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Recent advances in fermentative biohydrogen production

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Progress in Natural Science:Materials International 2008年第3期18卷 253-258页

作者： Xuemei Liu a,b, Nanqi Ren a, Funan Song b, Chuanping Yang b, Aijie Wang a a Harbin Institute of Technology, Harbin 150010, China b Northeast Forestry University, Harbin 150040, China Harbin Institute of Technology Harbin 150010 China Northeast Forestry University Harbin 150040 China

Hydrogen energy, as a kind of clean energy with great potential, has been a hotspot for study worldwide. Based on the recent research on biohydrogen production, this paper gives a brief review on the following aspects: fermentative hydrogen production process and the engineering control statagy, key factors affecting the effciency of hydrogen production, such as substrates, cysteine, metal ions, anaerobic fermentation terminal products, and formic acid and ammonia. Moreover, anaerobic fermentative hydrogen-producing strain and reg- ulation and control of enzyme gene in fermentative hydrogen production are also discussed. Finally, the prospect of anaerobic fermen- tative biohydrogen production is proposed in three study areas, namely developing new techniques for breeding hydrogen-producing bacteria, exploitations of more strains and gene resources, and intensifying the application of microbial molecular breeding in hydrogen production.

关键词： Fermentation Biohydrogen production Regulation and control Novel strains

Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 968-978页

作者： Ying-Qiao Zhang Qing-Hao Liu Lu Liu Peng-Yu Guo Run-Ze Wang Zhi-Chang Ba Department of Radiology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Department of Digestive Internal Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

BACKGROUND Traditional treatments for pancreatic cancer(PC)are *** therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including ***,the mitochondrial concentration of the photosensitizer,such as verteporfin,is *** To investigate the distribution of fluorescence of verteporfin in PC cells treated with antitumor drugs,*** Workable survival rates of PC cells(AsPC-1,BxPC-3)were determined with chemotherapy[doxorubicin(DOX)and gemcitabine(GEM)]and non-chemotherapy[sirolimus(SRL)and cetuximab(CTX)]drugs in vitro,with or without verteporfin,as measured via MTT,flow cytometry,and laser confocal *** cell proliferation was associated with GEM that was more enduring compared with *** laser microscopy allowed observation of GEM-and verteporfin-treated PC cells co-stained with 4’,6-diamidino-2-phenylindole and MitoTracker Green to differentiate living and dead cells and subcellular localization of verteporfin,*** Cell survival significantly dropped upon exposure to either chemotherapy drug,but not to SRL or *** cell lines responded similarly to *** intensity of fluorescence was associated with the concentration of *** experiments using GEM showed that survival rates of the PC cells treated with 10μmol/L verteporfin(but not less)were significantly lower relative to nil *** and dead stained cells treated with GEM were *** GEM treatment,verteporfin was observed primarily in the *** Verteporfin was observed in living *** GEM-treated human PC cells,verteporfin was particularly prevalent in the *** study supports further study of PDT for the treatment of PC after neoadjuvant chemotherapy.

关键词： Photodynamic therapy Pancreatic cancer Verteporfin Mitochondria Chemotherapy Gemcitabine

Clinical Application of the Jiuwei Point

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Journal of Traditional Chinese Medicine 2003年第1期23卷 45-46页

作者：滕殿君王薇 Civil Air Defense Hospital Harbin 150010Heilongjiang Province

Jiuwei (CV 15) is a point mainly used to treat epigastric pain, regurgitation, dysphagia, epilepsy, palpitation, vexation, cough and dyspnea.

关键词： Acupuncture Points Acupuncture Therapy Adult Deglutition Disorders Female Hiccup Humans Male Middle Aged

Arsenic trioxide inhibits metastatic potential of mouse hepatoma H₂₂ cells in vitro and in vivo

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Hepatobiliary & Pancreatic Diseases International 2009年第5期8卷 510-517页

作者： Xian-Shu Zhao Peng-Long Song Bei Sun Hong-Chi Jiang Tie-Fu Liu Department of Gastroenterology Fourth Affiliated Hospital Harbin Medical University Harbin 150010 China.

