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Pregnancy-induced leukocytosis:A case report

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World Journal of Clinical Cases 2022年第36期10卷 13349-13355页

作者： Xi Wang Yang-Yang Zhang Yang Xu department of obstetrics and {2. Peking University First HospitalBeijing 100034China

BACKGROUND Pregnancy is a complex physiological *** leukocytosis occurs often and is mainly associated with increased neutrophil counts,especially in the third trimester of ***-congenital leukocytosis with white blood cell counts above 2.×109/L lasting 13 wk during pregnancy is rare and has been reported ***,we present a case of pregnancy-induced *** SUMMARY We present the case of a 33-year-old Chinese woman at 2. wk of gestation who had a leukocytosis *** abnormalities were detected in the examinations before pregnancy or in the first *** the third trimester of pregnancy,the patient began to suffer from asymptomatic *** administered antibiotics to treat the patient;however,the complication persisted until the patient underwent a cesarean section after 40+3 wk of *** day after the cesarean section,the patient’s neutrophil count returned to *** 2.years of follow-up,we found that the patient and baby were *** Pregnancy-induced leukocytosis seems to be associated with immunoregulation and pregnancy termination may be the most effective treatment approach for pregnancies complicated with malignant leukocytosis.

关键词： Leukocytosis Pregnancy In vitro fertilization Malignancy Case report

ESTRAMUSTINE PHOSPHATE IN THE TREATMENT OF ENDOMETRIUM CARCINOMA

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Chinese Journal of Cancer Research 2000年第1期12卷 58-63页

作者：邓小虹段微李宝珠 department of Oncology Beijing Obstetrics and Gynecology Hospital Beijing China

Objective: To study the clinical effects and side effects of Estramustine phosphate (EMP) on the treatment of endometrial carcinoma. Methods: Fifty-eight patients with endometrial carcinoma diagnosed in our hospital from Oct. 1996 to Feb. 1998 were randomly divided into 3 groups and clinically observed. EMP group (n=2.): after oral EMP 2.0 mg, bid, for 2. days, surgical operation followed in one week. Radiotherapy (RT) group (n=19): surgical operation was preformed after intra-cavity irradiation with half of the standard dosage. Control group (n=18): surgical operation alone. Histopathological changes in the samples from the removed uterus were observed. Estrogen receptor/progestin receptor (ER/PR) and nuclear proliferate antigen (ki-67) index of the endometrial carcinoma tissues of the EMP group were tested by immunohistochemical methods. Results: The microscopic changes induced by irradiation were much heavier than those induced by chemotherapy. In EMP group, 5/2. cases were found with no tumor lesion in the postoperation samples, all of those 5 cases being with ER strong positive (++) and 4/5 cases well differentiated tumor before chemotherapy. In RT group, the tumor lesion was disappeared in 6/19 cases, and 5 cases of which being with the moderate differentiation. No significant difference was shown between those two groups. No any histopathological changes were seen in control group. Immunohistochemical tests revealed a significant decrease in ER staining after EMP treatment and a decrease in ki-67 index, especially for the ER positive tumors, ki-67 index reduced significantly from 49.5% before medication to 35.1% after medication (P<0.05). Only 5 cases in EMP group reported slight nausea and vomit at the beginning of taking medicine. No changes in body weight, blood pressure, WBC count, or liver and kidney functions were seen at all. However, some patients experienced symptoms and signs such as darkening of areola and perineum, an increase in vaginal discharge

关键词： Estramustine phosphate Endometrial carcinoma Chemotherapy

Anti-tumor effect of matrine combined with cisplatin on rat models of cervical cancer

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Asian Pacific Journal of Tropical Medicine 2015年第12期8卷 1025-1028页

作者： Guan-Li Zhang Ling Jiang Qian Yan Rong-Hui Liu Lu Zhang department of obstetrics and {2. Yantaishan Hospital Affiliated to Taishan Medical University

