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Allergic fungal rhinosinusitis accompanied by allergic bronchopulmonary aspergillosis: A case report and literature review

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World Journal of Clinical Cases 2019年第22期7卷 3821-3831页

作者： Ke-Jia Cheng Min-Li Zhou Yong-Cai Liu Shui-Hong Zhou department of otolaryngology The First Affiliated Hospital College of Medicine Zhejiang University

BACKGROUND Concomitant allergic fungal rhinosinusitis(AFRS)and allergic bronchopulmonary aspergillosis(ABPA)are extremely rare,with no more than 20 cases reported in the English *** SUMMARY A 52-year-old female patient complained of right-sided nasal obstruction,rhinorrhea,sneezing,epistaxis,and hyposmia for a period of around 5 *** examination detected paleness and edema of the nasal mucous membrane and a polyp in the right middle meatus.A computed tomography(CT)scan of the sinuses revealed a ground-glass opacity filling the right maxillary and ethmoid sinuses,along with bone absorption in the medial wall of the right maxillary *** resonance images were obtained with T1-weighted,T2-weighted,and gadolinium-enhanced T1-weighted sequences.A well-defined mass,located in the right maxillary and ethmoid sinuses and displaying obvious hypointense features,was observed on both T1-and T2-weighted images,with peripheral enhancement on gadolinium-enhanced T1-weighted *** patient also has a 20-year history of cough and *** CT revealed columned and cystiform bronchiectasis in the bilateral bronchus,surrounded by a large number of spotted and funicular high-density *** level of serum total IgE was>5000 kU/*** IgE levels related to house dust and aspergillus showed a positive result,with the values being 3.5 kU/L and 1.2 kU/*** performed functional endoscopic sinus surgery under local *** surgery,topical glucocorticoids and saline irrigation were applied in the nasal cavity until the present *** oral glucocorticoid(methylprednisolone 16 mg/d)and antifungal agent(itraconazole 200 mg/d)were also used for a period of 4 *** was prescribed at 10 mg/d until the present *** endoscopic examination showed that the patient was recovering well at 3 mo after *** Since different specialists treat ABPA and AFRS,their coexistence may be *** accompanied by ABPA requires surgical t

关键词： Allergic fungal rhinosinusitis Allergic bronchopulmonary aspergillosis Aspergillus Clinical characteristics Treatment Surgery

Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness:A retrospective pilot study

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World Journal of Clinical Cases 2022年第20期10卷 6811-6824页

作者： Toru Miwa Shin-ichi Kanemaru department of otolaryngology-Head and Neck Surgery Osaka Metropolitan UniversityOsaka 5458585Japan department of otolaryngology-Head and Neck Surgery Tazuke Kofukai Medical Research InstituteKitano HospitalOsaka 5308480Japan department of otolaryngology-Head and Neck Surgery Kyoto UniversityKyoto 7507501Japan

BACKGROUND Persistent postural-perceptual dizziness(PPPD)is a functional disorder,typically preceded by acute vestibular *** is characterized by a shift in processing spatial orientation information,to favor visual over vestibular and somatosensory inputs,and a failure of higher cortical *** date,no therapies for PPPD have been *** medicine hangebyakujutsutemmato(HBT)has been reported to alleviate disturbances of *** hypothesized that HBT would be a beneficial treatment for *** To examine the efficacy of HBT for the treatment of *** Patients with PPPD were enrolled and divided into two groups:The HBT group(n=24)and the non-HBT group(n=14).The participants completed questionnaire surveys[Niigata PPPD questionnaire(NPQ),dizziness handicap inventory,hospital anxiety and depression scale(HADS),orthostatic dysregulation questionnaire,pittsburg sleep quality index(PSQI),and motion sickness scores]before and after HBT ***,to identify HBT responders,multivariate regression analysis was performed using the results of the ques-tionnaire surveys and equilibrium tests;including stabilometry,and caloric,vestibular evoked myogenic response,and head-up tilt *** Thirty-eight outpatients were included in this study,of which 14 patients(3 men,11 women;mean age,63.5±15.9 years)received treatment without HBT,and 24(1 man,23 women;mean age,58.2±18.7 years)received combination treatment with *** HBT treatment,NPQ scores decreased significantly(baseline 40.1±10.0 vs 2 mo 24.6±17.7,P1).No statistically significant changes were observed in the NPQ scores in the non-HBT group(baseline 38.6±12.2 vs 2 mo 39.4±14.4,P=0.92).Multivariable regression analysis revealed that the results of stabilometry(P=0.02)and the caloric(P=0.03),and head-up tilt tests(P1),HADS(P=0.003),and PSQI(P=0.01)were associated with HBT responsiveness in PPPD *** HBT may be an effective adjunct therapy fo

关键词： Hangebyakujutsutemmato Kampo medicine Persistent postural-perceptual dizziness Niigata persistent postural-perceptual dizziness questionnaire score Sensory reweighting Treatment responder

Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux

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World Journal of Gastroenterology 2013年第31期19卷 5118-5124页

作者： Ryoji Tokashiki Isaku Okamoto Nobutoshi Funato Mamoru Suzuki department of otolaryngology Tokyo Medical University Tokyo 160-0023 Japan

AIM: To investigate the effect of rikkunshito on laryngopharyngeal reflux(LPR) symptoms and gastric emptying in patients with proton-pump inhibitor(PPI)refractory ***: In total,22 patients with LPR were *** a 2-wk treatment with PPI monotherapy,PPI-refractory LPR patients were randomly divided into two treatment groups(rikkunshito alone or rikkunshito plus the PPI,lansoprazole).LPR symptoms were assessed using a visual analog scale(VAS) score,gastrointestinal symptoms were assessed using the gastrointestinal symptom rating scale(GSRS),and gastric emptying was assessed using the radio-opaque marker method prior to and 4 wk following ***: The 4-wk treatment with rikkunshito alone and with rikkunshito plus the PPI significantly decreased the globus sensation VAS *** VAS score for sore throat was significantly decreased following treatment with rikkunshito plus PPI but not by rik kunshito *** treatment significantly changed the GSRS *** improved delayed gastric *** found a significant positive correlation between improvements in globus sensation and in gastric emptying(r2= 0.4582,P < 0.05).CONCLUSION: Rikkunshito improved globus sensation in patients with PPI-refractory LPR,in part,because of stimulation of gastric ***,rikkunshito is an effective treatment for PPI-refractory LPR.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux disease Globus sensation Gastric emptying Rikkunshito

Outcomes of endoscopic endonasal dacryocysto-rhinostomy for intractable lacrimal dacryostenosis and associated factors

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1471-1475页

作者： Tohru Tanigawa Hirokazu Sasaki Hiroshi Nonoyama Yuichiro Horibe Kunihiro Nishimura Tetsuro Hoshino Tetsuya Ogawa Kenta Murotani Hiromi Ueda Masahiro Kaneda department of otolaryngology Aichi Medical University department of otolaryngology Tono Kosei Hospital Division of Biostatistics Clinical Research CenterAichi Medical University department of Ophthalmology Tono Kosei Hospital

AIM：To examine the effects of patient age,canalicular obstruction,mode of anesthesia,and duration of nasolacrimal intubation on the outcomes of endoscopic endonasal dacryocystorhinostomy（DCR）. METHODS： Totally 56 eyes of 46 patients with prolonged epiphora underwent minimally invasive endoscopic endonasal DCR.A successful surgical outcome was defined as a significant improvement in symptoms,adequate water passage from the puncta to the nasal cavity,and patency of the DCR *** outcomes were assessed at least 6mo after ***＇s exact test was used to discuss the factors,and then the logistic regression analysis was made by SAS9.4 ***： The overall success rate was 75.0%,and complete resolution was observed in 27 *** success rate was higher for patients with ≥6mo intubation than for those with 〈6mo ***,there were no significant differences in outcomes between groups stratified by age（〈65 or ≥65y）,presence or absence of canalicular obstruction,mode of anesthesia（local or general）,and use or nonuse of a radiowave *** patient developed subcutaneous emphysema around the eye and nose and one developed subcutaneous hemorrhage after surgery. CONCLUSION： Endoscopic endonasal DCR can be considered safe and minimally invasive with reasonable success rates,particularly when the duration of nasolacrimal intubation is ≥6mo.

关键词： dacryocystorhinostomy endoscopy,, intubation epiphora

LOWER DOSE OF AMINOGLYCOSIDE OTOTOXIC EXPOSURE CAUSES PRESYNAPTIC ALTERATIONS ASSOICATED WITH HEARING LOSS

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Journal of Otology 2014年第1期9卷 36-42页

作者： LIU Ke WANG Xiaoyu LI Sijun TANG Siquan XU Yice WANG Xuefeng SUN Jianhe YANG Weiyan YANG Shiming department of otolaryngology-Head and Neck Surgery PLA General Hospital PLA Institute of Otolaryngology department of otolaryngology-Head and Neck Surgery the Affiliated Hospital North SiChuan Medical College department of otolaryngology-Head and Neck Surgery the First Affiliated Hospital Liaoning Medical University

Objective To study presynaptic alternations of cochlear ribbons arising from aminoglycoside ototoxic stimuli in C57BL/6J mice. Methods Animals were injected with low dose gentamicin (100 mg/kg/day) for 14 days, From the 14th to 28th days, the mice were maintained free of gentamicin treatment. Immunohisto-chemistry labeling was employed to trace RIBEYE, a major presynaptic componment of ribbon synapses. RIBEYE/CtBP2 expression levels were assessed and compared with hearing threshold shifts. Auditory func-tion was assessed by auditory brainstem responses. The stereocilia of outer hair cells (OHCs) and IHCs was examined by scanning electron microscopy (SEM). Results Hearing thresholds were elevated with peak hearing loss observed on the 7th day after gentamicin exposure, followed by improvement after the 7th day. RIBEYE/CtBP2 expression directly correlated with observed hearing threshold shifts. Strikingly, we did not see any obvious changes in stereocilia in both OHCs and IHCs until the 28th day. Mild changes in stereocil-ia were only observed in OHCs on the 28th day. Conclusions These findings indicate that presynapse co-chlear ribbons, rather than stereocilia, may be sensitive to aminoglycoside ototoxic exposure in mice cochle-ae. A pattern of RIBEYE/CtBP2 expression changes seems to parallel hearing threshold shifts and suggests presynaptic response properties to lower dosage of aminoglycoside ototoxic stimuli.

关键词： Inner Hair Cells Ribbon Synapse Aminoglycoside Ototoxicity RIBEYE/CtBP2 Stereocilia

Combined inhibitors of angiogenesis and histone deacetylase:Efficacy in rat hepatoma

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World Journal of Gastroenterology 2011年第31期17卷 3623-3629页

作者： Marion Ganslmayer Annette Zimmermann Steffen Zopf Christoph Herold Medical department 1 University hospital Erlangen-Nuernberg department of otolaryngology University of Marburg

AIM:To evaluate the antitumoral effect of combined inhibitors of angiogenesis and histone deacetylases in an experimental rat hepatoma ***:MH7777A hepatoma cells were injected into the liver of male Buffalo *** 7 d treatment with the vascular endothelial growth factor receptor antagonist PTK787/ZK222584(PTK/ZK),the histone deacetylase inhibitor MS-275,tamoxifen(TAM) and/or retinoic acid was initiated(n ≥ 8 animals/group).Natural tumor development was shown in untreated control groups(control 1 with n = 12,control 2 with n = 8).The control groups were initiated at different time points to demonstrate the stability of the hepatoma *** documentation of possible side effects,we documented any change in body weight,loss of fur and *** 21 d treatment,the rats were *** target parameters were tumor size and metastasis ***,immunohistochemistry for the proliferating cell nuclear antigen(PCNA) and TdT-mediated dUTP-biotin nick end labeling(TUNEL) assay were ***:The control groups developed large tumor nodules with extrahepatic tumor burden in the lung and abdominal organs(control 1:6.18 cm3 ± 4.14 cm3 and control 2:8.0 cm3 ± 4.44 cm3 28 d after tumor cell injection).The tumor volume did not differ significantly in the control groups(P = 0.13).As single agents MS-275 and PTK/ZK reduced tumor volume by 58.6% ± 2.6% and 48.7% ± 3.2% vs control group 1,which was significant only for MS-275(P = 0.025).The combination of MS-275 and PTK/ZK induced a nearly complete and highly significant tumor shrinkage by 90.3% ± 1%(P = 0.005).Addition of TAM showed no further efficacy,while quadruple therapy with retinoic acid increased antitumoral efficacy(tumor reduction by 93 ± 1%) and side *** positive cells were not significantly reduced by the single agents,while dual therapy(MS-275 and PTK/ZK) and quadruple therapy reduced the PCNA-positive cell fraction significantly by 9.1 and 20.6% vs control 1(P < 0.05).Th

关键词： PTK787 ZK222584 MS-275 Hepatocellular carcinoma Histone deacetylase inhibitor

From nuclear submarines to graduate medical education: applying David Marquet's intent-based leadership model

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Military Medical Research 2018年第1期5卷 90-91页

作者： Camilo Fernandez-Salvador Rebecca Oney Sungjin A.Song Macario Camacho department of otolaryngology Tripler Army Medical Center otolaryngology-Head and Neck Surgery Tripler Army Medical Center

*** Marquet,a decorated Navy Captain,transformed an under performing submarine crew by empowering his subordinates to be leaders and reach their full *** called this intent-based leadership(IBL).What would happen if Marquet’s model were implemented in Graduate Medical Education(GME)?In this letter to the editor,we summarize the potential of the IBL model in graduate medical education as opposed to the traditional leaderfollower *** harnesses human productivity toward the shared goals of GME,which are patient care and trainee *** shift in mindset could lead both teachers and trainees to focus more on the real reason that we undertake GME and change behaviors for the *** suggest that IBL can and should be adopted in GME and propose that both patients and providers will benefit from this action.