BACKGROUND:It has been pointed out that only low-dose arsenic trioxide(ATO)presents therapeutic benefits outweighing the toxic side ***-dose ATO can effectively alleviate acute promyelocytic leukemia(APL). However,it is quite challenging in treating solid tumors. The purpose of this study was to investigate the effect of ATO at low concentrations on the metastatic potential of mouse hepatoma H22 cells and the anti-metastatic mechanism of ATO. METHODS:The metastatic potential of H22 cells was evaluated by adhesion,migration and invasion assays after exposure to a low dose of ATO in *** mouse lung metastatic model induced by injection of H22 cells via the tail vein was adopted for the evaluation of metastatic potential. Different proteins in the lysate of H22 cells exposed to ATO at different concentrations were investigated by surface- enhanced laser desorption and ionization time-of-flight mass spectrometry(SELDI-TOF-MS).Finally,Western blotting analyses were made to detect the expression pattern of MMP-2 and nm23-M1 proteins. RESULTS:Significant cell death started at ATO concentrations above 2μmol/*** growth and adhesion potential of H22 cells was inhibited in a time-and dose- dependent manner,and the migration and invasion potential of H22 cells was inhibited in a dose-dependent manner while ATO concentration was below 2μmol/L. Mice injected with ATO at a dose of 0.5 mg/kg had fewer lung ***,mice injected with ATO at a dose of 2 mg/kg or 4 mg/kg had a high mortality rate and more liver injuries.A total of 15 different protein peaks were identified between the lysate of H22 cells treated with ATO and *** proteins that peaked atm/z 5302 and 17207 coincided with MMP-2(fragment) and nm23-M1,*** blotting analyses demonstrated that MMP-2 and MMP-2 fragments were down-regulated and nm23-M1 was up-regulated in H22 cells treated with 2μmol/L ATO for 48 hours. CONCLUSIONS:ATO at a low dose inhibits the metastatic pote

关键词： arsenic trioxide hepatocellular carcinoma neoplasm metastasis surface-enhanced laser desorption and ionization time-of-flight mass spectrometry Western blotting

慢性正已烷中毒11例临床分析与神经电生理检查

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中华劳动卫生职业病杂志 2006年第5期24卷 304-305页

作者：宋莉李晓军杨建军冯克玉 150010 哈尔滨

报告11例慢性正己烷中毒患者,临床主要表现为四肢末端疼痛、麻木、无力、泌汗异常、痛温觉减退、腱反射减弱和肌肉萎缩等,神经电生理检查9例有周围神经的损害,即运动神经和感觉神经传导速度减慢、动作电位的波幅异常及交感神经皮肤电反... 详细信息

报告11例慢性正己烷中毒患者,临床主要表现为四肢末端疼痛、麻木、无力、泌汗异常、痛温觉减退、腱反射减弱和肌肉萎缩等,神经电生理检查9例有周围神经的损害,即运动神经和感觉神经传导速度减慢、动作电位的波幅异常及交感神经皮肤电反应异常。参照诊断标准(GBZ84—2002), 2例诊断为重度中毒,4例中度中毒,5例轻度中毒。入院后给予B族维生素、神经生长因子(金路捷)、地塞米松、血栓通等药物治疗,于3个月后症状开始缓解。

关键词：慢性正己烷中毒交感神经皮肤电反应神经电生理

ROBUST CONTROL OF GAS TUNGSTEN ARC WELDING SYSTEM

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Chinese Journal of Mechanical Engineering 2007年第5期20卷 32-36页

作者： WU Junfeng CHEN Shanben ZHANG Mingjun Department of Automation Harbin University of Science and Technoiogy Harbin 150080. China Institute of Mechanics and Electricity Harbin University of Engineering Harbin 150010 China Welding Institute Shanghai Jiaotong University Shanghai 200030 China nstitute of Mechanics and EIectrcity Harbin University of Engineering Harbin 150010. China

The robust control law for gas tungsten arc welding dynamic process, which is a typical sampled-data system and full of uncertainties, is presented. By using the Lyapunov, second method, the robust control and robust optimal control for a class of sampled-data systems whose underlying continuous-time systems are subjected to structured uncertainties are discussed in time-domain. As a result, some sufficient conditions of robust stability and the corresponding robust control laws are derived. All these results are designed by solving a class of linear matrix inequalities （LMIs） and a class of dynamic optimization problem with LMIs constraints respectively. An example adapted under some experimental conditions in the dynamic process of gas tungsten arc welding system in which the controlled variable is the backside width of weld pool and controlling variable pulse duty ratio, is worked out to illustrate the proposed results, it is shown that the sampling period is the crucial design oarameter.

