijing Water Science and Technology Institute Chegongzhuang West Road 21 Haidian District Beijing 100048 China

Building a rainwater system based on the idea of low-impact development （LID） is an important aspect of the current ＂sponge city＂ construction in China. The ＂sponge city＂ concept emphasizes that the runoff can permeate the soil or be stored temporarily, and rainwater could be used again when it is needed. Beijing is one of the earliest cities to study rainwater harvesting and LID techniques in *** long-terua monitoring of rainfall, runoff flow, and water quality of a campus demonstration project in Beijing, the runoff quantity and pollutant concentration variations have been analyzed. Furthermore, the runoffreduction effects of single LID measure, such as green roof, filtration chamber, and permeable pavement, have been investigated. Additionally, the overall reduction effectiveness of the LID system on the average annual rainfall runoff and pollution load has been discussed.

关键词： Low-impact development Rainwater harvesting Non-point-source pollution reduction Campus

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Numerical analysis of the s1020 airfoils in tandem under different flapping configurations

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Acta Mechanica Sinica 2010年第2期26卷 191-207页

作者： K.B.Lim W.B.Tay Department of Mechanical Engineering National University of Singapore21 Lower Kent Ridge RoadSingapore 119077Singapore

The objective of this project is to improve the performance of the efficiency, thrust and lift of flapping wings in tandem arrangement. This research investigates the effect of the arrangement of the airfoils in tandem on the performance of the airfoils by varying the phase difference and distance between the airfoils. Three flapping configurations from an earlier phase of a research which gives high efficiency, thrust and lift are used in the tandem simulation. It is found all the different flapping configurations show improvement in the efficiency, thrust or lift when the distance between the two airfoils and the phase angle between the heaving positions of the two airfoils are optimal. The average thrust coefficient of the tandem arrangement managed to attain more than twice that of the single one （4.84 vs. 2.05）. On the other hand, the average lift coefficient of the tandem arrangement also increased to 4.59, as compared to the original single airfoil value of 3.04. All these results obtained will aid in the design of a better ornithopter with tandem wing arrangement.

关键词： Tandem Flapping· Airfoils Ornithopter·Immersed boundary

Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway