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Advances and global trends of precancerous lesions of gastric cancer:A bibliometric analysis

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 371-384页

作者： Yuan-Ping Jia Dian-Chun Liu Ting-Lan Cao Hui-Zhong Jiang Tao Li Yuan Li Xia Ding Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China School of Traditional Chinese medicine Beijing University of Chinese MedicineBeijing 100029China National institute of Traditional Chinese medicine Constitution and Preventive Treatment of Diseases Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Precancerous lesions of gastric cancer(PLGC)represent a critical pathological stage in the development of intestinal gastric *** detection and diagnosis are key to reducing the incidence of gastric *** advancements have been made in PLGC research in recent years,making it necessary to provide updated reviews using bibliometric *** hypothesize that this review will identify emerging trends,key research areas,and gaps in PLGC research,providing insights that could guide future studies and enhance prevention *** To comprehensively review the current state of research on PLGC,examining development trends and research *** We conducted a bibliometric analysis of PLGC-related studies published between 2.04 and 2.2. using the Web of Science Core Collection *** employed Software,including VOSviewer,CiteSpace,R software,and SCImago Graphica,to map scientific networks and visualize knowledge trends in terms of publication volume,countries/regions,institutions,journals,authors,and *** A total of 4097 articles were included,and overall publication volume showed an increasing *** the past two decades,China published the most articles,followed by the United States,Japan,South Korea,and *** the top 10 contributors,the United States ranked highest in institutions,authors,and citations and demonstrated the strongest international *** keywords in this field were clustered into three main categories:Risk factors,pathogenesis,and diagnosis and *** and molecular biomarkers remain key areas of *** research should explore the mechanisms of gut microbiota,immune microenvironment,metabolic reprogramming,and *** technologies,including single-cell sequencing,spatially resolved analysis,multi-omics approaches,artificial intelligence,and machine learning,will likely accelerate in-depth investigations of *** PLGC research

关键词： Precancerous lesions of gastric cancer Gastric precancerous lesion Dysplasia Bibliometric Visualization

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2.cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2.microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2.microglia,with a more pronounced inhibitory effect on M2.icroglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2.microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Chinese medicine for Treatment of COVID-19:A Review of Potential Pharmacological Components and Mechanisms

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Chinese Journal of Integrative medicine 2025年第1期31卷 83-95页

作者： XU Qian-qian YU Dong-dong FAN Xiao-dan CUI He-rong DAI Qian-qian ZHONG Xiao-ying ZHANG Xin-yi ZHAO Chen YOU Liang-zhen SHANG Hong-cai Key Laboratory of Chinese Internal medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China The Geriatrics Center First Affiliated HospitalAnhui University of Chinese MedicineHefei230031China School of Medical Information Engineering Guangzhou University of Chinese MedicineGuangzhou51006China institute of Basic Research in Clinical medicine China Academy of Chinese Medical SciencesBeijing100700China

Coronavirus disease 2.19(COVID-19)is an acute infectious respiratory disease that has been prevalent since December *** medicine(CM)has demonstrated its unique advantages in the fight against COVID-19 in the areas of disease prevention,improvement of clinical symptoms,and control of disease *** review summarized the relevant material components of CM in the treatment of COVID-19 by searching the relevant literature and reports on CM in the treatment of COVID-19 and combining with the physiological and pathological characteristics of the novel *** the basis of sorting out experimental methods in vivo and in vitro,the mechanism of herb action was further clarified in terms of inhibiting virus invasion and replication and improving related *** aim of the article is to explore the strengths and characteristics of CM in the treatment of COVID-19,and to provide a basis for the research and scientific,standardized treatment of COVID-19 with CM.

关键词： Chinese medicine COVID-19 SARS-CoV-2 substance component mechanism experimental method

Purinergic signaling by TCRaβ~+double-negative T regulatory cells ameliorates liver ischemia–reperfusion injury

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Science Bulletin 2025年第2期70卷 241-254页

作者： Hua Jin Mingyang Li Xiyu Wang Lu Yang Xinjie Zhong Zihan Zhang Xiaotong Han Jingjing Zhu Mengyi Li Songlin Wang Simon C.Robson Guangyong Sun Dong Zhang Immunology Research Center for Oral and Systemic Health Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Medical Research Center Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China General Surgery Department Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China beijing Laboratory of Oral Health Capital Medical University School of Basic MedicineBeijing 100069China Center for Inflammation Research Department of AnesthesiaCritical Care&Pain Medicineand Department of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02115USA