关键词： Sampled-data system Robust control Linear matrix inequalities (LMIs) Weld pool Pulse duty ratio

An Efficient Hybrid Algorithm for Mining Web Frequent Access Patterns

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Wuhan University Journal of Natural Sciences 2004年第5期9卷 557-560页

作者： ZHANLi-qiang LIUDa-xin InstituteofEconomicandManagement.NortheastForestryUniversity.Harbin150010 Heilongjiang.China DepartmentofScienceofComputer.HarbinEnginceringUniversity.Harbin150001.Heilongjiang.China

We propose an efficient hybrid algorithm WDHP in this paper for mining frequent access patterns. WDHP adopts the techniques of DHP to optimize its performance, which is using hash table to filter candidate set and trimming database. Whenever the database is trimmed to a size less than a specified threshold, the algorithm puts the database into main memory by constructing a tree, and finds frequent patterns on the tree. The experiment shows that WDHP outperform algorithm DHP and main memory based algorithm WAP in execution efficiency.

关键词： frequent access pattern AP-tree hash-table

Spatiotemporal Differences and Classification Regulation of Urbanization Impact on Agricultural Development in Shrinking Areas:A Case Study of 15 Shrinking Cities in Three Provinces of Northeast China

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Chinese Geographical Science 2023年第6期33卷 1053-1067页

作者： CHEN Xiaohong LIU Haihan AN Yongle DAI Yue PAN Wei WANG Ying TANG We College of Geography Science Harbin Normal UniversityHarbin150025China Harbin Urban and Rural Planning&Design Institute Harbin150010China

Studying the impact of urbanization on agricultural development in shrinking areas is important for maintaining food security and promoted agricultural development in *** on the measurement results of the shrinking cities in the three provinces of Northeast China,this paper selects 15 shrinking cities as the research object,and constructs a multi-dimensional index system to explore the impact of the urbanization level of the shrinking areas on the agricultural development in the region since 2007–2019,analyzes the influencing factors and their differences by using the geographically-weighted regression model and Geodetector,and proposes a targeted regulation *** results show that:1)overall,there is a negative correlation between the urbanization level and the agricultural development level in the contracted areas of the three northeastern *** urbanization level in these areas has a certain negative impact on the overall level of agricultural development;2)regarding the time dimension,the impact of urbanization level on the agricultural development level in the contracted areas of the three northeastern provinces gradually increases over time;3)regarding the spatial pattern,the overall impact of shrinking urbanization levels in the three provinces of Northeast China on the agricultural development shows a significant distribution pattern of high in the east and low in the west;4)the total population and natural population growth rate at the end of the year were the main factors influencing a certain level of urbanization on agricultural development in the shrinking cities while population density and the urban fixed asset investment rate were the secondary factors;and 5)the main reasons why the level of agricultural development in different cities was affected by the level of urbanization were ***,they can be categorized into areas of population loss and spatial construction,which can be further divided into area of population

关键词： urbanization agricultural development classification and regulation shrinking cities three provinces of Northeast China

Dynamic transfer and driving mechanisms of the coupling and coordination of agricultural resilience and rural land use efficiency in China

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Journal of Geographical Sciences 2024年第8期34卷 1589-1614页

作者： CHEN Xiaohong AN Yongle PAN Wei WANG Ying CHEN Lintao GU Yue LIU Haihan YANG Fan College of Geography Science Harbin Normal UniversityHarbin 150025China Harbin Urban and Rural Planning&Design Institute Harbin 150010China

The joint study of agriculture and rural areas is of great significance for safeguarding agricultural development,revitalizing rural areas,and enhancing farmers'*** paper aims to assess the spatiotemporal evolution characteristics of the coupling and coordination degree of agricultural resilience and rural land use efficiency and their dynamic transfer law and driving mechanisms,based on panel data of 31 provinces(municipalities and autonomous regions)in China from 2010 to *** results showed:(1)Good coupling and coordination of agricultural resilience and rural land use efficiency,with reduced temporal differentiation degrees between regions;(2)Significant spatial autocorrelation between the overall coupling and coordination degrees of agricultural resilience and rural land use efficiency,forming cold spot and hot spot spatial patterns in the western and eastern parts,respectively,with a central transition area;(3)A spillover effect of the dynamic transfer process,with a manifested specific law as"club convergence","Matthew effect",and progressive development characteristics;(4)The key roles of the natural,social,economic,and policy indicators in the coupling and coordination development process of agricultural resilience and rural land use ***,the selected indicators showed substantial spatial differences in their influences on the coupling and coordination process between provinces.

关键词： agricultural resilience rural land use efficiency coupling and coordination analysis dynamic transfer drivingmechanisms