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Recognition of a salivary effector by the TNL protein RCSP promotes effector-triggered immunity and systemic resistance in Nicotiana benthamiana

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Journal of Integrative plant Biology 2025年第1期67卷 150-168页

作者： Weiwei Rao Tingting Ma Jiayuan Cao Yajun Zhang Sisi Chen Shu Lin Xiaoxiao Liu Guangcun He Li Wan Key Laboratory of plant Design CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China National Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China

Insects secret chemosensory proteins(CSPs)into plant cells as potential effector proteins during *** molecular mechanisms underlying how CSPs activate plant immunity remain largely *** show that CSPs from six distinct insect orders induce dwarfism when overexpressed in Nicotiana ***-mediated transient expression of Nilaparvata lugens CSP11(NlCSP11)triggered cell death and plant dwarfism,both of which were dependent on ENHANCED DISEASE SUSCEPTIBILITY 1(EDS1),N requirement gene1(NRG1)and SENESCENCE-ASSOCIATED GENE 101(SAG101),indicating the activation of effector-triggered immunity(ETI)in *** of NlCSP11 led to stronger systemic resistance against Pseudomonas syringae DC3000 lacking effector HopQ1-1 and tobacco mosaic virus,and induced higher accumulation of salicylic acid(SA)in uninfiltrated leaves compared to another effector XopQ that is recognized by a Tollinterleukin-1 receptor(TIR)domain nucleotidebinding leucine-rich repeat receptor(TNL)called ROQ1 in ***,NlCSP11-induced dwarfism and systemic resistance,but not cell death,were abolished in *** transgenic line expressing the SA-degrading enzyme Nah *** large-scale virus-induced gene silencing screening,we identified a TNL protein that mediates the recognition of CSPs(RCSP),including aphid effector MP10 that triggers resistance against aphids in ***,bimolecular fluorescence complementation and Alpha Fold2.prediction unveiled an interaction between NlCSP11 and ***,RCSP does not contain the conserved catalytic glutamic acid in the TIR domain,which is required for TNL *** findings point to enhanced ETI and systemic resistance by a TNL protein via hyperactivation of the SA ***,RCSP is the first TNL identified to recognize an insect effector.

关键词： chemosensory protein effector effector-triggered immunity salicylic acid TIR-NBS-LRR

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The CK1-Opaque2.module orchestrates endosperm filling and nutrient storage in maize seeds

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The Crop Journal 2025年第1期13卷 192-203页

作者： Longyu Liao Yunqin Huang Shanshan Wang Haoyu Zhang Jingying Pan Zhenglan Long Yongcai Huang Xiaoling Li Di Chen Tao Yang State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina National Key Laboratory of plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

Phosphorylation is one of the major posttranslational modifications to control plant growth and ***2.O2.represents a central hub for endosperm filling,which largely determines seed yield and nutrient storage in ***,it still remains unclear how O2.phosphorylation orchestrates endosperm filling and nutrient ***,we systematically identified the phosphorylation sites of O2.during endosperm filling.A total of 18 phosphorylation sites were found in O2.and five sites were identified to apparently modulate its subcellular localization and transactivation *** addition,a conserved protein kinase CK1 was confirmed to interact with and phosphorylate O2.at the residue Threonine(T)2.2.to promote O2.mediated transactivation and protein *** of CK1 resulted in increased kernel size,100-kernel weight and nutrient ***-mimic O2.seeds at T2.2.exhibited enhanced kernel dimension,test weight,vitreous endosperm area and nutrient accumulation,whereas the phosphorylation-deficient O2.seeds did ***,this study establishes a comprehensive phosphocode atlas of O2.during endosperm filling and highlights the importance of phosphorylation modification in O2.to precisely orchestrate maize yield and nutrient quality.

关键词： Maize Endosperm Phosphorylation Opaque2 CK1

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Unlocking the power of tandem repeat variations to fine-tune rice phenotypes

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Science Bulletin 2025年第3期70卷 297-298页

作者： Kang Chong Key Laboratory of plant Molecular physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

The diversity of crop phenotypes is shaped by numerous genomic *** staple cereals like rice,lots of functional variants,including quantitative trait locus(QTLs),have been identified and used to improve various crop traits(yield,quality,architecture,etc.).To breed ideal crop cultivars for agricultural production,we need more and more precise modulation of phenotypes to obtain desirable *** the past decade,genome editing techniques have enabled us to precisely change crop genome sequences,and also functional variants[1],[2.,[3].