Objective:To observe the anti-tumor effect of matrine combined with cisplatin on U14 rat models of cervical ***:A total of 80 female Kunming rats were used to establish U14 rat models of cervical cancer and then divided into groups Ⅰ,Ⅱ,Ⅲ and Ⅳ,with 2. rats in *** Group Ⅰ,the control group,injection of normal saline was given around the *** Group Ⅱ,injection of 2.mg/kg cisplatin was given around the *** Group Ⅲ,injection of 75 mg/kg matrine was given around the tumors while the combined injection of matrine and cisplatin was given for Group Ⅳ with the same doses as Groups Ⅱand Ⅲ.The animals were sacrificed 10 d after the injection and tumors were taken out for the comparisons of tumor weights after injection and calculation of anti-tumor rates,while thymus and spleen were taken for thymus index and spleen *** in eyeball was collected for determination of changes in serum creatinine and urea nitrogen *** of tumor issue were prepared and morphological changes in tumor tissue cells were observed by using immunohistochemistry ***:After injection,the thymus index and spleen index in Groups Ⅲ and Ⅳ were significantly higher than those in Groups Ⅰ and Ⅱ(P<0.05)while the two indexes in Group Ⅱ were significantly lower than Group Ⅰ(P<0.05).The tumor weights in Groups Ⅱ and Ⅳ were significantly smaller than those in Groups Ⅰ and Ⅲ(P<0.05) with significantly higher anti-tumor rates than Groups Ⅰ and Ⅲ(P<0.05).The serum creatinine and urea nitrogen levels in Groups Ⅲ and Ⅳ were significantly lower than Group Ⅱ(P<0.05) and the two indicators in Group Ⅲ were significantly lower than those in Group Ⅳ(P<0.05).The observation under the histological microscope showed densely arranged tumor cells in Group Ⅰ,growing as a crumby structure and diffuse appearance,with hyperchromatic and large nuclei,and abundant *** the case of Group Ⅱ,it showed less tumor cells,with extensive degenerative necrosis,sparse arrangement

关键词： Cervical cancer Matrine Cisplatin Anti-tumor effec

Expression of the Inducible Nitric Oxide Synthase Isoform in Chorionic Villi in the Early Spontaneous Abortion

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2000年第4期20卷 338-339页

作者：夏革清孙永玉 department of obstetrics & {2. Xiehe Hospital Tongji Medical College Wuhan

To investigate the relationship between inducible nitric oxide synthase (iNOS) and the early spontaneous abortion. , in situ hybridization and immunohistochemistry were used to detect the expression of iNOS in trophoblasts in the early pregnancy with and without spontaneous abortion (group Ⅰ and group Ⅱ). By light microscopy and computer color magic image analysis system (CMIAS), light density (D) and the positive cell number per statistic square (N/S) in situ hybridiza- tion were used to analyze the positive cell index, while total positive cells (N) and the positive unit (Pu) were used in immunohistochemistry. By in situ hybridization, D and N/S in trophoblasts were 0.35±0. 02., 0. 07±0. 011 respectively in group Ⅰ and 0. 18±0.016,0. 015±0. 003 in group Ⅱ . In terms of immunohistochemical staining, N and Pu were 0. 058±0.007, 11. 94±2. 01 in group Ⅰand 0.013±0.009, 1.08±0. 35 in group Ⅱ in trophoblasts. Significant differences existed between two groups. It is concluded that the higher nitric oxide produced by the higher expression of iNOS in tro- phoblasts might play an important role in the early spontaneous abortion.

关键词： iNOS nitric oxide spontaneous abortion

Acute liver injury in a COVID-19 infected woman with mild symptoms:A case report

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World Journal of Clinical Cases 2023年第2期11卷 472-478页

作者： Pei-Hsuan Lai Dah-Ching Ding department of obstetrics and {2. Hualien Tzu Chi HospitalHualien 970Taiwan

