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Journal of Clinical and Nursing Research 2024年第5期8卷 200-205页

作者： Li Xu department of critical care medicine Shiyan Yunyang District People’s HospitalShiyan 442500HubeiChina

Objective:To implement humanized quality care in critical respiratory failure nursing,observe the effect,and analyze the ***:80 patients with severe respiratory failure were divided into 40 cases per group(admitted from February 2022 to December 2023)by double-blind method,the control group performed routine care,and the observation group was given humanized quality ***:After the nursing care,two respiratory function indexes of the observation group were lower than those of the control group,and two pulmonary function indexes were higher than those of the control group(Pcare satisfaction situation,the observation group had a higher level of total satisfaction(Pcare of critical respiratory failure can actively improve patients’respiratory status and lung function,reduce complications,and satisfy patients.

关键词： critical respiratory failure Humanized quality nursing Nursing satisfaction

Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway

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Chinese Journal of Integrative medicine 2024年第3期30卷 230-242页

作者： WANG Yi CHEN Ming-qi DAI Lin-feng ZHANG Hai-dong WANG Xing department of critical care medicine Changzhou Hospital of Traditional of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213000China department of critical care medicine Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210029China

Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo ***:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell *** pharmacology analysis identified the key molecular pathway associated with FFD in *** ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was ***:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(P14/FOXO signaling pathway during *** confirmed by in vitro cell experiments,FFD inhibited the MAPK14 signaling pathway or FOXO3A expression to relieve LPS-induced macrophage apoptosis and inflammation(P14/FOXO3A signaling pathway to inhibit LPS-induced macrophage apoptosis in the lung tissue of septic mice(P14/FOXO3A signaling pathway.

关键词： sepsis Fangji Fuling Decoction mitogen-activated protein kinase 14/Forkhead Box O 3A signaling pathway inflammatory response apoptosis lung injury Chinese medicine

Chinese expert consensus on sedation and analgesia for neurocritical care patients

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Chinese Medical Journal 2024年第11期137卷 1261-1263页

作者： Linlin Zhang Shuai Liu Shuya Wang Jian-Xin Zhou the National Center for Healthcare Quality Management in Neurological Diseases Chinese Society of critical care medicine Working group of the Expert Consensus on Sedation and Analgesia for Neurocritical care Patients department of critical care medicine Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China department of critical care medicine Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China 不详

Sedation and analgesia therapy are essential in neurocritical care,but there are ongoing controversies surrounding assessment,administration,and *** advances in neurocritical care medicine,updated evidence-based medicine,considering the variability in knowledge and practice,the National Center for Healthcare Quality Management in Neurological Diseases and the Chinese Society of critical care medicine organized experts in neurocritical care to form a working group[Supplementary File 1,http://***/CM9/B958]to update the“Expert Consensus on Sedation and Analgesia for Patients with Severe Brain Injury(2013)”.

关键词： analgesia critical advances

Prognostic value of time-varying dead space estimates in mechanically ventilated patients with acute respiratory distress syndrome

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Journal of Intensive medicine 2024年第2期4卷 187-193页

作者： Lianlian Jiang Hui Chen Jianfeng Xie Ling Liu Yi Yang Jiangsu Provincial Key Laboratory of critical care medicine Department of Critical Care MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuChina department of critical care medicine The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhouJiangsuChina

Background The dead space fraction(VD/VT)has proven to be a powerful predictor of higher mortality in acute respiratory distress syndrome(ARDS).However,its measurement relies on expired carbon dioxide,limiting its widespread application in clinical *** estimates employing routine variables have been found to be reliable substitutes for direct measurement of VD/*** this study,we evaluated the prognostic value of these dead space estimates obtained in the first 7 days following the initiation of *** This retrospective observational study was conducted using data from the Chinese database in intensive care(CDIC).Eligible participants were adult ARDS patients receiving invasive mechanical ventilation while in the intensive care unit between 1st January 2014 and 31st March *** collected data during the first 7 days of ventilation to calculate various dead space estimates,including ventilatory ratio(VR),corrected minute ventilation(V_(Ecorr)),VD/VT(Harris–Benedict),VD/VT(Siddiki estimate),and VD/VT(Penn State estimate)longitudinally.A time-dependent Cox model was used to handle these time-varying *** A total of 392 patients(median age 66[interquartile range:55–77]years,median SOFA score 9[interquartile range:7–12])were finally included in our analysis,among whom 132(33.7%)patients died within 28 days of ***(hazard ratio[HR]=1.04 per 0.1 increase,95%confidence interval[CI]:1.01 to 1.06;P=0.013),V_(Ecorr)(HR=1.08 per 1 increase,95%CI:1.04 to 1.12;P1),VD/VT(Harris–Benedict)(HR=1.25 per 0.1 increase,95%CI:1.06 to 1.47;P=0.006),and VD/VT(Penn State estimate)(HR=1.22 per 0.1 increase,95%CI:1.04 to 1.44;P=0.017)remained significant after adjustment,while VD/VT(Siddiki estimate)(HR=1.10 per 0.1 increase,95%CI:1.00 to 1.20;P=0.058)did *** a large number of negative values,VD/VT(Siddiki estimate)and VD/VT(Penn State estimate)were not recommended as reliable ***-term exposure to VR>1.3,V_(Ecorr)>7.53,a

关键词： Acute respiratory distress syndr ome Mechanical ventilation Dead space 28-day mortality

Clinical practice guidelines for nutritional assessment and monitoring of adult ICU patients in China

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Journal of Intensive medicine 2024年第2期4卷 137-159页

作者： Xiangdong Guan Dechang Chen Yuan Xu Chinese Society of critical care medicine department of critical care medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of critical care medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of critical care medicine Beijing Tsinghua Changgung HospitalBeijingChina 不详

The Chinese Society of critical care medicine(CSCCM)has developed clinical practice guidelines for nutrition assessment and monitoring for patients in adult intensive care units(ICUs)in *** guideline focuses on nutrition evaluation and metabolic monitoring to achieve optimal and personalized nutrition therapy for critically ill *** guideline was developed by experts in critical care medicine and evidence-based medicine methodology and was developed after a thorough review of the system and a summary of relevant trials or studies published from 2000 to July 2023.A total of 18 recommendations were formed and consensus was reached through discussions and reviews by expert groups in critical care medicine,parenteral and enteral nutrition,and *** recommendations are based on currently available evidence and cover several key fields,including screening and assessment,evaluation and assessment of enteral feeding intolerance,metabolic and nutritional measurement and monitoring during nutrition therapy,and organ function evaluation related to nutrition *** question was analyzed according to the Population,Intervention,Comparison,and Outcome(PICO)*** addition,interpretations were provided for four questions that did not reach a consensus but may have potential clinical and research *** plan is to update this nutrition assessment and monitoring guideline using the international guideline update method within 3–5 years.

关键词： Adults critical illness Intensive care unit Nutriti on Nutriti on assessment and monitoring Guideline Recommendations Chinese Society of critical care medicine-Chinese Medical Association(CSCCM-CMA)

Nasogastric tube syndrome:A Meta-summary of case reports

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World Journal of Clinical Cases 2024年第1期12卷 119-129页

作者： Deven Juneja Prashant Nasa Gunjan Chanchalani Ravi Jain department of critical care medicine Max Super Speciality HospitalNew Delhi 110017India department of critical care medicine NMC Specialty HospitalDubai 7832United Arab Emirates department of critical care medicine Karamshibhai Jethabhai Somaiya Hospital and Research CentreMumbai 400022India department of critical care medicine Mahatma Gandhi Medical College and HospitalJaipur 302022RajasthanIndia

BACKGROUND Since its description in 1790 by Hunter,the nasogastric tube(NGT)is commonly used in any healthcare setting for alleviating gastrointestinal symptoms or enteral ***,the risks associated with its placement are often *** airway obstruction with a NGT is an uncommon but potentially life-threatening *** syndrome is characterized by the presence of an NGT,throat pain and vocal cord(VC)paralysis,usually *** is poten-tially life–threatening,and early diagnosis is the key to the prevention of fatal upper airway ***,fewer cases may have been reported than might have occurred,primarily due to the clinicians'*** lack of specific signs and symptoms and the inability to prove temporal relation with NGT insertion has made diagnosing the syndrome quite *** To review and collate the data from the published case reports and case series to understand the possible risk factors,early warning signs and symptoms for timely detection to prevent the manifestation of the complete syndrome with life-threatening airway *** We conducted a systematic search for this meta-summary from the database of PubMed,EMBASE,Reference Citation Analysis(https://***/)and Google scholar,from all the past studies till August *** search terms included major MESH terms"Nasogastric tube","Intubation,Gastrointestinal","Vocal Cord Paralysis",and“Syndrome”.All the case reports and case series were evaluated,and the data were extracted for patient demographics,clinical symptomatology,diagnostic and therapeutic interventions,clinical course and outcomes.A datasheet for evaluation was further *** Twenty-seven cases,from five case series and 13 case reports,of NGT syndrome were retrieved from our *** was male predominance(17,62.96%),and age at presentation ranged from 28 to 86 *** patients had diabetes mellitus(37.04%),and nine were hyperte

关键词： Nasogastric tube Nasogastric tube syndrome Ryle’s tube Sofferman syndrome Vocal cord paralysis

Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

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World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： Yu-Cong Wang Xin-Yang Jin Zheng Lei Xiao-Jiao Liu Yu Liu Bang-Guo Zhang Jian Gong Lie-Tao Wang Lv-Yuan Shi Ding-Yuan Wan Xin Fu Lu-Ping Wang Ai-Jia Ma Yi-Song Cheng Jing Yang Min He Xiao-Dong Jin Yan Kang Bo Wang Zhong-Wei Zhang Qin Wu department of critical care medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina School of Pharmacy Macao University of Science and TechnologyMacao 999078China department of critical care medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina department of critical care medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina department of critical care medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina department of critical care medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina department of critical care medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is *** study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on *** To assess the incidence of GI symptoms associated with heatstroke and its impact on *** Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 *** history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or *** symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were *** characteristics of patients with heatstroke concomitant with GI symptoms were *** regression analyses were performed to determine significant predictors of GI *** A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one *** with GI symptoms had a significantly higher ICU stay compared with those *** mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI *** logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI *** The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence Sunstroke Intensive care units Diarrhea

Reimagining critical care:Trends and shifts in 21st century medicine

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World Journal of critical care medicine 2024年第3期13卷 5-10页

作者： Sai Doppalapudi Bilal Khan Muhammad Adrish Division of Pulmonary and critical care medicine Department of MedicineBronxCare Health System/Icahn School of Medicine at Mount SinaiBronxNY 10467United States Pulmonary William P.Clements High SchoolSugar LandTX 77479United States Section of Pulmonary and critical care medicine Ben Taub Hospital/Baylor College of MedicineHoustonTX 77030United States

primarily driven by advancements in technology,changes in healthcare delivery,and a deeper understanding of disease *** in technology have revolutionized patient monitoring,diagnosis,and treatment in the critical care *** minimally invasive procedures to advances imaging techniques,clinicians now have access to a wide array of tools to assess and manage critically ill patients more *** this editorial we comment on the review article published by Padte S et al wherein they concisely describe the latest developments in critical care medicine.

关键词： Artificintelligenceial Ventilators Extracorporeal organ support Telemedicine critical care

Bibliometric study of sepsis-associated liver injury from 2000 to 2023

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World Journal of Gastroenterology 2024年第30期30卷 3609-3624页

作者： Zheng Zhang Xiao-Jiao Tan Hai-Qing Shi Huan Zhang Jian-Bo Li Xue-Lian Liao department of critical care medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of critical care medicine West China Tianfu Hospital of Sichuan UniversityChengdu 610200Sichuan ProvinceChina

BACKGROUND Sepsis-associated liver injury(SLI)is a severe and prevalent complication of *** To explore the literature on SLI via a bibliometric *** Reviews and articles correlated with SLI published from January 1,2000 to October 28,2023 were searched from the Web of Science Core ***,the searched data were analyzed using VOSviewer,CiteSpace,and R *** There were 787 publications involved in this paper,comprising 745 articles and 42 ***,the United States,and Germany are the primary publication sources in this *** related to SLI primarily focused on mechanisms of pathogenesis,as evidenced by analyzing keywords,references,and the counting of original *** studies mainly involved tumor necrosis factor alpha,inflammation,oxidative stress,and nuclear factor-kappa *** There is significant growth in the research on *** investigations primarily involve basic experiments that aimed at uncovering pathogenic *** to the analyzed literature,the identified pathogenic mechanisms and potential therapeutic targets serve as the foundation for translating findings from basic research to clinical applications.

关键词： Sepsis Liver injury Bibliometric analysis Cite space VOS viewer

Lactate aggravates inflammation through the upregulation of ICAM-1 via GPR81-HSPA12B-mediated signaling in acute lung injury

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中华医学杂志(英文版) 2024年第15期137卷 1885-1887页

作者： Chang Wei Liu Xu Wang Haofei Zhu Xingxing Huang Wei Liu Ling Qiu Haibo Yang Yi department of critical care medicine Jiangsu Provincial Key Laboratory of Critical Care Medicine Zhongda Hospital School of Medicine Southeast University Nanjing Jiangsu China The Medical School Southeast University Nanjing Jiangsu China