Hepatic ischemia–reperfusion injury(HIRI)is an important cause of liver injury following liver transplantation and major resections,and neutrophils are the key effector cells in ***-negative T regulatory cells(DNT)are increasingly recognized as having critical regulatory functions in the immune *** DNT expresses distinct immunoregulatory mechanisms to modulate neutrophils,as in HIRI,remains largely *** this study,we found that murine and human DNT highly expressed CD39that protected DNT from extracellular ATP-induced apoptosis and generated adenosine in tandem with CD73,to induce high levels of neutrophil ***,extracellular adenosine enhanced DNT survival and suppressive function by upregulating survivin and NKG2. expression via the A2.R/pAKT/FOXO1 signaling *** transfer of DNT ameliorated HIRI in mice through the inhibition of neutrophils in a CD39-dependent ***,the adoptive transfer of A2.r^(-/-)DNT validated the importance of adenosine/A2.R signaling,in promoting DNT survival and immunomodulatory function to protect against HIRI in *** conclusion,purinergic signaling is crucial for DNT homeostasis in *** of CD39 or activation of A2.R signaling in DNT may provide novel therapeutic strategies to target innate immune disorders.?2.2. The *** by Elsevier *** behalf of Science China *** is an open accessarticle under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Double-negative T regulatory cells Hepatic ischemia and reperfusion injury CD39 Adenosine A2.R

Correlation between diabetic peripheral neuropathy and thyroid hormone sensitivity in elderly patients with type 2.diabetes mellitus

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World Journal of Diabetes 2025年第2期16卷 71-80页

作者： Si-Jia Fei Jing-Yi Luo Wei-Hao Wang Li-Xin Guo Qi Pan Department of Endocrinology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Diabetic peripheral neuropathy(DPN)is a common complication of type 2.diabetes mellitus(T2.M),significantly affecting patients’quality of life and imposing a substantial economic *** studies have highlighted the role of thyroid hormones in diabetes complications,particularly in elderly patients with ***,the relationship between thyroid hormone sensitivity and DPN remains *** To investigate the correlation between thyroid hormone sensitivity and DPN in elderly patients with *** In a cohort of 2.6 elderly patients with T2.M,propensity score matching was used to balance age,sex,and diabetes *** data were collected to calculate thyroid hormone sensitivity and analyze its correlation with DPN.A random forest model was used to evaluate the diagnostic value of free triiodothyronine/free thyroxine(FT_(3)/FT_(4))for *** Patients with DPN had a lower FT_(3)/FT_(4) ratio[(0.302.0.053)vs(0.316±0.049),P=0.040].Quartile stratification showed decreasing DPN prevalence with higher FT_(3)/FT_(4) ***’s correlation analysis showed that a lower FT_(3)/FT_(4) ratio was associated with higher glycated hemoglobin,fasting blood glucose,reduced nerve conduction velocity,and electrical skin *** regression indicated a positive relationship between the median FT_(3)/FT_(4) ratio and bilateral foot electrochemical skin conductance[odds ratio(OR):1.019;95%CI:1.005-1.034;P=0.007]and sural nerve sensory amplitude(OR:1.310;95%CI:1.008-1.703;P=0.043).Receiver operating characteristic analysis using a random forest model showed that incorporating FT_(3)/FT_(4) improved predictive performance for DPN,with an area under the curve of 0.74,sensitivity of 0.79,specificity of 0.64,and accuracy of *** In elderly patients with T2.M with euthyroidism,a lower FT_(3)/FT_(4) ratio is correlated with increased DPN incidence,affecting both large and small nerve ***_(3)/FT_(4) is an effective predicto

关键词： Diabetic peripheral neuropathy Thyroid hormone sensitivity Type 2.diabetes mellitus Elderly Free triiodothyronine/free thyroxine ratio

Health risks of rare earth elements exposure:Impact on mitochondrial DNA copy number and micronucleus frequency

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Journal of Environmental Sciences 2025年第5期151卷 150-160页

作者： Shiyi Hong Yali Zhang Qiaojian Zhang Zekang Su Guiping Hu Li Wang Shanfa Yu Xiaojun Zhu Guang Jia Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100083China School of Engineering medicine and beijing Advanced Innovation Center for Big Data-Based Precision medicine Beihang UniversityBeijing 100083China Department of Toxicology School of Public HealthBaotou Medical CollegeBaotouInner Mongolia 014040China Henan institute for Occupational medicine Zhengzhou 450052China National Center for Occupational Safety and Health Beijing 102308China beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety School of Public HealthPeking UniversityBeijing 100083China

Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements,while,the joint effects of mixed elements exposure in the population remain *** on the Occupational Chromate Exposure Dynamic Cohort of China,this study investigated the relationship between 15 blood rare earth elements(cerium,dysprosium,erbium,europium,gadolinium,holmium,lanthanum,lutetium,neodymium,praseodymium,samarium,terbium,thulium,yttrium,and ytterbium)and mitochondrial DNA copy number(MtDNACN)as well as peripheral blood lymphocyte micronucleus frequency(MNF).The elastic net was used to select elements highly correlated with effect indicators,whose dose-response relationships were further illustrated by restricted cubic *** kernel regressionwas employed to explore the combined effects of elements and the contributions of single *** results showed that most rare earth elementswere positively correlatedwith effect indicators,with yttrium showing the strongest association(β(95%CI):0.139(0.1089–0.189)for MtDNACN,0.937(0.345–1.684)for MNF).In the mixed exposure model,with the exposure level fixed at the 50th percentile as the reference,the effect estimates on MtDNACN and MNF increased by 0.2.8 and 0.598 units,respectively,at the 75th *** single effect analysis implied that yttrium,lanthanum and terbium contributed the most to the elevation of MtDNACN,while yttrium posed the highest risk for genetic damage,accordingly,we provided recommendations to prioritize these elements of *** addition,we observed a chief mediating effect of MtDNACN on the elevation of MNF caused by lanthanum,whereas further mechanistic exploration is required to confirm this finding.

关键词： Rare earth elements Mitochondrial DNA copy number Micronucleus frequency Mixed effect

Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina beijing institute for Stem Cell and Regenerative {2. BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

Stir-Fried Semen Armeniacae Amarum Suppresses Aristolochic AcidⅠ-Induced Nephrotoxicity and DNA Adducts

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Chinese Journal of Integrative medicine 2025年第2期31卷 142-152页

作者： LI Cheng-xian XIAO Xiao-he LI Xin-yu XIAO Da-ke WANG Yin-kang WANG Xian-ling ZHANG Ping LI Yu-rong NIU Ming BAI Zhao-fang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing(100102)China Department of Hepatology Military Institute of Chinese Materiathe Fifth Medical CentreGeneral Hospital of PLABeijing(100039)China National Key Laboratory of Kidney Beijing(100039)China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu(610075)China School of Traditional Chinese medicine Capital Medical UniversityBeijing(100069)China School of Traditional Chinese medicine Southern Medical UniversityGuangzhou(510515)China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing(100039)China Department of Military Patient Management the Fifth Medical Center of PLA General HospitalBeijing(100039)China Department of Hematology the Fifth Medical Center of Chinese PLA General HospitalBeijing(100071)China

Objective:To investigate the protective effects of stir-fried Semen Armeniacae Amarum(SAA)against aristolochic acidⅠ(AAⅠ)-induced nephrotoxicity and DNA adducts and elucidate the underlying mechanism involved for ensuring the safe use of Asari Radix et ***:In vitro,HEK2.3T cells overexpressing Flag-tagged multidrug resistance-associated protein 3(MRP3)were constructed by Lentiviral transduction,and inhibitory effect of top 10 common pairs of medicinal herbs with Asari Radix et Rhizoma in clinic on MRP3 activity was verified using a self-constructed fluorescence screening *** m RNA,protein expressions,and enzyme activity levels of NAD(P)H quinone dehydrogenase 1(NQO1)and cytochrome P4501A2.CYP1A2.were measured in differentiated Hepa RG *** toxicity after inhibition of AAⅠmetabolite transport was detected using cell counting kit-8 *** vivo,C57BL/6 mice were randomly divided into 5 groups according to a random number table,including:control(1%sodium bicarbonate),AAⅠ(10 mg/kg),stir-fried SAA(1.75 g/kg)and AAⅠ+stir-fried SAA(1.75 and 8.75 g/kg)groups,6 mice in each *** 7 days of continuous gavage administration,liver and kidney damages were assessed,and the protein expressions and enzyme activity of liver metabolic enzymes NQO1 and CYP1A2.were determined ***:In vivo,combination of 1.75 g/kg SAA and 10 mg/kg AAⅠsuppressed AAⅠ-induced nephrotoxicity and reduced d A-ALI formation by 2..7%,and these detoxification effects in a dose-dependent manner(P2.expression and enzymatic activity in vitro and in vivo,respectively(P<0.05 or P<0.01).Notably,SAA also reduced AAⅠ-induced hepatotoxicity throughout the detoxification process,as indicated by a 41.3%reduction in the number of liver adducts(P<0.01).Conclusions:Stirfried SAA is a novel drug candidate for the suppression of AAⅠ-induced liver and kidney dam

关键词： aristolochic acidⅠ stir-fried Semen Armeniacae Amarum detoxification principles of compatibility metabolic enzymes transporters

Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-Xia Xu Jian-Dang Liu Bang-Jiao Ye Zi-Wen Pan Jun Lin Jin-Liang Song Jian-Qing Cao Chao Yan Ying-Ping Hao Jin-Xing Cheng Qing-Bo Wang Shanghai institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of medicine Shanghai 200025China beijing institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2.to 3.5×10^(17)ions∕cm^(2.were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2.were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum