检索结果-南通市图书馆

mLife 2024年第2期3卷 291-306页

作者： Jianguo Li Tingyin Lu Yuefei Chu Yuejun Zhang Jing Zhang Wenzhen Fu Jian Sun Yahong Liu Xiao-Ping Liao Yu-Feng Zhou State Key Laboratory for Animal Disease Control and Prevention South China Agricultural UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety evaluation South China Agricultural UniversityGuangzhouChina Yantai Fushan center for Animal Disease Control and Prevention YantaiChina

Methicillin-resistant Staphylococcus aureus(MRSA)is a current global public health problem due to its increasing resistance to the most recent antibiotic *** critical approach is to develop ways to revitalize existing ***,we show that the phytogenic compound cinnamaldehyde(CIN)and β-lactam antibiotic combinations can functionally synergize and resensitize clinical MRSA isolates to β-lactam therapy and inhibit MRSA biofilm *** studies indicated that the CIN potentiation effect on β-lactams was primarily the result of inhibition of the mecA expression by targeting the staphylococcal accessory regulator *** alone or in combination with β-lactams decreased sarA gene expression and increased SarA protein phosphorylation that impaired SarA binding to the mecA promoter element and downregulated virulence genes such as those encoding biofilm,α-hemolysin,and *** of SarA-mecA binding thus interfered with PBP2a biosynthesis and this decreased MRSA resistance to β-***,CIN fully restored the anti-MRSA activities of β-lactam antibiotics in vivo in murine models of bacteremia and biofilm ***,our results indicated that CIN acts as a β-lactam adjuvant and can be applied as an alternative therapy to combat multidrug-resistant MRSA infections.

关键词： cinnamaldehyde MRSA SarA β-lactamresistance

Diagnostic values of questionnaires of Convergence Insufficiency Symptom Survey and College of Optometrists Vision Development Quality of Life in the screening of convergence insufficiency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第5期17卷 904-908页

作者： Ling Xiong Qian Chen Ye Wu Department of Ophthalmology West China HospitalSichuan University/Laboratory of Optometry and Vision ScienceWest China School of MedicineChengdu 610041Sichuan ProvinceChina Department of Clinical Research Management Center of BiostatisticsDesignMeasurement and EvaluationWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To compare and analyse the diagnostic efficacy of the College of Optometrists Vision Development Quality of Life Questionnaire(COVD-QOL)and the Convergence Insufficiency Symptom Survey(CISS)in detecting convergence insufficiency and to compare their diagnostic value in clinical ***:Using the diagnostic test method,62 adult patients with convergence insufficiency(age:24.74±3.75y)and 62 normal participants(age:23.61±3.13y)who visited the Optometry Clinic of West China Hospital of Sichuan University from April 2021 to January 2023 were *** subjects completed the CISS and *** analysis of the sensitivity and specificity of the CISS and COVD-QOL and comparison and joint experimental analysis of their diagnostic efficacy were ***:The sensitivity of the CISS and COVD-QOL for convergence insufficiency was 64.5%and 71.0%,respectively,while the specificity was 96.8%and 67.7%,*** to the CISS alone,the combination of the CISS and COVD-QOL demonstrated lower sensitivity and *** areas under the receiver operating characteristic curve of CISS,COVD-QOL and CISS combined with COVD-QOL were 0.806,0.694 and 0.782,***:Considering the low sensitivity of the CISS and the low specificity of the COVD-QOL,it is recommended to supplement these questionnaires with other screening tests for the detection of convergence insufficiency.

关键词： convergence insufficiency symptom survey College of Optometrists Vision Development Quality of Life Questionnaire convergence insufficiency asthenopia

Improving Satellite-Retrieved Cloud Base Height with Ground-Based Cloud Radar Measurements

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第11期41卷 2131-2140页

作者： Zhonghui TAN Ju WANG Jianping GUO Chao LIU Miao ZHANG Shuo MA College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation center on Forecast and evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration School of Atmospheric PhysicsNanjing University of Information Science&TechnologyNanjing 210044China National Satellite Meteorological center(National center for Space Weather) China Meteorological AdministrationBeijing 100081China

Cloud base height(CBH) is a crucial parameter for cloud radiative effect estimates, climate change simulations, and aviation guidance. However, due to the limited information on cloud vertical structures included in passive satellite radiometer observations, few operational satellite CBH products are currently available. This study presents a new method for retrieving CBH from satellite radiometers. The method first uses the combined measurements of satellite radiometers and ground-based cloud radars to develop a lookup table(LUT) of effective cloud water content(ECWC), representing the vertically varying cloud water content. This LUT allows for the conversion of cloud water path to cloud geometric thickness(CGT), enabling the estimation of CBH as the difference between cloud top height and CGT. Detailed comparative analysis of CBH estimates from the state-of-the-art ECWC LUT are conducted against four ground-based millimeter-wave cloud radar(MMCR) measurements, and results show that the mean bias(correlation coefficient) is0.18±1.79 km(0.73), which is lower(higher) than 0.23±2.11 km(0.67) as derived from the combined measurements of satellite radiometers and satellite radar-lidar(i.e., Cloud Sat and CALIPSO). Furthermore, the percentages of the CBH biases within 250 m increase by 5% to 10%, which varies by location. This indicates that the CBH estimates from our algorithm are more consistent with ground-based MMCR measurements. Therefore, this algorithm shows great potential for further improvement of the CBH retrievals as ground-based MMCR are being increasingly included in global surface meteorological observing networks, and the improved CBH retrievals will contribute to better cloud radiative effect estimates.

关键词： cloud base height passive radiometer ground-based cloud radar remote sensing

Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： Jian Ouyang Xiuping Li Changwei Liu Danmin Lu Jie Ouyang Fang Zhou Qi Liu Jianan Huang Zhonghua Liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Hunan Agricultural UniversityChangsha 410128China Co-Innovation center of Education Ministry for Utilization of Botanical Functional Ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for evaluation and Utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in preventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(P<0.05).In addition,JSTE increased the expression of intestinal tight junction proteins(P<0.05),relieved metabolic endotoxemia(P<0.05)and chronic low-grade inflammation in HFD *** of fecal samples showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

同方期刊数据库

Hierarchical Voronoi Structure Inspired by Cat Paw Pads Substantially Enhances Landing Impact Energy Dissipation

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第4期21卷 1847-1861页

作者： Da Lu Baoqing Pei Yangyang Xu Mengyuan Hu Shijia Zhang Le Zhang Xin Huang Yangwei Wang Xueqing Wu Beijing Key Laboratory for Design and evaluation Technology of Advanced Implantable&Interventional Medical Devices Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang University100083BeijingChina National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing Institute of Technology100081BeijingChina Shenzhen Institute of Beihang University 518000ShenzhenChina

When a human lands from a high drop,there is a high risk of serious injury to the lower *** the other hand,cats can withstand jumps and falls from heights without being fatally wounded,largely due to their impact-resistant paw *** aim of the present study was to investigate the biomechanism of impact resistance in cat paw pads,propose an optimal hierarchical Voronoi structure inspired by the paw pads,and apply the structure to bionic cushioning shoes to reduce the impact force of landing for *** microstructure of cat paw pads was observed via tissue section staining,and a simulation model was reconstructed based on CT to verify and optimize the structural cushioning *** distribution pattern,wall thickness of compartments,thickness ratio of epidermis and dermis,and number of compartments in the model were changed and simulated to achieve an optimal composed structure.A bionic sole was 3D-printed,and its performance was evaluated via compression test and a jumping-landing *** results show that cat paw pads are a spherical cap structure,divided from the outside to the inside into the epidermis,dermis,and compartments,each with different cushioning capacities.A finite element simulation of different cushioning structures was conducted in a cylinder with a diameter of 20 mm and a height of 10 mm,featuring a three-layer *** optimal configuration of the three layers should have a uniform distribution with 0.3–0.5 mm wall thickness,a 1:1–2 thickness ratio of epidermis and dermis,and 100–150 compartments.A bionic sole with an optimized structure can reduce the peak impact force and delay the peak arrival *** energy absorption rate is about 4 times that of standard *** jumping 80,100,and 120 cm,the normalized ground reaction force is also reduced by 8.7%,12.6%and 15.1%compared with standard *** study provides theoretical and technical support for effective protection against human lower limb landing injuries.

关键词： Cat paw pads Hierarchical Voronoi structure Landing impact Energy dissipation Bionic sole

Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2006-2025页

作者： Bingwen Ding Zhu Zhu Cong Guo Jiaxin Li Yong Gan Miaorong Yu State Key Laboratory of Drug Research and center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Pharmacy Henan UniversityKaifeng 475004China NMPA Key Laboratory for Quality Research and evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

Diabetes,characterized by hyperglycemia,is a major cause of death and disability ***,such as insulin and glucagon-like peptide-1(GLP-1)analogs,have shown promise as treatments for diabetes due to their ability to mimic or enhance insulin's actions in the *** to subcutaneous injection,oral administration of anti-diabetic peptides is a preferred ***,biological barriers significantly reduce the efficacy of oral peptide *** advancements in drug delivery systems and formulation techniques have greatly improved the oral delivery of peptide therapeutics and their efficacy in treating *** review will highlight(1)the benefits of oral anti-diabetic peptide therapeutics;(2)the biological barriers for oral peptide delivery,including pH and enzyme degradation,intestinal mucosa barrier,and biodistribution barrier;(3)the delivery platforms to overcome these biological ***,the review will discuss the prospects in this *** information provided in this review will serve as a valuable guide for future developments in oral anti-diabetic peptide therapeutics.

关键词： Oral peptides Diabetes Delivery platforms Insulin Glucagon-like peptide-1 Biodistribution Biological barriers Targeted delivery

Understanding livelihood vulnerability:a perspective from Western Sichuan’s ethnic rural settings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2024年第2期21卷 380-396页

作者： YU Yongqian JING Zheng WANG Yan QIU Xiaoping YANG Xueting XU Yun School of Geography and Resource Science Sichuan Normal UniversityChengdu 610101China Key Laboratory of land Resources evaluation and Monitoring in Southwest Ministry of EducationSichuan Normal UniversityChengdu 610101China Sichuan County Economic Development Research center Mianyang Normal UniversityMianyang 621000China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China

To explore the livelihood status and key influencing factors of rural households in the minority areas,we collected flat data from 284 rural households in 32 villages across 12 counties of Western Sichuan from 2021 to *** conducted participatory household survey on the livelihood status of the rural households and try to identify the key factors to influence their livelihood vulnerability using multiple linear *** results showed that:the livelihood situation of the rural households is relatively *** vulnerability varies significantly with the income levels,education levels,and income *** vulnerability of farm households,categorized from low to high livelihood types,follows the sequence:non-agricultural dominant households,non-agricultural households,agricultural dominant households,and pure agricultural *** degree of damage to the natural environment,education costs,loan opportunities,the proportion of agricultural income to annual household income,and the presence of sick people in the household have significant positive effects on the livelihood vulnerability index(LVI)of rural households;while help from relatives and friends,net income per capita,household size,household education,agricultural land area,participation in industrial organizations,number of livestock,purchase of commercial houses,drinking water source,and self-supply of food have significant negative *** on the findings,we believe that local rural households operate in a complex livelihood system and recommend continuous interventions targeting key influences to provide empirical research support for areas facing similar situations.

关键词： Livelihood Vulnerability Rural households Ethnic areas

Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein(RNP)to inhibit herpes simplex virus1 infection in vitro and in vivo

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1362-1379页

作者： Yuanda Wan Liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao NMPA Key Laboratory for Research and evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China center of Clinical Pharmacy Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Key Laboratory of Infectious Diseases Research in South China(Southern Medical University) Ministry of EducationGuangzhou 510515China

Extracellular vesicles(EVs)have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins(RNPs),owing to their ability to minimize off-target effects and immune ***,enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment within *** response,we employed the Fc/Spa interaction system,in which the human Fc domain was fused to the intracellular domain of PTGFRN-Δ687 and anchored to the EV ***,the B domain of the Spa protein was fused to the C domain of cargos such as Cre or *** to the robust interaction between Fc and Spa,this method enriched nearly twice the amount of cargo within the *** loaded with spCas9 RNP targeting the HSV1 genome exhibited significant inhibition of viral replication in vitro and in ***,following neuron-targeting peptide RVG modification,the in vivo dosage in neural tissues substantially increased,contributing to the clearance of the HSV1 virus in neural tissues and exhibiting a lower off-target *** findings establish a robust platform for efficient EV-based SpCas9 delivery,offering potential therapeutic advantages for HSV1 infections and other neurological disorders.

