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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 18-18页

作者： Kapadia N. Talib A. 刘超 201 al-nafisa bldg. Shahra-e-Iraq Sa ddar Karachi Pakistan Dr.

Aim. To study the efficacy, safety, and compliance of 500 mg azithromycin thr ice weekly for 12 weeks in acne vulgaris. Methods. An open-label, noncomparati ve studywas carried out for 12 weeks at the outpatient clinics of Aga Khan Unive rsity Hospital, Abassi Shaheed Hospital, and Burhani Community Hospital in Karac hi, Pakistan. Thirty-five adolescent and postadolescent patients with moderate to severe papulopustular acne vulgaris were enrolled. all patients completed th e study. Azithromycin, 500mg orally thrice weekly for 12weeks, was used. After t he baseline visit, patients were scheduled to return at four-weekly intervals for 12 weeks. Efficacy was gauged by the percentage clearance of papulopustular acne lesions. Safety assessments included the monitoring of adverse events, and compliance was checked at the four-weekly regular visits up to 12 weeks. Resul ts. Twenty-nine patients (82.9% )-showed remarkable improvement in the firs t 4 weeks with 60% reduction of their inflammatory papulopustular lesions. Max imum clearance (80% ) was observed at 12 weeks. Residual postinflammatory pigme ntation and pitted and linear scarring represented the aftermath of the relapsin g pattern of acne. Six patients (17.1% ) showed slow clearance with eruptions o f new lesions. Adverse events, such as heartburn and nausea, were reported by fo ur patients (11.4% ). all patients completed the 12- week study period. Conclu sion. Azithromycin, 500 mg thrice weekly for 12 weeks, is a safe and effective t reatment of acne vulgaris with excellent patient compliance.

关键词：阿齐红霉素寻常痤疮依从性首次就诊大学医院线状瘢痕色素沉着卡拉奇不良反应

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Development of Integroted Modular Water Reactor （IMR）

Development of Integroted Modular Water Reactor （IMR）

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第13届太平洋地区核能大会

作者： Kozo Tabuchi Yoshiaki Makihara AkimiSerizawa TomoakiKunugi TetsuoMatsumura IzumiKinoshita Kazuhiko Yamamoto Mitsubishi Heavy Industries 3-1 Minatomirai 3-Chome Nishi-kuYokohama 220-8401 Japan Mitsubishi Heavy Industries 3-1 Minatomirai 3-Chome Nishi-kuYokohama 220-8401 Japan Kyoto University Yoshida Sakyo Kyoto 606-8501 Japan Kyoto University Yoshida Sakyo Kyoto 606-8501 Japan Central Research Institute of Electric Power Industry 2-11-1 Iwado Kita Komae-shi Tokyo 201-8511 Japan Central Research Institute of Electric Power Industry 2-11-1 Iwado Kita Komae-shi Tokyo 201-8511 Japan The Japan Atomic Power Co. Mitoshiro Bldg. 1-1 Kanda-Mitoshiro-Cho Chiyoda-kuTokyo 101-0053 Japan

＜正＞Small-scale reactor named IMR （Integrated Modular Water Reactor） is beingdeveloped in Japan. The primary strategy in the development of small-scale reactors isto construct a new design concept which satisfies the requirements of enhanced safetyand construction cost reduction. For this goal, a reactor vessel with an integratedprimary system configuration is chosen as the most optimum reactor configuration inthe present work. This configuration adopts natural circulation and self-pressurizationsystems, which eliminate pressurizer, reactor coolant pumps and all main coolantpipes. In addition to these basic designs, we have also developed new concepts whichenhance safety and reduce construction cost as well. These incorporate the ideas ofHybrid Heat Transport System （HHTS） and Stand-alone Direct Heat Removal System（SDHS）. The HHTS has been designed to keep the stable and safe control of powerand system pressure. The SDHS was proposed to remove the decay heat directly fromthe reactor vessel to the atmosphere in case of accident.

关键词： Irttegrated reactor vessel Hybrid heat transport system Stand-alone direct heat removal system

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