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Human immune cells＇ behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model

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Cellular & Molecular Immunology 2013年第2期10卷 151-158页

作者： Paula Hoff Patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode Gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit Department of Rheumatelogy and Clinical Immunology Charite University Hospital Berlin Germany German Arthritis Research Center (DRFZ) Berlin Germany berlin-Brandenburg Center for Regenerative Therapies (BCRT) Berlin Germany Julius Wolff Institute Berlin Germany Department of Orthopedics Charite University Hospital Berlin Germany These authors contributed equally to this work

The initial inflammatory phase of bone fracture healing represents a critical step for the outcome of the healing process. However, both the mechanisms initiating this inflammatory phase and the function of immune cells present at the fracture site are poorly understood. In order to study the early events within a fracture hematoma, we established an in vitro fracture hematoma model： we cultured hematomas forming during an osteotomy （artificial bone fracture） of the femur during total hip arthroplasty （THA） in vitro under bioenergetically controlled conditions. This model allowed us to monitor immune cell populations, cell survival and cytokine expression during the early phase following a fracture. Moreover, this model enabled us to change the bioenergetical conditions in order to mimic the in vivo situation, which is assumed to be characterized by hypoxia and restricted amounts of nutrients. Using this model, we found that immune cells adapt to hypoxia via the expression of angiogenic factors, chemoattractants and pro-inflammatory molecules. In addition, combined restriction of oxygen and nutrient supply enhanced the selective survival of lymphocytes in comparison with that of myeloid derived cells （i.e., neutrophils）. Of note, non-restricted bioenergetical conditions did not show any similar effects regarding cytokine expression and/or different survival rates of immune cell subsets. In conclusion, we found that the bioenergetical conditions are among the crucial factors inducing the initial inflammatory phase of fracture healing and are thus a critical step for influencing survival and function of immune cells in the early fracture hematoma.

关键词： apoptosis fracture hematoma model hypoxia immune cells inflammation

Insights into the kinetics–morphology relationship of 1-, 2-, and 3D TiNb_(2)O_(7) anodes for Li-ion storage

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Nano Research 2024年第4期17卷 2770-2780页

作者： Wenlei Xu Yaolin Xu Veronika Grzimek Andrea Martin Thorsten Schultz Patrícia ARusso Yan Lu Norbert Koch Nicola Pinna Department of Chemistry IRIS Adlershof and the Center for the Science of Materials BerlinHumboldt-Universität zu BerlinBrook-Taylor-Str.212489 BerlinGermany Department of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und EnergieHahn-Meitner-Platz 114109 BerlinGermany Institut für Physik and IRIS Adlershof Humboldt-Universität zu BerlinBrook-Taylor-Str.212489 BerlinGermany Joint Research Group of Molecular Systems Helmholtz-Zentrum Berlin für Materialien und Energie12489 BerlinGermany

Understanding the influence of electrode material’s morphology on electrochemical behavior is of great significance for the development of rechargeable batteries,however,such studies are often limited by the inability to precisely control the morphology of electrode ***,nanostructured titanium niobium oxides(TiNb_(2)O_(7))with three different morphologies(one-dimensional(1D),two-dimensional(2D),and three-dimensional(3D))were synthesized via a facile microwave-assisted solvothermal *** influence of the morphological dimension of TiNb_(2)O_(7) as electrode material on the electrochemical performance in Li-ion batteries(LIBs)and the underlying correlation with the electrochemical kinetics were studied in detail.2D TiNb_(2)O_(7)(TNO-2D)shows a superior rate capability and cycling stability,associated with improved kinetics for charge transfer and Li-ion diffusion,compared to the 1D and 3D *** X-ray diffraction measurements reveal the structural stability and crystallographic evolution of TNO-2D upon lithiation and delithiation and correlate the Li-ion diffusion kinetics with the lattice evolution during battery charge and ***,carbon-coated TNO-2D achieves enhanced rate capability(205 mAh·g^(-1) at 50 C)and long-term cycling stability(87%after 1000 cycles at 5 C).This work provides insights into the rational morphology design of electrode materials for accelerated charge transfer and enhanced fast-charging capability,pushing forward the development of electrode materials for high-power rechargeable batteries in future energy storage.