BACKGROUND Coronavirus disease 2.19(COVID-19)has spread rapidly,resulting in a pandemic in January *** studies have focused on the natural history and consequences of acute liver injury(ALI)in mild or asymptomatic COVID-19 patients,manifested by elevated aminotransferase *** is usually expected for severe COVID-19 ***,we present a COVID-19 case with mild respiratory symptoms and significantly elevated alanine aminotransferase(ALT)and aspartate aminotransferase(AST)*** SUMMARY A 60-year-old woman without medical history or chronic illness received three COVID-19 vaccinations since the start of the *** patient was infected with severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.and presented with mild symptoms on July 12.h,***-recovery,she underwent an examination at our hospital on August 30th,*** and ALT levels in the liver function test were 2.7 U/L(normal value2.10.9-fold increase),*** patient was diagnosed with ALI,and no treatment was *** following week,blood tests showed a reduction in both levels(ALT 12. U/L,AST 318 U/L).Two weeks later,AST and ALT levels had decreased to near the expected upper limits(ALT 40 U/L,AST 76 U/L).CONCLUSION Clinicians should pay attention to liver function testing during COVID-19 recovery regardless of the disease’s severity.

关键词： COVID-19 Hepatitis Pneumonia Aspartate aminotransferase Alanine aminotransferase Case report

Dysregulation of the TGF-β Postreceptor Signaling Pathway in Cell Lines Derived from Primary or Metastatic Ovarian Cancer

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2004年第1期24卷 62-65页

作者：奚玲胡伟孟力周剑峰卢运萍王常玉马丁 department of obstetrics and {2. Anderson Cancer Center Southwestern Medical Center

Transforming growth factor beta (TGF β) may cause cell cycle arrest, terminal differentiation, or apoptosis in most normal epithelial cells, whereas most malignant cell lines are resistant to TGF β. Mechanisms of resistance to TGF β caused by modulation of cell cycle regulators and/or inactivation of components of the TGF β signaling transduction pathway such as C myc and Smad4 are not well understood. To investigate the potential association between loss of sensitivity to TGF β and expression status of transforming growth factor receptor Ⅱ (TβRⅡ), Smad4, CDC2.A and C myc in 14 cell lines derived from ovarian cancer, the expression levels of these genes were detected by semi quantitative RT PCR. Normal ovarian surface tissues were used as controls. The expression of TβRⅡ was detectable in all of 14 cell lines. The expression of Smad4 was decreased in 10 cell lines and 9 cell lines overexpressed CDC2.A, as compared to normal controls. CDC2.A gene was overexpressed with 88 % (8/9) in tumorigenic cell lines as determined by xenografts in nude mice, and only in 2. % (1/5) of non tumorigenic cell lines ( P 2.A. This overexpression of CDC2.A correlates with increased tumorigenicity of ovarian cancer cell lines. The loss of sensitivity to TGF β is not associated with a lack of TβRⅡ.

关键词： Transforming growth factor b CDC2.A Smad4 C myc TβRⅡ ovarian cancer cells

p16/Ki-67 dual-stained cytology used for triage in cervical cancer opportunistic screening

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Chinese Journal of Cancer Research 2020年第2期32卷 208-217页

作者： Qin Han Hongyan Guo Li Geng Yanjie Wang department of gynecology and {2. The Third Hospital of Peking UniversityBeijing 100191China

Objective:To evaluate the efficiency of p16/Ki-67 dual stain used as a triage in cervical cancer ***:In this study,we did 468 p16/Ki-67 dual stain in human papillomavirus(HPV)16/18-positive or 12.other high-risk HPV(OHR-HPV)positive Thinprep cytologic test(TCT)atypical squamous cells of undetermined significance(ASCUS)/lower-grade squamous intraepithelial lesion(LSIL)*** evaluated the sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)of the triage ***:The sensitivity,specificity,PPV and NPV of p16/Ki-67 dual stain in HPV 16/18-positive women were91.5%/68.4%,77.0%/75.0%,73.9%/59.1%and 92.8%/81.8%.In 12.OHR-HPV positive TCT ASCUS/LSIL women,the results were 79.1%/95.0%,88.5%/66.7%,88.5%/70.4%and 89.2./94.1%.The risk of precancerous lesions in p16/Ki-67 dual stain positive cases was much higher than before,and the negative cases had lower ***,there was no cervical intraepithelial neoplasia(CIN)III case missed after triaged by p16/Ki-67 dual-stained *** p16/Ki-67 dual-stained cytology positive women with benign pathology or CIN I,the 1-year progression rate is 2..5%and in p16/Ki-67 dual-stained cytology negative women,the 1-year progression rate is5.6%.Conclusions:hr-HPV genotyping test plays an important role in cervical cancer screening.p16/Ki-67 dual stain may be a promising triage *** for chronic cervicitis or CIN I patients,a positive p16/Ki-67 dual-stained cytology suggests a high risk in progression and need to be followed up closely.

