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Association of miR-499 rs3746444, miR-149 rs2.92.32.polymorphisms and their expression levels with helicobacter pylori-related gastric diseases and Traditional Chinese Medicine syndromes

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1024-1034页

作者： LIU Qi YU Chang YE Jintong ZHANG Ling LI Danyan DAI Yunkai ZHANG Yunzhan LUO Qi CHEN Weijing PAN Huaigeng LI Ruliu HU Ling institute of Gastroenterology Science and Technology Innovation CenterGuangzhou University of Chinese Medicine First Affiliated Hospital of Guangzhou University of Chinese Medicine

OBJECTIVE: To provide an objective experimental basis for the gastric mucosa pathological evolution and the transformation of different Traditional Chinese Medicine(TCM) syndromes in helicobacter pylori(H. pylori)-related gastric diseases(HPGD) patients, based on the combination of TCM syndrome differentiation, molecular biology and ***: A total of 2.3 participants were enrolled in this study. The expressions of miR-499/miR-149 and *** infection in the gastric tissues from all participants were detected. The genotyping for miR-499 rs3746444 and miR-149 rs2.92.32.was ***: In H. pylori positive subjects, the proportion of precancerous gastric lesions(PGL) in liver-stomach disharmony syndrome(LSDS) group was higher than in spleen Qi deficiency syndrome(SQDS) group(P 2.92.32.was linked to lower risk of gastric atrophy [miR-149 rs2.92.32.C vs T:adjusted odds ratio = 0.2.7; 95% confidence interval(0.043-0.989); P = 0.048]. Compared with healthy control(HC) group, the expression of miR-499 was significantly increased in GC group, while the expression of miR-149was significantly decreased in chronic inflammation group,PGL group and GC group(all P 2.92.32.may be a protective factor for gastric mucosal atrophy. *** may participate in the evolution of benign to malignant gastric mucosa lesions by inducing the overexpression of miR-499 and down regulation of miR-149. In addition, patients with H. pylori infection combined SQDS or LSDS may have higher risk of gastric mucosal malignant lesions.

关键词： helicobacter pylori microRNAs polymorphism, genetic stomach diseases syndrome complex

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Opportunities for production and property research of neutron-rich nuclei around N=12. at HIAF

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Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma Li-Na Sheng Xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-Jin Ong Zhi-Yu Sun Shu-Wen Tang Yu-Hong Yu Xin-Tong Du Xiao-Bao Wei institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=12. neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=12. and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 2.8 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=12. can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=12.,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=12. Mass measurement Lifetime

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Research and application of key technologies for data delivery in railway engineering design based on metadata

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High-Speed Railway 2024年第1期2卷 51-56页

作者： Xiangru Lyu Xunxiao Yin Kun Wang Yongwen Wei institute of Computing Technologies China Academy of Railway Sciences Corporation LimitedBeijing 100081China

In view of the problems of inconsistent data semantics,inconsistent data formats,and difficult data quality assurance between the railway engineering design phase and the construction and operation phase,as well as the difficulty in fully realizing the value of design results,this paper proposes a design and implementation scheme for a railway engineering collaborative design *** railway engineering collaborative design platform mainly includes functional modules such as metadata management,design collaboration,design delivery management,model component library,model rendering services,and Building Information Modeling(BIM)application *** on this,research is conducted on multi-disciplinary parameterized collaborative design technology for railway engineering,infrastructure data management and delivery technology,and design multi-source data fusion and application *** railway engineering collaborative design platform is compared with other railway design software to further validate its advantages and advanced *** platform has been widely applied in multiple railway construction projects,greatly improving the design and project management efficiency.

关键词： Railway engineering Metadata Data delivery Collaborative designplatform Design results BIM services

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Effect of zeolites on the alkylation of aromatics with alkanes using a Pd nanoparticle/solid acid cooperative catalytic system

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Green Carbon 2024年第3期2卷 282-290页

作者： Satoshi Misaki Moe Takabatake Shingo Hasegawa Yuichi Manaka Wang-Jae Chun Ken Motokura Department of Chemical Science and Engineering School of Materials and Chemical TechnologyTokyo Institute of Technology4259 Nagatsuta-choMidori-kuYokohama 226-8502Japan Department of Chemistry and Life Science Yokohama National University79-5 TokiwadaiHodogaya-kuYokohama 240-8501Japan Renewable Energy Research Center National Institute of Advanced Industrial Science and Technology(AIST)2-2-9 MachiikedaiKoriyama 963-0298Japan Graduate School of Arts and Sciences International Christian UniversityMitakaTokyo 181-8585Japan

The direct alkylation of benzene with alkanes is an effective method for alkylbenzene *** group previously discovered that a mixture of supported Pd nanoparticles and solid acids effectively promoted the alkylation of benzene with ***,the alkylation of toluene with n-heptane was catalyzed by physical mixture of H-mordenite and Pd nanoparticles supported on hydrotalcite to afford the corresponding C7 alkylation product with 87%selectivity and 14%toluene *** reaction slightly proceeded in the absence of Pd nanoparticles or H-mordenite,indicating cooperative catalysis by the two different solid ***,the high stability of the Pd nanoparticles on hydrotalcite was confirmed via reuse experiments and transmission electron microscopy(TEM)*** catalyst mixture was reused at least three times without any loss of product yield,and after three reuses,TEM analysis revealed that the size of the Pd nanoparticles following the initial catalytic reaction was similar to that of the *** transmission electron microscopy with energy dispersive spectroscopy(STEM-EDS)analysis of the recovered catalyst mixture revealed the preservation of Pd nanoparticles on the hydrotalcite surface,as well as the close positioning of the two different catalyst particles,thus suggesting interparticle hydrogen *** structure of the solid acid strongly affected the alkylation product *** example,H-mordenite showed high selectivity for the n-heptane alkylation product with a C7 alkyl chain,whereas the selectivity changed with other *** cooperative catalytic system can be applied to the alkylation of other substituted benzenes,such as xylenes and phenols,with good selectivity toward the desired alkylation product.

关键词： Alkylation Alkane Zeolite Palladium C-H bond activation

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Geochemical characteristics and exploration significance of ultra-deep Sinian oil and gas from Well Tashen 5,Tarim Basin,NW China

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Energy Geoscience 2024年第1期5卷 24-36页

作者： Zicheng Cao Anlai Ma Qinqi Xu Quanyong Pan Kai Shang Fan Feng Yongli Liu Northwest Petroleum Oilfield Company SINOPECUrumqi830011China Petroleum Exploration and Production Research institute SINOPEC102260BeijingChina

The Well Tashen 5(TS5),drilled and completed at a vertical depth of 9017 m in the Tabei Uplift of the Tarim Basin,NW China,is the deepest well in *** has been producing both oil and gas from the Sinian at a depth of 8780e8840 m,also the deepest in Asia in terms of oil *** this paper,the geochemical characteristics of Sinian oil and gas from the well were investigated and compared with those of Cambrian oil and gas discovered in the same *** oil samples,with Pr/Ph ratio of 0.78 and a whole oil carbon isotopic value of31.6‰,have geochemical characteristics similar to those of Ordovician oils from the No.1 fault in the North Shuntuoguole area(also named Shunbei area)and the Middle Cambrian oil from wells Zhongshen 1(ZS1)and Zhongshen 5(ZS5)of Tazhong *** maturity of light hydrocarbons,diamondoids and aromatic fractions all suggest an approximate maturity of 1.5%e1.7%Ro for the ***(4-+3-)methyldiamantane concentration of the samples is 113.5 mg/g,indicating intense cracking with a cracking degree of about 80%,which is consistent with the high bottom hole temperature(179℃).The Sinian gas samples are dry with a dryness coefficient of *** gas is a mixture of kerogen-cracking gas and oil-cracking gas and has Ro values ranging between 1.5%and 1.7%,and methane carbon isotopic values of41.6‰.Based on the equivalent vitrinite reflectance(R_(eqv)=1.51%e1.61%)and the thermal evolution of source rocks from the Cambrian Yu'ertusi Formation of the same well,it is proposed that the Sinian oil and gas be mainly sourced from the Cambrian Yu'ertusi Formation during the Himalayan period but probably also be joined by hydrocarbon of higher maturity that migrated from other source rocks in deeper *** discovery of Sinian oil and gas from Well TS5 suggests that the ancient ultra-deep strata in the northern Tarim Basin have the potential for finding volatile oil or condensate reservoirs.

关键词： Ultra-deep Sinian oil and gas Oil-cracking Well Tashen 5 Tarim Basin

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New Industrialization: Characteristics, System Development and Implementation Pathway

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China Economist 2024年第1期19卷 2-13页

作者：无 Research Group of the institute of Industrial Economics Chinese Academy of Social Sciences(CASS)BeijingChina

New industrialization in China, different from its past economic development pattern or patterns in developed nations, is the country’s theoretical innovation based on the positive and negative experiences of industrialization at home and worldwide. New industrialization has various novel characteristics, including new sources of efficiency, new factors of production, new organizational forms, and new constraints. In addition, it has certain particularities arising from modernization with Chinese characteristics. This article summarizes the characteristics of new industrialization from the perspectives of people-centered approach, quality-first concept, independent innovation, green low-carbon economics, digital-real integration, and open circulation. There are four systems for promoting new industrialization: A self-sustained scientific and technological system, a high-end advanced manufacturing system, a green low-carbon circular system, and a division of labor system with domestic and international circulation. The Chinese new industrialization proposes the pathway and policy measures considering the new global situation and the requirements of new goals of strengthening organization and leadership, reducing factor cost, accelerating independent technological innovation, smoothing domestic and international circulation, and optimizing competition environment.

关键词： New industrialization Chinese modernization system building policy measures

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EVALUATION　OF　REVERSE　PASSIVE　HEMAGGLUTINATION　（RPHA）　FECAL　OCCULT　BLOOD　TEST　IN　SCREENING　OF　COLORECTAL　NEOPLASIA

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Chinese Journal of Cancer Research 1994年第4期6卷 274-278页

作者：余海周伦郑备义邱培林郑树孙其荣邵毓文马新源 1. Cancer institute Zhejiang Medical University 310009 Hangzhou China 2. Haining Cancer institute 314400 Haining China 3. Jiashan Cancer institute 314100 Jiashan China

A high risk population consisting of 3034 people with history of rectal polyps or ulcers were screened for colorectal neoplasia with Reverse Passive Hemagglutination Fecal Occult Blood Test (RPHA FOB) and 60 cm fiberoptic colonoscopy. Among 2.53 subjects (84.1%)who completed both tests, 11 cases of colorectal malignancies and 465 cases of polyps were *** colonoscopic finding and histopathological examination as the 'gold standard' of diagnosis, results showed that FOB positivity of polyps was related to their size, macroscopic appearance and surface features but no correlation between bleeding of polyps and their location, numbers, pathological types were found. In this study the sensitivity of RPHA in screening of colorectal malignancy was 63.6% (7/11), while that for polyps was only 2..1% (98/465) . For screening of colorectal neoplasia (cancer+polyps) the overall sensitivity and specificity of RPHA FOB were 2..1% and 82.4%, the positive and negative predictive values were 2..3% and 82.2. respectively. Amoug 465 polyps there were 195 adenomas, further analysis showed that villous and tubulovillous adenomas had higher intestinal bleeding rate (FOB positive)than tubular type (45.5%,30.0% and 17.8% respectively, X2.5.8, p=0.05). The results indicate that although the sensitivity of RPHA FOB in screening for colorectal polyps was generally low, but about 40% (8/2.) of villous and tubulovillous adenoma which present higher tendency of malignant transformation can be detected by RPHA FOB as a screening Procedure. So the authors suggest that screening of colorectal neoplasia be not only a procedure of secondary prevention but also a measure of primary prevention for colorectal *** March 2., 1994

关键词： Colon/Rectum neoplasia Polyps Screening,Colonoscopy RPHA fecal occult blood test

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Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?