关键词： morphological dimension electrochemical kinetics lithium-ion batteries TiNb_(2)O_(7) structural evolution

Tuning two-dimensional electron and hole gases at LaInO_(3)/BaSnO_(3) interfaces by polar distortions,termination,and thickness

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npj Computational Materials 2021年第1期7卷 1584-1591页

作者： Wahib Aggoune Claudia Draxl Institut für Physik and IRIS Adlershof Humboldt-Universität zu Berlin12489 BerlinGermany

Two-dimensional electron gases(2DEG),arising due to quantum confinement at interfaces between transparent conducting oxides,have received tremendous attention in view of electronic ***,we explore the potential of interfaces formed by two lattice-matched wide-gap oxides of emerging interest,i.e.,the polar,orthorhombic perovskite LaInO_(3)and the nonpolar,cubic perovskite BaSnO_(3),employing first-principles *** find that the polar discontinuity at the interface is mainly compensated by electronic relaxation through charge transfer from the LaInO_(3)to the BaSnO_(3)*** leads to the formation of a 2DEG hosted by the highly dispersive Sn-s-derived conduction band and a 2D hole gas of O-p character,strongly localized inside LaInO_(3).We rationalize how polar distortions,termination,thickness,and dimensionality of the system(periodic or non-periodic)can be exploited in view of tailoring the 2DEG characteristics,and why this material is superior to the most studied prototype LaAlO_(3)/SrTiO_(3).

关键词： termination gases distortion

Hair follicles as a target structure for nanoparticles

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Journal of Innovative Optical Health Sciences 2015年第4期8卷 2-9页

作者： J.Lademann F.Knorr H.Richter S.Jung M.C.Meinke E.Rühl U.Alexiev M.Calderon A.Patzelt Center of Experimental and Applied Cutaneous Physiology Department of Dermatology Venereology and Allergology Charite-Universitatsmedizin Berlin Chariteplatz 1Berlin 10117Germany Physical Chemistry Institute of Chemistry and Biochemistry Freie Universitat Berlin Takustr.3Berlin 14195Germany Department of Physics Freie Universitat Berlin Arnimallee 14Berlin 14195Germany

For at least two decades,nanoparticles have been investigated for their capability to deliver topically applied substances through the skin *** on findings that nanoparticles are highly suitable for penetrating the blood--brain barrier,their use for drug delivery through the skin has become a topic of intense *** spite of the research efforts by academia and industry,a commercial product permitting the nanoparticle-assisted delivery of topically applied drugs has not yet been ***,nanoparticles of approximately 600 nm in diameter have been shown to penetrate fficiently into the hair fllieles where they can be stored for several *** successful loading of nanoparticles with drugs and their triggered release inside the hair fllile may present an ideal method for localized drug *** on the particle size,such a method would permit targeting specific structures in the hair fllicles such a stem ells or immune cells or blood vessels found in the vicinity of the hair follicles.

关键词： Skin barrier penetration stratum corrneum hair fllicles triggered release

Strength of adhesive contacts: Influence of contact geometry and material gradients

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Friction 2017年第3期5卷 308-325页

作者： Valentin L.POPOV Roman POHRT Qiang LI Institute of Mechanics Technische Universit(a)t Berlin Berlin 10623 GermanyNational Research Tomsk Polytechnic University Tomsk 634050 Russia Institute of Mechanics Technische Universit(a)t Berlin Berlin 10623 Germany

The strength of an adhesive contact between two bodies can strongly depend on the macroscopic and microscopic shape of the *** the past,the influence of roughness has been investigated ***,even in the presence of perfectly smooth surfaces,geometry can come into play in form of the macroscopic shape of the contacting *** we present numerical and experimental results for contacts of rigid punches with flat but oddly shaped face contacting a soft,adhesive *** it is carefully pulled off,we find that in contrast to circular shapes,detachment occurs not instantaneously but detachment fronts start at pointed comers and travel inwards,until the final configuration is reached which for macroscopically isotropic shapes is almost *** elongated indenters,the final shape resembles the original one with rounded *** describe the influence of the shape of the stamp both experimentally and *** simulations are performed using a new formulation of the boundary element method for simulation of adhesive contacts suggested by Pohrt and *** is based on a local,mesh dependent detachment criterion which is derived from the Griffith principle of balance of released elastic energy and the work of *** validation of the suggested method is made both by comparison with known analytical solutions and with *** method is applied for simulating the detachment of flat-ended indenters with square,triangle or rectangular shape of cross-section as well as shapes with various kinds of faults and to 'brushes'.The method is extended for describing power-law gradient media.

关键词： adhesion boundary element method (BEM) flat-ended indenters,gradient media

The Holocene Palaeoclimatic change in southern vicinity of Tengger Desert

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Chinese Science Bulletin 1999年第6期44卷 550-555页

作者： H.-J. Pachur B. Wuenneman Geomorphologic Lab. Institute of Geography FU BerlinGeomorphologic Lab. Institute of Geography FU Berlin 14195 Berlin Germany 14195 Berlin Germany

Through stratigraphy and chronology studies on Hongshui River section located at the southern vicinity of Tengger Desert, and based on the analysis results of TOC, TIC, elements, stable oxygen isotope that possess a h... 详细信息

关键词： Tengger Desert Holocene Paleaoclimate.