关键词： Cervical cancer screening hr-HPV genotyping test p16/Ki-67 dual-stained cytology triage test

Tranexamic acid for the management of uterine fibroid tumors:A systematic review of the current evidence

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World Journal of Clinical Cases 2014年第12期2卷 893-898页

作者： Panagiotis Peitsidis Anna Koukoulomati department of obstetrics and {2. Southend University Hospital Essex SS0 0RY United Kingdom department of obstetrics and {2. Iaso Maternity Hospital 17123 Athens Greece department of obstetrics and {2. Didymoteichon General Hospital 68300 Didymoteicho Greece

AIM: To conduct a detailed systematic review of the current evidence on the administration and efficacy of tranexamic acid in patients with menorrhagia due to uterine fibroids. METHODS: We conducted an electronic search on the following databases Pub Med and Medline(1950-2.13);(1980-2.13); Cochrane library(1993-2.13). RESULTS: A total of 36 articles were retrieved after the initial electronic search. Careful assessment of the retrieved studies led to the final selection of 5 articles for inclusion in the review. CONCLUSION: Tranexamic acid may reduce blood loss perioperatively in myomectomies. It may reduce the menorrhagia in patients with fibroids, however a stratification of fibroids by size and location is required to define the responses. It is safe in general, with mild adverse effects observed in some cases. More studies with a double-blind randomized design and larger numbers of participants are necessary to reach more precise and safe conclusions.

关键词： Tranexamic acid Uterine fibroids Fibrinolysis Menorrhagia Myomectomy

Association of a modified uterine manipulation method with improved recovery after laparoscopic radical hysterectomy: a retrospective cohort study

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生殖与发育医学(英文) 2024年第4期8卷 213-219页

作者： Sun Yu-Shu Bao Ling-Jie Xiao Yin-Ping Chang Kai-Kai Du Yan Yi Xiao-Fang department of gynecology Obstetrics and Gynecology Hospital Fudan University Shanghai China department of obstetrics and {2. of Shanghai Medical School Fudan University Shanghai China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai China department of Pathology Obstetrics and Gynecology Hospital Fudan University Shanghai China

Objective: Uterine manipulation with an intrauterine device is the surgical method used for early-stage cervical cancer. In this study, we explored a modified uterine manipulation method without the using an intrauterine device during laparoscopic radical hysterectomy (LRH) of patients with early-stage cervical ***: We retrospectively collected data of patients with early-stage cervical cancer who underwent LRH between January 2.15 and June 2.19. The clinicopathological characteristics and surgical outcomes of patients treated with the new method (Group S) were compared to those of patients treated with the conventional uterine manipulator (Group M).Results: A total of 100 patients were included in the study, with 54 patients in Group M and 46 patients in Group S. No significant difference was observed in clinicopathological characteristics between the two groups. Compared to Group M, Group S had a significantly shorter duration of postoperative fever (0vs. 3 days,P = 0.003) and a shorter duration of secondary antibiotic use (4vs. 5 days,P = 0.035). Additionally, the cost of antibiotics was lower in Group S ($95.45vs. $135.2.,P = 0.032.. The modified uterine manipulation method was associated with a lower risk of postoperative fever (P = 0.007). No difference was found in the 2.year disease-free survival (P = 0.409) and 2.year overall survival between the two groups (P = 0.718).Conclusions: The modified uterine suture suspension method is easy to perform, enhances postoperative recovery, and could be a viable option for patients with early-stage cervical cancer.

关键词： Early-stage cervical cancer Minimally invasive surgery Uterine suspension Uterine manipulator Prognosis