关键词： Extracellular vesicles CRISPR/Cas9 Ribonucleoproteins PTGFRN Fc/Spa HSV1 Neuron-targeting Delivery

Macrophage senescence in health and diseases

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第4期14卷 1508-1524页

作者： Longling Wang Wenxiang Hong Hong Zhu Qiaojun He Bo Yang Jiajia Wang Qinjie Weng center for Drug Safety evaluation and Research Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Nanhu Brain-Computer Interface Institute Hangzhou 311100China Taizhou Institute of Zhejiang University Taizhou 318000China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China

Macrophage senescence,manifested by the special form of durable cell cycle arrest and chronic low-grade inflammation like senescence-associated secretory phenotype,has long been consid-ered *** senescence of macrophages may lead to maladaptation,immune dysfunction,and finally the development of age-related diseases,infections,autoimmune diseases,and ***,it is a ubiquitous,multi-factorial,and dynamic complex phenomenon that also plays roles in remodeled processes,including wound repair and *** this review,we summarize some general molecular changes and several specific biomarkers during macrophage senescence,which may bring new sight to recognize senescent macrophages in different ***,we take an in-depth look at the functional changes in senescent macrophages,including metabolism,autophagy,polarization,phagocytosis,antigen presentation,and infiltration or ***,some degenerations and diseases associated with senescent macrophages as well as the mechanisms or relevant genetic regulations of senescent macrophages are integrated,not only emphasizing the possibility of regulating macrophage senescence to benefit age-associated diseases but also has an implication on the finding of potential tar-gets ordrugs clinically.

关键词： Macrophages Senescence Molecular changes Functional alterations Aging tissues Age-associated diseases Drug treatment Genetic regulation

Effects ofβ-1,3-glucan and ascorbic acid on the nutritional-immune response and antioxidant signaling pathways of live tiger grouper during simulated transport

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2024年第2期9卷 265-272页

作者： Bo Wu Zhenkun Xu Jie Cao Qi Wang Jun Mei Jing Xie College of Food Science and Technology Shanghai Ocean UniversityShanghai201306China National Experimental Teaching Demonstration center for Food Science and Engineering Shanghai Ocean UniversityShanghai201306China Shanghai Engineering Research center of Aquatic Product Processing and Preservation Shanghai201306China Shanghai Professional Technology Service Platform on Cold Chain Equipment Performance and Energy Saving evaluation Shanghai201306China

Transport in water is the most common method for transporting live fish in China,however,transport is a strong *** stress could lead to a reduced immune and antioxidant system function of tiger grouper,resulting in sickness and ***,tiger grouper were continuously stressed during transport,which resulted in quality *** is necessary that find a way to relieve the stress of transportation of tiger *** acid is not only a good anti-stress agent,but it is also an effective immunostimulant.β-1,3-glucan is a feed additive that can enhance the immune response of ***,this study evaluated the effects ofβ-1,3-glucan and ascorbic acid on the nutritional-immune response and antioxidant signaling pathways of live tiger grouper during simulated *** indicated that addingβ-1,3-glucan and ascorbic acid in transport-water muted the increase of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)*** addition,β-1,3-glucan and ascorbic acid activated Nrf2 and mediated TOR expression and then up-regulate related mRNA expression of antioxidant and immune *** concluded that the application ofβ-1,3-glucan and ascorbic acid inhibit the increase of metabolism enzymes and inflammatory factors and activate immune and antioxidant signaling pathways to relieve oxidant stress,immune response,and *** the loss of amino acids provided nutrients to relieve oxidative stress and immune response,which demonstrated immune-nutritional response in live tiger grouper during simulated *** results may provide a new solution for alleviating the decline of immune and antioxidant function of tiger grouper caused by transportation stress.

关键词： Tiger grouper β-1,3-Glucan Ascorbic acid Immune response Antioxidant signaling pathway