Absent MicroRNAs in Different Tissues of Patients with Acquired Cardiomyopathy

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 224-234页

作者： Christine S. Siegismund Maria Rohde Uwe Kiihl Felicitas Escher Heinz Peter Schultheiss Dirk Lassner Institute for Cardiac Diagnostics and Therapy(IKDT) 12203 BerlinGermany Department of Cardiology Campus VirchowCharite-University Hospital Berlin13353 BerlinGermany

MicroRNAs （miRNAs） can be found in a wide range of tissues and body fluids, and their specific signatures can be used to determine diseases or predict clinical courses. The miRNA profiles in biological samples （tissue, serum, peripheral blood mononuelear cells or other body fluids） differ significantly even in the same patient and therefore have their own specificity for the presented condition. Complex profiles of deregulated miRNAs are of high interest, whereas the importance of non-expressed miRNAs was ignored. Since miRNAs regulate gene expression rather negatively, absent miRNAs could indicate genes with unaltered expression that therefore are normally expressed in specific compartments or under specific disease situations. For the first time, non-detectable miRNAs in different tissues and body fluids from patients with different diseases （cardiomyopathies, Alzheimer＇s disease, bladder cancer, and ocular cancer） were analyzed and compared in this study, miRNA expression data were generated by microarray or TaqMan PCR-based platforms. Lists of absent miRNAs of primarily cardiac patients （myocardium, blood cells, and serum） were clustered and analyzed for potentially involved pathways using two prediction platforms, i.e., miRNA enrichment analysis and annotation tool （miEAA） and DIANA miRPath. Extensive search in biomedical publication databases for the relevance of non-expressed miRNAs in predicted pathways revealed no evidence for their involvement in heart-related pathways as indicated by software tools, confirming proposed approach.

关键词： Cardiomyopathy Heart muscle biopsy Absent mi RNAs Peripheral blood mononuclear cell Serum

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云南武定早寒武世关山动物群棘皮动物化石

科学通报 2006年第11期51卷 1366-1368页

作者：胡世学罗惠麟侯蜀光 Bernd-Dietrich Erdtmann 云南省地质科学研究所 Technische Universitt berlin D-13355 berlin Germany

报道了云南早寒武世乌龙箐组关山动物群中新发现的始海百合类棘皮动物化石．关山动物群始海百合是目前所发现的最早的始海百合类之一,具腕、萼和柄,其萼板形态简单,无缝孔和瘤突,腕长,呈旋卷状,柄较长,柄与萼的长度之比较大．关山动物... 详细信息

报道了云南早寒武世乌龙箐组关山动物群中新发现的始海百合类棘皮动物化石．关山动物群始海百合是目前所发现的最早的始海百合类之一,具腕、萼和柄,其萼板形态简单,无缝孔和瘤突,腕长,呈旋卷状,柄较长,柄与萼的长度之比较大．关山动物群始海百合类棘皮动物的发现,不仅对研究棘皮动物的早期演化提供了新的线索和材料,而且对研究早期棘皮动物和始海百合类生态习性变迁也有着重要的意义．

关键词：云南早寒武世乌龙箐组关山动物群始海百合

Bionic Photovoltaic Panels Bio-Inspired by Green Leaves

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Journal of Bionic Engineering 2010年第3期7卷 284-293页

作者： MatthiasZhr Dennis Friedrich Tania Y.Kloth Gerhard Goldmann Helmut Tributsch Technische Fachhochschule berlin Helmholtz-Zentrum

In strong solar light, silicon solar panels can heat up by 70℃ and, thereby, loose approximately one third of their efficiencyfor electricity generation. Leaf structures of plants on the other hand, have developed a series of technological adaptations,which allow them to limit their temperature to 40-45℃ in full sunlight, even if water evaporation is suppressed. This is accomplishedby several strategies such as limitation of leaf size, optimization of aerodynamics in wind, limitation of absorbedsolar energy only to the useful fraction of radiation and by efficient thermal emission. Optical and infrared thermographicmeasurements under a solar simulator and in a streaming channel were used to investigate the corresponding properties of leavesand to identify suitable bionic model systems. Experiments started with the serrated structure of ordinary green leaves distributedover typical twig structures and finally identified the Australian palm tree Licuala ramsayi as a more useful bionic model. Itcombines a large area for solar energy harvesting with optimized aerodynamic properties for cooling and is able to restructureitself as a protection against strong winds. The bionic models, which were constructed and built, are analyzed and discussed.

关键词： bionics photovoltaic panel green leaves heat control Licuala ramsayi