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Neural Regeneration Research 2024年第1期19卷 29-34页

作者： Marta Zagrebelsky Martin Korte Division of Cellular Neurobiology Zoological InstituteTU BraunschweigBraunschweigGermany Helmholtz Centre for Infection Research AG NINDBraunschweigGermany

Brain-derived neurotrophic factor signaling via its receptor tro pomyosin receptor kinase B regulates several crucial physiological *** has been shown to act in the brain,promoting neuronal survival,growth,and plasticity as well as in the rest of the body where it is involved in regulating for instance aspects of the *** to its crucial and very pleiotro pic activity,reduction of brain-derived neurotrophic factor levels and alterations in the brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling have been found to be associated with a wide spectrum of neurological *** r,because of its poor bioavailability and pharmacological properties,brain-derived neurotrophic factor itself has a very low therapeutic ***,the concomitant binding of exogenous brain-derived neurotrophic factor to the p75 neurotrophin receptor has the potential to elicit several unwanted and deleterious side *** re,developing tools and approaches to specifically promote tropomyosin receptor kinase B signaling has become an important goal of translational *** the newly developed tools are different categories of tropomyosin receptor kinase B receptor agonist *** this review,we give a comprehensive description of the diffe rent tro pomyosin receptor kinase B receptor agonist drugs developed so far and of the res ults of their application in animal models of several neurological ***,we discuss the main benefits of tropomyosin receptor kinase B receptor agonists,concentrating especially on the new tropomyosin receptor kinase B agonist *** benefits observed both in vitro and in vivo upon application of tropomyosin receptor kinase B receptor agonist drugs seem to predominantly depend on their general neuroprotective activity and their ability to promote neuronal ***,tro pomyosin receptor kinase B agonist antibodies have been shown to specifically bind the tropomyosin recepto

关键词： Alzheimer's disease brain-derived neurotrophic factor depression Parkinson's disease tropomyosin receptor kinase B receptor

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Generation of large fifth-order nonlinear phase shifts by use of lossless χ^((2.) cascaded nonlinear processes

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Science China(Physics,Mechanics & Astronomy) 2004年第1期47卷 1-7页

作者： XU Guang1, QIAN Liejia2. WANG Tao2. FAN Dianyuan1,2.& LI Fuming2.1. Shanghai institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 2.1800, China 2. State Key Laboratory for Advanced Photonic Materials and Devices, Fudan University, Shanghai 2.0433, China Correspondence should be addressed to Xu Guang (email: xuguany@***) Received March 9, 2.03 1. Shanghai institute of Optics and Fine Mechanics Chinese Academy of Sciences 201800 Shanghai China 2. State Key Laboratory for Advanced Photonic Materials and Devices Fudan University 200433 Shanghai China

It is shown that the cascaded fifth-order nonlinear phase shifts will increase with energy loss in the cascaded processes. Essentially different from the multi-photon absorption accompanied with inherent material nonlinearities, the loss of fundamental wave in a cascaded process is controllable and suppressible. By introducing difference frequencies generated from the reaction between the fundamental and its second harmonic after the cascaded processes, the fundamental wave can be free of energy loss, while the large cascaded fifth-order nonlinear phase shift is maintained.

关键词： cascaded nonlinear phase shifts, phase mismatching, harmonic conversions.

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The Akp-Btk value method and the resultsfor the retrieval of the parameters of the Earth's free core nutation

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Acta Seismologica Sinica(English Edition) 2000年第3期13卷 342-350,358页

作者：雷湘鄂贾民育李辉 1. Opening Laboratory of Dynamic Geodesy Institute of Geodesy and Geophysics Chinese Academy of Sciences 430077 Wuhan China 2. institute of Seismology China Seismological Bureau 430071 Wuhan China

The rotation of the Earth's liquid core creates the Nearly Diurnal Free Wobble (NDFW). It is one of the problems of researching the Earth's liquid core for us to retrieve the parameters of the Earth's Free Core Nutation (FCN),from the Earth's liquid core resonance of gravity tide waves on the diurnal frequency band. Since 1987, some scientists in many different countries have come to calculate the parameters of FCN by using the observational data of gravity tide waves on the diumal frequency band. They basically followed the Stacking method, which needed five diurnal waves for the resolution. In this paper, authors introduced the Aky-Btk value method with clearly geometrical meaning as a new method, which only requires three very high signal-noise-ratio waves o1, K1 and P1 for the resolution. Authors chose the observational data of the three superconducting gravimeter stations respectively located in Cantley of Canada, Wuhan of China and Brussels of Belgium, to compute the parameters of FCN. It was the first time that the observational results of the parameters of FCN obtained from gravitational tide were in accord with the parameters of FCN gained from VLBI since 1987.

关键词： Earth's liquid core resonance of gravity tide (LCR) parameters of Earth's free core nutation triangle of LCR Akp-Btk value method

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