关键词： cultivar cereal precise

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Magnaporthe oryzae infection triggers rice resistance to brown planthopper through the influence of jasmonic acid on the flavonoid biosynthesis pathway

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Insect Science 2025年第1期32卷 243-259页

作者： Su Chen Zhihuan Tao Yanjie Shen Rui Yang Siyuan Yan Zixu Chen Bo Sun Xiaofang Yang Precision Medicine Laboratory for Chronic Non-communicable Diseases of Shandong Province Institute of Precision MedicineJining Medical UniversityJiningShandong ProvinceChina Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghaiChina College of Medical Engineering&The Key Laboratory for Medical Functional Nanomaterials Jining Medical UniversityJiningShandong ProvinceChina institute of Bioengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhouChina

In agroecosystems,plants are constantly exposed to attack from diverse herbivorous insects and microbes,and infestation with one species may change the plant defense response to other *** our investigation of the relationships among rice plants,the brown planthopper Nilaparvata lugens(Stål)and the rice blast fungus Magnaporthe oryzae,we observed a significant increase in the resistance of rice treated with rice blast to ***,as evidenced by improved plant survival rates in a small population resistance *** transcriptome data analysis revealed that the rice blast fungus can induce the expression of genes in the jasmonic acid(JA)and flavonoid *** to the flavonoid pathway,the JA pathway also contains 2.types of genes that exhibit similar and opposite trends in response to *** and rice *** these genes,the osjaz1 mutant and the osmyc2.mutant were phenotypically confirmed to positively and negatively regulate rice resistance to *** and rice blast,*** mass spectrometry and quantification experiments showed that the exogenous application of methyl jasmonate(MeJA)can induce the accumulation of eriodictyol,naringenin and quercetin,as well as the expression of OsF3H,Os4CL5 and OsCHI in the flavonoid *** suggests a close connection between the JA pathway and the flavonoid ***,OsF3'H,which negatively regulates rice resistance to *** and rice blast,did not show increased *** and molecular experiments confirmed that OsMYC2.can bind to and inhibit the expression of OsF3'H,thus revealing the mechanism of rice resistance to *** after treatment with rice *** findings will deepen our understanding of the interactions among rice,*** and rice blast.

关键词： flavonoid jasmonic acid Nilaparvata lugens rice rice blast

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Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin Qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang Chen Qianxing Zhuang Department of physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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Artificial intelligence advances drug delivery system and its clinical transition

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Science Bulletin 2025年第3期70卷 305-308页

作者： Hui Wang Xiao-Yan You Guo-Ping Zhao Master Lab for Innovative Application of Nature Products National Center of Technology Innovation for Synthetic BiologyTianjin Institute of Industrial BiotechnologyChinese Academy of Sciences(CAS)Tianjin 300308China Henan Engineering Research Center of Food Microbiology College of Food and BioengineeringHenan University of Science and TechnologyLuoyang 471023China Haihe Laboratory of Synthetic Biology Tianjin 300308China CAS-Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Since November 2.2.,ChatGPT,an artificial intelligence(AI)chatbot,has rapidly captured global attention for its detailed responses and articulated answers across a broad spectrum of knowledge domains[1],[2..All industries will reorient around it,prompting a reevaluation of how this technology could further promote scientifical research and its clinical applications.

关键词： system transition spectrum

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The ABC transporter SmABCG1 mediates tanshinones export from the peridermic cells of Salvia miltiorrhiza root

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Journal of Integrative plant Biology 2025年第1期67卷 135-149页

作者： Yajing Li Junfeng Chen Jingyu Zhi Doudou Huang Yuchen Zhang Lei Zhang Xinyi Duan Pan Zhang Shi Qiu Jiaran Geng Jingxian Feng Ke Zhang Xu Yang Shouhong Gao Wenwen Xia Zheng Zhou Yuqi Qiao Bo Li Qing Li Tingzhao Li Wansheng Chen Ying Xiao The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmacy Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of plant Biology and Ecology College of Life SciencesNankai UniversityTianjin 300071China School of Pharmacy Naval Medical UniversityShanghai 200433China College of Life and Environmental Sciences Hangzhou Normal UniversityHangzhou 310000China Amway(shanghai)Innovation&Science Co. LtdShanghai 201203China

plants have mechanisms to transport secondary metabolites from where they are biosynthesized to the sites where they function,or to sites such as the vacuole for ***,current research has mainly focused on metabolite biosynthesis and regulation,and little is known about their ***,a class diterpenoid with medicinal properties,is biosynthesized in the periderm of Salvia miltiorrhiza ***,we discovered that tanshinone can be transported out of peridermal cells and secreted into the soil environment and that the ABC transporter SmABCG1 is involved in the efflux of tanshinoneⅡA and tanshinoneⅠ.The SmABCG1 gene is adjacent to the diterpene biosynthesis gene cluster in the *** *** temporal–spatial expression pattern of SmABCG1 is consistent with tanshinone accumulation ***1 is located on the plasma membrane and preferentially accumulates in the peridermal cells of *** *** expression in Xenopus laevis oocytes demonstrated that SmABCG1 can export tanshinoneⅡA and tanshinoneⅠ.CRISPR/Cas9-mediated mutagenesis of SmABCG1 in *** hairy roots resulted in a significant decrease in tanshinone contents in both hairy roots and the culture medium,whereas overexpression of this gene resulted in increased tanshinone ***76AH3 transcript levels increased in hairy roots overexpressing SmABCG1 and decreased in knockout lines,suggesting that SmABCG1 may affect the expression of CYP76AH3,indirectly regulating tanshinone ***,tanshinoneⅡA showed cytotoxicity to Arabidopsis *** findings offer new perspectives on plant diterpenoid transport and provide a new genetic tool for metabolic engineering and synthetic biology research.