关键词： David Marquet Leadership Graduate medical education Intent-based leadership

HSP90AA1 promotes lymphatic metastasis of hypopharyngeal squamous cell carcinoma by regulating epithelial-mesenchymal transition

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Oncology Research 2023年第5期31卷 787-803页

作者： FENGXIANG TANG YANSHI LI MIN PAN ZHIHAI WANG TAO LU CHUAN LIU XIN ZHOU GUOHUA HU department of otolaryngology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Lymphatic metastasis(LM)emerges as an independent prognostic marker for hypopharyngeal squamous cell carcinoma(HSPSCC),chiefly contributing to treatment *** study aimed to scrutinize the prognostic relevance of HSP90AA1 and its potential regulatory mechanism of concerning LM in ***:In a preceding investigation,HSP90AA1,a differential gene,was discovered through transcriptome sequencing of HPSCC tissues,considering both the presence and absence of *** of HSP90AA1 expression was accomplished via qRT-PCR,western-blotting(WB),and immunohistochemistry(IHC),while its prognostic significance was assessed employing Kaplan–Meier survival analysis(KMSA),log-rank test(LR),and Cox’s regression analysis(CRA).Bioinformatics techniques facilitated the prediction and analysis of its plausible mechanisms in LM,further substantiated by in vitro and in vivo experiments utilizing FaDu cell ***:HSP90AA1 is substantially upregulated in HPSCC with LM and is identified as an independent prognostic risk *** down-regulation of HSP90AA1 can achieve inhibition of tumor cell proliferation,migration and *** in vivo experiments and Bioinformatics exploration hint at promoting LM by Epithelial-mesenchymal transition(EMT),regulated by ***:HSP90AA1,by controlling EMT,can foster LM in *** finding sets the foundation for delving into new therapeutic targets for HPSCC.

关键词： Hypopharyngeal squamous cell carcinoma Lymphatic metastasis HSP90AA1 EMT HNSCC

Effects and mechanism of Chinese medicine Jiawei Yupingfeng in a mouse model of allergic rhinitis

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Journal of Integrative Medicine 2021年第4期19卷 354-361页

作者： Hui Chen Wei Feng Ye Lu Yi Yang Zhong-hai Xin Man Li Li Xin Ying-di Gong department of otolaryngology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China

Objective: Chinese medicine has the potential to modulate allergic rhinitis(AR). There have been studies investigating the treatment efficacy of Yupingfeng San, alone or in combination with other ingredients, in AR, though few have studied the potential mechanisms of these drugs. In the present study, we measured the effects of Jiawei Yupingfeng(JWYPF), a traditional Chinese medicine formula, on mice with ovalbumin-induced AR and explored its underlying mechanism of ***: Forty BALB/c mice were randomly divided into normal control, allergy control and two treatment groups of ten mice each. In the normal control group, mice were sensitized and challenged with saline. The mice in the allergy control and treatment groups were sensitized and challenged with ovalbumin and aluminum hydroxide gel. The treatments of JWYPF and Nasonex were administered intranasally in the AR mice for one week. Several signs of allergic inflammation, such as nasal eosinophils and inflammatory cytokines, were measured to determine the underlying ***: Mice in the JWYPF and Nasonex groups had significantly lower AR symptom scores than those in the allergy control group(the mean differences between JWYPF and the allergy control, and Nasonex and the allergy control were -2.00 ± 0.35 and -2.40 ± 0.32). After treatment with JWYPF and Nasonex, the levels of ovalbumin-specific Ig E and histamine were significantly reduced, as were the levels of interlukin-4 and transforming growth factor-b, while interferon-c levels were increased(all P 1,vs. allergy control). These two treatments also significantly inhibited eosinophil and mast cell infiltration into the nasal cavity but were not statistically different from ***: JWYPF has a potential therapeutic effect on AR via adjusting the rebalance of T helper 1 and T helper 2.

关键词： Chinese medicine Jiawei Yupingfeng Allergic rhinitis Mouse Inflammatory cytokines