关键词： ATP-binding cassette transporter biosynthesis gene cluster cytotoxicity export peridermic cells tanshinone

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China(Life Sciences) 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Innovation Research institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Experiment Center for Science and Technology Shanghai University of Traditional Chinese MedicineShanghai 201203China

Dear Editor,Phenotypic drug discovery,which observes compound effects on physiology,has given way to targeting specific molecules,but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al.,2.2.).Osteoarthritis(OA)is a prevalent chronic joint disorder,primarily affecting knee joints,with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2.2.).This imbalance and the discharge of inflammatory mediators perpetuate the cycle of inflammation and tissue ***,controlling inflammation and modulating osteoclastogenesis are critical therapeutic targets for managing OA.

关键词： inflammation drugs

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Peptide-based strategies for overcoming multidrug-resistance in cancer therapy

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Chinese Chemical Letters 2025年第1期36卷 110-118页

作者： Xiaofang Luo Ye Wu Xiaokun Zhang Min Tang Feiye Ju Zuodong Qin Gregory J Duns Wei-Dong Zhang Jiang-Jiang Qin Xin Luan Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and BioengineeringHunan University of Science and EngineeringYongzhou 425199China shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Medicinal Plant DevelopmentChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100700China

Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade *** demand for targeted therapeutics for multidrug-resistant cancer is more important than ***,as emerging alternatives to current anticancer drugs,offer exquisite versatility in facilitating the design of novel oncology drugs,with the core superiorities of good biocompatibility and a low tendency to induce drug *** review comprehensively introduces the pharmacological mechanisms of peptide-based drugs and strategies for overcoming multidrug resistance(MDR)in cancers,including inducing cell membrane lysis,targeting organelles,activating anticancer immune responses,enhancing drug uptake,targeting ATP-binding cassette(ABC)transporters,and targeting B-cell lymphoma-2.BCL-2.family ***,the current clinical applications of representative peptides in combating MDR cancers and their potential directions for medicinal chemistry research have been thoroughly *** review offers essential insights into the novel treatment approaches for MDR cancers and highlights the trends and perspectives in this field.

关键词： Drug resistance Antitumor peptides Mechanism of action Targeted therapeutics Immunotherapy Medicinal chemistry

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The miR3367–lncRNA67–GhCYP72.B module regulates male sterility by modulating brassinosteroid biosynthesis and interacting with Aorf2. in Gossypium hirsutum

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Journal of Integrative plant Biology 2025年第1期67卷 169-190页

作者： Anhui Guo Hushuai Nie Huijing Li Bin Li Cheng Cheng Kaiyun Jiang Shengwei Zhu Nan Zhao Jinping Hua Laboratory of Cotton Genetics Genomics and Breeding/Joint Laboratory for International Cooperation in Crop Molecular BreedingMinistry of Education/Beijing Key Laboratory of Crop Genetic ImprovementCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Key Laboratory of plant Molecular physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China

Cytoplasmic male sterile(CMS)lines play a crucial role in utilization of heterosis in crop ***,the mechanism underlying the manipulation of male sterility in cotton by long non-coding RNA(lncRNA)and brassinosteroids(BRs)remains ***,using an integrative approach combining lncRNA transcriptomic profiles with virus-induced gene silencing experiments,we identify a flower budspecific lncRNA in the maintainer line 2.74B,lncRNA67,negatively modulating with male sterility in upland cotton(Gossypium hirsutum).lncRNA67positively regulates cytochrome P2.4B(GhCYP72.B),which acted as an eTM(endogenous target mimic)for *** suppression of GhCYP72.B induced symptoms of BR deficiency and male semisterility in upland cotton as well as in tobacco,which resulted from a reduction in the endogenous BR ***72.B regulates BRs synthesis by interacting with GhDIM and GhCYP90B,two BRs biosynthesis ***,GhCYP72.B suppressed a unique chimeric open reading frame(Aorf2.)in 2.74A mitochondrial *** expression of Aorf2. in yeast inhibited cellular growth,and over expression of Aorf2. in tobacco showed male ***,the results proved that the miR3367–lncRNA67–GhCYP72.B module positively regulates male sterility by modulating BRs *** findings uncovered the function of lncRNA67–GhCYP72.B in male sterility,providing a new mechanism for understanding male sterility in upland cotton.

关键词： brassinosteroids GhCYP72.B lncRNA67 male sterility mitochondrial Aorf2. upland cotton(G.hirsutum)

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